JP2934742B2 - 新規化合物、その製法及びそれを含む医薬組成物 - Google Patents

新規化合物、その製法及びそれを含む医薬組成物

Info

Publication number
JP2934742B2
JP2934742B2 JP1258652A JP25865289A JP2934742B2 JP 2934742 B2 JP2934742 B2 JP 2934742B2 JP 1258652 A JP1258652 A JP 1258652A JP 25865289 A JP25865289 A JP 25865289A JP 2934742 B2 JP2934742 B2 JP 2934742B2
Authority
JP
Japan
Prior art keywords
methyl
compound
azabicyclo
group
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP1258652A
Other languages
English (en)
Japanese (ja)
Other versions
JPH02129186A (ja
Inventor
ハリー・ジョン・ワッズワース
マイケル・スチュワート・ハドレー
ポール・アドリアン・ワイマン
サラ・マーガレット・ジェンキンズ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BIICHAMU GURUUPU PLC
Original Assignee
BIICHAMU GURUUPU PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888823142A external-priority patent/GB8823142D0/en
Priority claimed from GB898920073A external-priority patent/GB8920073D0/en
Application filed by BIICHAMU GURUUPU PLC filed Critical BIICHAMU GURUUPU PLC
Publication of JPH02129186A publication Critical patent/JPH02129186A/ja
Application granted granted Critical
Publication of JP2934742B2 publication Critical patent/JP2934742B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP1258652A 1988-10-03 1989-10-03 新規化合物、その製法及びそれを含む医薬組成物 Expired - Lifetime JP2934742B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB8823142.8 1988-10-03
GB888823142A GB8823142D0 (en) 1988-10-03 1988-10-03 Novel compounds
GB8920073.7 1989-09-07
GB898920073A GB8920073D0 (en) 1989-09-07 1989-09-07 Novel compounds

Publications (2)

Publication Number Publication Date
JPH02129186A JPH02129186A (ja) 1990-05-17
JP2934742B2 true JP2934742B2 (ja) 1999-08-16

Family

ID=26294467

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1258652A Expired - Lifetime JP2934742B2 (ja) 1988-10-03 1989-10-03 新規化合物、その製法及びそれを含む医薬組成物

Country Status (8)

