FR2894966B1 - Nouvelle forme cristalline de la vinflunine - Google Patents

Nouvelle forme cristalline de la vinflunine

Info

Publication number
FR2894966B1
FR2894966B1 FR0512942A FR0512942A FR2894966B1 FR 2894966 B1 FR2894966 B1 FR 2894966B1 FR 0512942 A FR0512942 A FR 0512942A FR 0512942 A FR0512942 A FR 0512942A FR 2894966 B1 FR2894966 B1 FR 2894966B1
Authority
FR
France
Prior art keywords
vinflunine
crystalline form
new crystalline
new
crystalline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR0512942A
Other languages
English (en)
Other versions
FR2894966A1 (fr
Inventor
Jean Louis Maurel
Richard Pena
Jean Paul Ribet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre Medicament SA
Original Assignee
Pierre Fabre Medicament SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre Medicament SA filed Critical Pierre Fabre Medicament SA
Priority to FR0512942A priority Critical patent/FR2894966B1/fr
Priority to TW095145948A priority patent/TW200733962A/zh
Priority to PCT/EP2006/069843 priority patent/WO2007071648A1/fr
Priority to AU2006328560A priority patent/AU2006328560B2/en
Priority to US12/086,773 priority patent/US20090247564A1/en
Priority to BRPI0620143-1A priority patent/BRPI0620143A2/pt
Priority to CA002633769A priority patent/CA2633769A1/fr
Priority to UAA200809490A priority patent/UA91581C2/ru
Priority to NZ569884A priority patent/NZ569884A/en
Priority to JP2008546414A priority patent/JP2009519996A/ja
Priority to RU2008128317/04A priority patent/RU2426735C2/ru
Priority to CNA2006800476505A priority patent/CN101331139A/zh
Priority to EP06830683A priority patent/EP1971613A1/fr
Priority to KR1020087017456A priority patent/KR101437696B1/ko
Priority to ARP060105672A priority patent/AR058704A1/es
Publication of FR2894966A1 publication Critical patent/FR2894966A1/fr
Application granted granted Critical
Publication of FR2894966B1 publication Critical patent/FR2894966B1/fr
Priority to IL192249A priority patent/IL192249A0/en
Priority to TNP2008000268A priority patent/TNSN08268A1/en
Priority to ZA200806135A priority patent/ZA200806135B/xx
Priority to MA31122A priority patent/MA30164B1/fr
Priority to NO20083186A priority patent/NO20083186L/no
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
    • C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
FR0512942A 2005-12-20 2005-12-20 Nouvelle forme cristalline de la vinflunine Active FR2894966B1 (fr)

Priority Applications (20)

Application Number Priority Date Filing Date Title
FR0512942A FR2894966B1 (fr) 2005-12-20 2005-12-20 Nouvelle forme cristalline de la vinflunine
TW095145948A TW200733962A (en) 2005-12-20 2006-12-12 Novel crystalline form of vinflunine
KR1020087017456A KR101437696B1 (ko) 2005-12-20 2006-12-18 신규한 빈플루닌 결정 형태
US12/086,773 US20090247564A1 (en) 2005-12-20 2006-12-18 Crystalline Form of Vinflunine Ditartrate
BRPI0620143-1A BRPI0620143A2 (pt) 2005-12-20 2006-12-18 forma cristalina de ditartrato de vinflunina
CA002633769A CA2633769A1 (fr) 2005-12-20 2006-12-18 Forme cristalline de ditartrate de vinflunine
UAA200809490A UA91581C2 (en) 2005-12-20 2006-12-18 Crystalline form of vinflunine ditartrate
NZ569884A NZ569884A (en) 2005-12-20 2006-12-18 Crystalline form of vinflunine ditartrate
JP2008546414A JP2009519996A (ja) 2005-12-20 2006-12-18 ビンフルニンジタルトレートの結晶形態
RU2008128317/04A RU2426735C2 (ru) 2005-12-20 2006-12-18 Кристаллическая форма винфлунина дитартрата
PCT/EP2006/069843 WO2007071648A1 (fr) 2005-12-20 2006-12-18 Forme cristalline de ditartrate de vinflunine
EP06830683A EP1971613A1 (fr) 2005-12-20 2006-12-18 Forme cristalline de ditartrate de vinflunine
AU2006328560A AU2006328560B2 (en) 2005-12-20 2006-12-18 Crystalline form of vinflunine ditartrate
CNA2006800476505A CN101331139A (zh) 2005-12-20 2006-12-18 长春氟宁双酒石酸盐的晶型
ARP060105672A AR058704A1 (es) 2005-12-20 2006-12-20 Forma cristalina de vinflunina
IL192249A IL192249A0 (en) 2005-12-20 2008-06-17 Crystalline form of vinflunine ditartrate
TNP2008000268A TNSN08268A1 (en) 2005-12-20 2008-06-18 Crystalline form of vinflunine ditartrate
ZA200806135A ZA200806135B (en) 2005-12-20 2008-07-15 Crystalline form of vinflunine ditartrate
MA31122A MA30164B1 (fr) 2005-12-20 2008-07-16 Nouvelle forme cristalline de la vinflunine
NO20083186A NO20083186L (no) 2005-12-20 2008-07-17 Krystallform av vinfluninditartrat

