DK617189D0 - Anvendelse af bis(3,5-di-t-butyl-4-hydroxy-phenylthio)-methan til fremstilling af et laegemiddel mod atherosclerose og hypercholesterolaemi - Google Patents

Anvendelse af bis(3,5-di-t-butyl-4-hydroxy-phenylthio)-methan til fremstilling af et laegemiddel mod atherosclerose og hypercholesterolaemi

Info

Publication number
DK617189D0
DK617189D0 DK617189A DK617189A DK617189D0 DK 617189 D0 DK617189 D0 DK 617189D0 DK 617189 A DK617189 A DK 617189A DK 617189 A DK617189 A DK 617189A DK 617189 D0 DK617189 D0 DK 617189D0
Authority
DK
Denmark
Prior art keywords
bis
butyl
hypercholesterolaemia
methan
phenylthio
Prior art date
Application number
DK617189A
Other languages
English (en)
Other versions
DK617189A (da
Inventor
Simon Jen Tan Mao
Richard Lee Jackson
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of DK617189D0 publication Critical patent/DK617189D0/da
Publication of DK617189A publication Critical patent/DK617189A/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/065—Diphenyl-substituted acyclic alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK617189A 1988-12-08 1989-12-07 Anvendelse af bis(3,5-di-t-butyl-4-hydroxy-phenylthio)-methan til fremstilling af et laegemiddel mod atherosclerose og hypercholesterolaemi DK617189A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/281,433 US4900757A (en) 1988-12-08 1988-12-08 Hypocholesterolemic and antiatherosclerotic uses of bix(3,5-di-tertiary-butyl-4-hydroxyphenylthio)methane

Publications (2)

Publication Number Publication Date
DK617189D0 true DK617189D0 (da) 1989-12-07
DK617189A DK617189A (da) 1990-06-09

Family

ID=23077273

Family Applications (1)

Application Number Title Priority Date Filing Date
DK617189A DK617189A (da) 1988-12-08 1989-12-07 Anvendelse af bis(3,5-di-t-butyl-4-hydroxy-phenylthio)-methan til fremstilling af et laegemiddel mod atherosclerose og hypercholesterolaemi

Country Status (12)

