AU693460B2 - Novel antimitotic binary alkaloid derivatives extracted from catharanthus roseus - Google Patents

Novel antimitotic binary alkaloid derivatives extracted from catharanthus roseus

Info

Publication number
AU693460B2
AU693460B2 AU72666/94A AU7266694A AU693460B2 AU 693460 B2 AU693460 B2 AU 693460B2 AU 72666/94 A AU72666/94 A AU 72666/94A AU 7266694 A AU7266694 A AU 7266694A AU 693460 B2 AU693460 B2 AU 693460B2
Authority
AU
Australia
Prior art keywords
document
date
compounds
compound
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired, expires
Application number
AU72666/94A
Other languages
English (en)
Other versions
AU7266694A (en
Inventor
Christian Berrier
Dennis Bigg
Jacques Fahy
Jean-Claude Jacquesy
Marie-Paule Jouannetaud
Robert Kiss
Anna Kruczynski
Fabien Zunino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre Medicament SA
Original Assignee
Pierre Fabre Medicament SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9449457&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU693460(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pierre Fabre Medicament SA filed Critical Pierre Fabre Medicament SA
Publication of AU7266694A publication Critical patent/AU7266694A/en
Application granted granted Critical
Publication of AU693460B2 publication Critical patent/AU693460B2/en
Adjusted expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AU72666/94A 1993-07-21 1994-07-19 Novel antimitotic binary alkaloid derivatives extracted from catharanthus roseus Expired AU693460B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9308948A FR2707988B1 (fr) 1993-07-21 1993-07-21 Nouveaux dérivés antimitotiques des alcaloïdes binaires du catharantus rosesus, leur procédé de préparation et les compositions pharmaceutiques les comprenant.
FR9308948 1993-07-21
PCT/FR1994/000898 WO1995003312A1 (fr) 1993-07-21 1994-07-19 Derives antimitotiques des alcaloides binaires du catharanthus roseus

Publications (2)

Publication Number Publication Date
AU7266694A AU7266694A (en) 1995-02-20
AU693460B2 true AU693460B2 (en) 1998-07-02

Family

ID=9449457

Family Applications (1)

Application Number Title Priority Date Filing Date
AU72666/94A Expired AU693460B2 (en) 1993-07-21 1994-07-19 Novel antimitotic binary alkaloid derivatives extracted from catharanthus roseus

Country Status (15)

Country Link
US (1) US5620985A (enExample)
EP (1) EP0710240B1 (enExample)
JP (1) JP3606872B2 (enExample)
AT (1) ATE146477T1 (enExample)
AU (1) AU693460B2 (enExample)
BR (1) BR1100311A (enExample)
CA (1) CA2167694C (enExample)
DE (2) DE122010000012I1 (enExample)
DK (1) DK0710240T3 (enExample)
ES (1) ES2097659T3 (enExample)
FR (2) FR2707988B1 (enExample)
GR (1) GR3022659T3 (enExample)
LU (1) LU91660I2 (enExample)
NZ (2) NZ269172A (enExample)
WO (1) WO1995003312A1 (enExample)

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FR2737208A1 (fr) * 1995-07-28 1997-01-31 Pf Medicament Nouvelles fluorovindolines, precurseurs d'analogues de la vinblastine et de la vinorelbine,leurs procedes de preparation et leur utilisation comme medicament
FR2761990B1 (fr) 1997-04-10 1999-06-25 Pf Medicament Derives halogenes antimitotiques d'alcaloides de vinca
FR2783522A1 (fr) * 1998-09-21 2000-03-24 Pf Medicament Composes derives d'alcaloides de vinca, leur preparation et leur application en therapeutique
GB0011903D0 (en) * 2000-05-18 2000-07-05 Astrazeneca Ab Combination chemotherapy
US6890558B2 (en) * 2002-05-31 2005-05-10 R.P. Scherer Technologies, Inc. Oral pharmaceutical composition for soft capsules containing vinorelbine and method of treatment
AU2004296191B2 (en) 2003-12-04 2010-10-28 Albany Molecular Research, Inc. Vinca derivatives
US7235564B2 (en) 2003-12-04 2007-06-26 Amr Technology, Inc. Vinorelbine derivatives
FR2863891B1 (fr) * 2003-12-23 2006-03-24 Pf Medicament Composition pharmaceutique de vinflunine destinee a une administration parentale, procede de preparation et utilisation
US20110015221A1 (en) * 2003-12-23 2011-01-20 Pierre Fabre Medicament Pharmaceutical composition of vinflunine which is intended for parenteral administration preparation method thereof and use of same
US7422741B2 (en) 2004-03-05 2008-09-09 Vegenics Limited VEGFR-3 fusion proteins
FR2894966B1 (fr) * 2005-12-20 2008-03-14 Pierre Fabre Medicament Sa Nouvelle forme cristalline de la vinflunine
EP1989212B1 (en) * 2006-02-17 2013-06-19 Cascade Prodrug Inc. Treatment of hyperproliferative diseases with vinca alkaloid n-oxide and analogs
CN101108859A (zh) * 2006-07-17 2008-01-23 上海恒瑞医药有限公司 长春碱类化合物、其制备方法及其在医药上的用途
WO2008033935A2 (en) * 2006-09-12 2008-03-20 Amr Technology, Inc. Vinorelbine derivatives
WO2008033930A2 (en) * 2006-09-12 2008-03-20 Amr Technology, Inc. Vinca derivatives
FR2905949B1 (fr) * 2006-09-20 2008-11-21 Pierre Fabre Medicament Sa Derives fluores de catharanthine, leur preparation et leur utilisation comme precurseurs d'alcaloides dimeres de vinca
CN101235046B (zh) * 2007-01-29 2010-09-08 中国科学院上海药物研究所 长春碱衍生物、其制备方法和用途、以及包含该衍生物的药物组合物
FR2912406B1 (fr) * 2007-02-13 2009-05-08 Pierre Fabre Medicament Sa Sels cristalins anhydres de vinflunine, procede de preparation et utilisation en tant que medicament et moyen de purification de la vinflunine.
EP1997534A1 (en) * 2007-05-31 2008-12-03 Pierre Fabre Medicament Cancer treatment combination therapy comprising vinflunine and trastuzumab
FR2918567B1 (fr) * 2007-07-11 2012-08-03 Pf Medicament Composition pharmaceutique stable d'un sel hydrosoluble de vinorelbine.
FR2918566B1 (fr) 2007-07-11 2009-10-09 Pierre Fabre Medicament Sa Composition pharmaceutique stable d'un sel hydrosoluble de vinflunine.
US20090076055A1 (en) * 2007-09-14 2009-03-19 Protia, Llc Deuterium-enriched vinflunine
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
CL2009002206A1 (es) 2008-12-23 2011-08-26 Gilead Pharmasset Llc Compuestos derivados de pirrolo -(2-3-d]-pirimidin-7(6h)-tetrahidrofuran-2-il fosfonamidato, composicion farmaceutica; y su uso en el tratamiento de enfermedades virales.
AR074897A1 (es) 2008-12-23 2011-02-23 Pharmasset Inc Fosforamidatos de nucleosidos
MX2011006890A (es) 2008-12-23 2011-07-20 Pharmasset Inc Analogos de nucleosidos.
EP2547359B1 (en) 2010-03-15 2016-03-09 The Board of Trustees of the University of Illionis Inhibitors of beta integrin-g protein alpha subunit binding interactions
AP2012006535A0 (en) 2010-03-31 2012-10-31 Gilead Pharmasset Llc Stereoselective synthesis of phosphorous containing actives
US9029502B2 (en) 2010-12-20 2015-05-12 The Regents Of The University Of Michigan Inhibitors of the epidermal growth factor receptor-heat shock protein 90 binding interaction
CN103788117A (zh) * 2012-10-30 2014-05-14 何小解 一种脱水长春碱、长春瑞滨及长春氟宁连续化合成工艺
HU230462B1 (hu) 2013-05-30 2016-07-28 Richter Gedeon Nyrt. Új bisz-indol alkaloidok mint rákellenes gyógyszerek
US9783547B2 (en) 2014-01-15 2017-10-10 Centre National De La Recherche Scientifique (Cnrs) Water soluble 4-azapodophyllotoxin analogs
EP3250609A4 (en) 2015-01-26 2018-07-11 The University of Chicago Il13ra alpha 2 binding agents and use thereof in cancer treatment
EP3250611B1 (en) 2015-01-26 2021-04-21 The University of Chicago Car t-cells recognizing cancer-specific il 13r-alpha2
BR112018067637A2 (pt) * 2016-03-09 2019-01-02 Synbias Pharma Ag monotartrato de vinorelbina e seu uso farmacêutico
WO2018007554A1 (en) 2016-07-06 2018-01-11 Pierre Fabre Medicament Vinflunine and pd1 and/or pdl1 inhibitor as pharmaceutical combination
CA3071599A1 (en) 2017-08-07 2019-02-14 Amgen Inc. Treatment of triple negative breast cancer or colorectal cancer with liver metastases with an anti pd-l1 antibody and an oncolytic virus
WO2020191344A1 (en) 2019-03-20 2020-09-24 The Regents Of The University Of California Claudin-6 bispecific antibodies
DK3941946T3 (da) 2019-03-20 2025-03-24 Univ California Claudin-6-antistoffer og lægemiddelkonjugater
AU2020266083A1 (en) 2019-04-30 2021-09-23 Instituto de Medicina Molecular João Lobo Antunes Rank pathway inhibitors in combination with CDK inhibitors
EP3962521A1 (en) 2019-05-02 2022-03-09 University of Florida Research Foundation, Inc. Compositions for treatment of diffuse intrinsic pontine glioma
MX2021015937A (es) 2019-06-24 2022-02-03 Amgen Inc Inhibicion de sirp-gamma para el tratamiento del cancer.
US12703750B2 (en) 2020-04-11 2026-08-11 Northwestern University Humanized antibody targeting the tumor associated antigen IL13Ra2
FR3140369B1 (fr) 2022-10-04 2025-07-25 Univ Poitiers Procédé de fluoration et/ou cyclisation d’un alcène ou alcyne aminé en flux continu et installation pour la mise en œuvre du procédé

