JP3296845B2 - アミノオキシピロリジニルチオカルバペネム化合物 - Google Patents

アミノオキシピロリジニルチオカルバペネム化合物

Info

Publication number
JP3296845B2
JP3296845B2 JP17664592A JP17664592A JP3296845B2 JP 3296845 B2 JP3296845 B2 JP 3296845B2 JP 17664592 A JP17664592 A JP 17664592A JP 17664592 A JP17664592 A JP 17664592A JP 3296845 B2 JP3296845 B2 JP 3296845B2
Authority
JP
Japan
Prior art keywords
group
compound
hydrogen
ppm
carbon atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP17664592A
Other languages
English (en)
Japanese (ja)
Other versions
JPH05186467A (ja
Inventor
宥二 仙藤
誠 紀伊
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Priority to JP17664592A priority Critical patent/JP3296845B2/ja
Publication of JPH05186467A publication Critical patent/JPH05186467A/ja
Application granted granted Critical
Publication of JP3296845B2 publication Critical patent/JP3296845B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
JP17664592A 1991-07-04 1992-07-03 アミノオキシピロリジニルチオカルバペネム化合物 Expired - Fee Related JP3296845B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP17664592A JP3296845B2 (ja) 1991-07-04 1992-07-03 アミノオキシピロリジニルチオカルバペネム化合物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP16424791 1991-07-04
JP3-164247 1991-07-04
JP17664592A JP3296845B2 (ja) 1991-07-04 1992-07-03 アミノオキシピロリジニルチオカルバペネム化合物

Publications (2)

Publication Number Publication Date
JPH05186467A JPH05186467A (ja) 1993-07-27
JP3296845B2 true JP3296845B2 (ja) 2002-07-02

Family

ID=15789474

Family Applications (1)

Application Number Title Priority Date Filing Date
JP17664592A Expired - Fee Related JP3296845B2 (ja) 1991-07-04 1992-07-03 アミノオキシピロリジニルチオカルバペネム化合物

Country Status (10)

Country Link
US (2) US5360798A (OSRAM)
EP (1) EP0521524B1 (OSRAM)
JP (1) JP3296845B2 (OSRAM)
KR (1) KR100215514B1 (OSRAM)
AT (1) ATE151424T1 (OSRAM)
DE (1) DE69218843T2 (OSRAM)
DK (1) DK0521524T3 (OSRAM)
ES (1) ES2103014T3 (OSRAM)
GR (1) GR3023607T3 (OSRAM)
TW (1) TW208008B (OSRAM)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9515975D0 (en) 1995-08-04 1995-10-04 Zeneca Ltd Chemical compounds
AU4020897A (en) 1996-08-17 1998-03-06 Zeneca Limited 3-mercaptopyrrolidines as farnesyl protein transferase inhibitors
ES2198689T3 (es) * 1997-02-07 2004-02-01 Kyoto Pharmaceutical Industries, Ltd. Compuestos de carbapenem, su utilizacion y compuestos intermedios de los mismos.
PL343728A1 (en) 1998-05-01 2001-09-10 Kyoto Pharmaceutical Ind Carbapenem derivatives, utilization thereof and intermediate compounds of the same
GB9930318D0 (en) 1999-12-22 2000-02-09 Zeneca Ltd Novel compounds
GB9930317D0 (en) 1999-12-22 2000-02-09 Zeneca Ltd Novel compounds
BR0112656A (pt) * 2000-07-19 2003-06-24 Hoffmann La Roche Compostos, composições farmacêuticas que contêm os mesmos, utilização desses compostos,: processo para tratamento terapêutico e/ou profilático e processo para a preparação desses compostos
NZ530170A (en) * 2001-05-21 2005-09-30 Kyoto Pharma Ind Carbapenem compound

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4251541A (en) * 1979-01-09 1981-02-17 A. H. Robins Company, Inc. 1-Substituted-3-arylthio-4-hydroxypyrrolidines
EP0182213B1 (en) * 1984-11-08 1990-09-26 Sumitomo Pharmaceuticals Company, Limited Carbapenem compounds and production thereof
ES2051700T3 (es) * 1986-03-27 1994-07-01 Sumitomo Pharma Un proceso para la preparacion de un compuesto beta-lactama.
KR880006244A (ko) * 1986-11-24 1988-07-22 후지사와 도모 기찌 로 3-피롤리디닐티오-1-아자바이스클로[3.2.0]햅트2-엔-2-카르복실산 화합물 및 이의 제조방법
GB8811237D0 (en) * 1988-05-12 1988-06-15 Fujisawa Pharmaceutical Co 3-pyrrolidinylthio-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid derivatives

Also Published As

Publication number Publication date
DE69218843T2 (de) 1997-10-09
ATE151424T1 (de) 1997-04-15
US5523415A (en) 1996-06-04
DK0521524T3 (da) 1997-05-05
TW208008B (OSRAM) 1993-06-21
EP0521524A1 (en) 1993-01-07
JPH05186467A (ja) 1993-07-27
GR3023607T3 (en) 1997-08-29
DE69218843D1 (de) 1997-05-15
KR930002350A (ko) 1993-02-23
KR100215514B1 (ko) 1999-08-16
EP0521524B1 (en) 1997-04-09
US5360798A (en) 1994-11-01
ES2103014T3 (es) 1997-08-16

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