JP3372259B2 - カルシトリオール誘導体およびそれらの用途 - Google Patents

カルシトリオール誘導体およびそれらの用途

Info

Publication number
JP3372259B2
JP3372259B2 JP51294597A JP51294597A JP3372259B2 JP 3372259 B2 JP3372259 B2 JP 3372259B2 JP 51294597 A JP51294597 A JP 51294597A JP 51294597 A JP51294597 A JP 51294597A JP 3372259 B2 JP3372259 B2 JP 3372259B2
Authority
JP
Japan
Prior art keywords
vitamin
group
compound
compounds
carbon
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP51294597A
Other languages
English (en)
Japanese (ja)
Other versions
JPH11511475A (ja
Inventor
デルカ，ヘクター・エフ
シュノエス，ハインリッヒ・ケイ
カイ，ズィー・ヤン
フェルプス，メリー・イー
スミス，コニー・エム
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/531,403 external-priority patent/US5952317A/en
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Publication of JPH11511475A publication Critical patent/JPH11511475A/ja
Application granted granted Critical
Publication of JP3372259B2 publication Critical patent/JP3372259B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP51294597A 1995-09-21 1996-09-20 カルシトリオール誘導体およびそれらの用途 Expired - Fee Related JP3372259B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US53186795A 1995-09-21 1995-09-21
US08/531,403 1995-09-21
US08/531,403 US5952317A (en) 1995-09-21 1995-09-21 Calcitriol derivatives and their uses
US08/531,867 1995-09-21
PCT/US1996/015184 WO1997011053A1 (en) 1995-09-21 1996-09-20 Calcitriol derivatives and their uses

Publications (2)

Publication Number Publication Date
JPH11511475A JPH11511475A (ja) 1999-10-05
JP3372259B2 true JP3372259B2 (ja) 2003-01-27

Family

ID=27063537

Family Applications (1)

Application Number Title Priority Date Filing Date
JP51294597A Expired - Fee Related JP3372259B2 (ja) 1995-09-21 1996-09-20 カルシトリオール誘導体およびそれらの用途

Country Status (9)

Country Link
EP (1) EP1021401A1 (no)
JP (1) JP3372259B2 (no)
KR (1) KR100327922B1 (no)
AU (1) AU717238B2 (no)
CA (1) CA2229316C (no)
HU (1) HUP9802303A3 (no)
NO (1) NO981282L (no)
NZ (2) NZ501318A (no)
WO (1) WO1997011053A1 (no)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5305600A (en) * 1999-08-17 2001-03-13 Wisconsin Alumni Research Foundation Animal feed containing hydrolyzable calcitriol derivatives
KR100317935B1 (ko) * 1999-10-20 2001-12-22 유승필 대사성 골질환 치료용 약제조성물 및 이의 제조방법
AU2058701A (en) 1999-12-02 2001-06-12 F. Hoffmann-La Roche Ag Esters of vitamin D3 and uses thereof
US20030195175A1 (en) * 2002-03-25 2003-10-16 Deluca Hector F. Use of carbon-2-modified-vitamin D analogs to induce the formation of new bone
WO2005082375A2 (en) 2004-03-01 2005-09-09 Bioxell Spa Treatment of interstitial cystitis with vitamin d compounds
WO2006051106A1 (en) 2004-11-12 2006-05-18 Bioxell Spa Combined use of vitamin d derivatives and anti-proliferative agents for treating bladder cancer
US8426391B2 (en) 2006-02-03 2013-04-23 Proventiv Therapeutics, Llc Treating vitamin D insufficiency and deficiency with 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3
SI2679228T1 (en) 2006-06-21 2018-06-29 Opko Ireland Global Holdings, Ltd. THERAPY WITH THE USE OF VITAMIN D ADDITIONAL FIBER AND HORMON RESISTANCE OF VITAMIN D
DK3342405T3 (da) 2007-04-25 2019-11-11 Opko Ireland Global Holdings Ltd Kontrolleret frigivelse af 25-hydroxyvitamin d
ES2403107T3 (es) 2007-04-25 2013-05-14 Cytochroma Inc. Método de tratamiento de insuficiencia y deficiencia de vitamina D
EP2148685A4 (en) 2007-04-25 2010-07-28 Cytochroma Inc METHODS AND COMPOUNDS FOR THERAPY BASED ON VITAMIN D
WO2008134523A1 (en) 2007-04-25 2008-11-06 Proventiv Therapeutics, Llc Method of safely and effectively treating and preventing secondary hyperparathyroidism in chronic kidney disease
KR101852042B1 (ko) 2008-04-02 2018-04-25 사이토크로마 인코포레이티드 비타민 ｄ 결핍 및 관련 장애에 유용한 방법, 조성물, 용도 및 키트
EP3636280A1 (en) 2010-03-29 2020-04-15 Opko Ireland Global Holdings, Ltd. Methods and compositions for reducing parathyroid levels
KR101847947B1 (ko) 2013-03-15 2018-05-28 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 안정화되고 변형된 비타민 ｄ 방출 제형
SG10201911274TA (en) 2014-08-07 2020-02-27 Opko Ireland Global Holdings Ltd Adjunctive therapy with 25-hydroxyvitamin d
SG10201913863TA (en) 2016-03-28 2020-03-30 Opko Ireland Global Holdings Limited Methods of vitamin d treatment
KR101983654B1 (ko) * 2018-07-24 2019-05-29 한국과학기술원 Cfc 증후군 환자의 발달 저해를 완화할 수 있는 치료용 조성물
CN114681467B (zh) * 2022-03-30 2024-03-12 南通华山药业有限公司 一种阿法骨化醇杂环酯类衍生物在制备抗肿瘤药物中的应用
CN114656413B (zh) * 2022-03-30 2024-04-09 南通华山药业有限公司 一种阿法骨化醇杂环酯类衍生物及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4195027A (en) * 1978-01-16 1980-03-25 Wisconsin Alumni Research Foundation Process for preparing 1α-hydroxylated compounds
US4206131A (en) * 1978-06-19 1980-06-03 The Upjohn Company Compounds and process
US4188345A (en) * 1978-07-26 1980-02-12 Wisconsin Alumni Research Foundation Fluorovitamin D compounds and processes for their preparation
JPS5846508A (ja) * 1981-09-14 1983-03-18 日本石油化学株式会社 導電性材料の製法
IE55801B1 (en) * 1982-07-26 1991-01-16 Wisconsin Alumni Res Found Novel vitamin d analogs
JPH0825993B2 (ja) * 1990-08-20 1996-03-13 大同ほくさん株式会社 ビタミンｄ２およびｄ３又は活性型ビタミンｄ２およびｄ３の製造方法，並びにその中間体
JPH05339230A (ja) * 1992-03-12 1993-12-21 Nisshin Flour Milling Co Ltd 活性型ビタミンｄ２及びその誘導体の製造法
JP3182215B2 (ja) * 1992-06-26 2001-07-03 日清製粉株式会社 １−アシルオキシビタミンｄ誘導体

