JP2024534697A - 非環状脂質及びその使用方法 - Google Patents
非環状脂質及びその使用方法 Download PDFInfo
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- JP2024534697A JP2024534697A JP2024540673A JP2024540673A JP2024534697A JP 2024534697 A JP2024534697 A JP 2024534697A JP 2024540673 A JP2024540673 A JP 2024540673A JP 2024540673 A JP2024540673 A JP 2024540673A JP 2024534697 A JP2024534697 A JP 2024534697A
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- alkyl
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- alkylenyl
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- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/12—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
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- C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C219/06—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having the hydroxy groups esterified by carboxylic acids having the esterifying carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms of an acyclic saturated carbon skeleton
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
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- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
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- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
- C07C217/40—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the same carbon atom of the carbon skeleton, e.g. amino-ketals, ortho esters
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- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C219/08—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the hydroxy groups esterified by a carboxylic acid having the esterifying carboxyl group bound to an acyclic carbon atom of an acyclic unsaturated carbon skeleton
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- C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C219/10—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the hydroxy groups esterified by a carboxylic acid having the esterifying carboxyl group bound to an acyclic carbon atom of a carbon skeleton containing rings
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- C—CHEMISTRY; METALLURGY
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- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/20—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
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- C—CHEMISTRY; METALLURGY
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- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
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- C07C229/12—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
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- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
- C07C229/14—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of carbon skeletons containing rings
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- C07C239/22—Hydroxylamino compounds or their ethers or esters having oxygen atoms of hydroxylamino groups esterified
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
- C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
- C07C243/26—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C243/28—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of a saturated carbon skeleton
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163244152P | 2021-09-14 | 2021-09-14 | |
| US63/244,152 | 2021-09-14 | ||
| US202163293284P | 2021-12-23 | 2021-12-23 | |
| US63/293,284 | 2021-12-23 | ||
| US202263336018P | 2022-04-28 | 2022-04-28 | |
| US63/336,018 | 2022-04-28 | ||
| PCT/US2022/076430 WO2023044343A1 (en) | 2021-09-14 | 2022-09-14 | Acyclic lipids and methods of use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024534697A true JP2024534697A (ja) | 2024-09-20 |
| JP2024534697A5 JP2024534697A5 (enExample) | 2025-09-25 |
Family
ID=83691568
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024540673A Pending JP2024534697A (ja) | 2021-09-14 | 2022-09-14 | 非環状脂質及びその使用方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US12545636B2 (enExample) |
| EP (1) | EP4402121A1 (enExample) |
| JP (1) | JP2024534697A (enExample) |
| CN (1) | CN118317944A (enExample) |
| CA (1) | CA3231523A1 (enExample) |
| TW (1) | TW202325263A (enExample) |
