JP2875393B2 - Ｇ−タンパク質機能の阻害および増殖性疾患の治療に有用な三環式カルバメート化合物 - Google Patents

Ｇ−タンパク質機能の阻害および増殖性疾患の治療に有用な三環式カルバメート化合物

Info

Publication number
JP2875393B2
JP2875393B2 JP7511923A JP51192395A JP2875393B2 JP 2875393 B2 JP2875393 B2 JP 2875393B2 JP 7511923 A JP7511923 A JP 7511923A JP 51192395 A JP51192395 A JP 51192395A JP 2875393 B2 JP2875393 B2 JP 2875393B2
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JP
Japan
Prior art keywords
alkyl
compound
aryl
substituted
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP7511923A
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English (en)
Japanese (ja)
Other versions
JPH08510759A (ja
Inventor
ダブリュー． ロバート ビショップ，
ロナルド ジェイ． ドール，
アラン ケイ． マラムス，
エフ． ジョージ ヌジョルジ，
ジョアンヌ エム． ペットリン，
ジョーン ジェイ． ピウィンスキー，
ステイシー ダブリュー． レミスズースキー，
アーサー ジー． タベラス，
ロナルド エル． ウォリン，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SHEERINGU PURAU CORP
Original Assignee
SHEERINGU PURAU CORP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SHEERINGU PURAU CORP filed Critical SHEERINGU PURAU CORP
Publication of JPH08510759A publication Critical patent/JPH08510759A/ja
Application granted granted Critical
Publication of JP2875393B2 publication Critical patent/JP2875393B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
JP7511923A 1993-10-15 1994-10-12 Ｇ−タンパク質機能の阻害および増殖性疾患の治療に有用な三環式カルバメート化合物 Expired - Fee Related JP2875393B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13743593A 1993-10-15 1993-10-15
US08/137,435 1993-10-15
US137,435 1993-10-15

Publications (2)

Publication Number Publication Date
JPH08510759A JPH08510759A (ja) 1996-11-12
JP2875393B2 true JP2875393B2 (ja) 1999-03-31

Family

ID=22477422

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7511923A Expired - Fee Related JP2875393B2 (ja) 1993-10-15 1994-10-12 Ｇ−タンパク質機能の阻害および増殖性疾患の治療に有用な三環式カルバメート化合物

Country Status (18)

Country Link
EP (1) EP0723538B1 (https=)
JP (1) JP2875393B2 (https=)
AT (1) ATE210652T1 (https=)
AU (1) AU699043B2 (https=)
CA (1) CA2174105C (https=)
DE (1) DE69429438T2 (https=)
DK (1) DK0723538T3 (https=)
ES (1) ES2164716T3 (https=)
HU (1) HUT76066A (https=)
IL (1) IL111258A0 (https=)
MA (1) MA23353A1 (https=)
NZ (1) NZ274749A (https=)
PT (1) PT723538E (https=)
SG (1) SG48750A1 (https=)
TN (1) TNSN94104A1 (https=)
TW (1) TW308594B (https=)
WO (1) WO1995010515A1 (https=)
ZA (1) ZA947970B (https=)

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HU9600963D0 (en) 1996-06-28
ATE210652T1 (de) 2001-12-15
DE69429438T2 (de) 2002-08-08
AU7930994A (en) 1995-05-04
CA2174105A1 (en) 1995-04-20
AU699043B2 (en) 1998-11-19
DE69429438D1 (de) 2002-01-24
EP0723538A1 (en) 1996-07-31
HUT76066A (en) 1997-06-30
CA2174105C (en) 2002-02-12
SG48750A1 (en) 1998-05-18
PT723538E (pt) 2002-05-31
EP0723538B1 (en) 2001-12-12
ZA947970B (en) 1996-07-12
ES2164716T3 (es) 2002-03-01
MA23353A1 (fr) 1995-07-01
NZ274749A (en) 1998-05-27
JPH08510759A (ja) 1996-11-12
TW308594B (https=) 1997-06-21
WO1995010515A1 (en) 1995-04-20
TNSN94104A1 (fr) 1995-09-21
IL111258A0 (en) 1994-12-29
DK0723538T3 (da) 2002-03-18

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