JP2024535002A - Ｐｄ－１ ｔａｌｅｎノックダウンを使用したｔｉｌ製品を生成するためのプロセス - Google Patents

Ｐｄ－１ ｔａｌｅｎノックダウンを使用したｔｉｌ製品を生成するためのプロセス Download PDF

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JP2024535002A
JP2024535002A JP2024515844A JP2024515844A JP2024535002A JP 2024535002 A JP2024535002 A JP 2024535002A JP 2024515844 A JP2024515844 A JP 2024515844A JP 2024515844 A JP2024515844 A JP 2024515844A JP 2024535002 A JP2024535002 A JP 2024535002A
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days
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protein
period
tils
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JP2024535002A5 (enExample
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ヴィーラパスラン，アナンド
ワーデル，セス
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4271—Melanoma antigens
    • A—HUMAN NECESSITIES
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    • C12N15/90—Stable introduction of foreign DNA into chromosome
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/55—Lung
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
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    • C12N2501/20—Cytokines; Chemokines
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    • C12N2501/20—Cytokines; Chemokines
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JP2024515844A 2021-09-09 2022-09-08 Ｐｄ－１ ｔａｌｅｎノックダウンを使用したｔｉｌ製品を生成するためのプロセス Pending JP2024535002A (ja)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US202163242373P 2021-09-09 2021-09-09
US63/242,373 2021-09-09
US202163287670P 2021-12-09 2021-12-09
US63/287,670 2021-12-09
US202263322190P 2022-03-21 2022-03-21
US63/322,190 2022-03-21
US202263354605P 2022-06-22 2022-06-22
US63/354,605 2022-06-22
US202263394248P 2022-08-01 2022-08-01
US63/394,248 2022-08-01
PCT/US2022/076136 WO2023039488A1 (en) 2021-09-09 2022-09-08 Processes for generating til products using pd-1 talen knockdown

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JP2024535002A true JP2024535002A (ja) 2024-09-26
JP2024535002A5 JP2024535002A5 (enExample) 2025-09-11

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US (1) US20240424097A1 (enExample)
EP (1) EP4398915A1 (enExample)
JP (1) JP2024535002A (enExample)
KR (1) KR20240109615A (enExample)
AU (1) AU2022343729A1 (enExample)
CA (1) CA3231018A1 (enExample)
IL (1) IL311333A (enExample)
MX (1) MX2024002861A (enExample)
TW (1) TW202328439A (enExample)
WO (1) WO2023039488A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025006811A1 (en) * 2023-06-27 2025-01-02 Lyell Immunopharma, Inc. Methods for culturing immune cells
WO2025019790A1 (en) 2023-07-19 2025-01-23 Iovance Biotherapeutics, Inc. Treatment of cancer patients with tumor infiltrating lymphocyte therapies in combination with trop-2 targeting adc

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WO2021081378A1 (en) * 2019-10-25 2021-04-29 Iovance Biotherapeutics, Inc. Gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy
WO2021108619A1 (en) * 2019-11-27 2021-06-03 Board Of Regents, The University Of Texas System Engineered t cells and tumor-infiltrating lymphocytes to overcome immunosuppression in the tumor microenvironment

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