MX2024002861A - Procesos de generacion de productos de linfocitos infiltrantes del tumor (til) mediante atenuacion de nucleasa efectora similar al activador de transcripción (talen) de proteína de muerte programada (pd-1). - Google Patents

Procesos de generacion de productos de linfocitos infiltrantes del tumor (til) mediante atenuacion de nucleasa efectora similar al activador de transcripción (talen) de proteína de muerte programada (pd-1).

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Publication number
MX2024002861A
MX2024002861A MX2024002861A MX2024002861A MX2024002861A MX 2024002861 A MX2024002861 A MX 2024002861A MX 2024002861 A MX2024002861 A MX 2024002861A MX 2024002861 A MX2024002861 A MX 2024002861A MX 2024002861 A MX2024002861 A MX 2024002861A
Authority
MX
Mexico
Prior art keywords
tils
talen
knockdown
processes
methods
Prior art date
Application number
MX2024002861A
Other languages
English (en)
Spanish (es)
Inventor
Seth Wardell
Anand Veerapathran
Original Assignee
Iovance Biotherapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Iovance Biotherapeutics Inc filed Critical Iovance Biotherapeutics Inc
Publication of MX2024002861A publication Critical patent/MX2024002861A/es

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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4271—Melanoma antigens
    • A—HUMAN NECESSITIES
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MX2024002861A 2021-09-09 2022-09-08 Procesos de generacion de productos de linfocitos infiltrantes del tumor (til) mediante atenuacion de nucleasa efectora similar al activador de transcripción (talen) de proteína de muerte programada (pd-1). MX2024002861A (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US202163242373P 2021-09-09 2021-09-09
US202163287670P 2021-12-09 2021-12-09
US202263322190P 2022-03-21 2022-03-21
US202263354605P 2022-06-22 2022-06-22
US202263394248P 2022-08-01 2022-08-01
PCT/US2022/076136 WO2023039488A1 (en) 2021-09-09 2022-09-08 Processes for generating til products using pd-1 talen knockdown

Publications (1)

Publication Number Publication Date
MX2024002861A true MX2024002861A (es) 2024-06-28

Family

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MX2024002861A MX2024002861A (es) 2021-09-09 2022-09-08 Procesos de generacion de productos de linfocitos infiltrantes del tumor (til) mediante atenuacion de nucleasa efectora similar al activador de transcripción (talen) de proteína de muerte programada (pd-1).

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Country Link
US (1) US20240424097A1 (enExample)
EP (1) EP4398915A1 (enExample)
JP (1) JP2024535002A (enExample)
KR (1) KR20240109615A (enExample)
AU (1) AU2022343729A1 (enExample)
CA (1) CA3231018A1 (enExample)
IL (1) IL311333A (enExample)
MX (1) MX2024002861A (enExample)
TW (1) TW202328439A (enExample)
WO (1) WO2023039488A1 (enExample)

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WO2025006811A1 (en) * 2023-06-27 2025-01-02 Lyell Immunopharma, Inc. Methods for culturing immune cells
WO2025019790A1 (en) 2023-07-19 2025-01-23 Iovance Biotherapeutics, Inc. Treatment of cancer patients with tumor infiltrating lymphocyte therapies in combination with trop-2 targeting adc

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