JP2024178310A5 - - Google Patents
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- JP2024178310A5 JP2024178310A5 JP2024163474A JP2024163474A JP2024178310A5 JP 2024178310 A5 JP2024178310 A5 JP 2024178310A5 JP 2024163474 A JP2024163474 A JP 2024163474A JP 2024163474 A JP2024163474 A JP 2024163474A JP 2024178310 A5 JP2024178310 A5 JP 2024178310A5
- Authority
- JP
- Japan
- Prior art keywords
- alkylene
- nhc
- alkyl
- independently
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962839440P | 2019-04-26 | 2019-04-26 | |
| US62/839,440 | 2019-04-26 | ||
| US201962875169P | 2019-07-17 | 2019-07-17 | |
| US62/875,169 | 2019-07-17 | ||
| US202062978159P | 2020-02-18 | 2020-02-18 | |
| US62/978,159 | 2020-02-18 | ||
| JP2021563605A JP7561141B2 (ja) | 2019-04-26 | 2020-04-10 | カンプトテシン誘導体 |
| PCT/US2020/027831 WO2020219287A1 (en) | 2019-04-26 | 2020-04-10 | Camptothecin derivatives |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021563605A Division JP7561141B2 (ja) | 2019-04-26 | 2020-04-10 | カンプトテシン誘導体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024178310A JP2024178310A (ja) | 2024-12-24 |
| JP2024178310A5 true JP2024178310A5 (https=) | 2025-04-03 |
Family
ID=70465562
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021563605A Active JP7561141B2 (ja) | 2019-04-26 | 2020-04-10 | カンプトテシン誘導体 |
| JP2024163474A Pending JP2024178310A (ja) | 2019-04-26 | 2024-09-20 | カンプトテシン誘導体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021563605A Active JP7561141B2 (ja) | 2019-04-26 | 2020-04-10 | カンプトテシン誘導体 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US11229639B2 (https=) |
| EP (2) | EP3958977B1 (https=) |
| JP (2) | JP7561141B2 (https=) |
| KR (1) | KR20220027828A (https=) |
| CN (2) | CN119119176A (https=) |
| AU (1) | AU2020263231B2 (https=) |
| DK (1) | DK3958977T3 (https=) |
| ES (1) | ES2966473T3 (https=) |
| FI (1) | FI3958977T3 (https=) |
| HR (1) | HRP20231619T1 (https=) |
| HU (1) | HUE065484T2 (https=) |
| IL (2) | IL317911A (https=) |
| LT (1) | LT3958977T (https=) |
| PL (1) | PL3958977T3 (https=) |
| PT (1) | PT3958977T (https=) |
| RS (1) | RS64961B1 (https=) |
| SG (1) | SG11202110922QA (https=) |
| SI (1) | SI3958977T1 (https=) |
| TW (1) | TW202106691A (https=) |
| WO (1) | WO2020219287A1 (https=) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2018308088B2 (en) | 2017-07-25 | 2025-05-29 | Truebinding, Inc. | Treating cancer by blocking the interaction of TIM-3 and its ligand |
| AU2020214796A1 (en) | 2019-01-30 | 2021-07-29 | Truebinding, Inc. | Anti-Gal3 antibodies and uses thereof |
| JP7561141B2 (ja) * | 2019-04-26 | 2024-10-03 | イミュノジェン・インコーポレーテッド | カンプトテシン誘導体 |
| AU2021213421B2 (en) * | 2020-01-31 | 2025-02-06 | Innate Pharma | Treatment of cancer |
| MX2022010457A (es) | 2020-02-25 | 2022-11-16 | Mediboston Ltd | Derivados de camptotecina y conjugados de esta. |
