JP3379993B2 - アルファ−アノマーに富む２−デオキシ−２，２−ジフルオロ−ｄ−リボフラノシルスルホネートを製造する方法 - Google Patents

アルファ−アノマーに富む２−デオキシ−２，２−ジフルオロ−ｄ−リボフラノシルスルホネートを製造する方法

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Publication number
JP3379993B2
JP3379993B2 JP14916193A JP14916193A JP3379993B2 JP 3379993 B2 JP3379993 B2 JP 3379993B2 JP 14916193 A JP14916193 A JP 14916193A JP 14916193 A JP14916193 A JP 14916193A JP 3379993 B2 JP3379993 B2 JP 3379993B2
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Japan
Prior art keywords
sulfonate
ribofuranosyl
sulfonic acid
anomer
acid
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Expired - Fee Related
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JP14916193A
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English (en)
Japanese (ja)
Other versions
JPH0656865A (ja
Inventor
タ−セン・チョウ
チャールズ・デイビッド・ジョーンズ
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Eli Lilly and Co
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Eli Lilly and Co
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Publication of JPH0656865A publication Critical patent/JPH0656865A/ja
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Publication of JP3379993B2 publication Critical patent/JP3379993B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP14916193A 1992-06-22 1993-06-21 アルファ−アノマーに富む２−デオキシ−２，２−ジフルオロ−ｄ−リボフラノシルスルホネートを製造する方法 Expired - Fee Related JP3379993B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US902305 1992-06-22
US07/902,305 US5256798A (en) 1992-06-22 1992-06-22 Process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates

Publications (2)

Publication Number Publication Date
JPH0656865A JPH0656865A (ja) 1994-03-01
JP3379993B2 true JP3379993B2 (ja) 2003-02-24

Family

ID=25415655

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14916193A Expired - Fee Related JP3379993B2 (ja) 1992-06-22 1993-06-21 アルファ−アノマーに富む２−デオキシ−２，２−ジフルオロ−ｄ−リボフラノシルスルホネートを製造する方法

Country Status (14)

