JP2020535124A5 - - Google Patents
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- Publication number
- JP2020535124A5 JP2020535124A5 JP2020515000A JP2020515000A JP2020535124A5 JP 2020535124 A5 JP2020535124 A5 JP 2020535124A5 JP 2020515000 A JP2020515000 A JP 2020515000A JP 2020515000 A JP2020515000 A JP 2020515000A JP 2020535124 A5 JP2020535124 A5 JP 2020535124A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- cancer
- heteroaryl
- aryl
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CN(*)CCC(*)(C*)CN(C=Nc1c2c(*)c(*)c(*)c1*)C2=O Chemical compound CN(*)CCC(*)(C*)CN(C=Nc1c2c(*)c(*)c(*)c1*)C2=O 0.000 description 2
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023142246A JP2023164918A (ja) | 2017-09-26 | 2023-09-01 | 多発性骨髄腫を治療するための新規なｕｓｐ７阻害剤 |
| JP2025235397A JP2026031721A (ja) | 2017-09-26 | 2025-12-05 | 多発性骨髄腫を治療するための新規なｕｓｐ７阻害剤 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762563375P | 2017-09-26 | 2017-09-26 | |
| US62/563,375 | 2017-09-26 | ||
| PCT/US2018/052797 WO2019067503A1 (en) | 2017-09-26 | 2018-09-26 | NEW USP7 INHIBITORS FOR THE TREATMENT OF MULTIPLE MYELOMA |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023142246A Division JP2023164918A (ja) | 2017-09-26 | 2023-09-01 | 多発性骨髄腫を治療するための新規なｕｓｐ７阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020535124A JP2020535124A (ja) | 2020-12-03 |
| JP2020535124A5 true JP2020535124A5 (enExample) | 2023-09-12 |
| JP7402792B2 JP7402792B2 (ja) | 2023-12-21 |
Family
ID=65903565
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020515000A Active JP7402792B2 (ja) | 2017-09-26 | 2018-09-26 | 多発性骨髄腫を治療するための新規なｕｓｐ７阻害剤 |
| JP2023142246A Pending JP2023164918A (ja) | 2017-09-26 | 2023-09-01 | 多発性骨髄腫を治療するための新規なｕｓｐ７阻害剤 |
| JP2025235397A Pending JP2026031721A (ja) | 2017-09-26 | 2025-12-05 | 多発性骨髄腫を治療するための新規なｕｓｐ７阻害剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023142246A Pending JP2023164918A (ja) | 2017-09-26 | 2023-09-01 | 多発性骨髄腫を治療するための新規なｕｓｐ７阻害剤 |
| JP2025235397A Pending JP2026031721A (ja) | 2017-09-26 | 2025-12-05 | 多発性骨髄腫を治療するための新規なｕｓｐ７阻害剤 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US11465983B2 (enExample) |
| EP (1) | EP3687537A4 (enExample) |
| JP (3) | JP7402792B2 (enExample) |
| AU (1) | AU2018342089B2 (enExample) |
| CA (1) | CA3072353A1 (enExample) |
| WO (1) | WO2019067503A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11465983B2 (en) | 2017-09-26 | 2022-10-11 | Dana-Farber Cancer Institute, Inc. | USP7 inhibitors for treating multiple myeloma |
| JP7508449B2 (ja) * | 2018-10-22 | 2024-07-01 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | Ｕｓｐ７の阻害 |
| BR112021010645A2 (pt) * | 2018-12-06 | 2021-08-17 | Almac Discovery Limited | composto, 1-(((s)-7-((r)-3-ciclohexil-2-metilpropanoil)-10-hidroxi-7-azaspiro[4.5]decan-10-il)metil)-4-fenil-5-(piperazina-1-carbonila)piridin-2(1h)-ona, composição farmacêutica, métodos para tratamento de obesidade, de resistência à insulina, de diabetes tipo ii, de atrofia muscular, de câncer e para reduzir perda de massa muscular, e, inibidor de usp19 |
| WO2020227365A1 (en) * | 2019-05-06 | 2020-11-12 | Integral Early Discovery, Inc. | Inhibiting usp19 |
| CN115427076B (zh) | 2020-02-28 | 2025-01-03 | 免疫学有限公司 | 用于治疗冠状病毒感染的人去泛素化酶抑制剂 |
| CN112047933B (zh) * | 2020-10-15 | 2022-06-14 | 郑州大学 | 喹唑啉酮类usp7抑制剂及其制备方法和应用 |
| GB202104097D0 (en) * | 2021-03-24 | 2021-05-05 | Almac Discovery Ltd | Pharmaceutical compounds |
| WO2023003973A1 (en) * | 2021-07-20 | 2023-01-26 | Dana-Farber Cancer Institute, Inc. | Inhibitors targeting ubiquitin specific protease 7 (usp7) |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU3344099A (en) * | 1998-04-17 | 1999-11-08 | Kyowa Hakko Kogyo Co. Ltd. | Analgetic agent |
| AU2003218737B2 (en) | 2002-03-13 | 2008-04-10 | Janssen Pharmaceutica N.V. | Inhibitors of histone deacetylase |
| WO2007147217A1 (en) * | 2006-06-22 | 2007-12-27 | Prana Biotechnology Limited | Method of treatment of glioma brain tumour |
| EP2565186A1 (en) * | 2011-09-02 | 2013-03-06 | Hybrigenics S.A. | Selective and reversible inhibitors of ubiquitin specific protease 7 |
| HK1248220A1 (zh) | 2015-02-05 | 2018-10-12 | Forma Therapeutics, Inc. | 喹唑啉酮和偶氮喹唑啉作为泛特丁胺蛋白酶7抑制剂 |
| HK1248221A1 (zh) | 2015-02-05 | 2018-10-12 | Forma Therapeutics, Inc. | 异噻唑啉酮类，吡唑并嘧啶酮类和吡咯并嘧啶酮作为泛蛋白特异性蛋白酶7抑制剂 |
| HK1248222A1 (zh) * | 2015-02-05 | 2018-10-12 | Forma Therapeutics, Inc. | 噻吩并嘧啶酮作为泛素特异性蛋白酶7抑制剂 |
| GB201612938D0 (en) * | 2016-07-26 | 2016-09-07 | Almac Discovery Ltd | Pharmaceutical compounds |
| GB201617758D0 (en) * | 2016-10-20 | 2016-12-07 | Almac Discovery Limited | Pharmaceutical compounds |
| US11465983B2 (en) | 2017-09-26 | 2022-10-11 | Dana-Farber Cancer Institute, Inc. | USP7 inhibitors for treating multiple myeloma |
| JP7508449B2 (ja) | 2018-10-22 | 2024-07-01 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | Ｕｓｐ７の阻害 |
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2018
- 2018-09-26 US US16/650,727 patent/US11465983B2/en active Active
- 2018-09-26 AU AU2018342089A patent/AU2018342089B2/en active Active
- 2018-09-26 JP JP2020515000A patent/JP7402792B2/ja active Active
- 2018-09-26 WO PCT/US2018/052797 patent/WO2019067503A1/en not_active Ceased
- 2018-09-26 EP EP18862773.1A patent/EP3687537A4/en active Pending
- 2018-09-26 CA CA3072353A patent/CA3072353A1/en active Pending
-
2022
- 2022-09-02 US US17/902,512 patent/US20230265070A1/en active Pending
-
2023
- 2023-09-01 JP JP2023142246A patent/JP2023164918A/ja active Pending
-
2025
- 2025-12-05 JP JP2025235397A patent/JP2026031721A/ja active Pending