| WO2021242776A2 (en) | 2020-05-26 | 2021-12-02 | Truebinding, Inc. | Methods of treating inflammatory diseases by blocking galectin-3 |
| WO2022140504A1 (en) * | 2020-12-23 | 2022-06-30 | Shanghai Ruotuo Biosciences Co., Ltd. | Antibody-drug conjugates, pharmaceutical compositions, and therapeutic applications |
| AU2022207454A1 (en) * | 2021-01-15 | 2023-06-22 | R.P. Scherer Technologies, Llc | Camptothecine antibody-drug conjugates and methods of use thereof |
| WO2022155362A1 (en) * | 2021-01-15 | 2022-07-21 | R.P. Scherer Technologies, Llc | Dual-cleavage ester linkers for antibody-drug conjugates |
| KR20250120438A (ko) * | 2021-02-05 | 2025-08-08 | 쓰촨 케룬-바이오테크 바이오파마수티컬 컴퍼니 리미티드 | 캄프토테신 화합물, 그의 제조방법 및 그의 응용 |
| MX2023008895A (es) * | 2021-02-09 | 2023-08-09 | Medilink Therapeutics Suzhou Co Ltd | Conjugado de sustancia bioactiva, metodo de preparacion y uso del mismo. |
| US12521444B2 (en) * | 2021-02-25 | 2026-01-13 | Fortvita Biologics Limited | Anti-HER2 antibody-drug conjugates and uses thereof |
| IL308734A (en) * | 2021-05-27 | 2024-01-01 | Zymeworks Bc Inc | Camptothecin analogues, conjugates and methods of use |
| TW202320858A (zh) | 2021-07-19 | 2023-06-01 | 美商薩諾管理公司 | 免疫接合物及方法 |
| US11806405B1 (en) | 2021-07-19 | 2023-11-07 | Zeno Management, Inc. | Immunoconjugates and methods |
| CA3228345A1 (en) | 2021-08-19 | 2023-02-23 | Zhen Li | Camptothecin derivative, and pharmaceutical composition and use thereof |
| CN117881431A (zh) * | 2021-08-24 | 2024-04-12 | 昆山新蕴达生物科技有限公司 | 一种由可断裂连接子偶联的抗体偶联药物 |
| CN117940432B (zh) * | 2021-09-01 | 2025-12-23 | 上海弼领生物技术有限公司 | 一种喜树碱类化合物、其制备方法和用途 |
| EP4460330A1 (en) * | 2022-01-06 | 2024-11-13 | Virtuoso Binco, Inc. | Conjugates, compositions and methods of use |
| CN118434741A (zh) * | 2022-01-26 | 2024-08-02 | 苏州宜联生物医药有限公司 | 一种药物连接体偶联物的制备方法 |
| IL315366A (en) | 2022-03-23 | 2024-11-01 | Synaffix Bv | Antibody pairs for targeting PTK7-expressing tumors |
| IL315205A (en) | 2022-03-23 | 2024-10-01 | Synaffix Bv | Antibody-conjugates for targeting of tumours expressing carcinoembyronic antigen |
| KR20250024743A (ko) | 2022-03-23 | 2025-02-19 | 시나픽스 비.브이. | Trop-2를 발현하는 종양을 표적화하기 위한 항체-컨쥬게이트 |
| EP4496593A1 (en) | 2022-03-23 | 2025-01-29 | Synaffix B.V. | Antibody-conjugates for targeting of tumours expressing nectin-4 |
| IL315393A (en) | 2022-03-25 | 2024-11-01 | Zymeworks Bc Inc | Antibody preparations for drugs targeting alpha acid receptor and methods of use |
| EP4514350A1 (en) * | 2022-04-29 | 2025-03-05 | Shanghai MicuRx Pharmaceutical Co., Ltd. | Ligand-drug conjugate of camptothecin analogs, intermediates, preparation method therefor, pharmaceutical composition and application thereof |
| WO2023217227A1 (zh) | 2022-05-12 | 2023-11-16 | 先声再明医药有限公司 | 喜树碱类衍生物及配体-药物偶联物 |
| CN117143177A (zh) * | 2022-05-30 | 2023-12-01 | 苏州宜联生物医药有限公司 | 一种药物连接体偶联物的制备方法及其中间体 |
| EP4285935A1 (en) * | 2022-06-03 | 2023-12-06 | Emergence Therapeutics AG | Novel anti-nectin-4 antibody camptothecin derivative conjugates |
| JP2025524628A (ja) | 2022-07-12 | 2025-07-30 | シートムエックス セラピューティクス,インコーポレイテッド | Epcamイムノコンジュゲート及びその使用 |
| AU2023307126A1 (en) * | 2022-07-14 | 2025-02-13 | Medilink Therapeutics (Suzhou) Co., Ltd. | Antibody-drug conjugate, and preparation method therefor and use thereof |
| EP4309676A1 (en) * | 2022-07-22 | 2024-01-24 | Emergence Therapeutics AG | Novel anti-nectin-4 antibody camptothecin derivative conjugates |
| WO2024020734A1 (en) * | 2022-07-25 | 2024-02-01 | Immunogen, Inc. | Novel processes for preparing camptothecin derivatives |
| CN117510515A (zh) * | 2022-07-28 | 2024-02-06 | 明慧医药(杭州)有限公司 | 适用于抗体-药物偶联物的毒素分子 |
| WO2024050031A2 (en) * | 2022-08-31 | 2024-03-07 | Bionecure Therapeutics Inc | Novel camptothecin derivatves as antibody-drug conjugates (adc) payloads |
| WO2024054089A1 (ko) * | 2022-09-08 | 2024-03-14 | 주식회사 피노바이오 | 신규 캄토테신 유도체 및 이를 포함하는 운반체-약물 접합체 |
| TWI876557B (zh) * | 2022-09-30 | 2025-03-11 | 臺北醫學大學 | 用於前列腺癌診斷和早期發病的單株抗體 |
| PE20252282A1 (es) | 2022-10-09 | 2025-09-18 | Lanova Medicines Ltd | Compuestos, composiciones y metodos |
| KR20250089514A (ko) * | 2022-10-18 | 2025-06-18 | 자임워크스 비씨 인코포레이티드 | 글리피칸-3을 표적화하는 항체-약물 접합체 및 사용 방법 |
| EP4604949A2 (en) * | 2022-10-20 | 2025-08-27 | Solve Therapeutics, Inc. | Compositions and uses thereof |
| KR20250111373A (ko) * | 2022-11-25 | 2025-07-22 | 밍훼이 파마슈티컬 (항저우) 리미티드 | 항종양 화합물 및 이의 응용 |
| CN116712563A (zh) * | 2022-12-29 | 2023-09-08 | 杭州爱科瑞思生物医药有限公司 | N-卤代烷基取代的喜树碱衍生物的抗体偶联药物 |
| CN116712561A (zh) * | 2022-12-29 | 2023-09-08 | 杭州爱科瑞思生物医药有限公司 | 含n-亚甲基酰胺连接子的抗体-药物偶联物 |
| CN116870187A (zh) * | 2022-12-29 | 2023-10-13 | 杭州爱科瑞思生物医药有限公司 | N-氧杂环烷基取代的喜树碱衍生物的抗体偶联药物 |
| CN116253741B (zh) * | 2022-12-30 | 2024-02-02 | 上海禧耀医药科技有限公司 | 一种贝洛替康衍生物的合成方法 |
| CN120676967A (zh) * | 2023-02-10 | 2025-09-19 | 匹诺生物股份有限公司 | 抗体-药物偶联物连接子 |
| CN119630672B (zh) * | 2023-02-23 | 2026-01-30 | 一线医药(杭州)有限公司 | 喜树碱衍生物及其偶联物以及其制备方法和医药用途 |
| AU2024253122A1 (en) * | 2023-04-07 | 2025-10-23 | Innovent Biologics (Suzhou) Co., Ltd. | Antibody-drug conjugates of camptothecin derivatives and uses thereof |
| WO2024255740A1 (zh) * | 2023-06-13 | 2024-12-19 | 成都倍特药业股份有限公司 | 用于治疗或预防癌症的喜树碱衍生物及其抗体药物偶联物 |
| WO2025078841A2 (en) | 2023-10-11 | 2025-04-17 | Antikor Biopharma Limited | Antibodies, conjugates, and uses thereof |
| CN120058721A (zh) * | 2024-01-08 | 2025-05-30 | 杭州爱科瑞思生物医药有限公司 | 7-氟烷基取代的喜树碱衍生物的制备及其应用 |
| TW202529818A (zh) * | 2024-01-17 | 2025-08-01 | 中國商北京泰德製藥股份有限公司 | 含有噻唑[5,4-b]吡啶結構的抗體偶聯藥物及其用途 |
| WO2025184362A1 (en) * | 2024-02-28 | 2025-09-04 | Macrogenics Inc. | Adam9 antibody-drug conjugates |
