JP2811210B2 - ビス（３，５―ジー第三ブチル―４―ヒドロキシフェニルチオ）メタンの血液コレステロール低下及び抗アテローム性動脈硬化症剤としての用途 - Google Patents

ビス（３，５―ジー第三ブチル―４―ヒドロキシフェニルチオ）メタンの血液コレステロール低下及び抗アテローム性動脈硬化症剤としての用途

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Publication number
JP2811210B2
JP2811210B2 JP1317397A JP31739789A JP2811210B2 JP 2811210 B2 JP2811210 B2 JP 2811210B2 JP 1317397 A JP1317397 A JP 1317397A JP 31739789 A JP31739789 A JP 31739789A JP 2811210 B2 JP2811210 B2 JP 2811210B2
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JP
Japan
Prior art keywords
butyl
tert
bis
hydroxyphenylthio
methane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP1317397A
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English (en)
Japanese (ja)
Other versions
JPH02202817A (ja
Inventor
ジェン タン マオ シモン
リー ジャクソン リチャード
Original Assignee
メレルダウファーマスーティカルズ インコーポレーテッド
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Application filed by メレルダウファーマスーティカルズ インコーポレーテッド filed Critical メレルダウファーマスーティカルズ インコーポレーテッド
Publication of JPH02202817A publication Critical patent/JPH02202817A/ja
Application granted granted Critical
Publication of JP2811210B2 publication Critical patent/JP2811210B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/065—Diphenyl-substituted acyclic alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP1317397A 1988-12-08 1989-12-06 ビス（３，５―ジー第三ブチル―４―ヒドロキシフェニルチオ）メタンの血液コレステロール低下及び抗アテローム性動脈硬化症剤としての用途 Expired - Fee Related JP2811210B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US281,433 1988-12-08
US07/281,433 US4900757A (en) 1988-12-08 1988-12-08 Hypocholesterolemic and antiatherosclerotic uses of bix(3,5-di-tertiary-butyl-4-hydroxyphenylthio)methane

Publications (2)

Publication Number Publication Date
JPH02202817A JPH02202817A (ja) 1990-08-10
JP2811210B2 true JP2811210B2 (ja) 1998-10-15

Family

ID=23077273

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1317397A Expired - Fee Related JP2811210B2 (ja) 1988-12-08 1989-12-06 ビス（３，５―ジー第三ブチル―４―ヒドロキシフェニルチオ）メタンの血液コレステロール低下及び抗アテローム性動脈硬化症剤としての用途

Country Status (12)

Country Link
US (1) US4900757A (OSRAM)
EP (1) EP0372542B1 (OSRAM)
JP (1) JP2811210B2 (OSRAM)
KR (1) KR0150631B1 (OSRAM)
AT (1) ATE81451T1 (OSRAM)
AU (1) AU619926B2 (OSRAM)
DE (1) DE68903215T2 (OSRAM)
DK (1) DK617189A (OSRAM)
ES (1) ES2052871T3 (OSRAM)
GR (1) GR3006001T3 (OSRAM)
IE (1) IE62820B1 (OSRAM)
ZA (1) ZA899251B (OSRAM)

Families Citing this family (49)

