JP2024529347A - Ｋｒａｓの阻害剤としての三環式化合物 - Google Patents

Ｋｒａｓの阻害剤としての三環式化合物 Download PDF

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Publication number
JP2024529347A
JP2024529347A JP2024501854A JP2024501854A JP2024529347A JP 2024529347 A JP2024529347 A JP 2024529347A JP 2024501854 A JP2024501854 A JP 2024501854A JP 2024501854 A JP2024501854 A JP 2024501854A JP 2024529347 A JP2024529347 A JP 2024529347A
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alkyl
independently selected
haloalkyl
optionally substituted
membered heteroaryl
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Japanese (ja)
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JP2024529347A5 (https=
Inventor
リィ，ジェンウー
ユー，ジヨン
ローチ，ジェレミー
ホアン，ジア
フ，ビン
リィ，ゲンチョン
マカティー，ローリー
健 向井
ポリカルポ，ロッコ
サシック，ロバート
ワン，シャオジャオ
ヤオ，ウェンチン
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Incyte Corp
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Incyte Corp
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Publication of JP2024529347A publication Critical patent/JP2024529347A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2024501854A 2021-07-14 2022-07-13 Ｋｒａｓの阻害剤としての三環式化合物 Pending JP2024529347A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163221595P 2021-07-14 2021-07-14
US63/221,595 2021-07-14
PCT/US2022/036986 WO2023287896A1 (en) 2021-07-14 2022-07-13 Tricyclic compounds as inhibitors of kras

Publications (2)

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JP2024529347A true JP2024529347A (ja) 2024-08-06
JP2024529347A5 JP2024529347A5 (https=) 2025-07-22

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US (1) US12600717B2 (https=)
EP (1) EP4370515A1 (https=)
JP (1) JP2024529347A (https=)
CA (1) CA3224841A1 (https=)
WO (1) WO2023287896A1 (https=)

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JP2018511631A (ja) * 2015-04-15 2018-04-26 アラクセス ファーマ エルエルシー Ｋｒａｓの縮合三環系インヒビターおよびその使用の方法
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