JP3755536B2 - Ｍｎ遺伝子およびｍｎ蛋白質 - Google Patents

Ｍｎ遺伝子およびｍｎ蛋白質 Download PDF

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Publication number
JP3755536B2
JP3755536B2 JP51592893A JP51592893A JP3755536B2 JP 3755536 B2 JP3755536 B2 JP 3755536B2 JP 51592893 A JP51592893 A JP 51592893A JP 51592893 A JP51592893 A JP 51592893A JP 3755536 B2 JP3755536 B2 JP 3755536B2
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JP
Japan
Prior art keywords
protein
polypeptide
sequence
cells
seq
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Expired - Lifetime
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JP51592893A
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English (en)
Japanese (ja)
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JPH07508160A (ja
Inventor
ザバダ，ヤン
パストレコヴァ，シルヴィア
パストレク，ヤロミール
Original Assignee
バイエル コーポレーション
インスティテュート オブ ヴァイロロジー
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25745325&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP3755536(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by バイエル コーポレーション, インスティテュート オブ ヴァイロロジー filed Critical バイエル コーポレーション
Publication of JPH07508160A publication Critical patent/JPH07508160A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP51592893A 1992-03-11 1993-03-08 Ｍｎ遺伝子およびｍｎ蛋白質 Expired - Lifetime JP3755536B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CS709-92 1992-03-11
CS70992 1992-03-11
US964,589 1992-10-21
US07/964,589 US5387676A (en) 1992-03-11 1992-10-21 MN gene and protein
PCT/US1993/002024 WO1993018152A1 (en) 1992-03-11 1993-03-08 Mn gene and protein

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2005297594A Division JP4624900B2 (ja) 1992-03-11 2005-10-12 Ｍｎ遺伝子およびｍｎ蛋白質

Publications (2)

Publication Number Publication Date
JPH07508160A JPH07508160A (ja) 1995-09-14
JP3755536B2 true JP3755536B2 (ja) 2006-03-15

Family

ID=25745325

Family Applications (3)

Application Number Title Priority Date Filing Date
JP51592893A Expired - Lifetime JP3755536B2 (ja) 1992-03-11 1993-03-08 Ｍｎ遺伝子およびｍｎ蛋白質
JP2005297594A Expired - Lifetime JP4624900B2 (ja) 1992-03-11 2005-10-12 Ｍｎ遺伝子およびｍｎ蛋白質
JP2010200720A Expired - Lifetime JP4865896B2 (ja) 1992-03-11 2010-09-08 Ｍｎ遺伝子およびｍｎ蛋白質

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2005297594A Expired - Lifetime JP4624900B2 (ja) 1992-03-11 2005-10-12 Ｍｎ遺伝子およびｍｎ蛋白質
JP2010200720A Expired - Lifetime JP4865896B2 (ja) 1992-03-11 2010-09-08 Ｍｎ遺伝子およびｍｎ蛋白質

Country Status (8)

