JP2024533990A5 - - Google Patents
Info
- Publication number
- JP2024533990A5 JP2024533990A5 JP2024507995A JP2024507995A JP2024533990A5 JP 2024533990 A5 JP2024533990 A5 JP 2024533990A5 JP 2024507995 A JP2024507995 A JP 2024507995A JP 2024507995 A JP2024507995 A JP 2024507995A JP 2024533990 A5 JP2024533990 A5 JP 2024533990A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- optionally substituted
- formula
- group
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163231220P | 2021-08-09 | 2021-08-09 | |
| US202163231219P | 2021-08-09 | 2021-08-09 | |
| US63/231,219 | 2021-08-09 | ||
| US63/231,220 | 2021-08-09 | ||
| PCT/US2022/039696 WO2023018648A1 (en) | 2021-08-09 | 2022-08-08 | Phenol derivatives for use in the modulation of brm |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024533990A JP2024533990A (ja) | 2024-09-18 |
| JP2024533990A5 true JP2024533990A5 (enExample) | 2025-08-18 |
Family
ID=83149068
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024507995A Pending JP2024533990A (ja) | 2021-08-09 | 2022-08-08 | Ｂｒｍの調節に使用するためのフェノール誘導体 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11993599B2 (enExample) |
| EP (1) | EP4384517A1 (enExample) |
| JP (1) | JP2024533990A (enExample) |
| KR (1) | KR20240046498A (enExample) |
| AU (1) | AU2022328137A1 (enExample) |
| CA (1) | CA3225467A1 (enExample) |
| TW (1) | TW202321250A (enExample) |
| WO (1) | WO2023018648A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3225467A1 (en) | 2021-08-09 | 2023-02-16 | Genentech, Inc. | Phenol derivatives for use in the modulation of brm |
| EP4540242A1 (en) * | 2022-06-16 | 2025-04-23 | Plexium, Inc. | Compounds and pharmaceutical compositions that degrade swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily a |
| WO2024214019A1 (en) | 2023-04-12 | 2024-10-17 | Aurigene Oncology Limited | Tetracyclic compounds as smarca2 and/or smarca4 degraders |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA41598A (fr) * | 2015-02-25 | 2018-01-02 | Constellation Pharmaceuticals Inc | Composés thérapeutiques de pyridazine et leurs utilisations |
| WO2019207538A1 (en) | 2018-04-26 | 2019-10-31 | Aurigene Discovery Technologies Limited | Pyridazine derivatives as smarca2/4 degraders |
| EP3787747A4 (en) | 2018-04-30 | 2022-01-12 | Dana-Farber Cancer Institute, Inc. | POLYBROMO-1 (PBRM1) SMALL MOLECULE DEGRADATION PRODUCTS |
| EP3817822A4 (en) * | 2018-07-06 | 2022-07-27 | Kymera Therapeutics, Inc. | PROTEIN DEGRADANTS AND USES THEREOF |
| WO2020078933A1 (en) | 2018-10-16 | 2020-04-23 | Boehringer Ingelheim International Gmbh | Proteolysis targeting chimera (protacs) as degraders of smarca2 and/or smarca4 |
| FR3090393B1 (fr) | 2018-12-20 | 2021-04-23 | Ifp Energies Now | Procédé de traitement d’une charge alcool pour la production d’oléfines |
| WO2020172655A1 (en) | 2019-02-23 | 2020-08-27 | New York University | Photoswitchable protacs and synthesis and uses thereof |
| WO2020251971A1 (en) * | 2019-06-10 | 2020-12-17 | Kymera Therapeutics, Inc. | Smarca degraders and uses thereof |
| US20220324880A1 (en) * | 2019-06-10 | 2022-10-13 | Kymara Therapeutics, Inc. | Smarca inhibitors and uses thereof |
| WO2020251969A1 (en) * | 2019-06-10 | 2020-12-17 | Kymera Therapeutics, Inc. | Smarca degraders and uses thereof |
| BR112022004573A2 (pt) | 2019-09-12 | 2022-06-07 | Aurigene Discovery Tech Ltd | Método para identificar respondedores para degradadores de smarca2/4 |
| WO2021067606A1 (en) * | 2019-10-01 | 2021-04-08 | Arvinas Operations, Inc. | Brm targeting compounds and associated methods of use |
| EP4054724A4 (en) | 2019-10-28 | 2023-12-27 | C4 Therapeutics, Inc. | BIFUNCTIONAL CONNECTIONS |
| CN114728936A (zh) * | 2019-10-29 | 2022-07-08 | 豪夫迈·罗氏有限公司 | 用于治疗癌症的双功能化合物 |
| JP7706456B2 (ja) | 2020-01-10 | 2025-07-11 | アムジエン・インコーポレーテツド | Ｓｍａｒｃａ２－ｖｈｌ分解剤 |
| EP4132529A4 (en) | 2020-04-06 | 2024-05-01 | Foghorn Therapeutics Inc. | COMPOUNDS AND THEIR USES |
| JP2023529908A (ja) * | 2020-06-09 | 2023-07-12 | プレリュード・セラピューティクス・インコーポレイテッド | Ｂｒｍ標的化化合物及び関連する使用方法 |
| TW202216215A (zh) * | 2020-07-21 | 2022-05-01 | 美商建南德克公司 | Ｂｒｍ降解之抗體結合化學誘導物及其方法 |
| WO2022109396A1 (en) | 2020-11-20 | 2022-05-27 | Foghorn Therapeutics Inc. | Compounds and uses thereof |
| EP4259144A4 (en) | 2020-12-09 | 2025-08-20 | Kymera Therapeutics Inc | SMARCA DEGRADING AGENTS AND THEIR USES |
| WO2022183056A1 (en) | 2021-02-26 | 2022-09-01 | Salk Institute For Biological Studies | Modulating regulatory t cell function in autoimmune disease and cancer |
| CA3225467A1 (en) | 2021-08-09 | 2023-02-16 | Genentech, Inc. | Phenol derivatives for use in the modulation of brm |
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2022
- 2022-08-08 CA CA3225467A patent/CA3225467A1/en active Pending
- 2022-08-08 WO PCT/US2022/039696 patent/WO2023018648A1/en not_active Ceased
- 2022-08-08 KR KR1020247004828A patent/KR20240046498A/ko active Pending
- 2022-08-08 US US17/883,004 patent/US11993599B2/en active Active
- 2022-08-08 AU AU2022328137A patent/AU2022328137A1/en active Pending
- 2022-08-08 JP JP2024507995A patent/JP2024533990A/ja active Pending
- 2022-08-08 EP EP22761812.1A patent/EP4384517A1/en active Pending
- 2022-08-09 TW TW111129895A patent/TW202321250A/zh unknown
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2024
- 2024-03-13 US US18/604,314 patent/US12428419B2/en active Active