JP2020535124A5 - - Google Patents
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- Publication number
- JP2020535124A5 JP2020535124A5 JP2020515000A JP2020515000A JP2020535124A5 JP 2020535124 A5 JP2020535124 A5 JP 2020535124A5 JP 2020515000 A JP2020515000 A JP 2020515000A JP 2020515000 A JP2020515000 A JP 2020515000A JP 2020535124 A5 JP2020535124 A5 JP 2020535124A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- cancer
- heteroaryl
- aryl
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CN(*)CCC(*)(C*)CN(C=Nc1c2c(*)c(*)c(*)c1*)C2=O Chemical compound CN(*)CCC(*)(C*)CN(C=Nc1c2c(*)c(*)c(*)c1*)C2=O 0.000 description 2
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023142246A JP2023164918A (ja) | 2017-09-26 | 2023-09-01 | 多発性骨髄腫を治療するための新規なｕｓｐ７阻害剤 |
| JP2025235397A JP2026031721A (ja) | 2017-09-26 | 2025-12-05 | 多発性骨髄腫を治療するための新規なｕｓｐ７阻害剤 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762563375P | 2017-09-26 | 2017-09-26 | |
| US62/563,375 | 2017-09-26 | ||
| PCT/US2018/052797 WO2019067503A1 (en) | 2017-09-26 | 2018-09-26 | NEW USP7 INHIBITORS FOR THE TREATMENT OF MULTIPLE MYELOMA |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023142246A Division JP2023164918A (ja) | 2017-09-26 | 2023-09-01 | 多発性骨髄腫を治療するための新規なｕｓｐ７阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020535124A JP2020535124A (ja) | 2020-12-03 |
| JP2020535124A5 true JP2020535124A5 (enExample) | 2023-09-12 |
| JP7402792B2 JP7402792B2 (ja) | 2023-12-21 |
Family
ID=65903565
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020515000A Active JP7402792B2 (ja) | 2017-09-26 | 2018-09-26 | 多発性骨髄腫を治療するための新規なｕｓｐ７阻害剤 |
| JP2023142246A Pending JP2023164918A (ja) | 2017-09-26 | 2023-09-01 | 多発性骨髄腫を治療するための新規なｕｓｐ７阻害剤 |
| JP2025235397A Pending JP2026031721A (ja) | 2017-09-26 | 2025-12-05 | 多発性骨髄腫を治療するための新規なｕｓｐ７阻害剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023142246A Pending JP2023164918A (ja) | 2017-09-26 | 2023-09-01 | 多発性骨髄腫を治療するための新規なｕｓｐ７阻害剤 |
| JP2025235397A Pending JP2026031721A (ja) | 2017-09-26 | 2025-12-05 | 多発性骨髄腫を治療するための新規なｕｓｐ７阻害剤 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US11465983B2 (enExample) |
| EP (1) | EP3687537A4 (enExample) |
| JP (3) | JP7402792B2 (enExample) |
| AU (1) | AU2018342089B2 (enExample) |
| CA (1) | CA3072353A1 (enExample) |
| WO (1) | WO2019067503A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2018342089B2 (en) | 2017-09-26 | 2024-07-11 | Dana-Farber Cancer Institute, Inc. | Novel USP7 inhibitors for treating multiple myeloma |
| EP3870179A4 (en) * | 2018-10-22 | 2022-11-23 | Dana Farber Cancer Institute, Inc. | USP7 ESCAPEMENT |
| JP2022510700A (ja) * | 2018-12-06 | 2022-01-27 | アルマック・ディスカバリー・リミテッド | 治療において使用するｕｓｐ１９阻害剤 |
| CA3134564A1 (en) * | 2019-05-06 | 2020-11-12 | Lawrence Marcin | Inhibiting usp19 |
| WO2021170290A1 (en) | 2020-02-28 | 2021-09-02 | Immunologik Gmbh | Inhibitors of human deubiquitinases for the treatment of coronaviral infections |
