DK617189D0 - Anvendelse af bis(3,5-di-t-butyl-4-hydroxy-phenylthio)-methan til fremstilling af et laegemiddel mod atherosclerose og hypercholesterolaemi - Google Patents
Anvendelse af bis(3,5-di-t-butyl-4-hydroxy-phenylthio)-methan til fremstilling af et laegemiddel mod atherosclerose og hypercholesterolaemiInfo
- Publication number
- DK617189D0 DK617189D0 DK617189A DK617189A DK617189D0 DK 617189 D0 DK617189 D0 DK 617189D0 DK 617189 A DK617189 A DK 617189A DK 617189 A DK617189 A DK 617189A DK 617189 D0 DK617189 D0 DK 617189D0
- Authority
- DK
- Denmark
- Prior art keywords
- bis
- butyl
- hypercholesterolaemia
- methan
- phenylthio
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/065—Diphenyl-substituted acyclic alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/281,433 US4900757A (en) | 1988-12-08 | 1988-12-08 | Hypocholesterolemic and antiatherosclerotic uses of bix(3,5-di-tertiary-butyl-4-hydroxyphenylthio)methane |
Publications (2)
Publication Number | Publication Date |
---|---|
DK617189D0 true DK617189D0 (da) | 1989-12-07 |
DK617189A DK617189A (da) | 1990-06-09 |
Family
ID=23077273
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK617189A DK617189A (da) | 1988-12-08 | 1989-12-07 | Anvendelse af bis(3,5-di-t-butyl-4-hydroxy-phenylthio)-methan til fremstilling af et laegemiddel mod atherosclerose og hypercholesterolaemi |
Country Status (12)
Country | Link |
---|---|
US (1) | US4900757A (da) |
EP (1) | EP0372542B1 (da) |
JP (1) | JP2811210B2 (da) |
KR (1) | KR0150631B1 (da) |
AT (1) | ATE81451T1 (da) |
AU (1) | AU619926B2 (da) |
DE (1) | DE68903215T2 (da) |
DK (1) | DK617189A (da) |
ES (1) | ES2052871T3 (da) |
GR (1) | GR3006001T3 (da) |
IE (1) | IE62820B1 (da) |
ZA (1) | ZA899251B (da) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4959392A (en) * | 1989-07-24 | 1990-09-25 | Merrell Dow Pharmaceuticals Inc. | Method of treating diabetes mellitus |
US5122542A (en) * | 1990-06-19 | 1992-06-16 | Merrell Dow Pharmaceuticals Inc. | Hypotriglyceridemic use of certain bis (3,5-di-alkyl-4-hydroxyphenylthio)methanes |
AU651873B2 (en) * | 1991-03-18 | 1994-08-04 | Merrell Dow Pharmaceuticals Inc. | Method of inhibiting the progressive development of diabetes mellitus |
US5411741A (en) * | 1993-07-29 | 1995-05-02 | Zaias; Nardo | Method and composition for skin depigmentation |
ES2263094T3 (es) * | 1993-12-10 | 2006-12-01 | Aventis Inc. | Uso de 2,6-dialquil-4-silil-fenoles para tratar el xantoma. |
US5677291A (en) * | 1993-12-10 | 1997-10-14 | Hoechst Marion Roussel, Inc. | Method of lowering serum cholesterol levels with 2,6-di-alkyl-4-silyl-phenols |
US5608095A (en) * | 1996-04-30 | 1997-03-04 | Hoechst Marion Roussel, Inc. | Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents |
US5795876A (en) * | 1996-04-30 | 1998-08-18 | Hoechst Marion Rousssel, Inc. | Method of inhibiting vascular cell adhesion molecule-1 and treating chronic inflammatory diseases with 2, 6-di-alkyl-4-silyl-phenols |
US6114572A (en) * | 1996-11-20 | 2000-09-05 | Hoechst Marion Roussel, Inc. | Substituted phenols and thiophenols useful as antioxidant agents |
