SG11202005060YA - Compositions comprising circular polyribonucleotides and uses thereof - Google Patents
Compositions comprising circular polyribonucleotides and uses thereofInfo
- Publication number
- SG11202005060YA SG11202005060YA SG11202005060YA SG11202005060YA SG11202005060YA SG 11202005060Y A SG11202005060Y A SG 11202005060YA SG 11202005060Y A SG11202005060Y A SG 11202005060YA SG 11202005060Y A SG11202005060Y A SG 11202005060YA SG 11202005060Y A SG11202005060Y A SG 11202005060YA
- Authority
- SG
- Singapore
- Prior art keywords
- compositions
- circular polyribonucleotides
- polyribonucleotides
- circular
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43595—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from coelenteratae, e.g. medusae
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762599547P | 2017-12-15 | 2017-12-15 | |
| US201862676688P | 2018-05-25 | 2018-05-25 | |
| PCT/US2018/065836 WO2019118919A1 (en) | 2017-12-15 | 2018-12-14 | Compositions comprising circular polyribonucleotides and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202005060YA true SG11202005060YA (en) | 2020-06-29 |
Family
ID=66820668
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202005060YA SG11202005060YA (en) | 2017-12-15 | 2018-12-14 | Compositions comprising circular polyribonucleotides and uses thereof |
Country Status (13)
| Country | Link |
|---|---|
| US (8) | US20200306286A1 (en) |
| EP (1) | EP3724208A4 (en) |
| JP (2) | JP2021508490A (en) |
| KR (1) | KR20200127152A (en) |
| CN (1) | CN111819185A (en) |
| AU (2) | AU2018385757B2 (en) |
| BR (1) | BR112020011670A2 (en) |
| CA (1) | CA3084824A1 (en) |
| IL (1) | IL275205A (en) |
| MA (1) | MA51155A (en) |
| MX (1) | MX2020006150A (en) |
| SG (1) | SG11202005060YA (en) |
| WO (1) | WO2019118919A1 (en) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112020011670A2 (en) | 2017-12-15 | 2020-11-17 | Flagship Pioneering Innovations Vi, Llc. | compositions comprising circular polyribonucleotides and their uses |
| MX2020013236A (en) | 2018-06-06 | 2021-02-22 | Massachusetts Inst Technology | Circular rna for translation in eukaryotic cells. |
| KR20210135265A (en) | 2019-03-04 | 2021-11-12 | 플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 | Circular polyribonucleotides and pharmaceutical compositions thereof |
| CN111718929B (en) * | 2019-03-20 | 2022-10-18 | 中国科学院上海营养与健康研究所 | Protein translation using circular RNA and uses thereof |
| EP3946466A2 (en) | 2019-03-25 | 2022-02-09 | Flagship Pioneering Innovations VI, LLC | Compositions comprising modified circular polyribonucleotides and uses thereof |
| BR112021023411A2 (en) * | 2019-05-22 | 2022-02-01 | Massachusetts Inst Technology | Compositions and methods of circular rna |
| WO2020252436A1 (en) | 2019-06-14 | 2020-12-17 | Flagship Pioneering Innovations Vi, Llc | Circular rnas for cellular therapy |
| CA3140594A1 (en) | 2019-06-19 | 2020-12-24 | Avak Kahvejian | Methods of dosing circular polyribonucleotides |
| US20220305128A1 (en) | 2019-06-19 | 2022-09-29 | Flagship Pioneering Innovations Vi, Llc | Compositions comprising circular polyribonucleotides for protein modulation and uses thereof |
| CN112662659B (en) * | 2019-10-15 | 2022-08-19 | 武汉核圣生物技术有限公司 | Universal mRNA in-vitro cyclization method |
