JP2024518011A - 多様な免疫細胞のための単鎖および多鎖合成抗原受容体 - Google Patents

多様な免疫細胞のための単鎖および多鎖合成抗原受容体 Download PDF

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JP2024518011A
JP2024518011A JP2023551146A JP2023551146A JP2024518011A JP 2024518011 A JP2024518011 A JP 2024518011A JP 2023551146 A JP2023551146 A JP 2023551146A JP 2023551146 A JP2023551146 A JP 2023551146A JP 2024518011 A JP2024518011 A JP 2024518011A
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プリート エム． チャウダリー，
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
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    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
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JP2023551146A 2021-02-19 2022-02-21 多様な免疫細胞のための単鎖および多鎖合成抗原受容体 Pending JP2024518011A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163151421P 2021-02-19 2021-02-19
US63/151,421 2021-02-19
US202163245181P 2021-09-16 2021-09-16
US63/245,181 2021-09-16
PCT/US2022/017177 WO2022178367A2 (en) 2021-02-19 2022-02-21 Single-chain and multi-chain synthetic antigen receptors for diverse immune cells

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JP2024518011A true JP2024518011A (ja) 2024-04-24
JPWO2022178367A5 JPWO2022178367A5 (enExample) 2025-04-10

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US (1) US20240390496A1 (enExample)
EP (1) EP4297769A2 (enExample)
JP (1) JP2024518011A (enExample)
KR (1) KR20230153529A (enExample)
AU (1) AU2022224066A1 (enExample)
CA (1) CA3208717A1 (enExample)
IL (1) IL305175A (enExample)
WO (1) WO2022178367A2 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2898210T3 (es) 2017-07-14 2022-03-04 Immatics Biotechnologies Gmbh Molécula de polipéptido con especificidad dual mejorada
JP7368856B2 (ja) 2017-07-25 2023-10-25 トゥルーバインディング，インコーポレイテッド Ｔｉｍ－３とそのリガンドとの相互作用の遮断によるがん治療
EA202092945A1 (ru) * 2018-06-01 2021-04-29 Юниверсити Оф Саутерн Калифорния Различные антигенсвязывающие домены, новые платформы и другие улучшения для клеточной терапии
CN116063505B (zh) 2019-01-30 2024-05-03 真和制药有限公司 抗gal3抗体及其用途
CA3174575A1 (en) * 2020-03-02 2021-09-10 The Regents Of The University Of California Chimeric antigen receptors and related methods and compositions for the treatment of cancer
US12281166B2 (en) 2020-05-26 2025-04-22 Truebinding, Inc. Methods of treating inflammatory diseases by blocking Galectin-3
JP2024516699A (ja) 2021-05-05 2024-04-16 イマティクス バイオテクノロジーズ ゲーエムベーハー Ｂｍａ０３１抗原結合ポリペプチド
EP4334361A1 (en) 2021-05-05 2024-03-13 Immatics Biotechnologies GmbH Antigen binding proteins specifically binding prame
AR130387A1 (es) * 2022-09-08 2024-12-04 Hoffmann La Roche Receptores de linfocitos t recombinantes
CN118146393A (zh) * 2022-11-07 2024-06-07 武汉波睿达生物科技有限公司 一种信号肽序列优化的靶向cd19的嵌合抗原受体及其应用
WO2024102954A1 (en) * 2022-11-10 2024-05-16 Massachusetts Institute Of Technology Activation induced clipping system (aics)
KR20250133399A (ko) * 2023-01-05 2025-09-05 앤젤레스 테라퓨틱스, 인코포레이티드 유전자 전달 및 합성 및 면역 수용체의 활성을 제어하기 위한 방법 및 조성물
SE2350348A1 (en) * 2023-03-28 2024-09-29 Bjoerefeldt Andreas Microglial endocytic receptors for use in the treatment of neurodegenerative disease
AU2024266421A1 (en) * 2023-05-01 2025-11-06 Regeneron Pharmaceuticals, Inc. Mutant interleukin 15 expressing immune cells
WO2024238962A1 (en) * 2023-05-18 2024-11-21 A2 Biotherapeutics, Inc. Immune cells with paired receptors and uses thereof
WO2025029597A1 (en) * 2023-07-28 2025-02-06 Nkilt Therapeutics, Inc. Chimeric ilt receptor compositions and methods
AU2024220135A1 (en) * 2023-09-28 2025-04-17 PELL Bio-Med Technology Co., Ltd. ISOLATED NUCLEIC ACID MOLECULE COMPRISING NKp30 TRANSMEMBRANE DOMAIN AND CHIMERIC ANTIGEN RECEPTOR COMPRISING THE SAME
WO2025193475A1 (en) * 2024-03-14 2025-09-18 The Regents Of The University Of California Enhancing immune cell innate and adaptive responses
WO2025194049A1 (en) * 2024-03-15 2025-09-18 Dana-Farber Cancer Institute, Inc. Engineered immune cells and methods of using the same
WO2025235862A1 (en) * 2024-05-10 2025-11-13 Inndura Therapeutics Inc. A modified immune cell receptor comprising a target-binding domain and the extracellular domain of cd16a

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2350415A1 (en) * 1998-11-18 2000-05-25 Incyte Pharmaceuticals, Inc. Inflammation-associated genes
WO2006138005A2 (en) * 2005-05-10 2006-12-28 Monsanto Technology, Llc Genes and uses for plant improvement
WO2013033626A2 (en) * 2011-08-31 2013-03-07 Trustees Of Dartmouth College Nkp30 receptor targeted therapeutics
EP2892930B1 (en) * 2012-09-07 2019-08-14 University Of Miami Fusion proteins for promoting an immune response, nucleic acids encoding same, and methods of making and use thereof
JP7054622B2 (ja) * 2014-07-21 2022-04-14 ノバルティス アーゲー ヒト化抗ｂｃｍａキメラ抗原受容体を使用した癌の処置
EP3273993A4 (en) * 2015-03-27 2018-11-07 Nantkwest, Inc. Genetically modified nk-92 cells and monoclonal antibodies for the treatment of cancer
JP7015551B2 (ja) * 2016-02-23 2022-02-15 ソーク インスティテュート フォー バイオロジカル スタディーズ ウイルス動態への影響を最小限にするための治療用アデノウイルスにおける外因性遺伝子発現
BR112019011277A2 (pt) * 2016-12-02 2019-10-22 University Of Southern California polinucleotídeo, sistema de expressão recombinante, vetor, polipeptídeo, célula recombinante, polipeptídeo de receptor imune sintético isolado ou heterodímero de polipeptídeo, célula efetora imune ou célula-tronco, população de células imunes ou efetoras, métodos de fabricação de uma célula efetora imune que expressa sir, de geração de uma população de células modificadas por rna, de fornecimento de imunidade antidoença e de tratamento ou prevenção de uma doença, composição, uso ou método, kit, e, sequência de aminoácidos.
CN108728465A (zh) * 2017-04-14 2018-11-02 深圳新诺微环生物科技有限公司 一种表达靶细胞-效应细胞桥接器的微环dna载体及其制备方法和应用
JP7241161B2 (ja) * 2018-08-01 2023-03-16 イミュニティーバイオ、インコーポレイテッド 細胞免疫療法の安定した遺伝子改変のための、ホーミング受容体又はサイトカインとキメラ抗原受容体とを含むクアドリシストロニックシステム

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