Country Link
US (5) US5387676A (enExample)
EP (1) EP0637336B1 (enExample)
JP (3) JP3755536B2 (enExample)
AU (1) AU669694B2 (enExample)
CA (1) CA2131826C (enExample)
DE (1) DE69325577T2 (enExample)
NO (1) NO314191B1 (enExample)
WO (1) WO1993018152A1 (enExample)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030206899A1 (en) * 1991-03-29 2003-11-06 Genentech, Inc. Vascular endothelial cell growth factor antagonists
US5989838A (en) * 1992-03-11 1999-11-23 Institute Of Virology, Slovak Academy Of Sciences Immunological methods of detecting MN proteins and MN polypeptides
US6204370B1 (en) * 1992-03-11 2001-03-20 Institute Of Virology, Slovak Academy Of Sciences MN gene and protein
US5972353A (en) * 1992-03-11 1999-10-26 Institute Of Virology, Slovak Academy Of Sciences MN proteins, polypeptides, fusion proteins and fusion polypeptides
US6297051B1 (en) 1997-01-24 2001-10-02 Institute Of Virology, Slovak Academy Of Sciences MN gene and protein
US6027887A (en) * 1992-03-11 2000-02-22 Institute Of Virology, Solvak Academy Of Sciences MN gene and protein
US6774117B1 (en) * 1992-03-11 2004-08-10 Institute Of Virology, Slovak Academy Of Sciences MN gene and protein
US6297041B1 (en) 1992-03-11 2001-10-02 Institute Of Virology, Slovak Academy Of Sciences MN gene and protein
US5955075A (en) * 1992-03-11 1999-09-21 Institute Of Virology, Slovak Academy Of Sciences Method of inhibiting tumor growth using antibodies to MN protein
US5981711A (en) * 1992-03-11 1999-11-09 Institute Of Virology, Slovak Academy Of Sciences MN-specific antibodies and hybridomas
US6093548A (en) * 1992-03-11 2000-07-25 Institute Of Virology, Slovak Academy Of Sciences Detection and quantitation of MN-specific antibodies.
US6069242A (en) * 1992-03-11 2000-05-30 Institute Of Virology, Slovak Academy Of Sciences MN gene and protein
US5387676A (en) * 1992-03-11 1995-02-07 Ciba Corning Diagnostics Corp. MN gene and protein
WO1995034650A2 (en) * 1994-06-15 1995-12-21 Ciba Corning Diagnostics Corp. Mn gene and protein
ES2339461T3 (es) * 1994-06-15 2010-05-20 Institute Of Virology Gen y proteina mn.
US5744460A (en) * 1996-03-07 1998-04-28 Novartis Corporation Combination for treatment of proliferative diseases
US5858673A (en) * 1996-06-24 1999-01-12 Charlotte-Mecklenburg Hospital Authority Method for detecting prostate cells
US6087098A (en) * 1997-04-15 2000-07-11 The Trustees Of Columbia University In The City Of New York Enhanced reverse transcriptase polymerase chain assay to detect MN in patients with renal cell carcinoma
US7713704B1 (en) 1998-10-23 2010-05-11 Institute Of Virology Of The Slovak Academy Of Science MN gene and protein
US6403327B1 (en) 1999-08-05 2002-06-11 The Regents Of The University Of California Diagnostic method using expression of MN/CA9 protein in ASCUS Pap smears
US6379907B1 (en) 1999-08-05 2002-04-30 The Regents Of The University Of California Diagnostic method using expression of MN/CA9 protein in AGUS Pap smears
US20080146780A1 (en) * 1999-10-22 2008-06-19 Jan Zavada MN Gene and Protein
US20100135980A1 (en) * 2000-10-16 2010-06-03 Rodriguez Victorio C Therapeutic and prophylactic uses of cell specific carbonic anhydrase enzymes in treating aging, disorders of aging, cancer, as growth factors, and as an alternative to stem cell therapy
EP1733736B1 (en) 2001-02-07 2015-02-25 Wilex AG Method of producing recombinant antibodies against tumours
US20040077081A1 (en) * 2001-02-07 2004-04-22 Egbert Oosterwijk Hybridoma cell line g250 and its use for producing monoclonal antibodies
AU2002252724A1 (en) * 2001-04-23 2002-11-05 Quark Biotech, Inc. The 76a11 polypeptide and uses thereof
AU2002351208A1 (en) * 2001-12-03 2003-06-17 Abgenix, Inc. Antibodies against carbonic anhydrase IX (CA IX) tumor antigen
US7910549B2 (en) 2001-12-13 2011-03-22 Institute Of Virology Of The Slovak Academy Of Sciences MN gene and protein
ATE444308T1 (de) 2002-02-13 2009-10-15 Ludwig Inst Cancer Res Fusionsproteine humanisierter g250-spezifischer antikörper sowie verwendungen davon
AU2003217606C1 (en) * 2002-02-21 2008-07-17 Institute Of Virology Soluble Form of Carbonic Anhydrase IX (s-CA IX), Assays to Detect s-CA IX, CA IXs Coexpression with HER-2/neu/c-erbB-2 and CA IX-Specific Monoclonal Antibodies to Non-Immunodominant Epitopes
DK2508596T3 (en) 2002-02-21 2015-10-19 Inst Virology MN / CA IX-specific monoclonal antibodies generated from MN / CA IX-poor mice, as well as methods of use.
US20090162382A1 (en) * 2002-03-01 2009-06-25 Bernett Matthew J Optimized ca9 antibodies and methods of using the same
ATE437235T1 (de) * 2002-04-16 2009-08-15 Univ California Verfahren zur prognose von nierenzellkarzinom und behandlungsauswahl mit carboanhydrase ix
US20030232030A1 (en) * 2002-06-12 2003-12-18 L'oreal Compositions containing at least one oil structured with at least one silicone-polyamide polymer, and at least one gelling agent and methods of using the same
ATE537842T1 (de) * 2002-07-01 2012-01-15 Wilex Ag Zusammesetzungen von cg250 und il-2 oder von cg250 und ifn-alpha zur krebsbehandlung des nierenzell karzinoms
US20090252738A1 (en) * 2002-08-23 2009-10-08 Novartis Vaccines And Diagnostics, Inc. Compositions and methods of therapy for cancers characterized by expression of the tumor-associated antigen mn/ca ix
EP1569633A4 (en) 2002-11-26 2008-03-05 Inst Virology CA-IX SPECIFIC HEMMER
US7524634B2 (en) * 2003-10-16 2009-04-28 Institute Of Virology, Slovak Academy Of Sciences MN/CA IX and cancer prognosis
AU2005241093B2 (en) * 2004-05-04 2008-06-05 Institute Of Virology Of Slovak Academy Of Sciences MN/CA IX/ CA9 and renal cancer prognosis
EP1763367A2 (en) * 2004-07-02 2007-03-21 Wilex AG Improved adjuvant therapy of g250-expressing tumors
US20090196850A1 (en) 2005-01-06 2009-08-06 Novo Nordisk A/S Anti-Kir Combination Treatments and Methods
DOP2006000277A (es) * 2005-12-12 2007-08-31 Bayer Pharmaceuticals Corp Anticuerpos anti mn y métodos para su utilización
US20080038251A1 (en) * 2006-03-20 2008-02-14 Silvia Pastorekova MN/CA IX and MAPK inhibition
US20100056611A1 (en) * 2006-10-12 2010-03-04 Jaromir Pastorek MN/CA9 Splice Variants
US7820159B2 (en) * 2006-10-31 2010-10-26 Instiute of Virology of the Slovak Academy of Sciences MN/CA IX and EGFR pathway inhibition
US8097423B2 (en) * 2007-07-30 2012-01-17 Institute Of Virology MN/CA IX and breast cancer therapy
US7919006B2 (en) * 2007-10-31 2011-04-05 Freescale Semiconductor, Inc. Method of anti-stiction dimple formation under MEMS
WO2009056342A1 (en) 2007-11-02 2009-05-07 Wilex Ag Binding epitopes for g250 antibody
WO2009059281A1 (en) * 2007-11-02 2009-05-07 Health Research Inc. Compositions and methods for using ca9 protein to stimulate an immune response
ES2632353T3 (es) 2009-09-15 2017-09-12 Wilex Ag Detección selectiva de metástasis en carcinoma renal de células claras
US8993347B2 (en) * 2009-12-17 2015-03-31 Cornell University Methods for detecting antibodies in mucosal samples and device for sampling mucosal material
BR112015020061A8 (pt) 2013-02-22 2018-01-23 Wilex Ag composto alvo anidrase carbônica ix (caix) para tratamento de câncer, seus usos, composição farmcêutica, e método para diagnosticar, prognosticar e/ou classificar um câncer
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
WO2016070016A1 (en) 2014-10-31 2016-05-06 Massachusetts Institute Of Technology Compositions and methods for forming emulsions
US12625134B2 (en) 2014-10-31 2026-05-12 Massachusetts Institute Of Technology Complex liquid crystal droplets
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US20190170737A1 (en) 2016-09-19 2019-06-06 Massachusetts Institute Of Technology Systems including janus droplets
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US12274993B2 (en) 2019-09-18 2025-04-15 Massachusetts Institute Of Technology Systems and methods for affecting interactions of electromagnetic radiation with janus droplets for sensitive detection of species
IL292413A (en) 2019-11-05 2022-06-01 Mabpro A S Humanized anti-ca ix antibodies and methods of using them

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5225539A (en) * 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
EP0366707A1 (en) * 1987-05-06 1990-05-09 OOSTERWIJK, Egbert Monoclonal antibodies to renal cell carcinoma
IL162181A (en) * 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
US5981711A (en) * 1992-03-11 1999-11-09 Institute Of Virology, Slovak Academy Of Sciences MN-specific antibodies and hybridomas
US5387676A (en) * 1992-03-11 1995-02-07 Ciba Corning Diagnostics Corp. MN gene and protein
WO1995034650A2 (en) * 1994-06-15 1995-12-21 Ciba Corning Diagnostics Corp. Mn gene and protein

Also Published As

Publication number Publication date
EP0637336A1 (en) 1995-02-08
JP4624900B2 (ja) 2011-02-02
JP2006083179A (ja) 2006-03-30
EP0637336B1 (en) 1999-07-07
NO314191B1 (no) 2003-02-10
CA2131826A1 (en) 1993-09-16
AU669694B2 (en) 1996-06-20
NO943344L (no) 1994-09-09
NO943344D0 (no) 1994-09-09
WO1993018152A1 (en) 1993-09-16
US5387676A (en) 1995-02-07
DE69325577T2 (de) 2000-01-13
CA2131826C (en) 2000-05-16
US20080221309A1 (en) 2008-09-11
US7816496B2 (en) 2010-10-19
DE69325577D1 (de) 1999-08-12
US6051226A (en) 2000-04-18
AU3792793A (en) 1993-10-05
JP4865896B2 (ja) 2012-02-01
JPH07508160A (ja) 1995-09-14
US20070255043A1 (en) 2007-11-01
JP2011036254A (ja) 2011-02-24
US6004535A (en) 1999-12-21

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