| AU2020397956A1 (en) | 2019-12-04 | 2022-07-07 | Orna Therapeutics, Inc. | Circular RNA compositions and methods |
| TW202142689A (en) | 2020-01-29 | 2021-11-16 | 美商旗艦先鋒創新有限責任公司 | Compositions for translation and methods of use thereof |
| EP4096681A1 (en) | 2020-01-29 | 2022-12-07 | Flagship Pioneering Innovations VI, LLC | Delivery of compositions comprising circular polyribonucleotides |
| EP4121453A2 (en) * | 2020-03-20 | 2023-01-25 | Orna Therapeutics, Inc. | Circular rna compositions and methods |
| CA3179423A1 (en) * | 2020-05-19 | 2021-11-25 | Robert Alexander WESSELHOEFT | Circular rna compositions and methods |
| CA3179420A1 (en) | 2020-05-20 | 2021-11-25 | Avak Kahvejian | Coronavirus antigen compositions and their uses |
| EP4153152A1 (en) | 2020-05-20 | 2023-03-29 | Flagship Pioneering Innovations VI, LLC | Compositions and methods for producing human polyclonal antibodies |
| JP2023526423A (en) | 2020-05-20 | 2023-06-21 | フラッグシップ パイオニアリング イノベーションズ シックス，エルエルシー | Immunogenic compositions and uses thereof |
| CN111733243A (en) * | 2020-06-29 | 2020-10-02 | 中山大学孙逸仙纪念医院 | Method for improving accuracy of CircRNA detection |
| IL299261A (en) * | 2020-07-01 | 2023-02-01 | Elevatebio Tech Inc | Compositions and methods for cellular reprogramming using circular rna |
| CA3191433A1 (en) | 2020-08-12 | 2022-02-17 | Actym Therapeutics, Inc. | Immunostimulatory bacteria-based vaccines, therapeutics, and rna delivery platforms |
| WO2022051629A1 (en) | 2020-09-03 | 2022-03-10 | Flagship Pioneering Innovations Vi, Llc | Immunogenic compositions and uses thereof |
| EP4267157A1 (en) | 2020-12-23 | 2023-11-01 | Flagship Pioneering Innovations V, Inc. | In vitro assembly of anellovirus capsids enclosing rna |
| CN112562788B (en) * | 2020-12-28 | 2022-06-28 | 上海交通大学 | Construction method of circular RNA-RNA binding protein relation prediction model |
| EP4116421A1 (en) | 2021-03-10 | 2023-01-11 | Rznomics Inc. | Self-circularized rna structure |
| AR125216A1 (en) | 2021-03-26 | 2023-06-28 | Flagship Pioneering Innovations Vii Llc | PRODUCTION OF CIRCULAR POLYRIBONUCLEOTIDES IN A EUKARYOTA SYSTEM |
| EP4314281A1 (en) | 2021-03-26 | 2024-02-07 | Flagship Pioneering Innovations VII, LLC | Production of circular polyribonucleotides in a eukaryotic system |
| TW202305130A (en) | 2021-03-26 | 2023-02-01 | 美商旗艦先鋒創新有限責任（Ｖｉｉ）公司 | Production of circular polyribonucleotides in a prokaryotic system |
| US20220325287A1 (en) | 2021-03-31 | 2022-10-13 | Flagship Pioneering Innovations V, Inc. | Thanotransmission polypeptides and their use in treating cancer |
| KR20240026921A (en) | 2021-05-18 | 2024-02-29 | 플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 | Method for concentrating circular polyribonucleotides |
| JP2024521304A (en) | 2021-05-18 | 2024-05-31 | フラッグシップ パイオニアリング イノベーションズ シックス，エルエルシー | Method for concentrating circular polyribonucleotides |
| WO2023288288A1 (en) | 2021-07-15 | 2023-01-19 | Turn Biotechnologies, Inc. | Synthetic, persistent rna constructs with on/off mechanism for controlled expression and methods of use |
| WO2023288287A2 (en) * | 2021-07-15 | 2023-01-19 | Turn Biotechnologies, Inc. | Synthetic, persistent rna constructs and methods of use for cell rejuvenation and for treatment |
| CN117916371A (en) | 2021-07-27 | 2024-04-19 | 旗舰创业创新第六有限责任公司 | Apparatus, system and method for processing |
| WO2023044333A1 (en) | 2021-09-14 | 2023-03-23 | Renagade Therapeutics Management Inc. | Cyclic lipids and methods of use thereof |
| CA3231523A1 (en) | 2021-09-14 | 2023-03-23 | Renagade Therapeutics Management Inc. | Acyclic lipids and methods of use thereof |
| TW202330916A (en) | 2021-09-17 | 2023-08-01 | 美商旗艦先鋒創新有限責任公司 | Compositions and methods for producing circular polyribonucleotides |
| AU2022370530A1 (en) | 2021-10-18 | 2024-05-02 | Flagship Pioneering Innovations Vi, Llc | Compositions and methods for purifying polyribonucleotides |
| WO2023073228A1 (en) * | 2021-10-29 | 2023-05-04 | CureVac SE | Improved circular rna for expressing therapeutic proteins |
| WO2023086796A2 (en) | 2021-11-09 | 2023-05-19 | Actym Therapeutics, Inc. | Immunostimulatory bacteria for converting macrophages into a phenotype amenable to treatment, and companion diagnostic for identifying subjects for treatment |
| CA3239266A1 (en) | 2021-11-24 | 2023-06-01 | Flagship Pioneering Innovations Vi, Llc | Coronavirus immunogen compositions and their uses |
| CA3238735A1 (en) | 2021-11-24 | 2023-06-01 | Jennifer A. Nelson | Immunogenic compositions and their uses |
| AU2022397292A1 (en) | 2021-11-24 | 2024-05-30 | Flagship Pioneering Innovations Vi, Llc | Varicella-zoster virus immunogen compositions and their uses |
| KR102488280B1 (en) * | 2021-11-25 | 2023-01-16 | 주식회사 뉴클릭스바이오 | Novel splint DNA and use thereof |
| AR128002A1 (en) | 2021-12-17 | 2024-03-20 | Flagship Pioneering Innovations Vi Llc | CIRCULAR RNA ENRICHMENT METHODS UNDER DENATURALING CONDITIONS |
| WO2023122745A1 (en) | 2021-12-22 | 2023-06-29 | Flagship Pioneering Innovations Vi, Llc | Compositions and methods for purifying polyribonucleotides |
| WO2023122752A1 (en) | 2021-12-23 | 2023-06-29 | Renagade Therapeutics Management Inc. | Constrained lipids and methods of use thereof |
| WO2023122789A1 (en) | 2021-12-23 | 2023-06-29 | Flagship Pioneering Innovations Vi, Llc | Circular polyribonucleotides encoding antifusogenic polypeptides |
| WO2023143541A1 (en) * | 2022-01-28 | 2023-08-03 | Beijing Changping Laboratory | Circular rna vaccines and methods of use thereof |
| WO2023196931A1 (en) | 2022-04-07 | 2023-10-12 | Renagade Therapeutics Management Inc. | Cyclic lipids and lipid nanoparticles (lnp) for the delivery of nucleic acids or peptides for use in vaccinating against infectious agents |
| US20240042021A1 (en) | 2022-08-01 | 2024-02-08 | Flagship Pioneering Innovations Vii, Llc | Immunomodulatory proteins and related methods |
| KR20240034676A (en) | 2022-09-06 | 2024-03-14 | 알지노믹스 주식회사 | Construct of self-circularization RNA |
| WO2024054047A1 (en) | 2022-09-06 | 2024-03-14 | 알지노믹스 주식회사 | Self-circularization rna structure |
| US20240174732A1 (en) | 2022-10-05 | 2024-05-30 | Flagship Pioneering Innovations V, Inc. | Nucleic acid molecules encoding trif and additional polypeptides and their use in treating cancer |
| WO2024097664A1 (en) | 2022-10-31 | 2024-05-10 | Flagship Pioneering Innovations Vi, Llc | Compositions and methods for purifying polyribonucleotides |
| WO2024102799A1 (en) | 2022-11-08 | 2024-05-16 | Flagship Pioneering Innovations Vi, Llc | Compositions and methods for producing circular polyribonucleotides |
| WO2024129988A1 (en) | 2022-12-14 | 2024-06-20 | Flagship Pioneering Innovations Vii, Llc | Compositions and methods for delivery of therapeutic agents to bone |
| KR102581491B1 (en) * | 2023-01-20 | 2023-09-25 | 한국과학기술원 | A composition comprising RNA with lariat cap structure that enhance intracellular stability and translation of mRNA, and use thereof |
Family Cites Families (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5266684A (en) | 1988-05-02 | 1993-11-30 | The Reagents Of The University Of California | Peptide mixtures |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| EP0542874A4 (en) | 1990-07-25 | 1994-05-11 | Syngene Inc | Circular extension for generating multiple nucleic acid complements |
| US5426180A (en) | 1991-03-27 | 1995-06-20 | Research Corporation Technologies, Inc. | Methods of making single-stranded circular oligonucleotides |
| US5877160A (en) | 1991-05-31 | 1999-03-02 | Genta Incorporated | Compositions and methods of treatment of androgen-associated baldness using antisense oligomers |
| CA2118806A1 (en) | 1991-09-18 | 1993-04-01 | William J. Dower | Method of synthesizing diverse collections of oligomers |
| US5639603A (en) | 1991-09-18 | 1997-06-17 | Affymax Technologies N.V. | Synthesizing and screening molecular diversity |
| CA2127461A1 (en) | 1992-01-13 | 1993-07-22 | Michael D. Been | Enzymatic rna molecules |
| US5541061A (en) | 1992-04-29 | 1996-07-30 | Affymax Technologies N.V. | Methods for screening factorial chemical libraries |
| DE59309571D1 (en) | 1992-08-04 | 1999-06-17 | Thomson Brandt Gmbh | High voltage line transformer for a television receiver |
| US5288514A (en) | 1992-09-14 | 1994-02-22 | The Regents Of The University Of California | Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support |
| US5565324A (en) | 1992-10-01 | 1996-10-15 | The Trustees Of Columbia University In The City Of New York | Complex combinatorial chemical libraries encoded with tags |
| US5721099A (en) | 1992-10-01 | 1998-02-24 | Trustees Of Columbia University In The City Of New York | Complex combinatorial chemical libraries encoded with tags |
| US5773244A (en) | 1993-05-19 | 1998-06-30 | Regents Of The University Of California | Methods of making circular RNA |
| US5440016A (en) | 1993-06-18 | 1995-08-08 | Torrey Pines Institute For Molecular Studies | Peptides of the formula (KFmoc) ZZZ and their uses |
| US5593853A (en) | 1994-02-09 | 1997-01-14 | Martek Corporation | Generation and screening of synthetic drug libraries |
| US5688997A (en) | 1994-05-06 | 1997-11-18 | Pharmacopeia, Inc. | Process for preparing intermediates for a combinatorial dihydrobenzopyran library |
| US5525735A (en) | 1994-06-22 | 1996-06-11 | Affymax Technologies Nv | Methods for synthesizing diverse collections of pyrrolidine compounds |
| US5549974A (en) | 1994-06-23 | 1996-08-27 | Affymax Technologies Nv | Methods for the solid phase synthesis of thiazolidinones, metathiazanones, and derivatives thereof |
| US5463564A (en) | 1994-09-16 | 1995-10-31 | 3-Dimensional Pharmaceuticals, Inc. | System and method of automatically generating chemical compounds with desired properties |