US6121463A (en) * | 1997-06-24 | 2000-09-19 | Hoechst Marion Roussel, Inc. | Alkyl-4-silylheterocyclic phenols and thiophenols useful as antioxidant agents |
US6133467A (en) * | 1997-06-25 | 2000-10-17 | Hoechst Marion Roussel, Inc. | 2,6-di-t-butyl-4-[(dimethyl-4-methoxyphenylsilyl)-methyl-oxy]phenol and 2,6-di-t-butyl-4-[(dimethyl-2-methoxy-phenylsilyl)methyloxy]phenol |
EG26979A (en) | 2000-12-21 | 2015-03-01 | Astrazeneca Ab | Chemical compounds |
GB0121337D0 (en) | 2001-09-04 | 2001-10-24 | Astrazeneca Ab | Chemical compounds |
GB0121622D0 (en) | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
GB0121621D0 (en) | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
RU2305681C2 (ru) | 2001-09-08 | 2007-09-10 | Астразенека Аб | Производные бензотиадиазепина, способ их получения (варианты) |
GB0201850D0 (en) * | 2002-01-26 | 2002-03-13 | Astrazeneca Ab | Therapeutic treatment |
GB0209467D0 (en) | 2002-04-25 | 2002-06-05 | Astrazeneca Ab | Chemical compounds |
GB0213669D0 (en) | 2002-06-14 | 2002-07-24 | Astrazeneca Ab | Chemical compounds |
GB0304194D0 (en) | 2003-02-25 | 2003-03-26 | Astrazeneca Ab | Chemical compounds |
GB0307918D0 (en) | 2003-04-05 | 2003-05-14 | Astrazeneca Ab | Therapeutic use |
RS60901B1 (sr) | 2010-11-08 | 2020-11-30 | Albireo Ab | Ibat inhibitori za lečenje oboljenja jetre |
JO3301B1 (ar) | 2013-04-26 | 2018-09-16 | Albireo Ab | تعديلات بلورية على إيلوبيكسيبات |
KR102560954B1 (ko) | 2014-06-25 | 2023-07-31 | 이에이 파마 가부시키가이샤 | 고형 제제 및 그의 착색 방지 또는 착색 감소 방법 |
EP3012252A1 (en) | 2014-10-24 | 2016-04-27 | Ferring BV | Crystal modifications of elobixibat |
US10441604B2 (en) | 2016-02-09 | 2019-10-15 | Albireo Ab | Cholestyramine pellets and methods for preparation thereof |
US10441605B2 (en) | 2016-02-09 | 2019-10-15 | Albireo Ab | Oral cholestyramine formulation and use thereof |
US10786529B2 (en) | 2016-02-09 | 2020-09-29 | Albireo Ab | Oral cholestyramine formulation and use thereof |
WO2019032026A1 (en) | 2017-08-09 | 2019-02-14 | Albireo Ab | CHOLESTYRAMINE GRANULES, ORAL FORMULATIONS OF CHOLESTYRAMINE AND THEIR USE |
TW202015699A (zh) | 2018-06-05 | 2020-05-01 | 瑞典商艾爾比瑞歐公司 | 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽汁酸調節劑之用途 |
US10793534B2 (en) | 2018-06-05 | 2020-10-06 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
CN112312893A (zh) | 2018-06-20 | 2021-02-02 | 阿尔比里奥公司 | 奥德昔巴特的药物制剂 |
US11801226B2 (en) | 2018-06-20 | 2023-10-31 | Albireo Ab | Pharmaceutical formulation of odevixibat |
US11549878B2 (en) | 2018-08-09 | 2023-01-10 | Albireo Ab | In vitro method for determining the adsorbing capacity of an insoluble adsorbant |
US11007142B2 (en) | 2018-08-09 | 2021-05-18 | Albireo Ab | Oral cholestyramine formulation and use thereof |
US10722457B2 (en) | 2018-08-09 | 2020-07-28 | Albireo Ab | Oral cholestyramine formulation and use thereof |
US10941127B2 (en) | 2019-02-06 | 2021-03-09 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
US10975045B2 (en) | 2019-02-06 | 2021-04-13 | Aibireo AB | Benzothiazepine compounds and their use as bile acid modulators |
US11014898B1 (en) | 2020-12-04 | 2021-05-25 | Albireo Ab | Benzothiazepine compounds and their use as bile acid modulators |
