BR112018067637A2 - monotartrato de vinorelbina e seu uso farmacêutico - Google Patents

monotartrato de vinorelbina e seu uso farmacêutico

Info

Publication number
BR112018067637A2
BR112018067637A2 BR112018067637A BR112018067637A BR112018067637A2 BR 112018067637 A2 BR112018067637 A2 BR 112018067637A2 BR 112018067637 A BR112018067637 A BR 112018067637A BR 112018067637 A BR112018067637 A BR 112018067637A BR 112018067637 A2 BR112018067637 A2 BR 112018067637A2
Authority
BR
Brazil
Prior art keywords
pharmaceutical use
vinorelbine
vinorelbine monotartrate
monotartrate
crystalline
Prior art date
Application number
BR112018067637A
Other languages
English (en)
Inventor
Schickaneder Christian
Matviienko Iaroslav
Zabudkin Oleksandr
Matviyenko Viktor
Matha Vladimir
Sypchenko Volodymyr
Original Assignee
Synbias Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synbias Pharma Ag filed Critical Synbias Pharma Ag
Publication of BR112018067637A2 publication Critical patent/BR112018067637A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

a presente invenção é direcionada ao monotartrato de vinorelbina cristalina e seu uso para a prevenção e o tratamento de câncer, particularmente o câncer de pulmão de células não pequenas ou o câncer de mama. a presente invenção também se refere a um método para a fabricação de monotartrato de vinorelbina cristalino.
BR112018067637A 2016-03-09 2016-03-09 monotartrato de vinorelbina e seu uso farmacêutico BR112018067637A2 (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2016/055040 WO2017152972A1 (en) 2016-03-09 2016-03-09 Vinorelbine monotartrate and its pharmaceutical use

Publications (1)

Publication Number Publication Date
BR112018067637A2 true BR112018067637A2 (pt) 2019-01-02

Family

ID=55521706

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018067637A BR112018067637A2 (pt) 2016-03-09 2016-03-09 monotartrato de vinorelbina e seu uso farmacêutico

Country Status (11)

Country Link
US (1) US20190092792A1 (pt)
EP (1) EP3426665A1 (pt)
JP (1) JP2019508436A (pt)
CN (1) CN108779129A (pt)
AR (1) AR107829A1 (pt)
BR (1) BR112018067637A2 (pt)
CA (1) CA3014473A1 (pt)
RU (1) RU2730521C2 (pt)
TW (1) TW201734023A (pt)
UY (1) UY37139A (pt)
WO (1) WO2017152972A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115611927A (zh) * 2020-01-06 2023-01-17 刘力 长春抗肿瘤药物的新化合物
CN114621258A (zh) * 2022-04-08 2022-06-14 海南长春花药业有限公司 一种酒石酸长春瑞滨的纯化方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2707988B1 (fr) * 1993-07-21 1995-10-13 Pf Medicament Nouveaux dérivés antimitotiques des alcaloïdes binaires du catharantus rosesus, leur procédé de préparation et les compositions pharmaceutiques les comprenant.
US6627646B2 (en) * 2001-07-17 2003-09-30 Sepracor Inc. Norastemizole polymorphs
EP1530459B1 (en) 2002-05-31 2010-03-31 R.P. Scherer Technologies, LLC Oral pharmaceutical composition for soft capsules containing vinorelbine and method of treatment
CN1437942A (zh) * 2003-02-08 2003-08-27 杭州华卫制药技术开发有限公司 注射用长春瑞滨粉针剂及制备方法
CN1245409C (zh) * 2003-06-03 2006-03-15 浙江海正药业股份有限公司 长春瑞滨合成中间体脱水长春碱的制备方法
CN1552716A (zh) * 2003-06-03 2004-12-08 浙江海正药业股份有限公司 合成长春瑞滨的方法
AU2005321346B2 (en) 2004-12-30 2011-06-23 Pierre Fabre Medicament Stable solid dispersion of a derivative of vinca alkaloid and process for manufacturing it
FR2918567B1 (fr) * 2007-07-11 2012-08-03 Pf Medicament Composition pharmaceutique stable d'un sel hydrosoluble de vinorelbine.
CN101284842B (zh) * 2008-05-19 2010-06-09 华中科技大学 用硫酸长春碱合成长春瑞滨酒石酸盐的方法
CN102766149B (zh) * 2012-07-05 2014-09-24 深圳万乐药业有限公司 一种酒石酸长春瑞滨的制备方法
CN104725405A (zh) * 2013-12-20 2015-06-24 中国医药研究开发中心有限公司 长春瑞滨的制备方法

Also Published As

Publication number Publication date
RU2018129465A3 (pt) 2020-04-09
AR107829A1 (es) 2018-06-13
TW201734023A (zh) 2017-10-01
UY37139A (es) 2017-10-31
CN108779129A (zh) 2018-11-09
JP2019508436A (ja) 2019-03-28
US20190092792A1 (en) 2019-03-28
WO2017152972A1 (en) 2017-09-14
RU2730521C2 (ru) 2020-08-24
CA3014473A1 (en) 2017-09-14
RU2018129465A (ru) 2020-04-09
EP3426665A1 (en) 2019-01-16

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]

Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO EM FUNCAO DA REVOGACAO DO ART. 229-C DA LEI NO 9.279, DE 1996, POR FORCA DA LEI NO 14.195, DE 2021

B350 Update of information on the portal [chapter 15.35 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements