JPWO2022178367A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2022178367A5 JPWO2022178367A5 JP2023551146A JP2023551146A JPWO2022178367A5 JP WO2022178367 A5 JPWO2022178367 A5 JP WO2022178367A5 JP 2023551146 A JP2023551146 A JP 2023551146A JP 2023551146 A JP2023551146 A JP 2023551146A JP WO2022178367 A5 JPWO2022178367 A5 JP WO2022178367A5
- Authority
- JP
- Japan
- Prior art keywords
- domain
- cell
- antigen
- receptor
- sar
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 62
- 229920001184 polypeptide Polymers 0.000 claims 57
- 102000004196 processed proteins & peptides Human genes 0.000 claims 57
- 239000000427 antigen Substances 0.000 claims 50
- 108091007433 antigens Proteins 0.000 claims 50
- 102000036639 antigens Human genes 0.000 claims 50
- 108091008874 T cell receptors Proteins 0.000 claims 44
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 44
- 210000004027 cell Anatomy 0.000 claims 44
- 239000012634 fragment Substances 0.000 claims 33
- 102000005962 receptors Human genes 0.000 claims 20
- 108020003175 receptors Proteins 0.000 claims 20
- 230000011664 signaling Effects 0.000 claims 18
- 210000001744 T-lymphocyte Anatomy 0.000 claims 15
- 230000001086 cytosolic effect Effects 0.000 claims 15
- 239000012528 membrane Substances 0.000 claims 15
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 10
- 238000004873 anchoring Methods 0.000 claims 9
- 230000000139 costimulatory effect Effects 0.000 claims 9
- 102100029360 Hematopoietic cell signal transducer Human genes 0.000 claims 8
- 101000990188 Homo sapiens Hematopoietic cell signal transducer Proteins 0.000 claims 8
- 101000946860 Homo sapiens T-cell surface glycoprotein CD3 epsilon chain Proteins 0.000 claims 7
- 206010028980 Neoplasm Diseases 0.000 claims 7
- 102100035794 T-cell surface glycoprotein CD3 epsilon chain Human genes 0.000 claims 7
- 239000003795 chemical substances by application Substances 0.000 claims 7
- 230000000295 complement effect Effects 0.000 claims 7
- 108091033319 polynucleotide Proteins 0.000 claims 7
- 102000040430 polynucleotide Human genes 0.000 claims 7
- 239000002157 polynucleotide Substances 0.000 claims 7
- 108090000623 proteins and genes Proteins 0.000 claims 7
- 108060003951 Immunoglobulin Proteins 0.000 claims 6
- 102100029193 Low affinity immunoglobulin gamma Fc region receptor III-A Human genes 0.000 claims 6
- 102000018358 immunoglobulin Human genes 0.000 claims 6
- -1 KIR3DL4 Proteins 0.000 claims 5
- 239000012636 effector Substances 0.000 claims 5
- 230000014509 gene expression Effects 0.000 claims 5
- 239000003446 ligand Substances 0.000 claims 5
- 210000000822 natural killer cell Anatomy 0.000 claims 5
- 102100026094 C-type lectin domain family 12 member A Human genes 0.000 claims 4
- 101710188619 C-type lectin domain family 12 member A Proteins 0.000 claims 4
- 102000004127 Cytokines Human genes 0.000 claims 4
- 108090000695 Cytokines Proteins 0.000 claims 4
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims 4
- 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 claims 4
- 101000809875 Homo sapiens TYRO protein tyrosine kinase-binding protein Proteins 0.000 claims 4
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims 4
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims 4
- 108010004217 Natural Cytotoxicity Triggering Receptor 1 Proteins 0.000 claims 4
- 108010004222 Natural Cytotoxicity Triggering Receptor 3 Proteins 0.000 claims 4
- 102100032870 Natural cytotoxicity triggering receptor 1 Human genes 0.000 claims 4
- 102100032852 Natural cytotoxicity triggering receptor 3 Human genes 0.000 claims 4
- 102100038717 TYRO protein tyrosine kinase-binding protein Human genes 0.000 claims 4
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims 4
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims 4
- 108010053099 Vascular Endothelial Growth Factor Receptor-2 Proteins 0.000 claims 4
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 claims 4
- 210000004899 c-terminal region Anatomy 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- SEOVTRFCIGRIMH-UHFFFAOYSA-N indole-3-acetic acid Chemical compound C1=CC=C2C(CC(=O)O)=CNC2=C1 SEOVTRFCIGRIMH-UHFFFAOYSA-N 0.000 claims 4
- 230000001939 inductive effect Effects 0.000 claims 4
- 102100038078 CD276 antigen Human genes 0.000 claims 3
- 102100027221 CD81 antigen Human genes 0.000 claims 3
- 102100025064 Cellular tumor antigen p53 Human genes 0.000 claims 3
- 102000001301 EGF receptor Human genes 0.000 claims 3
- 108060006698 EGF receptor Proteins 0.000 claims 3
- 102100038083 Endosialin Human genes 0.000 claims 3
- 101150064015 FAS gene Proteins 0.000 claims 3
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 3
- 102100026122 High affinity immunoglobulin gamma Fc receptor I Human genes 0.000 claims 3
- 101000914479 Homo sapiens CD81 antigen Proteins 0.000 claims 3
- 101000721661 Homo sapiens Cellular tumor antigen p53 Proteins 0.000 claims 3
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 3
- 101000913074 Homo sapiens High affinity immunoglobulin gamma Fc receptor I Proteins 0.000 claims 3
- 101000878602 Homo sapiens Immunoglobulin alpha Fc receptor Proteins 0.000 claims 3
- 101000917826 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor II-a Proteins 0.000 claims 3
- 101001109501 Homo sapiens NKG2-D type II integral membrane protein Proteins 0.000 claims 3
- 101001117317 Homo sapiens Programmed cell death 1 ligand 1 Proteins 0.000 claims 3
- 101000934341 Homo sapiens T-cell surface glycoprotein CD5 Proteins 0.000 claims 3
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 3
- 101000655352 Homo sapiens Telomerase reverse transcriptase Proteins 0.000 claims 3
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 3
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 3
- 102100038005 Immunoglobulin alpha Fc receptor Human genes 0.000 claims 3
- 102100020943 Leukocyte-associated immunoglobulin-like receptor 1 Human genes 0.000 claims 3
- 102100029204 Low affinity immunoglobulin gamma Fc region receptor II-a Human genes 0.000 claims 3
- 102100022680 NKG2-D type II integral membrane protein Human genes 0.000 claims 3
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims 3
- 102000004245 Proteasome Endopeptidase Complex Human genes 0.000 claims 3
- 108090000708 Proteasome Endopeptidase Complex Proteins 0.000 claims 3
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims 3
- 102100025237 T-cell surface antigen CD2 Human genes 0.000 claims 3
- 102100025244 T-cell surface glycoprotein CD5 Human genes 0.000 claims 3
- 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 claims 3
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 3
- 102000006601 Thymidine Kinase Human genes 0.000 claims 3
- 108020004440 Thymidine kinase Proteins 0.000 claims 3
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 3
- 230000003213 activating effect Effects 0.000 claims 3
- 230000004913 activation Effects 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 3
- 108010025001 leukocyte-associated immunoglobulin-like receptor 1 Proteins 0.000 claims 3
- 108020001756 ligand binding domains Proteins 0.000 claims 3
- 201000001441 melanoma Diseases 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 230000019491 signal transduction Effects 0.000 claims 3
- 210000000130 stem cell Anatomy 0.000 claims 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 2