Also Published As

Publication number Publication date
MX9801943A (es) 1998-08-30
NZ501318A (en) 2001-07-27
CA2229316A1 (en) 1997-03-27
AU717238B2 (en) 2000-03-23
KR100327922B1 (ko) 2002-05-09
NO981282L (no) 1998-05-22
HUP9802303A3 (en) 1999-05-28
JPH11511475A (ja) 1999-10-05
CA2229316C (en) 2005-04-12
KR19990063628A (ko) 1999-07-26
HUP9802303A2 (hu) 1999-02-01
WO1997011053A1 (en) 1997-03-27
AU7242696A (en) 1997-04-09
NZ319819A (en) 2000-02-28
EP1021401A1 (en) 2000-07-26
NO981282D0 (no) 1998-03-20

Similar Documents

Publication Publication Date Title
JP3372259B2 (ja) カルシトリオール誘導体およびそれらの用途
US5840938A (en) 20(S)-25-hydroxy vitamin D compounds
US5976784A (en) Calcitriol derivatives and their uses
JPH09504549A (ja) （ｅ）−２０（２２）−デヒドロビタミンｄ化合物
US5952317A (en) Calcitriol derivatives and their uses
JP2505713B2 (ja) ビタミンｄ−２２−フェニルスルホン誘導体
EP0578494B1 (en) 24-cyclopropane vitamin D derivatives
JP3681390B2 (ja) ２６，２８−メチレン−１アルファ，２５−ジヒドロキシビタミンｄ２化合物
JP2007532540A (ja) ２−アルキリデン１８，１９−ジノル−ビタミンｄ化合物
JP5005340B2 (ja) ２−プロピリデン−１９−ノル−ビタミンｄ化合物
US4617297A (en) Method of treating disease states by the administration of 1α,25,26-trihydroxycholecalciferol
US5552393A (en) Method of treating metabolic bone diseases with 21-norvitamin D compounds
JP2927368B2 (ja) １α−ヒドロキシ−２４−ＥＰＩ−ビタミンＤ▲下４▼
FR2630739A1 (fr) Homologues a chaine laterale insaturee de vitamine d, compositions pharmaceutiques contenant ces composes, et leur utilisation
US5354744A (en) Side chain unsaturated 1 alpha-hydroxyvitamin D analogs
US5036061A (en) Process for the preparation of 1 alpha,25-dihydroxylated vitamin D2 and related compounds
AU2004260642A1 (en) 2-methylene-19-nor-20(S)-25-methyl-1alpha-hydroxycalciferol and its uses
MXPA98001943A (en) Derivatives of calcitriol and its u

Legal Events

Date Code Title Description
R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20071122

Year of fee payment: 5

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20081122

Year of fee payment: 6

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20091122

Year of fee payment: 7

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20091122

Year of fee payment: 7

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20101122

Year of fee payment: 8

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20111122

Year of fee payment: 9

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20111122

Year of fee payment: 9

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20121122

Year of fee payment: 10

LAPS Cancellation because of no payment of annual fees