| WO (1) | WO2023044343A1 (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2023121965A1 (en) * | 2021-12-20 | 2023-06-29 | Beam Therapeutics Inc. | Nanomaterial comprising diamines |
| WO2023138611A1 (en) * | 2022-01-19 | 2023-07-27 | Suzhou Abogen Biosciences Co., Ltd. | Lipid compounds and lipid nanoparticle compositions |
| WO2023240261A1 (en) * | 2022-06-10 | 2023-12-14 | Renagade Therapeutics Management Inc. | Nucleobase editing system and method of using same for modifying nucleic acid sequences |
| JP2025525569A (ja) | 2022-07-18 | 2025-08-05 | レナゲード セラピューティクス マネージメント インコーポレイテッド | 遺伝子編集成分、システム、及び使用方法 |
| WO2024032753A1 (zh) * | 2022-08-12 | 2024-02-15 | 上海蓝鹊生物医药有限公司 | 含氮链状化合物、其制备方法、包含其的组合物和应用 |
| AU2023329392A1 (en) | 2022-08-25 | 2025-02-27 | Renagade Therapeutics Management Inc. | Engineered retrons and methods of use |
| CN118108613B (zh) * | 2022-12-26 | 2025-05-06 | 北京新合睿恩生物医疗科技有限公司 | 一种阳离子脂质化合物及制备方法和应用、mRNA递送系统 |
| CN116178193B (zh) * | 2023-01-05 | 2023-07-28 | 北京悦康科创医药科技股份有限公司 | 高效低毒且稳定性表达的阳离子脂质化合物及其组合物 |
| CN116396178A (zh) * | 2023-01-05 | 2023-07-07 | 北京悦康科创医药科技股份有限公司 | 用于递送核酸的可电离阳离子脂质化合物和组合物及用途 |
| EP4680595A2 (en) | 2023-03-15 | 2026-01-21 | Renagade Therapeutics Management Inc. | Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents |
| WO2024223911A1 (en) * | 2023-04-28 | 2024-10-31 | Ziccum Ab | Nanoparticle formulations |
| EP4709361A1 (en) * | 2023-05-11 | 2026-03-18 | Agency for Science, Technology and Research | A compound for preparing lipid nanoparticles encapsulating an agent, nanoparticle composition comprising said compound and related methods thereof |
| EP4719352A1 (en) | 2023-05-31 | 2026-04-08 | Capstan Therapeutics, Inc. | Lipid nanoparticle formulations and compositions |
| EP4725938A1 (en) * | 2023-06-07 | 2026-04-15 | InnoVec Biotherapeutics | Ionizable lipid compound, lipid carrier comprising same and use thereof |
| WO2025007148A1 (en) | 2023-06-30 | 2025-01-02 | Orna Therapeutics, Inc. | Polymer lipid nanoparticle compositions for delivering circular polynucleotides |
| WO2025000542A1 (en) * | 2023-06-30 | 2025-01-02 | Shanghai Vitalgen Biopharma Co., Ltd. | Ionizable cationic lipid compounds for delivery of biologically active agents |
| CN116891423B (zh) * | 2023-07-07 | 2024-03-01 | 荣灿生物医药技术(上海)有限公司 | 脂质化合物、组合物及其制备方法和应用 |
| WO2025010554A1 (en) * | 2023-07-07 | 2025-01-16 | Yoltech Therapeutics Co., Ltd. | Lipid compounds for delivery of therapeutic agents and preparation method and its use thereof |
| TW202517607A (zh) * | 2023-07-19 | 2025-05-01 | 香港商正基基因科技有限公司 | 脂質和脂質奈米顆粒 |
| WO2025049690A1 (en) | 2023-08-29 | 2025-03-06 | Orna Therapeutics, Inc. | Circular polyethylene glycol lipids |
| EP4771154A2 (en) | 2023-09-01 | 2026-07-08 | Renagade Therapeutics Management Inc. | Gene editing systems, compositions, and methods for treatment of vexas syndrome |
| CN122228087A (zh) * | 2023-10-10 | 2026-06-16 | 新加坡科技研究局 | 用于制备包封药剂的脂质纳米颗粒的化合物、包含所述化合物的纳米颗粒组合物及其相关方法 |
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- 2022-09-14 WO PCT/US2022/076430 patent/WO2023044343A1/en not_active Ceased
- 2022-09-14 TW TW111134756A patent/TW202325263A/zh unknown
- 2022-09-14 CN CN202280071083.6A patent/CN118317944A/zh active Pending
- 2022-09-14 CA CA3231523A patent/CA3231523A1/en active Pending
- 2022-09-14 EP EP22789800.4A patent/EP4402121A1/en active Pending
- 2022-09-14 JP JP2024540673A patent/JP2024534697A/ja active Pending
- 2022-10-24 US US17/972,395 patent/US12545636B2/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018191719A1 (en) * | 2017-04-13 | 2018-10-18 | Acuitas Therapeutics, Inc. | Lipid delivery of therapeutic agents to adipose tissue |
| WO2020072605A1 (en) * | 2018-10-02 | 2020-04-09 | Intellia Therapeutics, Inc. | Ionizable amine lipids |
| WO2021055833A1 (en) * | 2019-09-19 | 2021-03-25 | Modernatx, Inc. | Branched tail lipid compounds and compositions for intracellular delivery of therapeutic agents |
Also Published As
| Publication number | Publication date |
|---|---|
| TW202325263A (zh) | 2023-07-01 |
| EP4402121A1 (en) | 2024-07-24 |
| WO2023044343A1 (en) | 2023-03-23 |
| CA3231523A1 (en) | 2023-03-23 |
| US20230202966A1 (en) | 2023-06-29 |
| CN118317944A (zh) | 2024-07-09 |
| US12545636B2 (en) | 2026-02-10 |
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