- RJBDSRWGVYNDHL-XNJNKMBASA-N (2S,4R,5S,6S)-2-[(2S,3R,4R,5S,6R)-5-[(2S,3R,4R,5R,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-[(2R,3S,4R,5R,6R)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(E,2R,3S)-3-hydroxy-2-(octadecanoylamino)octadec-4-enoxy]oxan-3-yl]oxy-3-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-5-amino-6-[(1S,2R)-2-[(2S,4R,5S,6S)-5-amino-2-carboxy-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxan-2-yl]oxy-1,3-dihydroxypropyl]-4-hydroxyoxane-2-carboxylic acid Chemical compound CCCCCCCCCCCCCCCCCC(=O)N[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O[C@@H]3O[C@H](CO)[C@H](O)[C@H](O)[C@H]3NC(C)=O)[C@H](O[C@@]3(C[C@@H](O)[C@H](N)[C@H](O3)[C@H](O)[C@@H](CO)O[C@@]3(C[C@@H](O)[C@H](N)[C@H](O3)[C@H](O)[C@H](O)CO)C(O)=O)C(O)=O)[C@H]2O)[C@H](O)[C@H]1O)[C@@H](O)\C=C\CCCCCCCCCCCCC RJBDSRWGVYNDHL-XNJNKMBASA-N 0.000 claims 2
- LTHJXDSHSVNJKG-UHFFFAOYSA-N 2-[2-[2-[2-(2-methylprop-2-enoyloxy)ethoxy]ethoxy]ethoxy]ethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCOCCOCCOCCOC(=O)C(C)=C LTHJXDSHSVNJKG-UHFFFAOYSA-N 0.000 claims 2
- 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 claims 2
- 102100029824 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 Human genes 0.000 claims 2
- 102100033793 ALK tyrosine kinase receptor Human genes 0.000 claims 2
- 102100026402 Adhesion G protein-coupled receptor E2 Human genes 0.000 claims 2
- 102100037982 Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A Human genes 0.000 claims 2
- 101710145634 Antigen 1 Proteins 0.000 claims 2
- 102000006306 Antigen Receptors Human genes 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 2
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims 2
- 108010051118 Bone Marrow Stromal Antigen 2 Proteins 0.000 claims 2
- 102100037086 Bone marrow stromal antigen 2 Human genes 0.000 claims 2
- 108700012439 CA9 Proteins 0.000 claims 2
- 102100024263 CD160 antigen Human genes 0.000 claims 2
- 102100027207 CD27 antigen Human genes 0.000 claims 2
- 101150013553 CD40 gene Proteins 0.000 claims 2
- 102100029390 CMRF35-like molecule 1 Human genes 0.000 claims 2
- 102000004631 Calcineurin Human genes 0.000 claims 2
- 108010042955 Calcineurin Proteins 0.000 claims 2
- 102100025570 Cancer/testis antigen 1 Human genes 0.000 claims 2
- 102100039510 Cancer/testis antigen 2 Human genes 0.000 claims 2
- 102100024423 Carbonic anhydrase 9 Human genes 0.000 claims 2
- 108010022366 Carcinoembryonic Antigen Proteins 0.000 claims 2
- 102100025475 Carcinoembryonic antigen-related cell adhesion molecule 5 Human genes 0.000 claims 2
- 101710181340 Chaperone protein DnaK2 Proteins 0.000 claims 2
- 208000035473 Communicable disease Diseases 0.000 claims 2
- 101100044298 Drosophila melanogaster fand gene Proteins 0.000 claims 2
- 102100030340 Ephrin type-A receptor 2 Human genes 0.000 claims 2
- 101710116743 Ephrin type-A receptor 2 Proteins 0.000 claims 2
- 108010066687 Epithelial Cell Adhesion Molecule Proteins 0.000 claims 2
- 102100031940 Epithelial cell adhesion molecule Human genes 0.000 claims 2
- 108010060374 FSH Receptors Proteins 0.000 claims 2
- 102100031507 Fc receptor-like protein 5 Human genes 0.000 claims 2
- 102100027627 Follicle-stimulating hormone receptor Human genes 0.000 claims 2
- 102100036939 G-protein coupled receptor 20 Human genes 0.000 claims 2
- 102100021197 G-protein coupled receptor family C group 5 member D Human genes 0.000 claims 2
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 claims 2
- 102000010956 Glypican Human genes 0.000 claims 2
- 108050001154 Glypican Proteins 0.000 claims 2
- 108050007237 Glypican-3 Proteins 0.000 claims 2
- 102100028976 HLA class I histocompatibility antigen, B alpha chain Human genes 0.000 claims 2
- 102100031547 HLA class II histocompatibility antigen, DO alpha chain Human genes 0.000 claims 2
- 101710154606 Hemagglutinin Proteins 0.000 claims 2
- 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 claims 2
- 101000794082 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 Proteins 0.000 claims 2
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 2
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 2
- 101000761938 Homo sapiens CD160 antigen Proteins 0.000 claims 2
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims 2
- 101000884279 Homo sapiens CD276 antigen Proteins 0.000 claims 2
- 101100382122 Homo sapiens CIITA gene Proteins 0.000 claims 2
- 101000990055 Homo sapiens CMRF35-like molecule 1 Proteins 0.000 claims 2
- 101000884275 Homo sapiens Endosialin Proteins 0.000 claims 2
- 101000846908 Homo sapiens Fc receptor-like protein 5 Proteins 0.000 claims 2
- 101001040713 Homo sapiens G-protein coupled receptor family C group 5 member D Proteins 0.000 claims 2
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 claims 2
- 101000866278 Homo sapiens HLA class II histocompatibility antigen, DO alpha chain Proteins 0.000 claims 2
- 101000998120 Homo sapiens Interleukin-3 receptor subunit alpha Proteins 0.000 claims 2
- 101000608935 Homo sapiens Leukosialin Proteins 0.000 claims 2
- 101000917824 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor II-b Proteins 0.000 claims 2
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims 2
- 101001109503 Homo sapiens NKG2-C type II integral membrane protein Proteins 0.000 claims 2
- 101000589305 Homo sapiens Natural cytotoxicity triggering receptor 2 Proteins 0.000 claims 2
- 101000971513 Homo sapiens Natural killer cells antigen CD94 Proteins 0.000 claims 2
- 101000633786 Homo sapiens SLAM family member 6 Proteins 0.000 claims 2
- 101000824971 Homo sapiens Sperm surface protein Sp17 Proteins 0.000 claims 2
- 101000831007 Homo sapiens T-cell immunoreceptor with Ig and ITIM domains Proteins 0.000 claims 2
- 101000934346 Homo sapiens T-cell surface antigen CD2 Proteins 0.000 claims 2
- 101000716102 Homo sapiens T-cell surface glycoprotein CD4 Proteins 0.000 claims 2
- 101000946843 Homo sapiens T-cell surface glycoprotein CD8 alpha chain Proteins 0.000 claims 2
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 claims 2
- 101000894428 Homo sapiens Transcriptional repressor CTCFL Proteins 0.000 claims 2
- 101001047681 Homo sapiens Tyrosine-protein kinase Lck Proteins 0.000 claims 2
- 108010001336 Horseradish Peroxidase Proteins 0.000 claims 2
- 241000701806 Human papillomavirus Species 0.000 claims 2
- 102100029616 Immunoglobulin lambda-like polypeptide 1 Human genes 0.000 claims 2
- 101710107067 Immunoglobulin lambda-like polypeptide 1 Proteins 0.000 claims 2
- 102100039688 Insulin-like growth factor 1 receptor Human genes 0.000 claims 2
- 102000003812 Interleukin-15 Human genes 0.000 claims 2
- 108090000172 Interleukin-15 Proteins 0.000 claims 2
- 108010002350 Interleukin-2 Proteins 0.000 claims 2
- 102100033493 Interleukin-3 receptor subunit alpha Human genes 0.000 claims 2
- 101150069255 KLRC1 gene Proteins 0.000 claims 2
- 102100031413 L-dopachrome tautomerase Human genes 0.000 claims 2
- 108010011942 LH Receptors Proteins 0.000 claims 2
- 102100025586 Leukocyte immunoglobulin-like receptor subfamily A member 2 Human genes 0.000 claims 2
- 101710196509 Leukocyte immunoglobulin-like receptor subfamily A member 2 Proteins 0.000 claims 2
- 102100039564 Leukosialin Human genes 0.000 claims 2
- 102100040788 Lutropin-choriogonadotropic hormone receptor Human genes 0.000 claims 2
- 102100033486 Lymphocyte antigen 75 Human genes 0.000 claims 2
- 101710157884 Lymphocyte antigen 75 Proteins 0.000 claims 2
- 108010010995 MART-1 Antigen Proteins 0.000 claims 2
- 102100026371 MHC class II transactivator Human genes 0.000 claims 2
- 108700002010 MHC class II transactivator Proteins 0.000 claims 2
- 101100404845 Macaca mulatta NKG2A gene Proteins 0.000 claims 2
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 claims 2
- 102100022682 NKG2-A/NKG2-B type II integral membrane protein Human genes 0.000 claims 2
- 102100022683 NKG2-C type II integral membrane protein Human genes 0.000 claims 2
- 102100032851 Natural cytotoxicity triggering receptor 2 Human genes 0.000 claims 2
- 102100021462 Natural killer cells antigen CD94 Human genes 0.000 claims 2
- 108010069196 Neural Cell Adhesion Molecules Proteins 0.000 claims 2
- 102100023616 Neural cell adhesion molecule L1-like protein Human genes 0.000 claims 2
- 102100025128 Olfactory receptor 51E2 Human genes 0.000 claims 2
- 101710187841 Olfactory receptor 51E2 Proteins 0.000 claims 2
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims 2
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims 2
- 102100032364 Pannexin-3 Human genes 0.000 claims 2
- 102100026181 Placenta-specific protein 1 Human genes 0.000 claims 2
- 102100026547 Platelet-derived growth factor receptor beta Human genes 0.000 claims 2
- 101100335198 Pneumocystis carinii fol1 gene Proteins 0.000 claims 2
- 102100023832 Prolyl endopeptidase FAP Human genes 0.000 claims 2
- 101710120463 Prostate stem cell antigen Proteins 0.000 claims 2
- 102100036735 Prostate stem cell antigen Human genes 0.000 claims 2
- 102100035703 Prostatic acid phosphatase Human genes 0.000 claims 2
- 101710176177 Protein A56 Proteins 0.000 claims 2
- 102100037686 Protein SSX2 Human genes 0.000 claims 2
- 101710149284 Protein SSX2 Proteins 0.000 claims 2
- 102100038098 Protein-glutamine gamma-glutamyltransferase 5 Human genes 0.000 claims 2
- 108010024221 Proto-Oncogene Proteins c-bcr Proteins 0.000 claims 2
- 102000015690 Proto-Oncogene Proteins c-bcr Human genes 0.000 claims 2
- 108010045108 Receptor for Advanced Glycation End Products Proteins 0.000 claims 2
- 102000005622 Receptor for Advanced Glycation End Products Human genes 0.000 claims 2
- 102100020718 Receptor-type tyrosine-protein kinase FLT3 Human genes 0.000 claims 2
- 102100027610 Rho-related GTP-binding protein RhoC Human genes 0.000 claims 2
- 102100029197 SLAM family member 6 Human genes 0.000 claims 2
- 206010039491 Sarcoma Diseases 0.000 claims 2
- 102100035748 Squamous cell carcinoma antigen recognized by T-cells 3 Human genes 0.000 claims 2
- 108010008038 Synthetic Vaccines Proteins 0.000 claims 2
- 102100024834 T-cell immunoreceptor with Ig and ITIM domains Human genes 0.000 claims 2
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 claims 2
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 claims 2
- 102100036494 Testisin Human genes 0.000 claims 2
- 102100029337 Thyrotropin receptor Human genes 0.000 claims 2
- 102100021393 Transcriptional repressor CTCFL Human genes 0.000 claims 2
- 102100031989 Transmembrane protease serine 2 Human genes 0.000 claims 2
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 claims 2
- 102100033732 Tumor necrosis factor receptor superfamily member 1A Human genes 0.000 claims 2
- 101710187743 Tumor necrosis factor receptor superfamily member 1A Proteins 0.000 claims 2
- 102100033733 Tumor necrosis factor receptor superfamily member 1B Human genes 0.000 claims 2
- 101710187830 Tumor necrosis factor receptor superfamily member 1B Proteins 0.000 claims 2
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 2
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims 2
- 102100024036 Tyrosine-protein kinase Lck Human genes 0.000 claims 2
- 102100022748 Wilms tumor protein Human genes 0.000 claims 2
- 101710127857 Wilms tumor protein Proteins 0.000 claims 2
- 108010034034 alpha-1,6-mannosylglycoprotein beta 1,6-N-acetylglucosaminyltransferase Proteins 0.000 claims 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims 2
- 108040005514 choriogonadotropin hormone receptor activity proteins Proteins 0.000 claims 2
- 210000000349 chromosome Anatomy 0.000 claims 2
- 230000004940 costimulation Effects 0.000 claims 2
- 102000003675 cytokine receptors Human genes 0.000 claims 2
- 108010057085 cytokine receptors Proteins 0.000 claims 2
- 210000004405 cytokine-induced killer cell Anatomy 0.000 claims 2
- 108010051081 dopachrome isomerase Proteins 0.000 claims 2
- 230000009977 dual effect Effects 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 108010072257 fibroblast activation protein alpha Proteins 0.000 claims 2
- 108010003374 fms-Like Tyrosine Kinase 3 Proteins 0.000 claims 2
- 230000006870 function Effects 0.000 claims 2
- 239000000185 hemagglutinin Substances 0.000 claims 2
- 239000003617 indole-3-acetic acid Substances 0.000 claims 2
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 108091008042 inhibitory receptors Proteins 0.000 claims 2
- 230000003834 intracellular effect Effects 0.000 claims 2
- 210000003734 kidney Anatomy 0.000 claims 2
- 239000003550 marker Substances 0.000 claims 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims 2
- 108010043671 prostatic acid phosphatase Proteins 0.000 claims 2
- RXWNCPJZOCPEPQ-NVWDDTSBSA-N puromycin Chemical compound C1=CC(OC)=CC=C1C[C@H](N)C(=O)N[C@H]1[C@@H](O)[C@H](N2C3=NC=NC(=C3N=C2)N(C)C)O[C@@H]1CO RXWNCPJZOCPEPQ-NVWDDTSBSA-N 0.000 claims 2
- 102000016914 ras Proteins Human genes 0.000 claims 2
- 108010073531 rhoC GTP-Binding Protein Proteins 0.000 claims 2
- 125000005630 sialyl group Chemical group 0.000 claims 2
- 230000004083 survival effect Effects 0.000 claims 2
- 210000001550 testis Anatomy 0.000 claims 2
- 108010058721 transglutaminase 5 Proteins 0.000 claims 2
- 230000005945 translocation Effects 0.000 claims 2
- 102000003298 tumor necrosis factor receptor Human genes 0.000 claims 2
- 230000003612 virological effect Effects 0.000 claims 2
- SSOORFWOBGFTHL-OTEJMHTDSA-N (4S)-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[(2S)-2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-5-carbamimidamido-1-[[(2S)-5-carbamimidamido-1-[[(1S)-4-carbamimidamido-1-carboxybutyl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-2-oxoethyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2,6-diaminohexanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-5-oxopentanoic acid Chemical compound CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCCN)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O SSOORFWOBGFTHL-OTEJMHTDSA-N 0.000 claims 1
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- WEVYNIUIFUYDGI-UHFFFAOYSA-N 3-[6-[4-(trifluoromethoxy)anilino]-4-pyrimidinyl]benzamide Chemical compound NC(=O)C1=CC=CC(C=2N=CN=C(NC=3C=CC(OC(F)(F)F)=CC=3)C=2)=C1 WEVYNIUIFUYDGI-UHFFFAOYSA-N 0.000 claims 1
- 102100040079 A-kinase anchor protein 4 Human genes 0.000 claims 1
- 101710109924 A-kinase anchor protein 4 Proteins 0.000 claims 1
- 102000017918 ADRB3 Human genes 0.000 claims 1
- 108060003355 ADRB3 Proteins 0.000 claims 1
- 101710168331 ALK tyrosine kinase receptor Proteins 0.000 claims 1
- 102100033350 ATP-dependent translocase ABCB1 Human genes 0.000 claims 1
- 102100022907 Acrosin-binding protein Human genes 0.000 claims 1
- 101710107749 Acrosin-binding protein Proteins 0.000 claims 1
- 206010000830 Acute leukaemia Diseases 0.000 claims 1
- 101710096292 Adhesion G protein-coupled receptor E2 Proteins 0.000 claims 1