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US4959392A (en) * 1989-07-24 1990-09-25 Merrell Dow Pharmaceuticals Inc. Method of treating diabetes mellitus
US5122542A (en) * 1990-06-19 1992-06-16 Merrell Dow Pharmaceuticals Inc. Hypotriglyceridemic use of certain bis (3,5-di-alkyl-4-hydroxyphenylthio)methanes
AU651873B2 (en) * 1991-03-18 1994-08-04 Merrell Dow Pharmaceuticals Inc. Method of inhibiting the progressive development of diabetes mellitus
US5411741A (en) * 1993-07-29 1995-05-02 Zaias; Nardo Method and composition for skin depigmentation
EP0732928B1 (en) * 1993-12-10 2004-12-22 Merrell Pharmaceuticals Inc. Method of lowering serum cholesterol levels with 2,6-di-alkyl-4-silyl-phenols
US5677291A (en) * 1993-12-10 1997-10-14 Hoechst Marion Roussel, Inc. Method of lowering serum cholesterol levels with 2,6-di-alkyl-4-silyl-phenols
RU2235541C2 (ru) * 1994-10-04 2004-09-10 Эмори Юниверсити Лечение атеросклероза и других сердечно-сосудистых и воспалительных заболеваний
US5795876A (en) * 1996-04-30 1998-08-18 Hoechst Marion Rousssel, Inc. Method of inhibiting vascular cell adhesion molecule-1 and treating chronic inflammatory diseases with 2, 6-di-alkyl-4-silyl-phenols
US5608095A (en) * 1996-04-30 1997-03-04 Hoechst Marion Roussel, Inc. Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents
US6114572A (en) * 1996-11-20 2000-09-05 Hoechst Marion Roussel, Inc. Substituted phenols and thiophenols useful as antioxidant agents
US6121463A (en) * 1997-06-24 2000-09-19 Hoechst Marion Roussel, Inc. Alkyl-4-silylheterocyclic phenols and thiophenols useful as antioxidant agents
US6133467A (en) * 1997-06-25 2000-10-17 Hoechst Marion Roussel, Inc. 2,6-di-t-butyl-4-[(dimethyl-4-methoxyphenylsilyl)-methyl-oxy]phenol and 2,6-di-t-butyl-4-[(dimethyl-2-methoxy-phenylsilyl)methyloxy]phenol
EG26979A (en) 2000-12-21 2015-03-01 Astrazeneca Ab Chemical compounds
GB0121337D0 (en) 2001-09-04 2001-10-24 Astrazeneca Ab Chemical compounds
GB0121621D0 (en) 2001-09-07 2001-10-31 Astrazeneca Ab Chemical compounds
GB0121622D0 (en) 2001-09-07 2001-10-31 Astrazeneca Ab Chemical compounds
EP1427423B9 (en) 2001-09-08 2017-12-20 AstraZeneca AB Benzothiazepine and benzothiadiazepine derivatives with ileal bile acid transport (ibat) inhibitory activity for the treatment hyperlipidaemia
GB0201850D0 (en) * 2002-01-26 2002-03-13 Astrazeneca Ab Therapeutic treatment
GB0209467D0 (en) 2002-04-25 2002-06-05 Astrazeneca Ab Chemical compounds
GB0213669D0 (en) 2002-06-14 2002-07-24 Astrazeneca Ab Chemical compounds
GB0304194D0 (en) 2003-02-25 2003-03-26 Astrazeneca Ab Chemical compounds
GB0307918D0 (en) 2003-04-05 2003-05-14 Astrazeneca Ab Therapeutic use
PL3400944T3 (pl) 2010-11-04 2020-11-16 Albireo Ab Inhibitory ibat w leczeniu chorób wątroby
JO3301B1 (ar) 2013-04-26 2018-09-16 Albireo Ab تعديلات بلورية على إيلوبيكسيبات
JP6751020B2 (ja) 2014-06-25 2020-09-02 Ｅａファーマ株式会社 固形製剤及びその着色防止又は着色低減方法
EP3012252A1 (en) 2014-10-24 2016-04-27 Ferring BV Crystal modifications of elobixibat
US10441604B2 (en) 2016-02-09 2019-10-15 Albireo Ab Cholestyramine pellets and methods for preparation thereof
US10786529B2 (en) 2016-02-09 2020-09-29 Albireo Ab Oral cholestyramine formulation and use thereof
US10441605B2 (en) 2016-02-09 2019-10-15 Albireo Ab Oral cholestyramine formulation and use thereof