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0010458A1 (fr) * 1978-08-24 1980-04-30 ANVAR Agence Nationale de Valorisation de la Recherche Composés bis-indoliques, compositions pharmaceutiques les contenant, procédé pour leur préparation
US4203898A (en) * 1977-08-29 1980-05-20 Eli Lilly And Company Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2296418B1 (enExample) * 1974-12-30 1978-07-21 Anvar
US4110330A (en) * 1977-05-27 1978-08-29 Eli Lilly And Company 5'-Acetonylvincristine and related compounds
US4320058A (en) * 1980-12-29 1982-03-16 Eli Lilly And Company 20'-Hydroxyvinblastine and related compounds
HU193772B (en) * 1985-06-12 1987-11-30 Richter Gedeon Vegyeszet Process for producing new nitro-bis-indole derivatives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4203898A (en) * 1977-08-29 1980-05-20 Eli Lilly And Company Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids
EP0010458A1 (fr) * 1978-08-24 1980-04-30 ANVAR Agence Nationale de Valorisation de la Recherche Composés bis-indoliques, compositions pharmaceutiques les contenant, procédé pour leur préparation

Also Published As

Publication number Publication date
JPH09500634A (ja) 1997-01-21
EP0710240A1 (fr) 1996-05-08
WO1995003312A1 (fr) 1995-02-02
FR2707988A1 (fr) 1995-01-27
DK0710240T3 (da) 1997-06-02
LU91660I2 (fr) 2010-05-10
EP0710240B1 (fr) 1996-12-18
CA2167694A1 (fr) 1995-02-02
AU7266694A (en) 1995-02-20
ATE146477T1 (de) 1997-01-15
ES2097659T3 (es) 1997-04-01
CA2167694C (fr) 2007-03-06
BR1100311A (pt) 1999-08-31
DE69401216T2 (de) 1997-07-03
NZ269172A (en) 1997-10-24
JP3606872B2 (ja) 2005-01-05
FR2707988B1 (fr) 1995-10-13
NZ328612A (en) 2000-05-26
DE69401216D1 (de) 1997-01-30
US5620985A (en) 1997-04-15
GR3022659T3 (en) 1997-05-31
FR10C0012I1 (enExample) 2010-04-16
DE122010000012I1 (de) 2010-07-08
FR10C0012I2 (enExample) 2011-04-01

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Legal Events

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired