JP3606872B2 - ニチニチソウからの抗有糸分裂性の２成分アルカロイド誘導体 - Google Patents

ニチニチソウからの抗有糸分裂性の２成分アルカロイド誘導体 Download PDF

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Publication number
JP3606872B2
JP3606872B2 JP50497395A JP50497395A JP3606872B2 JP 3606872 B2 JP3606872 B2 JP 3606872B2 JP 50497395 A JP50497395 A JP 50497395A JP 50497395 A JP50497395 A JP 50497395A JP 3606872 B2 JP3606872 B2 JP 3606872B2
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Japan
Prior art keywords
compound
general formula
producing
group
dihydrovinorelbine
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Expired - Lifetime
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JP50497395A
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English (en)
Japanese (ja)
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JPH09500634A (ja
Inventor
ジャクジー，ジャン‐クロード
ファイ，ジャック
ベリエ，クリスチャン
ビグ，ドゥニ
ジュアネトー，マリー‐ポール
ジュニノ，ファビアン
クルチンスキー，アンナ
キス，ロベール
Original Assignee
ピエール、ファーブル、メディカマン
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Application filed by ピエール、ファーブル、メディカマン filed Critical ピエール、ファーブル、メディカマン
Publication of JPH09500634A publication Critical patent/JPH09500634A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP50497395A 1993-07-21 1994-07-19 ニチニチソウからの抗有糸分裂性の２成分アルカロイド誘導体 Expired - Lifetime JP3606872B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR93/08948 1993-07-21
FR9308948A FR2707988B1 (fr) 1993-07-21 1993-07-21 Nouveaux dérivés antimitotiques des alcaloïdes binaires du catharantus rosesus, leur procédé de préparation et les compositions pharmaceutiques les comprenant.
PCT/FR1994/000898 WO1995003312A1 (fr) 1993-07-21 1994-07-19 Derives antimitotiques des alcaloides binaires du catharanthus roseus

Publications (2)

Publication Number Publication Date
JPH09500634A JPH09500634A (ja) 1997-01-21
JP3606872B2 true JP3606872B2 (ja) 2005-01-05

Family

ID=9449457

Family Applications (1)

Application Number Title Priority Date Filing Date
JP50497395A Expired - Lifetime JP3606872B2 (ja) 1993-07-21 1994-07-19 ニチニチソウからの抗有糸分裂性の２成分アルカロイド誘導体

Country Status (15)

Country Link
US (1) US5620985A (enExample)
EP (1) EP0710240B1 (enExample)
JP (1) JP3606872B2 (enExample)
AT (1) ATE146477T1 (enExample)
AU (1) AU693460B2 (enExample)
BR (1) BR1100311A (enExample)
CA (1) CA2167694C (enExample)
DE (2) DE122010000012I1 (enExample)
DK (1) DK0710240T3 (enExample)
ES (1) ES2097659T3 (enExample)
FR (2) FR2707988B1 (enExample)
GR (1) GR3022659T3 (enExample)
LU (1) LU91660I2 (enExample)
NZ (2) NZ269172A (enExample)
WO (1) WO1995003312A1 (enExample)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2737208A1 (fr) * 1995-07-28 1997-01-31 Pf Medicament Nouvelles fluorovindolines, precurseurs d'analogues de la vinblastine et de la vinorelbine,leurs procedes de preparation et leur utilisation comme medicament
FR2761990B1 (fr) * 1997-04-10 1999-06-25 Pf Medicament Derives halogenes antimitotiques d'alcaloides de vinca
FR2783522A1 (fr) * 1998-09-21 2000-03-24 Pf Medicament Composes derives d'alcaloides de vinca, leur preparation et leur application en therapeutique
GB0011903D0 (en) * 2000-05-18 2000-07-05 Astrazeneca Ab Combination chemotherapy
US6890558B2 (en) * 2002-05-31 2005-05-10 R.P. Scherer Technologies, Inc. Oral pharmaceutical composition for soft capsules containing vinorelbine and method of treatment
JP5448299B2 (ja) 2003-12-04 2014-03-19 アルバニー モレキュラー リサーチ， インコーポレイテッド ビンカ誘導体
EP1694330A4 (en) 2003-12-04 2009-06-24 Amr Technology Inc DERIVATIVES OF VINORELBINE
FR2863891B1 (fr) * 2003-12-23 2006-03-24 Pf Medicament Composition pharmaceutique de vinflunine destinee a une administration parentale, procede de preparation et utilisation
US20110015221A1 (en) * 2003-12-23 2011-01-20 Pierre Fabre Medicament Pharmaceutical composition of vinflunine which is intended for parenteral administration preparation method thereof and use of same
ATE507240T1 (de) * 2004-03-05 2011-05-15 Vegenics Pty Ltd Materialien und verfahren für wachstumsfaktorbindende konstrukte
FR2894966B1 (fr) * 2005-12-20 2008-03-14 Pierre Fabre Medicament Sa Nouvelle forme cristalline de la vinflunine
JP5596924B2 (ja) * 2006-02-17 2014-09-24 カスケード プロドラッグ インコーポレイテッド ビンカアルカロイドｎ酸化物および類似体による過剰増殖疾患の処置
CN101108859A (zh) * 2006-07-17 2008-01-23 上海恒瑞医药有限公司 长春碱类化合物、其制备方法及其在医药上的用途
US20080125451A1 (en) * 2006-09-12 2008-05-29 Amr Technology, Inc. Vinorelbine derivatives
US8039453B2 (en) * 2006-09-12 2011-10-18 Albany Molecular Research, Inc. Vinca derivatives
FR2905949B1 (fr) * 2006-09-20 2008-11-21 Pierre Fabre Medicament Sa Derives fluores de catharanthine, leur preparation et leur utilisation comme precurseurs d'alcaloides dimeres de vinca
CN101235046B (zh) * 2007-01-29 2010-09-08 中国科学院上海药物研究所 长春碱衍生物、其制备方法和用途、以及包含该衍生物的药物组合物
FR2912406B1 (fr) 2007-02-13 2009-05-08 Pierre Fabre Medicament Sa Sels cristalins anhydres de vinflunine, procede de preparation et utilisation en tant que medicament et moyen de purification de la vinflunine.
EP1997534A1 (en) * 2007-05-31 2008-12-03 Pierre Fabre Medicament Cancer treatment combination therapy comprising vinflunine and trastuzumab
FR2918566B1 (fr) * 2007-07-11 2009-10-09 Pierre Fabre Medicament Sa Composition pharmaceutique stable d'un sel hydrosoluble de vinflunine.
FR2918567B1 (fr) * 2007-07-11 2012-08-03 Pf Medicament Composition pharmaceutique stable d'un sel hydrosoluble de vinorelbine.
US20090076055A1 (en) * 2007-09-14 2009-03-19 Protia, Llc Deuterium-enriched vinflunine
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
TW201026715A (en) 2008-12-23 2010-07-16 Pharmasset Inc Nucleoside phosphoramidates
JP6104504B2 (ja) 2008-12-23 2017-03-29 ギリアド ファーマセット エルエルシー ヌクレオシド類似体
CL2009002206A1 (es) 2008-12-23 2011-08-26 Gilead Pharmasset Llc Compuestos derivados de pirrolo -(2-3-d]-pirimidin-7(6h)-tetrahidrofuran-2-il fosfonamidato, composicion farmaceutica; y su uso en el tratamiento de enfermedades virales.
ES2575160T3 (es) 2010-03-15 2016-06-24 The Board Of Trustees Of The University Of Illinois Inhibidores de las interacciones que unen la subunidad alfa de la beta integrina-proteína G
CL2011000716A1 (es) 2010-03-31 2012-04-20 Gilead Pharmasset Llc Formas cristalinas 1 6 de (s)-isopropil-2-(((s)-(((2r.3r.4r.5r)-5-(2,4-dioxo-3,4-dihidropirimidin-1(2h)-il)-4-fluoro-3-hidroxi-4-metil tetrahidrofuran-2-il)metoxi)(fenoxi)fosforil)amino)propanoato; composicion y combinacion farmaceutica; y su uso para tratar una infeccion por el virus de la hepatitis c.
EP2655401B1 (en) 2010-12-20 2016-03-09 The Regents of the University of Michigan Inhibitors of the epidermal growth factor receptor-heat shock protein 90 binding interaction
CN103788117A (zh) * 2012-10-30 2014-05-14 何小解 一种脱水长春碱、长春瑞滨及长春氟宁连续化合成工艺
HU230462B1 (hu) 2013-05-30 2016-07-28 Richter Gedeon Nyrt. Új bisz-indol alkaloidok mint rákellenes gyógyszerek
EP3094622A1 (en) 2014-01-15 2016-11-23 Centre National de la Recherche Scientifique (C.N.R.S.) Water soluble 4-azapodophyllotoxin analogs
EP3250611B1 (en) 2015-01-26 2021-04-21 The University of Chicago Car t-cells recognizing cancer-specific il 13r-alpha2
JP7264592B2 (ja) 2015-01-26 2023-04-25 ザ ユニバーシティー オブ シカゴ ＩＬ１３Ｒα２結合剤及び癌治療におけるその使用
CA3014473A1 (en) * 2016-03-09 2017-09-14 Synbias Pharma Ag Vinorelbine monotartrate and its pharmaceutical use
EP3481422A1 (en) 2016-07-06 2019-05-15 Pierre Fabre Medicament Vinflunine and pd1 and/or pdl1 inhibitor as pharmaceutical combination
MA49849A (fr) 2017-08-07 2020-06-17 Amgen Inc Traitement du cancer du sein triple négatif ou du cancer colorectal comportant des métastases hépatiques par un anticorps anti-pd-l1 et un virus oncolytique
WO2020191344A1 (en) 2019-03-20 2020-09-24 The Regents Of The University Of California Claudin-6 bispecific antibodies
SG11202109986TA (en) 2019-03-20 2021-10-28 Univ California Claudin-6 antibodies and drug conjugates
JP2022530241A (ja) 2019-04-30 2022-06-28 インスチトゥート デ メディシーナ モリクラール ジョアン ロボ アントゥネス Ｃｄｋ阻害剤と組み合わせたｒａｎｋ経路阻害剤
WO2020242720A1 (en) 2019-05-02 2020-12-03 University Of Florida Research Foundation, Inc. Compositions for treatment of diffuse intrinsic pontine glioma
EP3986441A1 (en) 2019-06-24 2022-04-27 Amgen Inc. Inhibition of sirp-gamma for cancer treatment
FR3140369B1 (fr) 2022-10-04 2025-07-25 Univ Poitiers Procédé de fluoration et/ou cyclisation d’un alcène ou alcyne aminé en flux continu et installation pour la mise en œuvre du procédé

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2296418B1 (enExample) * 1974-12-30 1978-07-21 Anvar
US4110330A (en) * 1977-05-27 1978-08-29 Eli Lilly And Company 5'-Acetonylvincristine and related compounds
US4203898A (en) * 1977-08-29 1980-05-20 Eli Lilly And Company Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids
US4307100A (en) * 1978-08-24 1981-12-22 Agence Nationale De Valorisation De La Recherche (Anvar) Nor bis-indole compounds usable as medicaments
US4320058A (en) * 1980-12-29 1982-03-16 Eli Lilly And Company 20'-Hydroxyvinblastine and related compounds
HU193772B (en) * 1985-06-12 1987-11-30 Richter Gedeon Vegyeszet Process for producing new nitro-bis-indole derivatives

Also Published As

Publication number Publication date
WO1995003312A1 (fr) 1995-02-02
DE69401216T2 (de) 1997-07-03
FR10C0012I1 (enExample) 2010-04-16
JPH09500634A (ja) 1997-01-21
FR10C0012I2 (enExample) 2011-04-01
CA2167694C (fr) 2007-03-06
US5620985A (en) 1997-04-15
BR1100311A (pt) 1999-08-31
ATE146477T1 (de) 1997-01-15
FR2707988B1 (fr) 1995-10-13
DE122010000012I1 (de) 2010-07-08
GR3022659T3 (en) 1997-05-31
CA2167694A1 (fr) 1995-02-02
AU7266694A (en) 1995-02-20
DK0710240T3 (da) 1997-06-02
NZ328612A (en) 2000-05-26
EP0710240B1 (fr) 1996-12-18
EP0710240A1 (fr) 1996-05-08
FR2707988A1 (fr) 1995-01-27
AU693460B2 (en) 1998-07-02
ES2097659T3 (es) 1997-04-01
NZ269172A (en) 1997-10-24
LU91660I2 (fr) 2010-05-10
DE69401216D1 (de) 1997-01-30

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