- 102100026423 Adhesion G protein-coupled receptor E5 Human genes 0.000 claims 1
- 108060003345 Adrenergic Receptor Proteins 0.000 claims 1
- 102000017910 Adrenergic receptor Human genes 0.000 claims 1
- 102100026882 Alpha-synuclein Human genes 0.000 claims 1
- 102100032187 Androgen receptor Human genes 0.000 claims 1
- 102000009840 Angiopoietins Human genes 0.000 claims 1
- 108010009906 Angiopoietins Proteins 0.000 claims 1
- 102100023003 Ankyrin repeat domain-containing protein 30A Human genes 0.000 claims 1
- 102100030343 Antigen peptide transporter 2 Human genes 0.000 claims 1
- 101100208111 Arabidopsis thaliana TRX5 gene Proteins 0.000 claims 1
- 102000030431 Asparaginyl endopeptidase Human genes 0.000 claims 1
- 241000271566 Aves Species 0.000 claims 1
- 102100029822 B- and T-lymphocyte attenuator Human genes 0.000 claims 1
- 102100025218 B-cell differentiation antigen CD72 Human genes 0.000 claims 1
- 102100038080 B-cell receptor CD22 Human genes 0.000 claims 1
- 108091007065 BIRCs Proteins 0.000 claims 1
- 101710149863 C-C chemokine receptor type 4 Proteins 0.000 claims 1
- 102100024217 CAMPATH-1 antigen Human genes 0.000 claims 1
- 102100032976 CCR4-NOT transcription complex subunit 6 Human genes 0.000 claims 1
- 102100038077 CD226 antigen Human genes 0.000 claims 1
- 101710185679 CD276 antigen Proteins 0.000 claims 1
- 108010058905 CD44v6 antigen Proteins 0.000 claims 1
- 108010065524 CD52 Antigen Proteins 0.000 claims 1
- 108060001253 CD99 Proteins 0.000 claims 1
- 102000024905 CD99 Human genes 0.000 claims 1
- 108091008048 CMVpp65 Proteins 0.000 claims 1
- 102100024152 Cadherin-17 Human genes 0.000 claims 1
- 102100022529 Cadherin-19 Human genes 0.000 claims 1
- 102100029756 Cadherin-6 Human genes 0.000 claims 1
- 101100518995 Caenorhabditis elegans pax-3 gene Proteins 0.000 claims 1
- 101710120600 Cancer/testis antigen 1 Proteins 0.000 claims 1
- 101710120595 Cancer/testis antigen 2 Proteins 0.000 claims 1
- 102000013392 Carboxylesterase Human genes 0.000 claims 1
- 108010051152 Carboxylesterase Proteins 0.000 claims 1
- 102000004046 Caspase-2 Human genes 0.000 claims 1
- 108090000552 Caspase-2 Proteins 0.000 claims 1
- 102100026550 Caspase-9 Human genes 0.000 claims 1
- 108090000566 Caspase-9 Proteins 0.000 claims 1
- 102000000844 Cell Surface Receptors Human genes 0.000 claims 1
- 108010001857 Cell Surface Receptors Proteins 0.000 claims 1
- 102100034231 Cell surface A33 antigen Human genes 0.000 claims 1
- 102100021396 Cell surface glycoprotein CD200 receptor 1 Human genes 0.000 claims 1
- 102000011045 Chloride Channels Human genes 0.000 claims 1
- 101710128223 Chloride channel protein Proteins 0.000 claims 1
- 102000002029 Claudin Human genes 0.000 claims 1
- 108050009302 Claudin Proteins 0.000 claims 1
- 102100038449 Claudin-6 Human genes 0.000 claims 1
- 108090000229 Claudin-6 Proteins 0.000 claims 1
- 102100035167 Coiled-coil domain-containing protein 54 Human genes 0.000 claims 1
- 206010010144 Completed suicide Diseases 0.000 claims 1
- 102000016736 Cyclin Human genes 0.000 claims 1
- 108050006400 Cyclin Proteins 0.000 claims 1
- 108010015742 Cytochrome P-450 Enzyme System Proteins 0.000 claims 1
- 102000003849 Cytochrome P450 Human genes 0.000 claims 1
- 102100039061 Cytokine receptor common subunit beta Human genes 0.000 claims 1
- 102000000311 Cytosine Deaminase Human genes 0.000 claims 1
- 108010080611 Cytosine Deaminase Proteins 0.000 claims 1
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims 1
- 102100027816 Cytotoxic and regulatory T-cell molecule Human genes 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 102100020986 DNA-binding protein RFX5 Human genes 0.000 claims 1
- 102100021044 DNA-binding protein RFXANK Human genes 0.000 claims 1
- 101100481408 Danio rerio tie2 gene Proteins 0.000 claims 1
- 101710088194 Dehydrogenase Proteins 0.000 claims 1
- 102100036466 Delta-like protein 3 Human genes 0.000 claims 1
- 108010045579 Desmoglein 1 Proteins 0.000 claims 1
- 102000007577 Desmoglein 3 Human genes 0.000 claims 1
- 108010032035 Desmoglein 3 Proteins 0.000 claims 1
- 102100034579 Desmoglein-1 Human genes 0.000 claims 1
- 101000903039 Drosophila melanogaster Deoxynucleoside kinase Proteins 0.000 claims 1
- 101150029707 ERBB2 gene Proteins 0.000 claims 1
- 102100031334 Elongation factor 2 Human genes 0.000 claims 1
- 102100038132 Endogenous retrovirus group K member 6 Pro protein Human genes 0.000 claims 1
- 101710144543 Endosialin Proteins 0.000 claims 1
- 108010001687 Enterotoxin Receptors Proteins 0.000 claims 1
- 101710121417 Envelope glycoprotein Proteins 0.000 claims 1
- 102100023721 Ephrin-B2 Human genes 0.000 claims 1
- 108010044090 Ephrin-B2 Proteins 0.000 claims 1
- 102300064574 Epidermal growth factor receptor isoform 2 Human genes 0.000 claims 1
- 108010087819 Fc receptors Proteins 0.000 claims 1
- 102000009109 Fc receptors Human genes 0.000 claims 1
- 102000010451 Folate receptor alpha Human genes 0.000 claims 1
- 108050001931 Folate receptor alpha Proteins 0.000 claims 1
- 102000010449 Folate receptor beta Human genes 0.000 claims 1
- 108050001930 Folate receptor beta Proteins 0.000 claims 1
- 102000003817 Fos-related antigen 1 Human genes 0.000 claims 1
- 108090000123 Fos-related antigen 1 Proteins 0.000 claims 1
- 108010084795 Fusion Oncogene Proteins Proteins 0.000 claims 1
- 102000005668 Fusion Oncogene Proteins Human genes 0.000 claims 1
- 101710108873 G-protein coupled receptor 20 Proteins 0.000 claims 1
- 102000027583 GPCRs class C Human genes 0.000 claims 1
- 108091008882 GPCRs class C Proteins 0.000 claims 1
- 102000044445 Galectin-8 Human genes 0.000 claims 1
- 108010015776 Glucose oxidase Proteins 0.000 claims 1
- 239000004366 Glucose oxidase Substances 0.000 claims 1
- 108010081687 Glutamate-cysteine ligase Proteins 0.000 claims 1
- 102100039696 Glutamate-cysteine ligase catalytic subunit Human genes 0.000 claims 1
- 102000003886 Glycoproteins Human genes 0.000 claims 1
- 108090000288 Glycoproteins Proteins 0.000 claims 1
- 101150112082 Gpnmb gene Proteins 0.000 claims 1
- 102100028113 Granulocyte-macrophage colony-stimulating factor receptor subunit alpha Human genes 0.000 claims 1
- 102100022662 Guanylyl cyclase C Human genes 0.000 claims 1
- 102100028972 HLA class I histocompatibility antigen, A alpha chain Human genes 0.000 claims 1
- 102100028971 HLA class I histocompatibility antigen, C alpha chain Human genes 0.000 claims 1
- 102100028970 HLA class I histocompatibility antigen, alpha chain E Human genes 0.000 claims 1
- 102100028967 HLA class I histocompatibility antigen, alpha chain G Human genes 0.000 claims 1
- 102100031546 HLA class II histocompatibility antigen, DO beta chain Human genes 0.000 claims 1
- 108010075704 HLA-A Antigens Proteins 0.000 claims 1
- 102000025850 HLA-A2 Antigen Human genes 0.000 claims 1
- 108010074032 HLA-A2 Antigen Proteins 0.000 claims 1
- 108010058607 HLA-B Antigens Proteins 0.000 claims 1
- 108010052199 HLA-C Antigens Proteins 0.000 claims 1
- 108010010378 HLA-DP Antigens Proteins 0.000 claims 1
- 102000015789 HLA-DP Antigens Human genes 0.000 claims 1
- 108010062347 HLA-DQ Antigens Proteins 0.000 claims 1
- 108010058597 HLA-DR Antigens Proteins 0.000 claims 1
- 102000006354 HLA-DR Antigens Human genes 0.000 claims 1
- 108010024164 HLA-G Antigens Proteins 0.000 claims 1
- 102100040407 Heat shock 70 kDa protein 1B Human genes 0.000 claims 1
- 101710178419 Heat shock protein 70 2 Proteins 0.000 claims 1
- 108010007712 Hepatitis A Virus Cellular Receptor 1 Proteins 0.000 claims 1
- 102100034459 Hepatitis A virus cellular receptor 1 Human genes 0.000 claims 1
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 claims 1
- 241000709721 Hepatovirus A Species 0.000 claims 1
- 102100022132 High affinity immunoglobulin epsilon receptor subunit gamma Human genes 0.000 claims 1
- 241000545744 Hirudinea Species 0.000 claims 1
- 108010088652 Histocompatibility Antigens Class I Proteins 0.000 claims 1
- 101000718211 Homo sapiens Adhesion G protein-coupled receptor E2 Proteins 0.000 claims 1
- 101000718243 Homo sapiens Adhesion G protein-coupled receptor E5 Proteins 0.000 claims 1
- 101000834898 Homo sapiens Alpha-synuclein Proteins 0.000 claims 1
- 101000757191 Homo sapiens Ankyrin repeat domain-containing protein 30A Proteins 0.000 claims 1
- 101000864344 Homo sapiens B- and T-lymphocyte attenuator Proteins 0.000 claims 1
- 101000934359 Homo sapiens B-cell differentiation antigen CD72 Proteins 0.000 claims 1
- 101000884305 Homo sapiens B-cell receptor CD22 Proteins 0.000 claims 1
- 101000884298 Homo sapiens CD226 antigen Proteins 0.000 claims 1
- 101000762247 Homo sapiens Cadherin-17 Proteins 0.000 claims 1
- 101000899410 Homo sapiens Cadherin-19 Proteins 0.000 claims 1
- 101000794604 Homo sapiens Cadherin-6 Proteins 0.000 claims 1
- 101000856237 Homo sapiens Cancer/testis antigen 1 Proteins 0.000 claims 1
- 101000889345 Homo sapiens Cancer/testis antigen 2 Proteins 0.000 claims 1
- 101000983528 Homo sapiens Caspase-8 Proteins 0.000 claims 1
- 101000983523 Homo sapiens Caspase-9 Proteins 0.000 claims 1
- 101000996823 Homo sapiens Cell surface A33 antigen Proteins 0.000 claims 1
- 101000969553 Homo sapiens Cell surface glycoprotein CD200 receptor 1 Proteins 0.000 claims 1
- 101000737052 Homo sapiens Coiled-coil domain-containing protein 54 Proteins 0.000 claims 1
- 101001033280 Homo sapiens Cytokine receptor common subunit beta Proteins 0.000 claims 1
- 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 claims 1
- 101001075432 Homo sapiens DNA-binding protein RFX5 Proteins 0.000 claims 1
- 101001075464 Homo sapiens DNA-binding protein RFXANK Proteins 0.000 claims 1
- 101000928513 Homo sapiens Delta-like protein 3 Proteins 0.000 claims 1
- 101600123877 Homo sapiens Epidermal growth factor receptor (isoform 2) Proteins 0.000 claims 1
- 101100334515 Homo sapiens FCGR3A gene Proteins 0.000 claims 1
- 101100334524 Homo sapiens FCGR3B gene Proteins 0.000 claims 1
- 101001071355 Homo sapiens G-protein coupled receptor 20 Proteins 0.000 claims 1
- 101001099051 Homo sapiens GPI inositol-deacylase Proteins 0.000 claims 1
- 101000608769 Homo sapiens Galectin-8 Proteins 0.000 claims 1
- 101000916625 Homo sapiens Granulocyte-macrophage colony-stimulating factor receptor subunit alpha Proteins 0.000 claims 1
- 101000986085 Homo sapiens HLA class I histocompatibility antigen, alpha chain E Proteins 0.000 claims 1
- 101000866281 Homo sapiens HLA class II histocompatibility antigen, DO beta chain Proteins 0.000 claims 1
- 101001068133 Homo sapiens Hepatitis A virus cellular receptor 2 Proteins 0.000 claims 1
- 101000824104 Homo sapiens High affinity immunoglobulin epsilon receptor subunit gamma Proteins 0.000 claims 1
- 101000606465 Homo sapiens Inactive tyrosine-protein kinase 7 Proteins 0.000 claims 1
- 101001042104 Homo sapiens Inducible T-cell costimulator Proteins 0.000 claims 1
- 101001027081 Homo sapiens Killer cell immunoglobulin-like receptor 2DL1 Proteins 0.000 claims 1
- 101000945371 Homo sapiens Killer cell immunoglobulin-like receptor 2DL2 Proteins 0.000 claims 1
- 101000945333 Homo sapiens Killer cell immunoglobulin-like receptor 2DL3 Proteins 0.000 claims 1
- 101000945331 Homo sapiens Killer cell immunoglobulin-like receptor 2DL4 Proteins 0.000 claims 1
- 101000945337 Homo sapiens Killer cell immunoglobulin-like receptor 2DL5A Proteins 0.000 claims 1
- 101000945335 Homo sapiens Killer cell immunoglobulin-like receptor 2DL5B Proteins 0.000 claims 1
- 101000945340 Homo sapiens Killer cell immunoglobulin-like receptor 2DS1 Proteins 0.000 claims 1
- 101000945339 Homo sapiens Killer cell immunoglobulin-like receptor 2DS2 Proteins 0.000 claims 1
- 101000945343 Homo sapiens Killer cell immunoglobulin-like receptor 2DS3 Proteins 0.000 claims 1
- 101000945342 Homo sapiens Killer cell immunoglobulin-like receptor 2DS4 Proteins 0.000 claims 1
- 101000945346 Homo sapiens Killer cell immunoglobulin-like receptor 2DS5 Proteins 0.000 claims 1
- 101000945351 Homo sapiens Killer cell immunoglobulin-like receptor 3DL1 Proteins 0.000 claims 1
- 101000945490 Homo sapiens Killer cell immunoglobulin-like receptor 3DL2 Proteins 0.000 claims 1
- 101000945492 Homo sapiens Killer cell immunoglobulin-like receptor 3DS1 Proteins 0.000 claims 1
- 101001049181 Homo sapiens Killer cell lectin-like receptor subfamily B member 1 Proteins 0.000 claims 1
- 101000971533 Homo sapiens Killer cell lectin-like receptor subfamily G member 1 Proteins 0.000 claims 1
- 101000868279 Homo sapiens Leukocyte surface antigen CD47 Proteins 0.000 claims 1
- 101001137987 Homo sapiens Lymphocyte activation gene 3 protein Proteins 0.000 claims 1
- 101001065550 Homo sapiens Lymphocyte antigen 6K Proteins 0.000 claims 1
- 101000628547 Homo sapiens Metalloreductase STEAP1 Proteins 0.000 claims 1
- 101001023712 Homo sapiens Nectin-3 Proteins 0.000 claims 1
- 101000589399 Homo sapiens Pannexin-3 Proteins 0.000 claims 1
- 101000691463 Homo sapiens Placenta-specific protein 1 Proteins 0.000 claims 1
- 101001064779 Homo sapiens Plexin domain-containing protein 2 Proteins 0.000 claims 1
- 101001117312 Homo sapiens Programmed cell death 1 ligand 2 Proteins 0.000 claims 1
- 101000611936 Homo sapiens Programmed cell death protein 1 Proteins 0.000 claims 1
- 101001136981 Homo sapiens Proteasome subunit beta type-9 Proteins 0.000 claims 1
- 101000979565 Homo sapiens Protein NLRC5 Proteins 0.000 claims 1
- 101001075466 Homo sapiens Regulatory factor X-associated protein Proteins 0.000 claims 1
- 101000633784 Homo sapiens SLAM family member 7 Proteins 0.000 claims 1
- 101100420560 Homo sapiens SLC39A6 gene Proteins 0.000 claims 1
- 101000650817 Homo sapiens Semaphorin-4D Proteins 0.000 claims 1
- 101000884271 Homo sapiens Signal transducer CD24 Proteins 0.000 claims 1
- 101000652359 Homo sapiens Spermatogenesis-associated protein 2 Proteins 0.000 claims 1
- 101000873927 Homo sapiens Squamous cell carcinoma antigen recognized by T-cells 3 Proteins 0.000 claims 1
- 101000687808 Homo sapiens Suppressor of cytokine signaling 2 Proteins 0.000 claims 1
- 101000596234 Homo sapiens T-cell surface protein tactile Proteins 0.000 claims 1
- 101000714168 Homo sapiens Testisin Proteins 0.000 claims 1
- 101000772267 Homo sapiens Thyrotropin receptor Proteins 0.000 claims 1
- 101000638154 Homo sapiens Transmembrane protease serine 2 Proteins 0.000 claims 1
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims 1
- 101000818543 Homo sapiens Tyrosine-protein kinase ZAP-70 Proteins 0.000 claims 1
- 101000808105 Homo sapiens Uroplakin-2 Proteins 0.000 claims 1
- 241000713772 Human immunodeficiency virus 1 Species 0.000 claims 1
- 108010031794 IGF Type 1 Receptor Proteins 0.000 claims 1
- GRSZFWQUAKGDAV-KQYNXXCUSA-N IMP Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]1N1C(NC=NC2=O)=C2N=C1 GRSZFWQUAKGDAV-KQYNXXCUSA-N 0.000 claims 1
- 102100039813 Inactive tyrosine-protein kinase 7 Human genes 0.000 claims 1
- 102100039615 Inactive tyrosine-protein kinase transmembrane receptor ROR1 Human genes 0.000 claims 1
- 102100021317 Inducible T-cell costimulator Human genes 0.000 claims 1
- 102000055031 Inhibitor of Apoptosis Proteins Human genes 0.000 claims 1
- 101710184277 Insulin-like growth factor 1 receptor Proteins 0.000 claims 1
- 102100034349 Integrase Human genes 0.000 claims 1
- 102100025390 Integrin beta-2 Human genes 0.000 claims 1
- 102000003815 Interleukin-11 Human genes 0.000 claims 1
- 108090000177 Interleukin-11 Proteins 0.000 claims 1
- 102000004553 Interleukin-11 Receptors Human genes 0.000 claims 1
- 108010017521 Interleukin-11 Receptors Proteins 0.000 claims 1
- 102100020793 Interleukin-13 receptor subunit alpha-2 Human genes 0.000 claims 1
- 101710112634 Interleukin-13 receptor subunit alpha-2 Proteins 0.000 claims 1
- 102100030704 Interleukin-21 Human genes 0.000 claims 1
- 108010002586 Interleukin-7 Proteins 0.000 claims 1
- 101150074862 KLRC3 gene Proteins 0.000 claims 1
- 101150018199 KLRC4 gene Proteins 0.000 claims 1
- 102100034872 Kallikrein-4 Human genes 0.000 claims 1
- 102100037363 Killer cell immunoglobulin-like receptor 2DL1 Human genes 0.000 claims 1
- 102100033599 Killer cell immunoglobulin-like receptor 2DL2 Human genes 0.000 claims 1
- 102100033634 Killer cell immunoglobulin-like receptor 2DL3 Human genes 0.000 claims 1
- 102100033633 Killer cell immunoglobulin-like receptor 2DL4 Human genes 0.000 claims 1
- 102100033629 Killer cell immunoglobulin-like receptor 2DL5A Human genes 0.000 claims 1
- 102100033628 Killer cell immunoglobulin-like receptor 2DL5B Human genes 0.000 claims 1
- 102100033631 Killer cell immunoglobulin-like receptor 2DS1 Human genes 0.000 claims 1
- 102100033630 Killer cell immunoglobulin-like receptor 2DS2 Human genes 0.000 claims 1
- 102100033625 Killer cell immunoglobulin-like receptor 2DS3 Human genes 0.000 claims 1
- 102100033624 Killer cell immunoglobulin-like receptor 2DS4 Human genes 0.000 claims 1
- 102100033626 Killer cell immunoglobulin-like receptor 2DS5 Human genes 0.000 claims 1
- 102100033627 Killer cell immunoglobulin-like receptor 3DL1 Human genes 0.000 claims 1
- 102100034840 Killer cell immunoglobulin-like receptor 3DL2 Human genes 0.000 claims 1
- 102100034833 Killer cell immunoglobulin-like receptor 3DS1 Human genes 0.000 claims 1
- 102100023678 Killer cell lectin-like receptor subfamily B member 1 Human genes 0.000 claims 1
- 102100021457 Killer cell lectin-like receptor subfamily G member 1 Human genes 0.000 claims 1
- 102000017578 LAG3 Human genes 0.000 claims 1
- 108010017736 Leukocyte Immunoglobulin-like Receptor B1 Proteins 0.000 claims 1
- 102100025584 Leukocyte immunoglobulin-like receptor subfamily B member 1 Human genes 0.000 claims 1
- 102100032913 Leukocyte surface antigen CD47 Human genes 0.000 claims 1
- 101710099301 Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims 1
- 102100029185 Low affinity immunoglobulin gamma Fc region receptor III-B Human genes 0.000 claims 1
- 108010064548 Lymphocyte Function-Associated Antigen-1 Proteins 0.000 claims 1
- 102100032129 Lymphocyte antigen 6K Human genes 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 108010009254 Lysosomal-Associated Membrane Protein 1 Proteins 0.000 claims 1
- 102100035133 Lysosome-associated membrane glycoprotein 1 Human genes 0.000 claims 1
- 102000016200 MART-1 Antigen Human genes 0.000 claims 1
- 102100028389 Melanoma antigen recognized by T-cells 1 Human genes 0.000 claims 1
- 108050008953 Melanoma-associated antigen Proteins 0.000 claims 1
- 102000008840 Melanoma-associated antigen 1 Human genes 0.000 claims 1
- 108050000731 Melanoma-associated antigen 1 Proteins 0.000 claims 1
- 108010047230 Member 1 Subfamily B ATP Binding Cassette Transporter Proteins 0.000 claims 1
- 108010061593 Member 14 Tumor Necrosis Factor Receptors Proteins 0.000 claims 1
- 102000003735 Mesothelin Human genes 0.000 claims 1
- 108090000015 Mesothelin Proteins 0.000 claims 1
- 102100026712 Metalloreductase STEAP1 Human genes 0.000 claims 1
- 102100025825 Methylated-DNA-protein-cysteine methyltransferase Human genes 0.000 claims 1
- 101710104913 Methylated-DNA-protein-cysteine methyltransferase Proteins 0.000 claims 1
- 102100034256 Mucin-1 Human genes 0.000 claims 1
- 108010008707 Mucin-1 Proteins 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 101100010421 Mus musculus Dsg1a gene Proteins 0.000 claims 1
- 101100518997 Mus musculus Pax3 gene Proteins 0.000 claims 1
- 101100351020 Mus musculus Pax5 gene Proteins 0.000 claims 1
- 101100481410 Mus musculus Tek gene Proteins 0.000 claims 1
- 102100022701 NKG2-E type II integral membrane protein Human genes 0.000 claims 1
- 102100022700 NKG2-F type II integral membrane protein Human genes 0.000 claims 1
- 102100038082 Natural killer cell receptor 2B4 Human genes 0.000 claims 1
- 101710141230 Natural killer cell receptor 2B4 Proteins 0.000 claims 1
- 102100035487 Nectin-3 Human genes 0.000 claims 1
- 102100035486 Nectin-4 Human genes 0.000 claims 1
- 101710043865 Nectin-4 Proteins 0.000 claims 1
- 101100007739 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) crmA gene Proteins 0.000 claims 1
- 102100024964 Neural cell adhesion molecule L1 Human genes 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 102000004459 Nitroreductase Human genes 0.000 claims 1
- KUIFHYPNNRVEKZ-VIJRYAKMSA-N O-(N-acetyl-alpha-D-galactosaminyl)-L-threonine Chemical compound OC(=O)[C@@H](N)[C@@H](C)O[C@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1NC(C)=O KUIFHYPNNRVEKZ-VIJRYAKMSA-N 0.000 claims 1
- 108700020796 Oncogene Proteins 0.000 claims 1
- 108700026244 Open Reading Frames Proteins 0.000 claims 1
- 240000007019 Oxalis corniculata Species 0.000 claims 1
- 108060006580 PRAME Proteins 0.000 claims 1
- 102000036673 PRAME Human genes 0.000 claims 1
- 102100040891 Paired box protein Pax-3 Human genes 0.000 claims 1
- 101710149060 Paired box protein Pax-3 Proteins 0.000 claims 1
- 102100037504 Paired box protein Pax-5 Human genes 0.000 claims 1
- 101710149067 Paired box protein Pax-5 Proteins 0.000 claims 1
- 101710165197 Pannexin-3 Proteins 0.000 claims 1
- 108091005804 Peptidases Proteins 0.000 claims 1
- 108010077519 Peptide Elongation Factor 2 Proteins 0.000 claims 1
- 108091000080 Phosphotransferase Proteins 0.000 claims 1
- 108050005093 Placenta-specific protein 1 Proteins 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 108010051742 Platelet-Derived Growth Factor beta Receptor Proteins 0.000 claims 1
- 101710164680 Platelet-derived growth factor receptor beta Proteins 0.000 claims 1
- 102100037891 Plexin domain-containing protein 1 Human genes 0.000 claims 1
- 108050009432 Plexin domain-containing protein 1 Proteins 0.000 claims 1
- 102100031889 Plexin domain-containing protein 2 Human genes 0.000 claims 1
- 101710101148 Probable 6-oxopurine nucleoside phosphorylase Proteins 0.000 claims 1
- 102100024213 Programmed cell death 1 ligand 2 Human genes 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 239000004365 Protease Substances 0.000 claims 1
- 102100035764 Proteasome subunit beta type-9 Human genes 0.000 claims 1
- 102000001253 Protein Kinase Human genes 0.000 claims 1
- 102100023432 Protein NLRC5 Human genes 0.000 claims 1
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 1
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 claims 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 claims 1
- 102000030764 Purine-nucleoside phosphorylase Human genes 0.000 claims 1
- 108010006700 Receptor Tyrosine Kinase-like Orphan Receptors Proteins 0.000 claims 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 1
- 101710100968 Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 1
- 102100021043 Regulatory factor X-associated protein Human genes 0.000 claims 1
- 102100029198 SLAM family member 7 Human genes 0.000 claims 1
- 102100027744 Semaphorin-4D Human genes 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- 101000629318 Severe acute respiratory syndrome coronavirus 2 Spike glycoprotein Proteins 0.000 claims 1
- 102100038081 Signal transducer CD24 Human genes 0.000 claims 1
- 108091027967 Small hairpin RNA Proteins 0.000 claims 1
- 102100037253 Solute carrier family 45 member 3 Human genes 0.000 claims 1
- 102100022441 Sperm surface protein Sp17 Human genes 0.000 claims 1
- 101710185775 Squamous cell carcinoma antigen recognized by T-cells 3 Proteins 0.000 claims 1
- 102100024784 Suppressor of cytokine signaling 2 Human genes 0.000 claims 1
- 101800001271 Surface protein Proteins 0.000 claims 1
- 101100215487 Sus scrofa ADRA2A gene Proteins 0.000 claims 1
- 102100035268 T-cell surface protein tactile Human genes 0.000 claims 1
- 101800000849 Tachykinin-associated peptide 2 Proteins 0.000 claims 1
- 101150117918 Tacstd2 gene Proteins 0.000 claims 1
- 102100028082 Tapasin Human genes 0.000 claims 1
- 108010017842 Telomerase Proteins 0.000 claims 1
- 108050003829 Testisin Proteins 0.000 claims 1
- 108010000499 Thromboplastin Proteins 0.000 claims 1
- 108090000253 Thyrotropin Receptors Proteins 0.000 claims 1
- 102100030859 Tissue factor Human genes 0.000 claims 1
- 101710081844 Transmembrane protease serine 2 Proteins 0.000 claims 1
- 102100029690 Tumor necrosis factor receptor superfamily member 13C Human genes 0.000 claims 1
- 101710178300 Tumor necrosis factor receptor superfamily member 13C Proteins 0.000 claims 1
- 102100028785 Tumor necrosis factor receptor superfamily member 14 Human genes 0.000 claims 1
- 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 claims 1
- 102100033254 Tumor suppressor ARF Human genes 0.000 claims 1
- 101710102803 Tumor suppressor ARF Proteins 0.000 claims 1
- 102100027212 Tumor-associated calcium signal transducer 2 Human genes 0.000 claims 1
- 102000003425 Tyrosinase Human genes 0.000 claims 1
- 108060008724 Tyrosinase Proteins 0.000 claims 1
- 102100022596 Tyrosine-protein kinase ABL1 Human genes 0.000 claims 1
- 101710098624 Tyrosine-protein kinase ABL1 Proteins 0.000 claims 1
- 102100021125 Tyrosine-protein kinase ZAP-70 Human genes 0.000 claims 1
- 108010065940 Uroplakin II Proteins 0.000 claims 1
- 102000013532 Uroplakin II Human genes 0.000 claims 1
- 102100038851 Uroplakin-2 Human genes 0.000 claims 1
- 210000001766 X chromosome Anatomy 0.000 claims 1
- 108010027570 Xanthine phosphoribosyltransferase Proteins 0.000 claims 1
- 101100351021 Xenopus laevis pax5 gene Proteins 0.000 claims 1
- 102100026497 Zinc finger protein 654 Human genes 0.000 claims 1
- 102100023144 Zinc transporter ZIP6 Human genes 0.000 claims 1
- 102000005421 acetyltransferase Human genes 0.000 claims 1
- 108020002494 acetyltransferase Proteins 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000012082 adaptor molecule Substances 0.000 claims 1
- QLTCHMYAEJEXBT-UHFFFAOYSA-N alpha-beta-D-glucopyranosyloxy-isobutyronitrile Natural products N#CC(C)(C)OC1OC(CO)C(O)C(O)C1O QLTCHMYAEJEXBT-UHFFFAOYSA-N 0.000 claims 1
- 108010080146 androgen receptors Proteins 0.000 claims 1
- 108010055066 asparaginylendopeptidase Proteins 0.000 claims 1
- 229960002685 biotin Drugs 0.000 claims 1
- 235000020958 biotin Nutrition 0.000 claims 1
- 239000011616 biotin Substances 0.000 claims 1
- 229930189065 blasticidin Natural products 0.000 claims 1
- 230000011748 cell maturation Effects 0.000 claims 1
- 108010072917 class-I restricted T cell-associated molecule Proteins 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 108010079940 cyanogenic beta-glucosidase Proteins 0.000 claims 1
- 230000002950 deficient Effects 0.000 claims 1
- 229940127276 delta-like ligand 3 Drugs 0.000 claims 1
- 210000004443 dendritic cell Anatomy 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 230000004069 differentiation Effects 0.000 claims 1
- 239000000539 dimer Substances 0.000 claims 1
- 108010087914 epidermal growth factor receptor VIII Proteins 0.000 claims 1
- 125000002446 fucosyl group Chemical group C1([C@@H](O)[C@H](O)[C@H](O)[C@@H](O1)C)* 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 102000011778 gamma-delta T-Cell Antigen Receptors Human genes 0.000 claims 1
- 108010062214 gamma-delta T-Cell Antigen Receptors Proteins 0.000 claims 1
- PFJKOHUKELZMLE-VEUXDRLPSA-N ganglioside GM3 Chemical compound O[C@@H]1[C@@H](O)[C@H](OC[C@@H]([C@H](O)/C=C/CCCCCCCCCCCCC)NC(=O)CCCCCCCCCCCCC\C=C/CCCCCCCC)O[C@H](CO)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@]2(O[C@H]([C@H](NC(C)=O)[C@@H](O)C2)[C@H](O)[C@H](O)CO)C(O)=O)[C@@H](O)[C@@H](CO)O1 PFJKOHUKELZMLE-VEUXDRLPSA-N 0.000 claims 1
- 150000002270 gangliosides Chemical class 0.000 claims 1
- 229940116332 glucose oxidase Drugs 0.000 claims 1
- 235000019420 glucose oxidase Nutrition 0.000 claims 1
- 210000003714 granulocyte Anatomy 0.000 claims 1
- 102000048448 human CASP8 Human genes 0.000 claims 1
- 208000037797 influenza A Diseases 0.000 claims 1
- 230000000977 initiatory effect Effects 0.000 claims 1
- 235000013902 inosinic acid Nutrition 0.000 claims 1
- 108010074108 interleukin-21 Proteins 0.000 claims 1
- 230000000968 intestinal effect Effects 0.000 claims 1
- 108010024383 kallikrein 4 Proteins 0.000 claims 1
- QLTCHMYAEJEXBT-ZEBDFXRSSA-N linamarin Chemical compound N#CC(C)(C)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O QLTCHMYAEJEXBT-ZEBDFXRSSA-N 0.000 claims 1
- CRTWQTRFSBJGLK-UHFFFAOYSA-N linamarin Natural products CC(C)(C#N)C1OC(CO)C(O)C(O)C1O CRTWQTRFSBJGLK-UHFFFAOYSA-N 0.000 claims 1
- 210000002540 macrophage Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 210000003071 memory t lymphocyte Anatomy 0.000 claims 1
- 210000001616 monocyte Anatomy 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 108020001162 nitroreductase Proteins 0.000 claims 1
- 101710135378 pH 6 antigen Proteins 0.000 claims 1
- 230000002688 persistence Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 102000020233 phosphotransferase Human genes 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 229920001481 poly(stearyl methacrylate) Polymers 0.000 claims 1
- 108010082091 pre-T cell receptor alpha Proteins 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 108010079891 prostein Proteins 0.000 claims 1
- 229950010131 puromycin Drugs 0.000 claims 1
- 238000003259 recombinant expression Methods 0.000 claims 1
- 210000003289 regulatory T cell Anatomy 0.000 claims 1
- 230000001177 retroviral effect Effects 0.000 claims 1
- 102200006531 rs121913529 Human genes 0.000 claims 1
- 239000004055 small Interfering RNA Substances 0.000 claims 1
- 108010087686 src-Family Kinases Proteins 0.000 claims 1
- 102000009076 src-Family Kinases Human genes 0.000 claims 1
- 108010059434 tapasin Proteins 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 1
- 230000026683 transduction Effects 0.000 claims 1
- 238000010361 transduction Methods 0.000 claims 1