CA3158195A1 (en) | 2019-12-04 | 2021-06-10 | Per-Goran Gillberg | Benzothia(di)azepine compounds and their use as bile acid modulators |
CA3158276A1 (en) | 2019-12-04 | 2021-06-10 | Per-Goran Gillberg | Benzothia(di)azepine compounds and their use as bile acid modulators |
EP4069247A1 (en) | 2019-12-04 | 2022-10-12 | Albireo AB | Benzothiadiazepine compounds and their use as bile acid modulators |
EP4069361B1 (en) | 2019-12-04 | 2024-01-03 | Albireo AB | Benzothia(di)azepine compounds and their use as bile acid modulators |
CA3186857A1 (en) | 2020-08-03 | 2022-02-10 | Per-Goran Gillberg | Benzothia(di)azepine compounds and their use as bile acid modulators |
JP2023549226A (ja) | 2020-11-12 | 2023-11-22 | アルビレオ エービー | 進行性家族性肝内胆汁うっ滞症(pfic)を処置するためのオデビキシバット |
CA3198216A1 (en) | 2020-12-04 | 2022-06-09 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1199871A (en) * | 1967-05-11 | 1970-07-22 | Consolidation Coal Co | Improvements in or relating to Sulfur-Containing Bisphenols |
NL154666B (nl) * | 1967-05-11 | 1977-10-17 | Dow Chemical Co | Werkwijze ter bereiding van een hypocholesteremisch preparaat, alsmede de onder toepassing van deze werkwijze verkregen, gevormde preparaten. |
US3862332A (en) * | 1967-05-11 | 1975-01-21 | Dow Chemical Co | Method of lowering serum cholesterol |
US3576883A (en) * | 1969-06-30 | 1971-04-27 | Consolidation Coal Co | Alkylidenedithiobisphenols |
-
1988
- 1988-12-08 US US07/281,433 patent/US4900757A/en not_active Expired - Lifetime
-
1989
- 1989-12-04 AU AU45884/89A patent/AU619926B2/en not_active Ceased
- 1989-12-04 ZA ZA899251A patent/ZA899251B/xx unknown
- 1989-12-06 JP JP1317397A patent/JP2811210B2/ja not_active Expired - Fee Related
- 1989-12-07 ES ES89122545T patent/ES2052871T3/es not_active Expired - Lifetime
- 1989-12-07 IE IE392289A patent/IE62820B1/en not_active IP Right Cessation
- 1989-12-07 DK DK617189A patent/DK617189A/da not_active Application Discontinuation
- 1989-12-07 EP EP89122545A patent/EP0372542B1/en not_active Expired - Lifetime
- 1989-12-07 AT AT89122545T patent/ATE81451T1/de not_active IP Right Cessation
- 1989-12-07 DE DE8989122545T patent/DE68903215T2/de not_active Expired - Fee Related
- 1989-12-07 KR KR1019890018078A patent/KR0150631B1/ko not_active IP Right Cessation
-
1992
- 1992-10-15 GR GR920402321T patent/GR3006001T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
ZA899251B (en) | 1990-09-26 |
JP2811210B2 (ja) | 1998-10-15 |
DE68903215T2 (de) | 1993-04-22 |
IE62820B1 (en) | 1995-03-08 |
GR3006001T3 (da) | 1993-06-21 |
JPH02202817A (ja) | 1990-08-10 |
US4900757A (en) | 1990-02-13 |
DK617189A (da) | 1990-06-09 |
KR900009079A (ko) | 1990-07-02 |
EP0372542A3 (en) | 1990-10-17 |
EP0372542B1 (en) | 1992-10-14 |
AU619926B2 (en) | 1992-02-06 |
KR0150631B1 (ko) | 1998-10-15 |
DE68903215D1 (de) | 1992-11-19 |
IE893922L (en) | 1990-06-08 |
ATE81451T1 (de) | 1992-10-15 |
ES2052871T3 (es) | 1994-07-16 |
EP0372542A2 (en) | 1990-06-13 |
AU4588489A (en) | 1990-06-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
AHB | Application shelved due to non-payment |