| US5688696A (en) | 1994-12-12 | 1997-11-18 | Selectide Corporation | Combinatorial libraries having a predetermined frequency of each species of test compound |
| DK0839152T3 (en) | 1995-06-21 | 2002-07-08 | Martek Biosciences Corp | Combinatorial libraries of labeled biochemical compounds and processes for their preparation |
| US5766903A (en) * | 1995-08-23 | 1998-06-16 | University Technology Corporation | Circular RNA and uses thereof |
| CA2158237A1 (en) | 1995-09-13 | 1997-03-14 | Paolo Favaretto | Chair with a pivoting backrest |
| US5731423A (en) | 1996-03-21 | 1998-03-24 | Transcell Technologies, Inc. | Process for preparing sulfoxides |
| US6429301B1 (en) | 1998-04-17 | 2002-08-06 | Whitehead Institute For Biomedical Research | Use of a ribozyme to join nucleic acids and peptides |
| US6210931B1 (en) | 1998-11-30 | 2001-04-03 | The United States Of America As Represented By The Secretary Of Agriculture | Ribozyme-mediated synthesis of circular RNA |
| AUPR604101A0 (en) | 2001-06-29 | 2001-07-26 | Unisearch Limited | Aptamers |
| DE10132780A1 (en) * | 2001-07-06 | 2003-01-16 | Icon Genetics Ag | Plastid gene expression via autonomously replicating vectors |
| EP2385123B1 (en) | 2001-09-28 | 2018-04-25 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Microrna molecules |
| US7683036B2 (en) | 2003-07-31 | 2010-03-23 | Regulus Therapeutics Inc. | Oligomeric compounds and compositions for use in modulation of small non-coding RNAs |
| US20050069938A1 (en) * | 2003-09-26 | 2005-03-31 | Youxiang Wang | Amplification of polynucleotides by rolling circle amplification |
| US8084599B2 (en) | 2004-03-15 | 2011-12-27 | City Of Hope | Methods and compositions for the specific inhibition of gene expression by double-stranded RNA |
| WO2007145612A1 (en) * | 2005-06-06 | 2007-12-21 | 454 Life Sciences Corporation | Paired end sequencing |
| EP1917357A2 (en) | 2005-08-01 | 2008-05-07 | Purdue Research Foundation | Multivalent rna nanoparticles for delivery of active agents to a cell |
| DE102005046490A1 (en) | 2005-09-28 | 2007-03-29 | Johannes-Gutenberg-Universität Mainz | New nucleic acid molecule comprising promoter, a transcriptable nucleic acid sequence, a first and second nucleic acid sequence for producing modified RNA with transcriptional stability and translational efficiency |
| JP5296328B2 (en) | 2007-05-09 | 2013-09-25 | 独立行政法人理化学研究所 | Single-stranded circular RNA and method for producing the same |
| AU2009336191B2 (en) | 2008-12-18 | 2017-08-24 | Dicerna Pharmaceuticals, Inc. | Extended dicer substrate agents and methods for the specific inhibition of gene expression |
| WO2010084371A1 (en) | 2009-01-26 | 2010-07-29 | Mitoprod | Novel circular interfering rna molecules |
| WO2010093788A2 (en) | 2009-02-11 | 2010-08-19 | Dicerna Pharmaceuticals, Inc. | Multiplex dicer substrate rna interference molecules having joining sequences |
| KR101938548B1 (en) | 2011-06-23 | 2019-01-15 | (주)아모레퍼시픽 | Composition for regulating expression of pigmentation-related genes containing microRNA |
| WO2013053481A1 (en) | 2011-10-11 | 2013-04-18 | Secutech International Pte. Ltd. | Dimethyl sulfoxide as solvent for nucleic acids |
| WO2013113326A1 (en) * | 2012-01-31 | 2013-08-08 | Curevac Gmbh | Pharmaceutical composition comprising a polymeric carrier cargo complex and at least one protein or peptide antigen |
| JP6284181B2 (en) * | 2012-02-09 | 2018-02-28 | 国立研究開発法人理化学研究所 | Method for producing circular RNA and protein |
| EP2833892A4 (en) | 2012-04-02 | 2016-07-20 | Moderna Therapeutics Inc | Modified polynucleotides for the production of oncology-related proteins and peptides |
| US9878056B2 (en) | 2012-04-02 | 2018-01-30 | Modernatx, Inc. | Modified polynucleotides for the production of cosmetic proteins and peptides |
| WO2013151666A2 (en) | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Modified polynucleotides for the production of biologics and proteins associated with human disease |
| PT2800811T (en) | 2012-05-25 | 2017-08-17 | Univ California | Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription |
| WO2014082644A1 (en) | 2012-11-30 | 2014-06-05 | WULFF, Peter, Samuel | Circular rna for inhibition of microrna |
| US20160022840A1 (en) | 2013-03-09 | 2016-01-28 | Moderna Therapeutics, Inc. | Heterologous untranslated regions for mrna |
| DE102013005361A1 (en) | 2013-03-28 | 2014-10-02 | Eberhard Karls Universität Tübingen Medizinische Fakultät | polyribonucleotide |
| WO2014186334A1 (en) | 2013-05-15 | 2014-11-20 | Robert Kruse | Intracellular translation of circular rna |
| JP2016528897A (en) | 2013-08-16 | 2016-09-23 | ラナ セラピューティクス インコーポレイテッド | Compositions and methods for modulating RNA |
| US20160194368A1 (en) * | 2013-09-03 | 2016-07-07 | Moderna Therapeutics, Inc. | Circular polynucleotides |
| EP3058082A4 (en) * | 2013-10-18 | 2017-04-26 | ModernaTX, Inc. | Compositions and methods for tolerizing cellular systems |
| BR112016024644A2 (en) | 2014-04-23 | 2017-10-10 | Modernatx Inc | nucleic acid vaccines |
| AU2015289656A1 (en) * | 2014-07-16 | 2017-02-16 | Modernatx, Inc. | Circular polynucleotides |
| EP3054017A1 (en) | 2015-02-03 | 2016-08-10 | Johann Wolfgang Goethe-Universität, Frankfurt am Main | Circular RNA for the diagnosis and treatment of cardiovascular diseases |
| US10227594B2 (en) | 2015-03-20 | 2019-03-12 | Conopco, Inc. | Antiperspirant composition |
| US11000547B2 (en) | 2015-06-05 | 2021-05-11 | Dana-Farber Cancer Institute, Inc. | Compositions related to rna in circularized form |
| DK3317411T3 (en) * | 2015-06-30 | 2021-03-15 | Ethris Gmbh | ATP BINDING CASSETTE FAMILY ENCODING POLYRIBONUCLEOTIDES AND FORMULATIONS THEREOF |
| JP2018526007A (en) * | 2015-09-04 | 2018-09-13 | トカジェン インコーポレーテッド | Recombinant vector containing 2A peptide |
| AU2017280943B2 (en) | 2016-06-20 | 2023-05-18 | Emory University | Circular RNAs and their use in immunomodulation |
| CN106222174B (en) * | 2016-08-12 | 2020-08-04 | 青岛大学 | Use of circRNA CHIF nucleotides in the treatment of cardiac disorders |
| US11753434B2 (en) | 2017-04-14 | 2023-09-12 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for transient gene therapy with enhanced stability |
| US11756183B2 (en) | 2017-06-23 | 2023-09-12 | Cornell University | RNA molecules, methods of producing circular RNA, and treatment methods |
| BR112020011670A2 (en) | 2017-12-15 | 2020-11-17 | Flagship Pioneering Innovations Vi, Llc. | compositions comprising circular polyribonucleotides and their uses |
| MX2020013236A (en) | 2018-06-06 | 2021-02-22 | Massachusetts Inst Technology | Circular rna for translation in eukaryotic cells. |
