CN1069733A - 6-氧化-氮杂吲哚及其生产方法和中间产品以及药物应用 - Google Patents

6-氧化-氮杂吲哚及其生产方法和中间产品以及药物应用 Download PDF

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Publication number
CN1069733A
CN1069733A CN92108977A CN92108977A CN1069733A CN 1069733 A CN1069733 A CN 1069733A CN 92108977 A CN92108977 A CN 92108977A CN 92108977 A CN92108977 A CN 92108977A CN 1069733 A CN1069733 A CN 1069733A
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China
Prior art keywords
group
formula
compound
alkyl group
represent
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Pending
Application number
CN92108977A
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English (en)
Chinese (zh)
Inventor
W·本森
K·V·查尔多博
P·C·格雷戈里
K·U·沃尔福
u·普罗舍夫
M·图泊
T·赫肯伯格
I·V·威格登
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Abbott Products GmbH
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Kali Chemie Pharma GmbH
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Filing date
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Application filed by Kali Chemie Pharma GmbH filed Critical Kali Chemie Pharma GmbH
Publication of CN1069733A publication Critical patent/CN1069733A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
CN92108977A 1991-07-31 1992-07-30 6-氧化-氮杂吲哚及其生产方法和中间产品以及药物应用 Pending CN1069733A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4125292A DE4125292A1 (de) 1991-07-31 1991-07-31 6-oxo-azepinoindol-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DEP4125292.6 1991-07-31

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN96100699A Division CN1141773A (zh) 1991-07-31 1996-01-19 含6-氧代-氮杂䓬吲哚的药物的制备方法

Publications (1)

Publication Number Publication Date
CN1069733A true CN1069733A (zh) 1993-03-10

Family

ID=6437366

Family Applications (2)

Application Number Title Priority Date Filing Date
CN92108977A Pending CN1069733A (zh) 1991-07-31 1992-07-30 6-氧化-氮杂吲哚及其生产方法和中间产品以及药物应用
CN96100699A Pending CN1141773A (zh) 1991-07-31 1996-01-19 含6-氧代-氮杂䓬吲哚的药物的制备方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN96100699A Pending CN1141773A (zh) 1991-07-31 1996-01-19 含6-氧代-氮杂䓬吲哚的药物的制备方法

Country Status (21)

Country Link
US (1) US5272143A (enExample)
EP (1) EP0525584B1 (enExample)
JP (1) JP3174158B2 (enExample)
KR (1) KR930002353A (enExample)
CN (2) CN1069733A (enExample)
AT (1) ATE161012T1 (enExample)
AU (1) AU649153B2 (enExample)
CA (1) CA2075102A1 (enExample)
CZ (1) CZ239392A3 (enExample)
DE (2) DE4125292A1 (enExample)
ES (1) ES2110454T3 (enExample)
FI (1) FI923440A7 (enExample)
HU (2) HU211105B (enExample)
IE (1) IE922310A1 (enExample)
IL (1) IL102503A (enExample)
MX (1) MX9204457A (enExample)
NO (1) NO300375B1 (enExample)
NZ (1) NZ243715A (enExample)
RU (1) RU2078765C1 (enExample)
TW (1) TW207541B (enExample)
ZA (1) ZA925093B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100418967C (zh) * 1999-01-11 2008-09-17 阿古龙制药公司 聚(adp-核糖)聚合酶的三环抑制剂

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5414130A (en) * 1993-12-23 1995-05-09 The Dow Chemical Company Process for the preparation of diaminoresorcinol
ECSP003637A (es) 1999-08-31 2002-03-25 Agouron Pharma Inhibidores triciclicos de poli (adp-ribosa) polimerasas
EP1793830A2 (en) * 2004-09-22 2007-06-13 Pfizer, Inc. Therapeutic combinations comprising poly(adp-ribose) polymerases inhibitor
KR100876520B1 (ko) * 2004-09-22 2008-12-31 화이자 인코포레이티드 폴리(ａｄｐ-리보오스) 폴리머라제 억제제의 제조 방법
CN102046176B (zh) 2008-05-29 2013-08-07 阿尔巴尼分子研究公司 5-ht3受体调节剂、其制备方法和用途
JP5745283B2 (ja) * 2010-02-12 2015-07-08 ファイザー・インク ８−フルオロ−２−｛４−［（メチルアミノ）メチル］フェニル｝−１，３，４，５−テトラヒドロ−６Ｈ−アゼピノ［５，４，３−ｃｄ］インドール−６−オンの塩および多形体
US10513515B2 (en) 2017-08-25 2019-12-24 Biotheryx, Inc. Ether compounds and uses thereof
EP3830093A1 (en) 2018-07-27 2021-06-09 Biotheryx, Inc. Bifunctional compounds as cdk modulators
US11897930B2 (en) 2020-04-28 2024-02-13 Anwita Biosciences, Inc. Interleukin-2 polypeptides and fusion proteins thereof, and their pharmaceutical compositions and therapeutic applications

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4910193A (en) * 1985-12-16 1990-03-20 Sandoz Ltd. Treatment of gastrointestinal disorders

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100418967C (zh) * 1999-01-11 2008-09-17 阿古龙制药公司 聚(adp-核糖)聚合酶的三环抑制剂

Also Published As

Publication number Publication date
TW207541B (enExample) 1993-06-11
NO923004L (no) 1993-02-01
NZ243715A (en) 1995-03-28
IL102503A0 (en) 1993-01-14
AU649153B2 (en) 1994-05-12
HU211105B (en) 1995-10-30
IL102503A (en) 1995-12-31
AU2067792A (en) 1993-02-04
HUT65453A (en) 1994-06-28
HU9202430D0 (en) 1992-10-28
NO923004D0 (no) 1992-07-30
ZA925093B (en) 1993-04-28
DE59209055D1 (de) 1998-01-22
MX9204457A (es) 1993-05-01
US5272143A (en) 1993-12-21
RU2078765C1 (ru) 1997-05-10
CZ239392A3 (en) 1993-04-14
DE4125292A1 (de) 1993-02-04
ATE161012T1 (de) 1997-12-15
HU210217A9 (en) 1995-02-28
JPH05202052A (ja) 1993-08-10
NO300375B1 (no) 1997-05-20
EP0525584B1 (de) 1997-12-10
JP3174158B2 (ja) 2001-06-11
FI923440A0 (fi) 1992-07-30
ES2110454T3 (es) 1998-02-16
IE922310A1 (en) 1993-02-10
KR930002353A (ko) 1993-02-23
FI923440A7 (fi) 1993-02-01
CA2075102A1 (en) 1993-02-01
CN1141773A (zh) 1997-02-05
EP0525584A1 (de) 1993-02-03

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