GB1382460A - Vincristine separation process - Google Patents

Vincristine separation process

Info

Publication number
GB1382460A
GB1382460A GB5587772A GB5587772A GB1382460A GB 1382460 A GB1382460 A GB 1382460A GB 5587772 A GB5587772 A GB 5587772A GB 5587772 A GB5587772 A GB 5587772A GB 1382460 A GB1382460 A GB 1382460A
Authority
GB
United Kingdom
Prior art keywords
vincristine
separation process
fraction
desmethylvinblastine
formylating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5587772A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Priority to GB5587772A priority Critical patent/GB1382460A/en
Publication of GB1382460A publication Critical patent/GB1382460A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1382460 Separation process for vincristine RICHTER GEDEON VEGYESZETI GYAR RT 4 Dec 1972 55877/72 Heading C2C Vincristine is isolated from Vinca rosea Linn by formylating a dimeric alkaloid fraction obtained therefrom (with, e.g. HCOOH/ (CH 3 CO) 2 O) to convert N-desmethylvinblastine contained in the fraction to vincristine, followed by isolation of the total vincristine content.
GB5587772A 1972-12-04 1972-12-04 Vincristine separation process Expired GB1382460A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB5587772A GB1382460A (en) 1972-12-04 1972-12-04 Vincristine separation process

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB5587772A GB1382460A (en) 1972-12-04 1972-12-04 Vincristine separation process

Publications (1)

Publication Number Publication Date
GB1382460A true GB1382460A (en) 1975-01-29

Family

ID=10475103

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5587772A Expired GB1382460A (en) 1972-12-04 1972-12-04 Vincristine separation process

Country Status (1)

Country Link
GB (1) GB1382460A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4070358A (en) * 1975-10-28 1978-01-24 Richter Gedeon Vegyeszeti Gyar Rt Process for the preparation of diindole alkaloids or of the acid addition salts thereof
EP0079785A2 (en) * 1981-11-16 1983-05-25 Eli Lilly And Company Method of preparing 1-formyl congeners of indole-dihydroindole dimers

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4070358A (en) * 1975-10-28 1978-01-24 Richter Gedeon Vegyeszeti Gyar Rt Process for the preparation of diindole alkaloids or of the acid addition salts thereof
EP0079785A2 (en) * 1981-11-16 1983-05-25 Eli Lilly And Company Method of preparing 1-formyl congeners of indole-dihydroindole dimers
EP0079785A3 (en) * 1981-11-16 1984-03-28 Eli Lilly And Company Method of preparing 1-formyl congeners of indole-dihydroindole dimers

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee