JP2024527567A - Ｋｒａｓの阻害剤としての三環式化合物 - Google Patents

Ｋｒａｓの阻害剤としての三環式化合物 Download PDF

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Publication number
JP2024527567A
JP2024527567A JP2024500207A JP2024500207A JP2024527567A JP 2024527567 A JP2024527567 A JP 2024527567A JP 2024500207 A JP2024500207 A JP 2024500207A JP 2024500207 A JP2024500207 A JP 2024500207A JP 2024527567 A JP2024527567 A JP 2024527567A
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JP
Japan
Prior art keywords
fluoro
methyl
quinolin
triazolo
acetonitrile
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Pending
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JP2024500207A
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Japanese (ja)
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JP2024527567A5 (https=
Inventor
ガン，ペイ
ヤン，ジェフリー
リィ，ヨン
ジャオ，ルァ
ホァ，チュンホン
マーシャル ロウ，チュンイン
ワン，シャオジャオ
ヤオ，ウェンチン
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Incyte Corp
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Incyte Corp
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Publication of JP2024527567A publication Critical patent/JP2024527567A/ja
Publication of JP2024527567A5 publication Critical patent/JP2024527567A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2024500207A 2021-07-07 2022-07-06 Ｋｒａｓの阻害剤としての三環式化合物 Pending JP2024527567A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202163219274P 2021-07-07 2021-07-07
US63/219,274 2021-07-07
US202163292774P 2021-12-22 2021-12-22
US63/292,774 2021-12-22
US202263310811P 2022-02-16 2022-02-16
US63/310,811 2022-02-16
PCT/US2022/036172 WO2023283213A1 (en) 2021-07-07 2022-07-06 Tricyclic compounds as inhibitors of kras

Publications (2)

Publication Number Publication Date
JP2024527567A true JP2024527567A (ja) 2024-07-25
JP2024527567A5 JP2024527567A5 (https=) 2025-07-10

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JP2024500207A Pending JP2024527567A (ja) 2021-07-07 2022-07-06 Ｋｒａｓの阻害剤としての三環式化合物

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Country Link
US (1) US12441727B2 (https=)
EP (1) EP4367117A1 (https=)
JP (1) JP2024527567A (https=)
KR (1) KR20240032915A (https=)
AU (1) AU2022306671A1 (https=)
CA (1) CA3224674A1 (https=)
CL (1) CL2024000043A1 (https=)
CO (1) CO2024001285A2 (https=)
CR (1) CR20240059A (https=)
EC (1) ECSP24009853A (https=)
IL (1) IL309642A (https=)
MX (1) MX2024000357A (https=)
PE (1) PE20241127A1 (https=)
TW (1) TW202317565A (https=)
WO (1) WO2023283213A1 (https=)

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