KR100327922B1 - 칼시트리올유도체및그의용도 - Google Patents

칼시트리올유도체및그의용도 Download PDF

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Publication number
KR100327922B1
KR100327922B1 KR1019980702077A KR19980702077A KR100327922B1 KR 100327922 B1 KR100327922 B1 KR 100327922B1 KR 1019980702077 A KR1019980702077 A KR 1019980702077A KR 19980702077 A KR19980702077 A KR 19980702077A KR 100327922 B1 KR100327922 B1 KR 100327922B1
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KR
South Korea
Prior art keywords
group
vitamin
hydrogen
acyl
compound
Prior art date
Application number
KR1019980702077A
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English (en)
Korean (ko)
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KR19990063628A (ko
Inventor
헥터 에프. 델루카
하인리히 카. 쉬뇌스
쭈 윤 카이
매리 이. 펠프스
코니 엠. 스미쓰
Original Assignee
리차드 에이취 리저
위스콘신 얼럼나이 리서어치 화운데이션
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/531,403 external-priority patent/US5952317A/en
Application filed by 리차드 에이취 리저, 위스콘신 얼럼나이 리서어치 화운데이션 filed Critical 리차드 에이취 리저
Publication of KR19990063628A publication Critical patent/KR19990063628A/ko
Application granted granted Critical
Publication of KR100327922B1 publication Critical patent/KR100327922B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Nutrition Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1019980702077A 1995-09-21 1996-09-20 칼시트리올유도체및그의용도 KR100327922B1 (ko)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US53186795A 1995-09-21 1995-09-21
US8/531403 1995-09-21
US8/531,867 1995-09-21
US08/531,403 US5952317A (en) 1995-09-21 1995-09-21 Calcitriol derivatives and their uses
US8/531867 1995-09-21
US08/531403 1995-09-21
US08/531,867 1995-09-21
PCT/US1996/015184 WO1997011053A1 (en) 1995-09-21 1996-09-20 Calcitriol derivatives and their uses

Publications (2)

Publication Number Publication Date
KR19990063628A KR19990063628A (ko) 1999-07-26
KR100327922B1 true KR100327922B1 (ko) 2002-05-09

Family

ID=27063537

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019980702077A KR100327922B1 (ko) 1995-09-21 1996-09-20 칼시트리올유도체및그의용도

Country Status (9)