Country Link
US (1) US4900757A (da)
EP (1) EP0372542B1 (da)
JP (1) JP2811210B2 (da)
KR (1) KR0150631B1 (da)
AT (1) ATE81451T1 (da)
AU (1) AU619926B2 (da)
DE (1) DE68903215T2 (da)
DK (1) DK617189A (da)
ES (1) ES2052871T3 (da)
GR (1) GR3006001T3 (da)
IE (1) IE62820B1 (da)
ZA (1) ZA899251B (da)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4959392A (en) * 1989-07-24 1990-09-25 Merrell Dow Pharmaceuticals Inc. Method of treating diabetes mellitus
US5122542A (en) * 1990-06-19 1992-06-16 Merrell Dow Pharmaceuticals Inc. Hypotriglyceridemic use of certain bis (3,5-di-alkyl-4-hydroxyphenylthio)methanes
AU651873B2 (en) * 1991-03-18 1994-08-04 Merrell Dow Pharmaceuticals Inc. Method of inhibiting the progressive development of diabetes mellitus
US5411741A (en) * 1993-07-29 1995-05-02 Zaias; Nardo Method and composition for skin depigmentation
US5677291A (en) * 1993-12-10 1997-10-14 Hoechst Marion Roussel, Inc. Method of lowering serum cholesterol levels with 2,6-di-alkyl-4-silyl-phenols
AU681731B2 (en) * 1993-12-10 1997-09-04 Aventis Inc. Method of lowering serum cholesterol levels with 2,6-di-alkyl-4-silyl-phenols
US5608095A (en) * 1996-04-30 1997-03-04 Hoechst Marion Roussel, Inc. Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents
US5795876A (en) * 1996-04-30 1998-08-18 Hoechst Marion Rousssel, Inc. Method of inhibiting vascular cell adhesion molecule-1 and treating chronic inflammatory diseases with 2, 6-di-alkyl-4-silyl-phenols
US6114572A (en) * 1996-11-20 2000-09-05 Hoechst Marion Roussel, Inc. Substituted phenols and thiophenols useful as antioxidant agents
US6121463A (en) * 1997-06-24 2000-09-19 Hoechst Marion Roussel, Inc. Alkyl-4-silylheterocyclic phenols and thiophenols useful as antioxidant agents
US6133467A (en) * 1997-06-25 2000-10-17 Hoechst Marion Roussel, Inc. 2,6-di-t-butyl-4-[(dimethyl-4-methoxyphenylsilyl)-methyl-oxy]phenol and 2,6-di-t-butyl-4-[(dimethyl-2-methoxy-phenylsilyl)methyloxy]phenol
EG26979A (en) 2000-12-21 2015-03-01 Astrazeneca Ab Chemical compounds
GB0121337D0 (en) 2001-09-04 2001-10-24 Astrazeneca Ab Chemical compounds
GB0121621D0 (en) 2001-09-07 2001-10-31 Astrazeneca Ab Chemical compounds
GB0121622D0 (en) 2001-09-07 2001-10-31 Astrazeneca Ab Chemical compounds
RU2305681C2 (ru) 2001-09-08 2007-09-10 Астразенека Аб Производные бензотиадиазепина, способ их получения (варианты)
GB0201850D0 (en) * 2002-01-26 2002-03-13 Astrazeneca Ab Therapeutic treatment
GB0209467D0 (en) 2002-04-25 2002-06-05 Astrazeneca Ab Chemical compounds
GB0213669D0 (en) 2002-06-14 2002-07-24 Astrazeneca Ab Chemical compounds
GB0304194D0 (en) 2003-02-25 2003-03-26 Astrazeneca Ab Chemical compounds
GB0307918D0 (en) 2003-04-05 2003-05-14 Astrazeneca Ab Therapeutic use
BR112013010157B1 (pt) 2010-11-08 2020-02-04 Albireo Ab iinibidores do ibat, seus usos, e composição e combinações farmacêuticas
JO3301B1 (ar) 2013-04-26 2018-09-16 Albireo Ab تعديلات بلورية على إيلوبيكسيبات
CN106659726A (zh) 2014-06-25 2017-05-10 Ea制药株式会社 固体制剂及其着色防止或着色减少方法
EP3012252A1 (en) 2014-10-24 2016-04-27 Ferring BV Crystal modifications of elobixibat
US10441605B2 (en) 2016-02-09 2019-10-15 Albireo Ab Oral cholestyramine formulation and use thereof
US10441604B2 (en) 2016-02-09 2019-10-15 Albireo Ab Cholestyramine pellets and methods for preparation thereof
US10786529B2 (en) 2016-02-09 2020-09-29 Albireo Ab Oral cholestyramine formulation and use thereof
JP2020530448A (ja) 2017-08-09 2020-10-22 アルビレオ・アクチボラグ コレスチラミン顆粒、経口コレスチラミン製剤、及びそれらの使用
ES2942443T3 (es) 2018-06-05 2023-06-01 Albireo Ab Compuestos de benzotia(di)azepina y su uso como moduladores de ácidos biliares
US10793534B2 (en) 2018-06-05 2020-10-06 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
US11801226B2 (en) 2018-06-20 2023-10-31 Albireo Ab Pharmaceutical formulation of odevixibat
CN112262130A (zh) 2018-06-20 2021-01-22 阿尔比里奥公司 奥德昔巴特的结晶修饰物
US11549878B2 (en) 2018-08-09 2023-01-10 Albireo Ab In vitro method for determining the adsorbing capacity of an insoluble adsorbant
US11007142B2 (en) 2018-08-09 2021-05-18 Albireo Ab Oral cholestyramine formulation and use thereof
US10722457B2 (en) 2018-08-09 2020-07-28 Albireo Ab Oral cholestyramine formulation and use thereof
US10975045B2 (en) 2019-02-06 2021-04-13 Aibireo AB Benzothiazepine compounds and their use as bile acid modulators
US10941127B2 (en) 2019-02-06 2021-03-09 Albireo Ab Benzothiadiazepine compounds and their use as bile acid modulators
US11014898B1 (en) 2020-12-04 2021-05-25 Albireo Ab Benzothiazepine compounds and their use as bile acid modulators
CN114786772B (zh) 2019-12-04 2024-04-09 阿尔比里奥公司 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途
JP2023504644A (ja) 2019-12-04 2023-02-06 アルビレオ・アクチボラグ ベンゾチアジアゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用
CA3158181A1 (en) 2019-12-04 2021-06-10 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
PL4069360T3 (pl) 2019-12-04 2024-04-29 Albireo Ab Związki benzotio(di)azepinowe i ich zastosowanie jako modulatory kwasów żółciowych
EP4188541A1 (en) 2020-08-03 2023-06-07 Albireo AB Benzothia(di)azepine compounds and their use as bile acid modulators
AU2021379076A1 (en) 2020-11-12 2023-06-08 Albireo Ab Odevixibat for treating progressive familial intrahepatic cholestasis (pfic)
AU2021390172A1 (en) 2020-12-04 2023-06-22 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL154666B (nl) * 1967-05-11 1977-10-17 Dow Chemical Co Werkwijze ter bereiding van een hypocholesteremisch preparaat, alsmede de onder toepassing van deze werkwijze verkregen, gevormde preparaten.
US3862332A (en) * 1967-05-11 1975-01-21 Dow Chemical Co Method of lowering serum cholesterol
GB1199871A (en) * 1967-05-11 1970-07-22 Consolidation Coal Co Improvements in or relating to Sulfur-Containing Bisphenols
US3576883A (en) * 1969-06-30 1971-04-27 Consolidation Coal Co Alkylidenedithiobisphenols