| WO2025199665A1 (en) * | 2024-03-23 | 2025-10-02 | Ranok Therapeutics (Hangzhou) Co. Ltd. | Methods and compositions for targeted protein degradation |
| WO2025252894A1 (en) * | 2024-06-06 | 2025-12-11 | BioNTech SE | Ca19-9 binding molecule |
| CN119101060B (zh) * | 2024-06-13 | 2025-10-31 | 天津中医药大学 | 喜树碱衍生物及其制备方法和应用 |
| CN119350434B (zh) * | 2024-12-24 | 2025-04-29 | 苏州共康医药科技有限公司 | 一种可切割连接子Ala-Ala-Ala的工艺合成方法 |
Family Cites Families (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| JPH0615547B2 (ja) * | 1988-01-20 | 1994-03-02 | 株式会社ヤクルト本社 | 新規なカンプトテシン誘導体 |
| US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| ATE136898T1 (de) * | 1991-10-29 | 1996-05-15 | Glaxo Wellcome Inc | Wasserlösliche camptothecinderivate |
| US5559235A (en) * | 1991-10-29 | 1996-09-24 | Glaxo Wellcome Inc. | Water soluble camptothecin derivatives |
| ES2149768T3 (es) | 1992-03-25 | 2000-11-16 | Immunogen Inc | Conjugados de agentes enlazantes de celulas derivados de cc-1065. |
| US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
| US20080152586A1 (en) | 1992-09-25 | 2008-06-26 | Avipep Pty Limited | High avidity polyvalent and polyspecific reagents |
| US6355780B1 (en) | 1995-02-22 | 2002-03-12 | Yeda Research And Development Co. Ltd. | Antibodies to the death domain motifs of regulatory proteins |
| DE19640207A1 (de) * | 1996-09-30 | 1998-04-02 | Bayer Ag | Glycokonjugate von modifizierten Camptothecin-Derivaten (A- oder B-Ring-Verknüpfung) |
| US7115396B2 (en) | 1998-12-10 | 2006-10-03 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
| ES2276708T3 (es) | 1999-11-24 | 2007-07-01 | Immunogen, Inc. | Agentes citotoxicos que comprenden taxanos y su uso terapeutico. |
| US6268375B1 (en) * | 1999-12-29 | 2001-07-31 | Research Triangle Institute | 10, 11-difluoromethylenedioxycamptothecin compounds with topoisomerase I inhibition |
| DE60140474D1 (de) | 2000-09-08 | 2009-12-24 | Univ Zuerich | Sammlung von proteinen mit sich wiederholenden sequenzen (repeat proteins), die repetitive sequenzmodule enthalten |
| US6855720B2 (en) * | 2001-03-01 | 2005-02-15 | California Pacific Medical Center | Nitrogen-based camptothecin derivatives |
| US6441163B1 (en) | 2001-05-31 | 2002-08-27 | Immunogen, Inc. | Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents |
| US6716821B2 (en) | 2001-12-21 | 2004-04-06 | Immunogen Inc. | Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same |
| US8877901B2 (en) * | 2002-12-13 | 2014-11-04 | Immunomedics, Inc. | Camptothecin-binding moiety conjugates |
| US6756397B2 (en) | 2002-04-05 | 2004-06-29 | Immunogen, Inc. | Prodrugs of CC-1065 analogs |
| CN100522955C (zh) | 2002-08-02 | 2009-08-05 | 伊缪诺金公司 | 含有新型强效紫杉烷的细胞毒性剂及其治疗用途 |
| JP2006500364A (ja) | 2002-08-16 | 2006-01-05 | イムノージェン インコーポレーテッド | 高い反応性と溶解度を有する架橋剤および小分子薬物の標的化送達用コンジュゲートの調製におけるそれらの使用 |
| BR0316101A (pt) | 2002-11-07 | 2005-09-27 | Immunogen Inc | Anticorpos anticd33 e processo para tratamento de leucemia melóide aguda usando os mesmos |
| US8088387B2 (en) | 2003-10-10 | 2012-01-03 | Immunogen Inc. | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
| US7276497B2 (en) | 2003-05-20 | 2007-10-02 | Immunogen Inc. | Cytotoxic agents comprising new maytansinoids |
| US7067666B2 (en) * | 2003-06-27 | 2006-06-27 | Research Triangle Institute | 7-substituted camptothecin and camptothecin analogs and methods for producing the same |
| EP1718667B1 (en) | 2004-02-23 | 2013-01-09 | Genentech, Inc. | Heterocyclic self-immolative linkers and conjugates |
| CA2597407C (en) | 2005-02-11 | 2013-09-10 | Immunogen, Inc. | Process for preparing stable drug conjugates |
| BRPI0613593A2 (pt) | 2005-07-08 | 2011-01-18 | Univ Zuerich | método de teste "phage display" filamentoso, vetor de fago ou de fagomìdeo e biblioteca de vetores de fago ou fagomìdeo |
| EP3539572A1 (en) | 2005-08-24 | 2019-09-18 | ImmunoGen, Inc. | Process for preparing maytansinoid antibody conjugates |
| EP2535346B1 (en) | 2005-08-31 | 2017-08-02 | The Regents of The University of California | Cellular libraries of peptide sequences (CLiPS) and methods of using the same |
| WO2007062466A1 (en) | 2005-11-29 | 2007-06-07 | The University Of Sydney | Demibodies: dimerisation-activated therapeutic agents |
| US7897568B2 (en) | 2006-03-03 | 2011-03-01 | Vinay K. Singh | Compositions for treatment of cancer |
| ES2567402T3 (es) | 2006-05-30 | 2016-04-22 | Genentech, Inc. | Anticuerpos anti CD22, sus inmunoconjugados y usos de los mismos |
| CA2655379A1 (en) | 2006-06-22 | 2007-12-27 | Walter And Eliza Hall Institute Of Medical Research | Structure of the insulin receptor ectodomain |
| CA2697032C (en) | 2007-08-22 | 2021-09-14 | The Regents Of The University Of California | Activatable binding polypeptides and methods of identification and use thereof |
| CA2700391A1 (en) | 2007-09-24 | 2009-04-02 | University Of Zuerich | Designed armadillo repeat proteins |
| KR20200058590A (ko) | 2008-04-30 | 2020-05-27 | 이뮤노젠 아이엔씨 | 가교제 및 그 용도 |
| EP2276506A4 (en) | 2008-04-30 | 2014-05-07 | Immunogen Inc | EFFICIENT CONJUGATES AND HYDROPHILIC BINDER |
| KR101098335B1 (ko) | 2008-07-18 | 2011-12-26 | 성균관대학교산학협력단 | 신코나 기재 이작용성 유기 촉매 및 이를 이용한 메소-고리산무수물의 비대칭 고리 열림 반응을 통한 키랄성헤미에스터의 제조방법 |
| BRPI0919881B1 (pt) | 2008-10-31 | 2021-09-08 | Centocor Ortho Biotech Inc | Proteína de arcabouço e seu método de geração, biblioteca e seu método de construção, molécula de ácido nucleico, vetor de ácido nucleico, célula hospedeira, composição, dispositivo médico e artigo de fabricação |
| US20100189651A1 (en) | 2009-01-12 | 2010-07-29 | Cytomx Therapeutics, Llc | Modified antibody compositions, methods of making and using thereof |