Country Link
US (1) US5091397A (pt)
EP (1) EP0363085A3 (pt)
JP (1) JP2934742B2 (pt)
KR (1) KR900006339A (pt)
AU (1) AU4242689A (pt)
CA (1) CA2000042A1 (pt)
DK (1) DK484589A (pt)
PT (1) PT91872B (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8717446D0 (en) * 1987-07-23 1987-08-26 Merck Sharp & Dohme Chemical compounds
EP0402056A3 (en) * 1989-06-06 1991-09-04 Beecham Group p.l.c. Azabicyclic compounds, process for their preparation and pharmaceutical compositions containing them
GB8917957D0 (en) * 1989-08-05 1989-09-20 Beecham Group Plc Novel compounds
ATE136031T1 (de) * 1989-10-07 1996-04-15 Beecham Group Plc Azabizyklische verbindungen, verfahren und zwischenprodukte zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen
ES2149767T5 (es) * 1991-09-20 2005-06-16 Glaxo Group Limited Nuevo uso medico para antagonistas de taquiquininas.
AU2782792A (en) * 1991-10-15 1993-05-21 Warner-Lambert Company Azabicyclo oxime and amine cholinergic agents and methods of treatment
US5622976A (en) * 1991-12-31 1997-04-22 Fujisawa Pharmaceutical Co., Ltd. Oxadiazole derivatives having acetylcholinesterase-inhibitory and muscarinic agonist activity
US5244907A (en) * 1992-03-26 1993-09-14 A. H. Robins Company, Incorporated Carbocyclic carboxylic acid amides and esters of azabicyclic compounds as gastric prokinetic, antiemetic, anxiolytic and antiarrhythmic agents
US5190953A (en) * 1992-03-26 1993-03-02 A. H. Robins Company, Incorporated Heterocyclic carboxylic acid amides and esters of azabicyclic compounds as gastric prokinetic, antiemetic, anxiolytic and antiarrhythmic agents
SE9201478D0 (sv) * 1992-05-11 1992-05-11 Kabi Pharmacia Ab Heteroaromatic quinuclidinenes, their use and preparation
US5312785A (en) * 1993-05-18 1994-05-17 The Dow Chemical Company Sintered self-reinforced silicon nitride
US5859004A (en) * 1995-02-17 1999-01-12 Novo Nordisk A/S Use of heterocyclic compounds for the treatment of conditions caused by malfunctioning of the nicotinic cholinergic system
WO1997001558A1 (en) * 1995-06-29 1997-01-16 Novo Nordisk A/S Novel substituted azabicyclic compounds
US5914338A (en) * 1996-04-02 1999-06-22 Novo Nordisk Heterocyclic compounds and their preparation and use
US5733912A (en) * 1997-02-19 1998-03-31 Abbott Laboratories 7A-heterocycle substituted hexahydro-1H-pyrrolizine compounds useful in controlling chemical synaptic transmission
RU2323217C2 (ru) * 2002-08-14 2008-04-27 Ньюросерч А/С Новые хинуклидиновые производные и их применение
EP1937068A4 (en) * 2005-08-18 2010-08-04 Glaxo Group Ltd ANTAGONISTS OF ACETYLCHOLINE MUSCARINIC RECEPTORS
US7968484B2 (en) * 2007-09-07 2011-06-28 Ut-Battelle, Llc Use of additives to improve microstructures and fracture resistance of silicon nitride ceramics
KR101427092B1 (ko) * 2012-01-13 2014-08-07 제일모직주식회사 α-메틸렌락톤의 제조 방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ203861A (en) 1982-04-14 1986-07-11 Beecham Group Plc Bicyclic heterocyclic compounds and pharmaceutical compositions containing such
NZ219646A (en) * 1986-03-27 1990-10-26 Merck Sharp & Dohme Oxadiazole derivatives of azacyclics for treating cns disorders
GB8615785D0 (en) 1986-06-27 1986-08-06 Beecham Group Plc Compounds
ES2061502T3 (es) 1986-06-27 1994-12-16 Beecham Group Plc Nuevos n-heterociclos biciclicos puenteados.
DE3854932T2 (de) 1987-04-15 1996-06-13 Beecham Group Plc Am Brückenkopf substituierte Azabicyclenderivate
GB8717446D0 (en) * 1987-07-23 1987-08-26 Merck Sharp & Dohme Chemical compounds
EP0322182A3 (en) * 1987-12-22 1992-01-02 Beecham Group Plc Azabicyclic compounds, process for their preparation and pharmaceutical compositions containing them

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Ｆａｒｍａｋｏｌｏｇｉｙａ ｉ Ｔｏｋｓｉｋｏｌｏｇｉｙａ，ｖｏｌ．３７，Ｎｏ．５，（１９７４）ｐａｇｅｓ ５５３−５５５
Ｋｈｉｍｉｋｏ−Ｆｏｒｍａｔｓｖｅｔｉｃｈｅｓｋｉｊ Ｚｈｕｒｎａｌ，ｖｏｌ．２１，Ｎｏ．７（１９８７） ｐａｇｅｓ ８０８−８１１
Ｋｈｉｍｉｋｏ−Ｆｏｒｍａｔｓｖｅｔｉｃｈｅｓｋｉｊ Ｚｈｕｒｎａｌ，ｖｏｌ．７，Ｎｏ．１２（１９７３） ｐａｇｅｓ ２３−２６

Also Published As

Publication number Publication date
CA2000042A1 (en) 1990-04-03
US5091397A (en) 1992-02-25
PT91872B (pt) 1995-05-31
KR900006339A (ko) 1990-05-08
JPH02129186A (ja) 1990-05-17
PT91872A (pt) 1990-04-30
DK484589A (da) 1990-04-04
EP0363085A2 (en) 1990-04-11
AU4242689A (en) 1990-04-26
EP0363085A3 (en) 1991-03-27
DK484589D0 (da) 1989-10-02

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