Also Published As

Publication number Publication date
DE68903215T2 (de) 1993-04-22
ZA899251B (en) 1990-09-26
EP0372542A3 (en) 1990-10-17
GR3006001T3 (da) 1993-06-21
IE62820B1 (en) 1995-03-08
EP0372542A2 (en) 1990-06-13
DE68903215D1 (de) 1992-11-19
JPH02202817A (ja) 1990-08-10
EP0372542B1 (en) 1992-10-14
KR900009079A (ko) 1990-07-02
US4900757A (en) 1990-02-13
IE893922L (en) 1990-06-08
AU4588489A (en) 1990-06-14
ES2052871T3 (es) 1994-07-16
AU619926B2 (en) 1992-02-06
ATE81451T1 (de) 1992-10-15
DK617189A (da) 1990-06-09
JP2811210B2 (ja) 1998-10-15
KR0150631B1 (ko) 1998-10-15

Similar Documents

Publication Publication Date Title
DK617189A (da) Anvendelse af bis(3,5-di-t-butyl-4-hydroxy-phenylthio)-methan til fremstilling af et laegemiddel mod atherosclerose og hypercholesterolaemi
FR2626180B1 (fr) Cartouche, appareil et procedes d'hemodiafiltration
DK264888D0 (da) Fremgangsmaade til stabilisering af vanadiumtetrachlorid mod dekomponering og staliliseret vanadiumtetrachloridsammensaetning
FR2552655B1 (fr) Dispositif chirurgical, notamment guide de percage et pince chirurgicale et ensemble d'instruments chirurgicaux les comprenant
FR2621245B1 (fr) Table d'operation orthopedique pour membres et notamment pour membres inferieurs
NO891896L (no) Fremgangsmaate og innretning for behandling av medisinsk spesialavfall.
NO893769D0 (no) Fremgangsmaate for behandling av naturgass.
DK69587D0 (da) Forbedringer i og angaaende et dispenseringsapparattil en dispenseringsbeholder med trykgas
DK268189A (da) Aromatiske forbindelser og fremgangsmaader til fremstilling deraf
ATE81662T1 (de) Polyester.
IL87566A0 (en) Medical composition for the treatment of diabetes comprising a benzamide derivative
DK0476113T3 (da) Lægemiddel til behandling af hyperlipidæmi og/eller atherosklerose
DK431489D0 (da) Lipoprotein i (ompi) af pseudomonas aeruginosa, dets fremstilling og anvendelse
NO902949D0 (no) Fiberoptisk kanisteradhesiv og anvendelse derav.
FR2656138B1 (fr) Appareil combine d'enseignement et d'exercice dentaires.
DK160944C (da) Modificerede beta2-mikroglobuliner og farmaceutiske praeparater indeholdende disse
DK591787A (da) Anvendelse af 5-(substitueret phenyl)-oxa-zolidinonderivater til fremstilling af et til behandling af depressioner egnet laegemiddel
DK0458537T3 (da) Anvendelse af en terapeutisk forbindelse til behandling af bronkitis
NO905221D0 (no) Steriliseringsblandinger og anvendelse derav.
DK213988A (da) Dihydropyridinforbindelser samt medisinsk anvendelse af disse og beslaegtede forbindelser og farmaceutiske praeparater indholdende disse.
DK36387D0 (da) Desinficerende og steriliserende praeparat
AU2716592A (en) Treatment of anxiety in benzodiazepine-withdrawn patients
DK226688D0 (da) Middel til behandling og forebyggelse af asthma
DK641189A (da) Praeparat til behandling af glaucom og fremgangsmaade til fremstilling af et saadant praeparat
DK152388D0 (da) Blegemiddelkompostion og blegeproces

Legal Events

Date Code Title Description
AHB Application shelved due to non-payment