| CA3107683A1 (en) | 2018-07-24 | 2020-01-30 | Flagship Pioneering Innovations Vi, Llc | Compositions comprising circular polyribonucleotides and uses thereof |
| CN111603477B (en) | 2019-02-25 | 2023-06-02 | 中国科学院分子细胞科学卓越创新中心 | Application of annular RNA in preparation of therapeutic drugs for systemic lupus erythematosus |
| WO2020180752A1 (en) | 2019-03-01 | 2020-09-10 | Flagship Pioneering Innovations Vi, Llc | Polyribonucleotides and cosmetic uses thereof |
| KR20210134716A (en) | 2019-03-01 | 2021-11-10 | 플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 | Compositions, methods, and kits for the delivery of polyribonucleotides |
| KR20210135265A (en) | 2019-03-04 | 2021-11-12 | 플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 | Circular polyribonucleotides and pharmaceutical compositions thereof |
| EP3946466A2 (en) | 2019-03-25 | 2022-02-09 | Flagship Pioneering Innovations VI, LLC | Compositions comprising modified circular polyribonucleotides and uses thereof |
| WO2020252436A1 (en) | 2019-06-14 | 2020-12-17 | Flagship Pioneering Innovations Vi, Llc | Circular rnas for cellular therapy |
| CA3140594A1 (en) | 2019-06-19 | 2020-12-24 | Avak Kahvejian | Methods of dosing circular polyribonucleotides |
| US20220305128A1 (en) | 2019-06-19 | 2022-09-29 | Flagship Pioneering Innovations Vi, Llc | Compositions comprising circular polyribonucleotides for protein modulation and uses thereof |
| EP4096681A1 (en) | 2020-01-29 | 2022-12-07 | Flagship Pioneering Innovations VI, LLC | Delivery of compositions comprising circular polyribonucleotides |
| WO2021155177A1 (en) | 2020-01-29 | 2021-08-05 | Flagship Pioneering Innovations Vi, Llc | Compositions comprising linear polyribonucleotides for protein modulation and uses thereof |
| TW202142689A (en) | 2020-01-29 | 2021-11-16 | 美商旗艦先鋒創新有限責任公司 | Compositions for translation and methods of use thereof |
| CA3179420A1 (en) | 2020-05-20 | 2021-11-25 | Avak Kahvejian | Coronavirus antigen compositions and their uses |
| EP4153152A1 (en) | 2020-05-20 | 2023-03-29 | Flagship Pioneering Innovations VI, LLC | Compositions and methods for producing human polyclonal antibodies |
| JP2023526423A (en) | 2020-05-20 | 2023-06-21 | フラッグシップ パイオニアリング イノベーションズ シックス，エルエルシー | Immunogenic compositions and uses thereof |
-
2018
- 2018-12-14 BR BR112020011670-0A patent/BR112020011670A2/en unknown
- 2018-12-14 KR KR1020207019809A patent/KR20200127152A/en not_active Application Discontinuation
- 2018-12-14 EP EP18887999.3A patent/EP3724208A4/en active Pending
- 2018-12-14 US US16/772,678 patent/US20200306286A1/en active Pending
- 2018-12-14 MA MA051155A patent/MA51155A/en unknown
- 2018-12-14 JP JP2020552672A patent/JP2021508490A/en active Pending
- 2018-12-14 AU AU2018385757A patent/AU2018385757B2/en active Active
- 2018-12-14 MX MX2020006150A patent/MX2020006150A/en unknown
- 2018-12-14 WO PCT/US2018/065836 patent/WO2019118919A1/en unknown
- 2018-12-14 CA CA3084824A patent/CA3084824A1/en active Pending
- 2018-12-14 SG SG11202005060YA patent/SG11202005060YA/en unknown
- 2018-12-14 CN CN201880081133.2A patent/CN111819185A/en active Pending
-
2019
- 2019-06-11 US US16/438,073 patent/US10953033B2/en active Active
-
2020
- 2020-06-08 IL IL275205A patent/IL275205A/en unknown