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0512942A FR2894966B1 (fr) 2005-12-20 2005-12-20 Nouvelle forme cristalline de la vinflunine

Publications (2)

Publication Number Publication Date
FR2894966A1 FR2894966A1 (fr) 2007-06-22
FR2894966B1 true FR2894966B1 (fr) 2008-03-14

Family

ID=36169082

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0512942A Active FR2894966B1 (fr) 2005-12-20 2005-12-20 Nouvelle forme cristalline de la vinflunine

Country Status (20)

Country Link
US (1) US20090247564A1 (fr)
EP (1) EP1971613A1 (fr)
JP (1) JP2009519996A (fr)
KR (1) KR101437696B1 (fr)
CN (1) CN101331139A (fr)
AR (1) AR058704A1 (fr)
AU (1) AU2006328560B2 (fr)
BR (1) BRPI0620143A2 (fr)
CA (1) CA2633769A1 (fr)
FR (1) FR2894966B1 (fr)
IL (1) IL192249A0 (fr)
MA (1) MA30164B1 (fr)
NO (1) NO20083186L (fr)
NZ (1) NZ569884A (fr)
RU (1) RU2426735C2 (fr)
TN (1) TNSN08268A1 (fr)
TW (1) TW200733962A (fr)
UA (1) UA91581C2 (fr)
WO (1) WO2007071648A1 (fr)
ZA (1) ZA200806135B (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2912406B1 (fr) 2007-02-13 2009-05-08 Pierre Fabre Medicament Sa Sels cristalins anhydres de vinflunine, procede de preparation et utilisation en tant que medicament et moyen de purification de la vinflunine.
FR2918566B1 (fr) * 2007-07-11 2009-10-09 Pierre Fabre Medicament Sa Composition pharmaceutique stable d'un sel hydrosoluble de vinflunine.
EP3481422A1 (fr) * 2016-07-06 2019-05-15 Pierre Fabre Medicament Combinaison pharmaceutique comprenant la vinflunine et l'inhibiteur de pd1 et/ou de pdl1

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2154314A1 (en) * 1971-09-28 1973-05-11 Richter Gedeon Vegyeszet Vinca rosea alkaloids - vinblastine, vinleurosine and vincristine selective isolation
JPS5283900A (en) * 1976-01-01 1977-07-13 Lilly Co Eli Novel acidic and ester derivatives of vinblastine vincrystine and roylocidine
HU173379B (hu) * 1976-02-13 1979-04-28 Richter Gedeon Vegyeszet Sposob poluchenija 4-dezacetoksi-vinblastina i kislo-additivnykh solejj
GB2089806B (en) * 1977-11-07 1982-11-24 Lilly Co Eli 4-desacetoxy-oxo-indole-dyhydroindole intermediates
FR2707988B1 (fr) * 1993-07-21 1995-10-13 Pf Medicament Nouveaux dérivés antimitotiques des alcaloïdes binaires du catharantus rosesus, leur procédé de préparation et les compositions pharmaceutiques les comprenant.
FR2761990B1 (fr) 1997-04-10 1999-06-25 Pf Medicament Derives halogenes antimitotiques d'alcaloides de vinca
AR024852A1 (es) * 2000-01-12 2002-10-30 Eriochem Sa Procedimiento para la produccion de ditartrato de 5'-nor-anhidrovinblastina a partir de especies vegetales del genero catharanthus y procedimiento a escala industrial.
US20060147518A1 (en) * 2004-12-30 2006-07-06 Pierre Fabre Medicament Stable solid dispersion of a derivative of vinca alkaloid and process for manufacturing it

Also Published As

Publication number Publication date
KR20080077696A (ko) 2008-08-25
ZA200806135B (en) 2009-08-26
KR101437696B1 (ko) 2014-09-03
NO20083186L (no) 2008-09-11
AU2006328560A1 (en) 2007-06-28
FR2894966A1 (fr) 2007-06-22
TW200733962A (en) 2007-09-16
NZ569884A (en) 2011-03-31
RU2008128317A (ru) 2010-01-27
MA30164B1 (fr) 2009-01-02
UA91581C2 (en) 2010-08-10
BRPI0620143A2 (pt) 2011-11-01
IL192249A0 (en) 2008-12-29
CA2633769A1 (fr) 2007-06-28
US20090247564A1 (en) 2009-10-01
AU2006328560B2 (en) 2012-03-22
JP2009519996A (ja) 2009-05-21
WO2007071648A1 (fr) 2007-06-28
RU2426735C2 (ru) 2011-08-20
EP1971613A1 (fr) 2008-09-24
AR058704A1 (es) 2008-02-20
TNSN08268A1 (en) 2009-10-30
CN101331139A (zh) 2008-12-24

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