JP2024500919A - 重水素化コロニー刺激因子-1受容体(csf-1r)阻害剤 - Google Patents

重水素化コロニー刺激因子-1受容体(csf-1r)阻害剤 Download PDF

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Publication number
JP2024500919A
JP2024500919A JP2023538678A JP2023538678A JP2024500919A JP 2024500919 A JP2024500919 A JP 2024500919A JP 2023538678 A JP2023538678 A JP 2023538678A JP 2023538678 A JP2023538678 A JP 2023538678A JP 2024500919 A JP2024500919 A JP 2024500919A
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alkyl
compound
methyl
cycloalkyl
heteroaryl
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Japanese (ja)
Inventor
ジョン・エル・ケイン・ジュニア
ネルウィン・エー・ヘイガン
マリア・エー・フィッツジェラルド
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Genzyme Corp
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Genzyme Corp
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Priority claimed from PCT/US2021/064831 external-priority patent/WO2022140528A1/fr
Publication of JP2024500919A publication Critical patent/JP2024500919A/ja
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05Isotopically modified compounds, e.g. labelled

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2023538678A 2020-12-23 2021-12-22 重水素化コロニー刺激因子-1受容体(csf-1r)阻害剤 Pending JP2024500919A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063129939P 2020-12-23 2020-12-23
US63/129,939 2020-12-23
US202163226549P 2021-07-28 2021-07-28
US63/226,549 2021-07-28
PCT/US2021/064831 WO2022140528A1 (fr) 2020-12-23 2021-12-22 Inhibiteurs deutérés du récepteur du facteur 1 de stimulation des colonies (csp-1r)

Publications (1)

Publication Number Publication Date
JP2024500919A true JP2024500919A (ja) 2024-01-10

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JP2023538678A Pending JP2024500919A (ja) 2020-12-23 2021-12-22 重水素化コロニー刺激因子-1受容体(csf-1r)阻害剤

Country Status (3)

Country Link
US (1) US11530216B2 (fr)
EP (1) EP4267573A1 (fr)
JP (1) JP2024500919A (fr)

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US11530216B2 (en) 2022-12-20
EP4267573A1 (fr) 2023-11-01
US20220204504A1 (en) 2022-06-30

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