-
2021
- 2021-02-11 US US17/173,991 patent/US11058706B2/en active Active
- 2021-05-06 US US17/313,963 patent/US11160822B2/en active Active
- 2021-09-22 US US17/482,346 patent/US11458156B2/en active Active
-
2022
- 2022-08-30 US US17/898,947 patent/US20230070937A1/en active Pending
- 2022-11-16 US US17/988,007 patent/US11844759B2/en active Active
-
2023
- 2023-07-04 JP JP2023109861A patent/JP2023126888A/en active Pending
- 2023-12-18 US US18/543,966 patent/US20240122959A1/en active Pending
-
2024
- 2024-01-17 AU AU2024200298A patent/AU2024200298A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2018385757B2 (en) | 2023-10-19 |
| AU2024200298A1 (en) | 2024-02-01 |
| IL275205A (en) | 2020-07-30 |
| MX2020006150A (en) | 2020-11-11 |
| JP2023126888A (en) | 2023-09-12 |
| EP3724208A1 (en) | 2020-10-21 |
| AU2018385757A1 (en) | 2020-06-25 |
| US20230070937A1 (en) | 2023-03-09 |
| US20230201241A1 (en) | 2023-06-29 |
| US10953033B2 (en) | 2021-03-23 |
| US11160822B2 (en) | 2021-11-02 |
| CN111819185A (en) | 2020-10-23 |
| MA51155A (en) | 2020-10-21 |
| US11058706B2 (en) | 2021-07-13 |
| US20210275565A1 (en) | 2021-09-09 |
| KR20200127152A (en) | 2020-11-10 |
| US20190307785A1 (en) | 2019-10-10 |
| BR112020011670A2 (en) | 2020-11-17 |
| US20200306286A1 (en) | 2020-10-01 |
| JP2021508490A (en) | 2021-03-11 |
| WO2019118919A1 (en) | 2019-06-20 |
| US11458156B2 (en) | 2022-10-04 |
| US11844759B2 (en) | 2023-12-19 |
| US20240122959A1 (en) | 2024-04-18 |
| EP3724208A4 (en) | 2021-09-01 |
| US20220023331A1 (en) | 2022-01-27 |
| US20210161938A1 (en) | 2021-06-03 |
| CA3084824A1 (en) | 2019-06-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL275205A (en) | Compositions comprising circular polyribonucleotides and uses thereof | |
| IL280354A (en) | Compositions comprising circular polyribonucleotides and uses thereof | |
| GB2564307B (en) | Foam compositions and uses thereof | |
| HK1251922A1 (en) | Antimicrobial compositions and uses thereof | |
| IL271275A (en) | Compositions comprising curons and uses thereof | |
| IL268970A (en) | Novel compositions and methods | |
| IL286621A (en) | Compositions comprising modified circular polyribonucleotides and uses thereof | |
| ZA201702213B (en) | Interleukin-15 compositions and uses thereof | |
| ZA201803875B (en) | Interleukin-15 compositions and uses thereof | |
| HUE065174T2 (en) | Hla-based methods and compositions and uses thereof | |
| IL267925B (en) | Hsd17b13 variants and uses thereof | |
| GB201807325D0 (en) | Compositions and methods | |
| GB202201860D0 (en) | Novel methods and compositions | |
| GB201502002D0 (en) | Uses and compositions | |
| GB201608762D0 (en) | Compositions and uses thereof | |
| GB202004930D0 (en) | Composition and uses thereof | |
| GB201502026D0 (en) | Uses and compositions | |
| GB201501991D0 (en) | Uses and compositions | |
| ZA202004533B (en) | Skin-brightening compositions and methods | |
| GB201712592D0 (en) | Novel compositions and uses thereof | |
| GB201614897D0 (en) | Compositions and uses thereof | |
| GB201602409D0 (en) | Compositions and uses thereof | |
| GB201522814D0 (en) | Compositions and uses thereof | |
| GB201511886D0 (en) | Uses and compositions | |
| GB201812952D0 (en) | Compositions and uses thereof |