Country Link
US (1) US5256798A (enExample)
EP (1) EP0577302B1 (enExample)
JP (1) JP3379993B2 (enExample)
AT (1) ATE155476T1 (enExample)
BR (1) BR9302429A (enExample)
CA (1) CA2098882C (enExample)
DE (1) DE69312176T2 (enExample)
DK (1) DK0577302T3 (enExample)
ES (1) ES2105114T3 (enExample)
GR (1) GR3024975T3 (enExample)
HU (1) HU216832B (enExample)
IL (1) IL106077A (enExample)
MX (1) MX9303712A (enExample)
TW (1) TW224101B (enExample)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69311000T2 (de) * 1992-06-22 1997-11-27 Lilly Co Eli Verfahren zur Herstellung von mit Alpha-Anomeren angereicherten 1-Halogen-2-Deoxy-2,2-Difluor-D-Ribofuranosyl-Derivaten
UA41261C2 (uk) * 1992-06-22 2001-09-17 Елі Ліллі Енд Компані Спосіб одержання збагачених бета-аномером нуклеозидів
RU2131880C1 (ru) * 1992-06-22 1999-06-20 Эли Лилли Энд Компани Способ получения обогащенных бета-аномером нуклеозидов
US5424416A (en) * 1993-08-25 1995-06-13 Eli Lilly And Company Process for preparation of 2-deoxy-2,2-difluoro-D-ribofuranosyl-3,5-hydroxy protected-1-alkyl and aryl sulfonates and their use in preparation of 2',2'-difluoro-2'-deoxy nucleosides
US7214791B2 (en) * 2004-07-01 2007-05-08 Shenzhen Hande Technology Co., Ltd. Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material
CN101023094B (zh) 2004-07-21 2011-05-18 法莫赛特股份有限公司 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备
SG158136A1 (en) * 2004-09-14 2010-01-29 Pharmasset Inc Preparation of 2`-fluoro-2`- alkyl- substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives
CA2598895A1 (en) * 2005-03-04 2006-09-08 Dabur Pharma Limited Intermediate and process for preparing of beta- anomer enriched 21deoxy, 21 ,21-difluoro-d-ribofuranosyl nucleosides
BRPI0610950A2 (pt) * 2005-06-03 2010-08-03 Scinopharm Taiwan Ltd processo para produção de um sulfonato de 2-deoxi-2, 2-difluoro-d-ribofuranosil enriquecido de alfa anÈmero, e uso do mesmo para produção de um beta nocleosìdeo
AU2011202539B2 (en) * 2005-06-03 2012-07-05 Scinopharm Taiwan, Ltd. Process of making an alpha-anomer enriched 2-deoxy-2,2-difluoro-d-ribofuranosyl sulfonate and use thereof for making a beta nucleoside
AT502221A1 (de) * 2005-07-20 2007-02-15 Pharmacon Forschung & Beratung Gmbh Homogemcitabine, verfahren zu ihrer herstellung sowie deren verwendung
WO2007092705A2 (en) * 2006-02-07 2007-08-16 Chemagis Ltd. Process for preparing gemcitabine and associated intermediates
US20070249823A1 (en) * 2006-04-20 2007-10-25 Chemagis Ltd. Process for preparing gemcitabine and associated intermediates
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
CN101024667B (zh) * 2007-03-30 2011-01-26 湖北益泰药业有限公司 盐酸吉西他宾的合成方法
US20080262215A1 (en) * 2007-04-23 2008-10-23 Chemagis Ltd. Gemcitabine production process
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
BRPI0923815A2 (pt) * 2008-12-23 2015-07-14 Pharmasset Inc Síntese de nucleosídeos de purina
TWI598358B (zh) 2009-05-20 2017-09-11 基利法瑪席特有限責任公司 核苷磷醯胺
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
SI3290428T1 (sl) 2010-03-31 2022-01-31 Gilead Pharmasset Llc Tableta, ki obsega kristalinični (S)-izopropil 2-(((S)-(((2R,3R,4R,5R) -5-(2,4-diokso-3,4-dihidropirimidin-1(2H)-il)-4-fluoro-3-hidroksi-4- metiltetrahidrofuran-2-il)metoksi)(fenoksi)fosforil)amino)propanoat
PL3290428T3 (pl) 2010-03-31 2022-02-07 Gilead Pharmasset Llc Tabletka zawierająca krystaliczny (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-diokso-3,4-dihydropirymidyn-1(2H)-ylo)-4-fluoro-3-hydroksy-4-metylotetrahydrofuran-2-ylo)metoksy)(fenoksy)fosforylo)amino)propanian izopropylu
ES2716158T3 (es) 2010-11-30 2019-06-10 Gilead Pharmasset Llc 2'-spiro-nucleótidos para el tratamiento de hepatitis C
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
CN102603838B (zh) * 2012-02-14 2015-02-18 江苏八巨药业有限公司 一种制备吉西他滨盐酸盐的方法
WO2015030853A1 (en) 2013-08-27 2015-03-05 Gilead Pharmasset Llc Combination formulation of two antiviral compounds
CN103692332B (zh) * 2013-12-31 2015-12-09 景宁畲族自治县通用机械配件厂（普通合伙） 全自动抛光除油机
CN107793334A (zh) * 2017-09-27 2018-03-13 九江善水科技股份有限公司 芳基磺酸铵盐化合物、其制备方法及应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
DE3856158T2 (de) * 1987-08-28 1998-08-20 Lilly Co Eli Verfahren zur Herstellung von Zwischenverbindungen verwendbar in der Herstellung von 2',2'-Difluoronucleosiden
US4965374A (en) * 1987-08-28 1990-10-23 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ＳＹＮＴＨＥＳＩＳ，Ｎｏ．６，ｐ．５６５−５７０，Ｊｕｎｅ １９９２

Also Published As

Publication number Publication date
DE69312176D1 (de) 1997-08-21
HU216832B (hu) 1999-09-28
HUT65207A (en) 1994-05-02
CA2098882A1 (en) 1993-12-23
ATE155476T1 (de) 1997-08-15
IL106077A0 (en) 1993-10-20
MX9303712A (es) 1994-05-31
TW224101B (enExample) 1994-05-21
ES2105114T3 (es) 1997-10-16
DK0577302T3 (da) 1997-10-06
CA2098882C (en) 2004-05-04
US5256798A (en) 1993-10-26
EP0577302A1 (en) 1994-01-05
EP0577302B1 (en) 1997-07-16
JPH0656865A (ja) 1994-03-01
BR9302429A (pt) 1994-01-11
IL106077A (en) 1998-07-15
GR3024975T3 (en) 1998-01-30
HU9301825D0 (en) 1993-09-28
DE69312176T2 (de) 1997-12-11

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