JP3174158B2 - ６−オキソ−アゼピノインドール化合物、該化合物を含有する、胃の運動機能を調整する作用を有する医薬品および抗偏頭痛作用するセロトニン拮抗作用を有する医薬品並びに該化合物を製造する方法および該化合物を製造するための中間生成物 - Google Patents

６−オキソ−アゼピノインドール化合物、該化合物を含有する、胃の運動機能を調整する作用を有する医薬品および抗偏頭痛作用するセロトニン拮抗作用を有する医薬品並びに該化合物を製造する方法および該化合物を製造するための中間生成物

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Publication number
JP3174158B2
JP3174158B2 JP20377092A JP20377092A JP3174158B2 JP 3174158 B2 JP3174158 B2 JP 3174158B2 JP 20377092 A JP20377092 A JP 20377092A JP 20377092 A JP20377092 A JP 20377092A JP 3174158 B2 JP3174158 B2 JP 3174158B2
Authority
JP
Japan
Prior art keywords
group
compound
formula
lower alkyl
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP20377092A
Other languages
English (en)
Japanese (ja)
Other versions
JPH05202052A (ja
Inventor
ベンソン ヴェルナー
ファン シャルルドルプ カーリン
コリン グレゴリー ペーター
ヴォルフ クラウス−ウルリッヒ
プロイショフ ウルフ
トゥルプ マルティン
フルケンベルク トン
ファン ヴィーンガールデン イネケ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Products GmbH
Original Assignee
Abbott Products GmbH
Solvay Pharmaceuticals GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Products GmbH, Solvay Pharmaceuticals GmbH filed Critical Abbott Products GmbH
Publication of JPH05202052A publication Critical patent/JPH05202052A/ja
Application granted granted Critical
Publication of JP3174158B2 publication Critical patent/JP3174158B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
JP20377092A 1991-07-31 1992-07-30 ６−オキソ−アゼピノインドール化合物、該化合物を含有する、胃の運動機能を調整する作用を有する医薬品および抗偏頭痛作用するセロトニン拮抗作用を有する医薬品並びに該化合物を製造する方法および該化合物を製造するための中間生成物 Expired - Fee Related JP3174158B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4125292A DE4125292A1 (de) 1991-07-31 1991-07-31 6-oxo-azepinoindol-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE4125292.6 1991-07-31

Publications (2)

Publication Number Publication Date
JPH05202052A JPH05202052A (ja) 1993-08-10
JP3174158B2 true JP3174158B2 (ja) 2001-06-11

Family

ID=6437366

Family Applications (1)

Application Number Title Priority Date Filing Date
JP20377092A Expired - Fee Related JP3174158B2 (ja) 1991-07-31 1992-07-30 ６−オキソ−アゼピノインドール化合物、該化合物を含有する、胃の運動機能を調整する作用を有する医薬品および抗偏頭痛作用するセロトニン拮抗作用を有する医薬品並びに該化合物を製造する方法および該化合物を製造するための中間生成物

Country Status (21)

Country Link
US (1) US5272143A (enExample)
EP (1) EP0525584B1 (enExample)
JP (1) JP3174158B2 (enExample)
KR (1) KR930002353A (enExample)
CN (2) CN1069733A (enExample)
AT (1) ATE161012T1 (enExample)
AU (1) AU649153B2 (enExample)
CA (1) CA2075102A1 (enExample)
CZ (1) CZ239392A3 (enExample)
DE (2) DE4125292A1 (enExample)
ES (1) ES2110454T3 (enExample)
FI (1) FI923440A7 (enExample)
HU (2) HU211105B (enExample)
IE (1) IE922310A1 (enExample)
IL (1) IL102503A (enExample)
MX (1) MX9204457A (enExample)
NO (1) NO300375B1 (enExample)
NZ (1) NZ243715A (enExample)
RU (1) RU2078765C1 (enExample)
TW (1) TW207541B (enExample)
ZA (1) ZA925093B (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5414130A (en) * 1993-12-23 1995-05-09 The Dow Chemical Company Process for the preparation of diaminoresorcinol
TR200102005T2 (tr) * 1999-01-11 2001-12-21 Agouron Pharmaceuticals,Inc. Poli(adp-ribaz) polimerazların trisiklik inhibitörleri.
ECSP003637A (es) 1999-08-31 2002-03-25 Agouron Pharma Inhibidores triciclicos de poli (adp-ribosa) polimerasas
EP1793830A2 (en) * 2004-09-22 2007-06-13 Pfizer, Inc. Therapeutic combinations comprising poly(adp-ribose) polymerases inhibitor
KR100876520B1 (ko) * 2004-09-22 2008-12-31 화이자 인코포레이티드 폴리(ａｄｐ-리보오스) 폴리머라제 억제제의 제조 방법
CN102046176B (zh) 2008-05-29 2013-08-07 阿尔巴尼分子研究公司 5-ht3受体调节剂、其制备方法和用途
JP5745283B2 (ja) * 2010-02-12 2015-07-08 ファイザー・インク ８−フルオロ−２−｛４−［（メチルアミノ）メチル］フェニル｝−１，３，４，５−テトラヒドロ−６Ｈ−アゼピノ［５，４，３−ｃｄ］インドール−６−オンの塩および多形体
US10513515B2 (en) 2017-08-25 2019-12-24 Biotheryx, Inc. Ether compounds and uses thereof
EP3830093A1 (en) 2018-07-27 2021-06-09 Biotheryx, Inc. Bifunctional compounds as cdk modulators
US11897930B2 (en) 2020-04-28 2024-02-13 Anwita Biosciences, Inc. Interleukin-2 polypeptides and fusion proteins thereof, and their pharmaceutical compositions and therapeutic applications

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4910193A (en) * 1985-12-16 1990-03-20 Sandoz Ltd. Treatment of gastrointestinal disorders

Also Published As

Publication number Publication date
TW207541B (enExample) 1993-06-11
NO923004L (no) 1993-02-01
NZ243715A (en) 1995-03-28
IL102503A0 (en) 1993-01-14
AU649153B2 (en) 1994-05-12
HU211105B (en) 1995-10-30
IL102503A (en) 1995-12-31
AU2067792A (en) 1993-02-04
HUT65453A (en) 1994-06-28
HU9202430D0 (en) 1992-10-28
NO923004D0 (no) 1992-07-30
ZA925093B (en) 1993-04-28
DE59209055D1 (de) 1998-01-22
MX9204457A (es) 1993-05-01
US5272143A (en) 1993-12-21
RU2078765C1 (ru) 1997-05-10
CZ239392A3 (en) 1993-04-14
CN1069733A (zh) 1993-03-10
DE4125292A1 (de) 1993-02-04
ATE161012T1 (de) 1997-12-15
HU210217A9 (en) 1995-02-28
JPH05202052A (ja) 1993-08-10
NO300375B1 (no) 1997-05-20
EP0525584B1 (de) 1997-12-10
FI923440A0 (fi) 1992-07-30
ES2110454T3 (es) 1998-02-16
IE922310A1 (en) 1993-02-10
KR930002353A (ko) 1993-02-23
FI923440A7 (fi) 1993-02-01
CA2075102A1 (en) 1993-02-01
CN1141773A (zh) 1997-02-05
EP0525584A1 (de) 1993-02-03

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