Country Link
EP (1) EP1021401A1 (no)
JP (1) JP3372259B2 (no)
KR (1) KR100327922B1 (no)
AU (1) AU717238B2 (no)
CA (1) CA2229316C (no)
HU (1) HUP9802303A3 (no)
NO (1) NO981282L (no)
NZ (2) NZ501318A (no)
WO (1) WO1997011053A1 (no)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5305600A (en) * 1999-08-17 2001-03-13 Wisconsin Alumni Research Foundation Animal feed containing hydrolyzable calcitriol derivatives
KR100317935B1 (ko) * 1999-10-20 2001-12-22 유승필 대사성 골질환 치료용 약제조성물 및 이의 제조방법
AU2058701A (en) 1999-12-02 2001-06-12 F. Hoffmann-La Roche Ag Esters of vitamin D3 and uses thereof
US20030195175A1 (en) * 2002-03-25 2003-10-16 Deluca Hector F. Use of carbon-2-modified-vitamin D analogs to induce the formation of new bone
WO2005082375A2 (en) 2004-03-01 2005-09-09 Bioxell Spa Treatment of interstitial cystitis with vitamin d compounds
WO2006051106A1 (en) 2004-11-12 2006-05-18 Bioxell Spa Combined use of vitamin d derivatives and anti-proliferative agents for treating bladder cancer
US8426391B2 (en) 2006-02-03 2013-04-23 Proventiv Therapeutics, Llc Treating vitamin D insufficiency and deficiency with 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3
SI2679228T1 (en) 2006-06-21 2018-06-29 Opko Ireland Global Holdings, Ltd. THERAPY WITH THE USE OF VITAMIN D ADDITIONAL FIBER AND HORMON RESISTANCE OF VITAMIN D
DK3342405T3 (da) 2007-04-25 2019-11-11 Opko Ireland Global Holdings Ltd Kontrolleret frigivelse af 25-hydroxyvitamin d
ES2403107T3 (es) 2007-04-25 2013-05-14 Cytochroma Inc. Método de tratamiento de insuficiencia y deficiencia de vitamina D
EP2148685A4 (en) 2007-04-25 2010-07-28 Cytochroma Inc METHODS AND COMPOUNDS FOR THERAPY BASED ON VITAMIN D
WO2008134523A1 (en) 2007-04-25 2008-11-06 Proventiv Therapeutics, Llc Method of safely and effectively treating and preventing secondary hyperparathyroidism in chronic kidney disease
KR101852042B1 (ko) 2008-04-02 2018-04-25 사이토크로마 인코포레이티드 비타민 ｄ 결핍 및 관련 장애에 유용한 방법, 조성물, 용도 및 키트
EP3636280A1 (en) 2010-03-29 2020-04-15 Opko Ireland Global Holdings, Ltd. Methods and compositions for reducing parathyroid levels
KR101847947B1 (ko) 2013-03-15 2018-05-28 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 안정화되고 변형된 비타민 ｄ 방출 제형
SG10201911274TA (en) 2014-08-07 2020-02-27 Opko Ireland Global Holdings Ltd Adjunctive therapy with 25-hydroxyvitamin d
SG10201913863TA (en) 2016-03-28 2020-03-30 Opko Ireland Global Holdings Limited Methods of vitamin d treatment
KR101983654B1 (ko) * 2018-07-24 2019-05-29 한국과학기술원 Cfc 증후군 환자의 발달 저해를 완화할 수 있는 치료용 조성물
CN114681467B (zh) * 2022-03-30 2024-03-12 南通华山药业有限公司 一种阿法骨化醇杂环酯类衍生物在制备抗肿瘤药物中的应用
CN114656413B (zh) * 2022-03-30 2024-04-09 南通华山药业有限公司 一种阿法骨化醇杂环酯类衍生物及其制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1979000513A1 (en) * 1978-01-16 1979-08-09 Wisconsin Alumni Res Found Process for preparing 1a-hydroxylated compounds
WO1980000339A1 (en) * 1978-07-26 1980-03-06 Wisconsin Alumni Res Found Process for preparing 1-fluorinated vitamin d compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4206131A (en) * 1978-06-19 1980-06-03 The Upjohn Company Compounds and process
JPS5846508A (ja) * 1981-09-14 1983-03-18 日本石油化学株式会社 導電性材料の製法
IE55801B1 (en) * 1982-07-26 1991-01-16 Wisconsin Alumni Res Found Novel vitamin d analogs
JPH0825993B2 (ja) * 1990-08-20 1996-03-13 大同ほくさん株式会社 ビタミンｄ２およびｄ３又は活性型ビタミンｄ２およびｄ３の製造方法，並びにその中間体
JPH05339230A (ja) * 1992-03-12 1993-12-21 Nisshin Flour Milling Co Ltd 活性型ビタミンｄ２及びその誘導体の製造法
JP3182215B2 (ja) * 1992-06-26 2001-07-03 日清製粉株式会社 １−アシルオキシビタミンｄ誘導体

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1979000513A1 (en) * 1978-01-16 1979-08-09 Wisconsin Alumni Res Found Process for preparing 1a-hydroxylated compounds
WO1980000339A1 (en) * 1978-07-26 1980-03-06 Wisconsin Alumni Res Found Process for preparing 1-fluorinated vitamin d compounds

Also Published As

Publication number Publication date
MX9801943A (es) 1998-08-30
NZ501318A (en) 2001-07-27
CA2229316A1 (en) 1997-03-27
AU717238B2 (en) 2000-03-23
NO981282L (no) 1998-05-22
HUP9802303A3 (en) 1999-05-28
JPH11511475A (ja) 1999-10-05
CA2229316C (en) 2005-04-12
JP3372259B2 (ja) 2003-01-27
KR19990063628A (ko) 1999-07-26
HUP9802303A2 (hu) 1999-02-01
WO1997011053A1 (en) 1997-03-27
AU7242696A (en) 1997-04-09
NZ319819A (en) 2000-02-28
EP1021401A1 (en) 2000-07-26
NO981282D0 (no) 1998-03-20

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