- 230000009452 underexpressoin Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163151421P | 2021-02-19 | 2021-02-19 | |
| US63/151,421 | 2021-02-19 | ||
| US202163245181P | 2021-09-16 | 2021-09-16 | |
| US63/245,181 | 2021-09-16 | ||
| PCT/US2022/017177 WO2022178367A2 (en) | 2021-02-19 | 2022-02-21 | Single-chain and multi-chain synthetic antigen receptors for diverse immune cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024518011A JP2024518011A (ja) | 2024-04-24 |
| JPWO2022178367A5 true JPWO2022178367A5 (enExample) | 2025-04-10 |
Family
ID=82932320
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023551146A Pending JP2024518011A (ja) | 2021-02-19 | 2022-02-21 | 多様な免疫細胞のための単鎖および多鎖合成抗原受容体 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20240390496A1 (enExample) |
| EP (1) | EP4297769A2 (enExample) |
| JP (1) | JP2024518011A (enExample) |
| KR (1) | KR20230153529A (enExample) |
| AU (1) | AU2022224066A1 (enExample) |
| CA (1) | CA3208717A1 (enExample) |
| IL (1) | IL305175A (enExample) |
| WO (1) | WO2022178367A2 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2871146T3 (es) | 2017-07-14 | 2021-10-28 | Immatics Biotechnologies Gmbh | Molécula de polipéptido con especificidad dual mejorada |
| AU2018308088B2 (en) | 2017-07-25 | 2025-05-29 | Truebinding, Inc. | Treating cancer by blocking the interaction of TIM-3 and its ligand |
| AU2019279084B2 (en) * | 2018-06-01 | 2025-04-17 | Angeles Therapeutics, Inc. | Diverse antigen binding domains, novel platforms and other enhancements for cellular therapy |
| EP4114861A4 (en) * | 2020-03-02 | 2024-05-08 | The Regents Of The University Of California | CHIMERIC ANTIGEN RECEPTORS AND RELATED COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER |
| US12281166B2 (en) | 2020-05-26 | 2025-04-22 | Truebinding, Inc. | Methods of treating inflammatory diseases by blocking Galectin-3 |
| US12162940B2 (en) | 2021-05-05 | 2024-12-10 | Immatics Biotechnologies Gmbh | BMA031 antigen binding polypeptides |
| BR112023022765A2 (pt) | 2021-05-05 | 2024-01-02 | Immatics Biotechnologies Gmbh | Proteínas de ligação ao antígeno que ligam especificamente o prame |
| AR130387A1 (es) * | 2022-09-08 | 2024-12-04 | Hoffmann La Roche | Receptores de linfocitos t recombinantes |
| CN118146393A (zh) * | 2022-11-07 | 2024-06-07 | 武汉波睿达生物科技有限公司 | 一种信号肽序列优化的靶向cd19的嵌合抗原受体及其应用 |
| WO2024102954A1 (en) * | 2022-11-10 | 2024-05-16 | Massachusetts Institute Of Technology | Activation induced clipping system (aics) |
| IL321737A (en) * | 2023-01-05 | 2025-08-01 | Angeles Therapeutics Inc | Methods and compositions for gene transformation and control of activity of synthetic and immune receptors |
| SE2350348A1 (en) * | 2023-03-28 | 2024-09-29 | Bjoerefeldt Andreas | Microglial endocytic receptors for use in the treatment of neurodegenerative disease |
| EP4619421A2 (en) * | 2023-05-01 | 2025-09-24 | Seattle Children's Hospital d/b/a Seattle Children's Research Institute | Mutant interleukin 15 expressing immune cells |
| WO2024238962A1 (en) * | 2023-05-18 | 2024-11-21 | A2 Biotherapeutics, Inc. | Immune cells with paired receptors and uses thereof |
| WO2025029597A1 (en) * | 2023-07-28 | 2025-02-06 | Nkilt Therapeutics, Inc. | Chimeric ilt receptor compositions and methods |
| US20250108114A1 (en) * | 2023-09-28 | 2025-04-03 | PELL Bio-Med Technology Co., Ltd. | Isolated nucleic acid molecule comprising nkp30 transmembrane domain and chimeric antigen receptor comprising the same |
| WO2025193475A1 (en) * | 2024-03-14 | 2025-09-18 | The Regents Of The University Of California | Enhancing immune cell innate and adaptive responses |
| WO2025194049A1 (en) * | 2024-03-15 | 2025-09-18 | Dana-Farber Cancer Institute, Inc. | Engineered immune cells and methods of using the same |
| WO2025235862A1 (en) * | 2024-05-10 | 2025-11-13 | Inndura Therapeutics Inc. | A modified immune cell receptor comprising a target-binding domain and the extracellular domain of cd16a |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1131425A2 (en) * | 1998-11-18 | 2001-09-12 | Incyte Pharmaceuticals, Inc. | Inflammation-associated genes |
| EP2478760A1 (en) * | 2005-05-10 | 2012-07-25 | Monsanto Technology LLC | Genes and uses for plant improvement |
| US9833476B2 (en) * | 2011-08-31 | 2017-12-05 | The Trustees Of Dartmouth College | NKP30 receptor targeted therapeutics |
| WO2014039961A1 (en) * | 2012-09-07 | 2014-03-13 | University Of Miami | Fusion proteins for promoting an immune response, nucleic acids encoding same, and methods of making and use thereof |
| WO2016014565A2 (en) * | 2014-07-21 | 2016-01-28 | Novartis Ag | Treatment of cancer using humanized anti-bcma chimeric antigen receptor |
| KR102751730B1 (ko) * | 2015-03-27 | 2025-01-10 | 이뮤너티바이오, 인크. | 암의 치료를 위한 유전적으로 변형된 nk-92 세포 및 모노클로날 항체 |
| JP7015551B2 (ja) * | 2016-02-23 | 2022-02-15 | ソーク インスティテュート フォー バイオロジカル スタディーズ | ウイルス動態への影響を最小限にするための治療用アデノウイルスにおける外因性遺伝子発現 |
| CA3044682A1 (en) * | 2016-12-02 | 2018-06-07 | University Of Southern California | Synthetic immune receptors and methods of use thereof |
| CN108728465A (zh) * | 2017-04-14 | 2018-11-02 | 深圳新诺微环生物科技有限公司 | 一种表达靶细胞-效应细胞桥接器的微环dna载体及其制备方法和应用 |
| IL296050B2 (en) * | 2018-08-01 | 2024-12-01 | Immunitybio Inc | A quadricistronic system comprising a homing receptor or a cytokine, and chimeric antigen receptor for genetic modification of immunotherapies |
-
2022
- 2022-02-21 CA CA3208717A patent/CA3208717A1/en active Pending
- 2022-02-21 WO PCT/US2022/017177 patent/WO2022178367A2/en not_active Ceased
- 2022-02-21 EP EP22757078.5A patent/EP4297769A2/en active Pending
- 2022-02-21 KR KR1020237031803A patent/KR20230153529A/ko active Pending
- 2022-02-21 US US18/275,957 patent/US20240390496A1/en active Pending
- 2022-02-21 IL IL305175A patent/IL305175A/en unknown
- 2022-02-21 AU AU2022224066A patent/AU2022224066A1/en active Pending
- 2022-02-21 JP JP2023551146A patent/JP2024518011A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPWO2022178367A5 (enExample) | ||
| US20240390496A1 (en) | Single-chain and multi-chain synthetic antigen receptors for diverse immune cells | |
| IL273201B1 (en) | Novel platforms for co-stimulation, novel car designs and other enhancements for adoptive cellular therapy | |
| JP2020500530A5 (enExample) | ||
| JPWO2021188599A5 (enExample) | ||
| JP2021500861A5 (enExample) | ||
| JP2025037871A5 (enExample) | ||
| US11760806B2 (en) | CD-38 directed chimeric antigen receptor constructs | |
| JP2019518424A5 (enExample) | ||
| JP2019525956A5 (enExample) | ||
| US20220389075A1 (en) | Engineered t cell receptors and uses thereof | |
| AU2021307614A1 (en) | Engineered immune cell for allotransplantation | |
| JP2017513818A5 (enExample) | ||
| KR20210126008A (ko) | 세포 면역 치료의 조합 | |
| RU2018122106A (ru) | Буферы для стабилизации лентивирусных препаратов | |
| IL297514A (en) | Vectors and methods for in vivo transduction | |
| WO2020057641A1 (zh) | 表达有趋化因子的细胞及用途 | |
| WO2021030153A2 (en) | Engineered t cell receptors and uses thereof | |
| EP3728322A1 (en) | Single- and multi-chain chimeric antigen receptors | |
| WO2021030182A1 (en) | Bifunctional single variable domain t cell receptors and uses thereof | |
| JP2020512009A (ja) | キメラポリペプチド及びそれらの細胞膜における局在を変更する方法 | |
| CN110511912A (zh) | 免疫细胞的功能调节 | |
| JPWO2021071962A5 (enExample) | ||
| CN117202921A (zh) | 用于多种免疫细胞的单链和多链合成抗原受体 | |
| CN117683139A (zh) | 组成型嵌合细胞因子受体及表达其的免疫细胞及应用 |