CN111032019B (zh) 2017-08-09 2022-07-05 阿尔比里奥公司 考来烯胺颗粒、口服考来烯胺制剂及其用途
US10793534B2 (en) 2018-06-05 2020-10-06 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
TW202015699A (zh) 2018-06-05 2020-05-01 瑞典商艾爾比瑞歐公司 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽汁酸調節劑之用途
US11801226B2 (en) 2018-06-20 2023-10-31 Albireo Ab Pharmaceutical formulation of odevixibat
KR20210024033A (ko) 2018-06-20 2021-03-04 알비레오 에이비 오데빅시바트의 약학 제제
US11007142B2 (en) 2018-08-09 2021-05-18 Albireo Ab Oral cholestyramine formulation and use thereof
US10722457B2 (en) 2018-08-09 2020-07-28 Albireo Ab Oral cholestyramine formulation and use thereof
US11549878B2 (en) 2018-08-09 2023-01-10 Albireo Ab In vitro method for determining the adsorbing capacity of an insoluble adsorbant
US10975045B2 (en) 2019-02-06 2021-04-13 Aibireo AB Benzothiazepine compounds and their use as bile acid modulators
KR20210126053A (ko) 2019-02-06 2021-10-19 알비레오 에이비 벤조티아디아제핀 화합물 및 담즙산 조절제로서의 그의 용도
US10941127B2 (en) 2019-02-06 2021-03-09 Albireo Ab Benzothiadiazepine compounds and their use as bile acid modulators
EP4069361B1 (en) 2019-12-04 2024-01-03 Albireo AB Benzothia(di)azepine compounds and their use as bile acid modulators
CA3158276A1 (en) 2019-12-04 2021-06-10 Per-Goran Gillberg Benzothia(di)azepine compounds and their use as bile acid modulators
US11014898B1 (en) 2020-12-04 2021-05-25 Albireo Ab Benzothiazepine compounds and their use as bile acid modulators
ES3029063T3 (en) 2019-12-04 2025-06-23 Albireo Ab Benzothiadiazepine compounds and their use as bile acid modulators
CN114761079B (zh) 2019-12-04 2024-05-28 阿尔比里奥公司 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途
EP4188541B1 (en) 2020-08-03 2024-12-25 Albireo AB Benzothia(di)azepine compounds and their use as bile acid modulators
EP4243831A1 (en) 2020-11-12 2023-09-20 Albireo AB Odevixibat for treating progressive familial intrahepatic cholestasis (pfic)
EP4255565A1 (en) 2020-12-04 2023-10-11 Albireo AB Benzothia(di)azepine compounds and their use as bile acid modulators
TW202313579A (zh) 2021-06-03 2023-04-01 瑞典商艾爾比瑞歐公司 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3862332A (en) * 1967-05-11 1975-01-21 Dow Chemical Co Method of lowering serum cholesterol
NL154666B (nl) * 1967-05-11 1977-10-17 Dow Chemical Co Werkwijze ter bereiding van een hypocholesteremisch preparaat, alsmede de onder toepassing van deze werkwijze verkregen, gevormde preparaten.
GB1199871A (en) * 1967-05-11 1970-07-22 Consolidation Coal Co Improvements in or relating to Sulfur-Containing Bisphenols
US3576883A (en) * 1969-06-30 1971-04-27 Consolidation Coal Co Alkylidenedithiobisphenols

Also Published As

Publication number Publication date
DE68903215T2 (de) 1993-04-22
DE68903215D1 (de) 1992-11-19
ES2052871T3 (es) 1994-07-16
ATE81451T1 (de) 1992-10-15
EP0372542B1 (en) 1992-10-14
AU619926B2 (en) 1992-02-06
US4900757A (en) 1990-02-13
DK617189D0 (da) 1989-12-07
IE62820B1 (en) 1995-03-08
EP0372542A2 (en) 1990-06-13
IE893922L (en) 1990-06-08
GR3006001T3 (OSRAM) 1993-06-21
DK617189A (da) 1990-06-09
KR0150631B1 (ko) 1998-10-15
AU4588489A (en) 1990-06-14
KR900009079A (ko) 1990-07-02
ZA899251B (en) 1990-09-26
EP0372542A3 (en) 1990-10-17
JPH02202817A (ja) 1990-08-10

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