| CN112047933B (zh) * | 2020-10-15 | 2022-06-14 | 郑州大学 | 喹唑啉酮类usp7抑制剂及其制备方法和应用 |
| GB202104097D0 (en) * | 2021-03-24 | 2021-05-05 | Almac Discovery Ltd | Pharmaceutical compounds |
| JP2024526849A (ja) * | 2021-07-20 | 2024-07-19 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | ユビキチン特異的プロテアーゼ７（ｕｓｐ７）を標的とする阻害剤 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU5679398A (en) | 1997-01-31 | 1998-08-25 | Kyowa Hakko Kogyo Co. Ltd. | Piperidine derivatives |
| JPH11171774A (ja) | 1997-12-05 | 1999-06-29 | Kyowa Hakko Kogyo Co Ltd | 血球増多剤 |
| WO1999053924A1 (en) * | 1998-04-17 | 1999-10-28 | Kyowa Hakko Kogyo Co., Ltd. | Analgetic agent |
| CA2476583C (en) | 2002-03-13 | 2011-07-05 | Kristof Van Emelen | Aminocarbonyl-derivatives as novel inhibitors of histone deacetylase |
| JP5415942B2 (ja) | 2006-06-22 | 2014-02-12 | プラナ バイオテクノロジー リミティッド | 処置の方法およびその処置に有用な薬剤 |
| EP2565186A1 (en) * | 2011-09-02 | 2013-03-06 | Hybrigenics S.A. | Selective and reversible inhibitors of ubiquitin specific protease 7 |
| TWI698436B (zh) | 2014-12-30 | 2020-07-11 | 美商佛瑪治療公司 | 作為泛素特異性蛋白酶７抑制劑之吡咯并及吡唑并嘧啶 |
| MA41291A (fr) | 2014-12-30 | 2017-11-07 | Forma Therapeutics Inc | Dérivés de la pyrrolotriazinone et de l'imidazotriazinone en tant qu'inhibiteurs de la protéase spécifique de l'ubiquitine n° 7 (usp7) pour le traitement d'un cancer |
| HK1248221A1 (zh) | 2015-02-05 | 2018-10-12 | Forma Therapeutics, Inc. | 异噻唑啉酮类，吡唑并嘧啶酮类和吡咯并嘧啶酮作为泛蛋白特异性蛋白酶7抑制剂 |
| EP3253765A1 (en) * | 2015-02-05 | 2017-12-13 | Forma Therapeutics, Inc. | Thienopyrimidinones as ubiquitin-specific protease 7 inhibitors |
| EP3253738A1 (en) * | 2015-02-05 | 2017-12-13 | Forma Therapeutics, Inc. | Quinazolinones and azaquinazolinones as ubiquitin-specific protease 7 inhibitors |
| GB201612938D0 (en) | 2016-07-26 | 2016-09-07 | Almac Discovery Ltd | Pharmaceutical compounds |
| GB201617758D0 (en) | 2016-10-20 | 2016-12-07 | Almac Discovery Limited | Pharmaceutical compounds |
| AU2018342089B2 (en) | 2017-09-26 | 2024-07-11 | Dana-Farber Cancer Institute, Inc. | Novel USP7 inhibitors for treating multiple myeloma |
| EP3870179A4 (en) | 2018-10-22 | 2022-11-23 | Dana Farber Cancer Institute, Inc. | USP7 ESCAPEMENT |
| JP2024526849A (ja) | 2021-07-20 | 2024-07-19 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | ユビキチン特異的プロテアーゼ７（ｕｓｐ７）を標的とする阻害剤 |
-
2018
- 2018-09-26 AU AU2018342089A patent/AU2018342089B2/en active Active
- 2018-09-26 CA CA3072353A patent/CA3072353A1/en active Pending
- 2018-09-26 JP JP2020515000A patent/JP7402792B2/ja active Active
- 2018-09-26 WO PCT/US2018/052797 patent/WO2019067503A1/en not_active Ceased
- 2018-09-26 EP EP18862773.1A patent/EP3687537A4/en active Pending
- 2018-09-26 US US16/650,727 patent/US11465983B2/en active Active
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2022
- 2022-09-02 US US17/902,512 patent/US12692250B2/en active Active
-
2023
- 2023-09-01 JP JP2023142246A patent/JP2023164918A/ja active Pending
-
2025
- 2025-12-05 JP JP2025235397A patent/JP2026031721A/ja active Pending