FR2154314A1 - Vinca rosea alkaloids - vinblastine, vinleurosine and vincristine selective isolation - Google Patents

Vinca rosea alkaloids - vinblastine, vinleurosine and vincristine selective isolation

Info

Publication number
FR2154314A1
FR2154314A1 FR7134931A FR7134931A FR2154314A1 FR 2154314 A1 FR2154314 A1 FR 2154314A1 FR 7134931 A FR7134931 A FR 7134931A FR 7134931 A FR7134931 A FR 7134931A FR 2154314 A1 FR2154314 A1 FR 2154314A1
Authority
FR
France
Prior art keywords
iii
vinleurosine
vinblastine
vincristine
acid addition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7134931A
Other languages
French (fr)
Other versions
FR2154314B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Nyrt
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Nyrt
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Nyrt, Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Nyrt
Priority to FR7134931A priority Critical patent/FR2154314A1/en
Publication of FR2154314A1 publication Critical patent/FR2154314A1/en
Application granted granted Critical
Publication of FR2154314B1 publication Critical patent/FR2154314B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Vinblastine (I), vinleurosine (II) and vincristine (III) or their salts, known cytostatic agents, are recovered in improved yields from Vinca rosea L by (a) extracting with neutral aqs. methanol, (b) dissolving the alkaloid mixture obtained in a known manner from the extract in ethanol contg. is not >10% acid and crystallising (I)-(III) from the ethanol soln. in the form of their acid addition salts; (c) chromatographing the mixture of acid addition salts, opt. after conversion into the free bases, on Al2O3 partially deactivated with water and fractionally eluting, and (d) recovering (I)-(III) or their acid addition salts from the eluate fractions and purifying them if required. The process involves less phase interchanges than prior methods and the chromatographic separation is less complicated.
FR7134931A 1971-09-28 1971-09-28 Vinca rosea alkaloids - vinblastine, vinleurosine and vincristine selective isolation Granted FR2154314A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7134931A FR2154314A1 (en) 1971-09-28 1971-09-28 Vinca rosea alkaloids - vinblastine, vinleurosine and vincristine selective isolation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7134931A FR2154314A1 (en) 1971-09-28 1971-09-28 Vinca rosea alkaloids - vinblastine, vinleurosine and vincristine selective isolation

Publications (2)

Publication Number Publication Date
FR2154314A1 true FR2154314A1 (en) 1973-05-11
FR2154314B1 FR2154314B1 (en) 1974-11-15

Family

ID=9083610

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7134931A Granted FR2154314A1 (en) 1971-09-28 1971-09-28 Vinca rosea alkaloids - vinblastine, vinleurosine and vincristine selective isolation

Country Status (1)

Country Link
FR (1) FR2154314A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2894966A1 (en) * 2005-12-20 2007-06-22 Pierre Fabre Medicament Sa New crystalline form of vinflunine ditartrate, useful for treating cancer

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2894966A1 (en) * 2005-12-20 2007-06-22 Pierre Fabre Medicament Sa New crystalline form of vinflunine ditartrate, useful for treating cancer
WO2007071648A1 (en) * 2005-12-20 2007-06-28 Pierre Fabre Medicament Crystalline form of vinflunine ditartrate

Also Published As

Publication number Publication date
FR2154314B1 (en) 1974-11-15

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