| BRPI1008532B1 (pt) | 2009-02-12 | 2021-12-14 | Janssen Biotech, Inc | Arcabouço de proteína isolada, método para construção de uma biblioteca de arcabouço de proteína isolada, molécula de ácido nucleico isolada, vetor de ácido nucleico isolado, célula hospedeira de bactéria ou fungo, composição, dispositivo médico e artigo de manufatura para uso farmacêutico ou de diagnóstico em seres humanos |
| SG181814A1 (en) | 2009-12-23 | 2012-07-30 | Avipep Pty Ltd | Immuno-conjugates and methods for producing them 2 |
| CN103037900B (zh) | 2010-02-24 | 2016-04-06 | 伊缪诺金公司 | 叶酸受体1抗体与免疫缀合物以及其用途 |
| SG183542A1 (en) | 2010-03-12 | 2012-10-30 | Immunogen Inc | Cd37-binding molecules and immunoconjugates thereof |
| EP3569256B1 (en) | 2010-04-30 | 2022-06-15 | Janssen Biotech, Inc. | Stabilized fibronectin domain compositions, methods and uses |
| CN103298489A (zh) | 2010-10-29 | 2013-09-11 | 伊缪诺金公司 | 新型egfr结合分子及其免疫偶联物 |
| CN105399831A (zh) | 2010-10-29 | 2016-03-16 | 伊缪诺金公司 | 非拮抗性egfr结合分子及其免疫偶联物 |
| JP6049642B2 (ja) | 2011-02-15 | 2016-12-21 | イミュノジェン・インコーポレーテッド | 複合体の調製方法 |
| IL281714B2 (en) | 2011-04-01 | 2023-11-01 | Immunogen Inc | Methods for increasing the effectiveness of FOLR1 cancer therapy |
| EP2524929A1 (en) | 2011-05-17 | 2012-11-21 | Sanofi | Use of anti-CD19 maytansinoid immunoconjugate antibody for the treatment of CD19+ B-cell malignancies syptoms |
| WO2013189266A1 (zh) * | 2012-06-18 | 2013-12-27 | Li Yuliang | 喜树碱类化合物及其制备和用途 |
| US9309510B2 (en) | 2012-08-10 | 2016-04-12 | Cytomx Therapeutics, Inc. | Protease-resistant systems for polypeptide display and methods of making and using thereof |
| CA2925106C (en) | 2013-09-25 | 2023-11-14 | Cytomx Therapeutics, Inc. | Matrix metalloproteinase substrates and other cleavable moieties and methods of use thereof |
| LT3424955T (lt) | 2013-12-25 | 2025-06-25 | Daiichi Sankyo Company, Limited | Anti-trop2 antikūno ir vaisto konjugato gamybos būdas |
| IL270562B (en) | 2014-01-31 | 2022-08-01 | Cytomx Therapeutics Inc | Polypeptide substrates that activate matriptase and u-plasminogen and other cleavable groups, preparations containing them and their uses |
| MA41374A (fr) | 2015-01-20 | 2017-11-28 | Cytomx Therapeutics Inc | Substrats clivables par métalloprotéase matricielle et clivables par sérine protéase et procédés d'utilisation de ceux-ci |
| CN107849133B (zh) | 2015-05-04 | 2022-08-23 | 西托姆克斯治疗公司 | 抗cd166抗体、可活化抗cd166抗体及其使用方法 |
| SI3558391T1 (sl) | 2016-12-23 | 2022-06-30 | Immunogen, Inc. | Imunokonjugati, ciljno usmerjeni na ADAM9, in načini njihove uporabe |
| CA3094313A1 (en) * | 2018-04-06 | 2019-10-10 | Seattle Genetics, Inc. | Camptothecin peptide conjugates |
| JP7561141B2 (ja) * | 2019-04-26 | 2024-10-03 | イミュノジェン・インコーポレーテッド | カンプトテシン誘導体 |
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2020
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2024
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