JP2025024130A5 - - Google Patents
Info
- Publication number
- JP2025024130A5 JP2025024130A5 JP2024201685A JP2024201685A JP2025024130A5 JP 2025024130 A5 JP2025024130 A5 JP 2025024130A5 JP 2024201685 A JP2024201685 A JP 2024201685A JP 2024201685 A JP2024201685 A JP 2024201685A JP 2025024130 A5 JP2025024130 A5 JP 2025024130A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- heterocycloalkyl
- cycloalkyl
- deuteroalkyl
- haloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163251469P | 2021-10-01 | 2021-10-01 | |
| US63/251,469 | 2021-10-01 | ||
| US202263339597P | 2022-05-09 | 2022-05-09 | |
| US63/339,597 | 2022-05-09 | ||
| US202263402835P | 2022-08-31 | 2022-08-31 | |
| US63/402,835 | 2022-08-31 | ||
| PCT/US2022/045415 WO2023056039A1 (en) | 2021-10-01 | 2022-09-30 | Azetidine and pyrrolidine parp1 inhibitors and uses thereof |
| JP2024518681A JP7592220B2 (ja) | 2021-10-01 | 2022-09-30 | アゼチジン及びピロリジンｐａｒｐ１阻害剤及びその使用 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024518681A Division JP7592220B2 (ja) | 2021-10-01 | 2022-09-30 | アゼチジン及びピロリジンｐａｒｐ１阻害剤及びその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2025024130A JP2025024130A (ja) | 2025-02-19 |
| JP2025024130A5 true JP2025024130A5 (https=) | 2025-10-07 |
Family
ID=85783565
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024518681A Active JP7592220B2 (ja) | 2021-10-01 | 2022-09-30 | アゼチジン及びピロリジンｐａｒｐ１阻害剤及びその使用 |
| JP2024201685A Pending JP2025024130A (ja) | 2021-10-01 | 2024-11-19 | アゼチジン及びピロリジンｐａｒｐ１阻害剤及びその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024518681A Active JP7592220B2 (ja) | 2021-10-01 | 2022-09-30 | アゼチジン及びピロリジンｐａｒｐ１阻害剤及びその使用 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US20230159525A1 (https=) |
| EP (1) | EP4408420A4 (https=) |
| JP (2) | JP7592220B2 (https=) |
| KR (2) | KR102867210B1 (https=) |
| CN (2) | CN120058698A (https=) |
| AU (2) | AU2022356286B2 (https=) |
| CA (1) | CA3232775A1 (https=) |
| CL (2) | CL2024000877A1 (https=) |
| CO (1) | CO2024003949A2 (https=) |
| CR (1) | CR20240144A (https=) |
| DO (1) | DOP2024000060A (https=) |
| IL (2) | IL311376B2 (https=) |
| MX (2) | MX2024003922A (https=) |
| PE (1) | PE20241129A1 (https=) |
| TW (2) | TWI876212B (https=) |
| WO (1) | WO2023056039A1 (https=) |
| ZA (1) | ZA202404648B (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102867210B1 (ko) | 2021-10-01 | 2025-10-14 | 신테라, 인크. | 아제티딘 및 피롤리딘 parp1 저해제, 및 이의 용도 |
| CN120081844A (zh) | 2022-01-21 | 2025-06-03 | 新特拉有限公司 | Parp1抑制剂及其用途 |
| AU2023235233A1 (en) | 2022-03-14 | 2024-09-12 | Slap Pharmaceuticals Llc | Multicyclic compounds |
| AU2023259236B2 (en) | 2022-04-28 | 2025-01-09 | Xinthera, Inc. | Tricyclic parp1 inhibitors and uses thereof |
| CN119487027A (zh) * | 2022-04-28 | 2025-02-18 | 宁波新湾科技发展有限公司 | 作为parp1抑制剂的化合物 |
| EP4534537A4 (en) * | 2022-05-25 | 2025-12-10 | Xizang Haisco Pharmaceutical Co Ltd | BICYCLE-DERIVED PARP INHIBITOR AND ITS USE |
| CN118119629A (zh) * | 2022-09-30 | 2024-05-31 | 中国医药研究开发中心有限公司 | 含氮杂环类化合物及其医药用途 |
| WO2024099416A1 (zh) * | 2022-11-10 | 2024-05-16 | 上海海和药物研究开发股份有限公司 | 一种稠合三环类parp1抑制剂、其制备方法及用途 |
| KR20250103668A (ko) * | 2022-11-10 | 2025-07-07 | 치아타이 티안큉 파마수티컬 그룹 주식회사 | 축합 이환 화합물 |
| WO2024206172A1 (en) * | 2023-03-24 | 2024-10-03 | Xinthera, Inc. | Crystalline forms of an azetidine parp1 inhibitor |
| TW202506680A (zh) * | 2023-04-28 | 2025-02-16 | 美商思諾維新醫藥公司 | 作為ｐａｒｐ１抑制劑之雜環化合物 |
| CN121358725A (zh) | 2023-06-14 | 2026-01-16 | 海思科医药集团股份有限公司 | 双环衍生物parp抑制剂及其用途 |
| TW202535877A (zh) * | 2023-11-01 | 2025-09-16 | 大陸商正大天晴藥業集團股份有限公司 | 含有稠合雙環的化合物、藥物組合物及其用途 |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPS137402A0 (en) | 2002-03-26 | 2002-05-09 | Fujisawa Pharmaceutical Co., Ltd. | Novel tricyclic compounds |
| US8404713B2 (en) | 2007-10-26 | 2013-03-26 | Janssen Pharmaceutica Nv | Quinolinone derivatives as PARP inhibitors |
| BRPI0820701A2 (pt) * | 2007-12-11 | 2015-06-16 | Cytopathfinder Inc | Composto de carboxamida e seu uso como agonistas do receptor de quimiocina |
| CN102341394B (zh) | 2009-01-23 | 2015-04-15 | 武田药品工业株式会社 | 聚(adp-核糖)聚合酶(parp)抑制剂 |
| EP2459561A1 (en) | 2009-07-30 | 2012-06-06 | Takeda Pharmaceutical Company Limited | Poly (adp-ribose) polymerase (parp) inhibitors |
| PL2912032T3 (pl) | 2012-10-26 | 2020-11-16 | Nerviano Medical Sciences S.R.L. | Pochodne 4-karboksyamido-izoindolinonu jako selektywne inhibitory parp-1 |
| CA2941716A1 (en) | 2014-03-07 | 2015-09-11 | The Johns Hopkins University | Inhibitors of histone lysine specific demethylase (lsd1) and histone deacetylases (hdacs) |
| CN105753814A (zh) | 2015-01-01 | 2016-07-13 | 成都贝斯凯瑞生物科技有限公司 | 取代氮杂环衍生物及其应用 |
| MX375707B (es) | 2015-06-09 | 2025-03-06 | Onconic Therapeutics Inc | Compuesto derivativo triciclico, metodo para prepararlo y composicion farmaceutica que comprende el mismo. |
| CR20180168A (es) * | 2015-08-17 | 2018-06-27 | Lupin Ltd | Derivados de heteroarilo como inhibidores de parp |
| AU2018273356B2 (en) | 2017-05-22 | 2021-09-16 | Amgen Inc. | KRAS G12C inhibitors and methods of using the same |
| IL283127B1 (en) | 2018-11-14 | 2026-02-01 | Smilebiotek Zhuhai Ltd | Animal-based models, scanning methods, and methods of treating intraocular diseases or disorders |
| SI3999506T1 (sl) | 2019-07-19 | 2025-06-30 | Astrazeneca Ab | Zaviralci PARP1 |
| US12459899B2 (en) * | 2019-10-30 | 2025-11-04 | DIGMBIO, Inc. | Isoquinolinone derivatives, method for preparing the same, and pharmaceutical composition for preventing or treating poly(ADP-ribose) polymerase-1-related diseases, comprising the same as active ingredient |
| US11795158B2 (en) | 2020-06-25 | 2023-10-24 | Astrazeneca Ab | Chemical compounds |
| US11591331B2 (en) | 2021-04-19 | 2023-02-28 | Xinthera, Inc. | PARP1 inhibitors and uses thereof |
| EP4328224A4 (en) | 2021-04-22 | 2025-06-18 | Wigen Biomedicine Technology (Shanghai) Co., Ltd. | PARP INHIBITOR WITH PIPERAZINE STRUCTURE, MANUFACTURING METHOD THEREOF AND PHARMACEUTICAL USE THEREOF |
| WO2022222966A1 (zh) | 2021-04-23 | 2022-10-27 | 成都百裕制药股份有限公司 | 一种选择性parp1抑制剂及其应用 |
| CN115702156A (zh) | 2021-04-23 | 2023-02-14 | 南京明德新药研发有限公司 | 吡啶酰胺类化合物 |
| WO2022222965A1 (zh) | 2021-04-23 | 2022-10-27 | 成都百裕制药股份有限公司 | 吡啶衍生物及其在医药上的应用 |
| AU2022261029A1 (en) | 2021-04-23 | 2023-10-19 | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. | Heterocyclic derivative inhibitor and preparation method therefor and application thereof |
| WO2022228387A1 (en) * | 2021-04-26 | 2022-11-03 | Fochon Biosciences, Ltd. | Compounds as parp inhibitors |
| BR112023022496A2 (pt) | 2021-05-24 | 2024-01-16 | Jiangsu Hengrui Pharmaceuticals Co Ltd | Composto heterocíclico contendo nitrogênio, método de preparação do mesmo, e aplicação do mesmo em medicamentos |
| CN115403595A (zh) | 2021-05-27 | 2022-11-29 | 江苏恒瑞医药股份有限公司 | 含氮杂环类化合物、其制备方法及其在医药上的应用 |
| BR112023024942A2 (pt) | 2021-06-16 | 2024-02-15 | Repare Therapeutics Inc | Uso de inibidores de atr em combinação com inibidores de parp para tratamento de câncer |
| AU2022334408A1 (en) | 2021-08-27 | 2024-02-15 | Impact Therapeutics (Shanghai), Inc. | Substituted tricyclic compounds as parp inhibitors and use thereof |
| CN118119618A (zh) | 2021-09-09 | 2024-05-31 | 南京奥利墨斯医药科技有限公司 | 一种杂芳环类化合物及其应用 |
| WO2023046034A1 (zh) | 2021-09-22 | 2023-03-30 | 明慧医药（杭州）有限公司 | 一种含氮杂环化合物、其制备方法、其中间体及其应用 |
| WO2023046158A1 (zh) | 2021-09-26 | 2023-03-30 | 张文燕 | 氮杂喹啉酮类化合物及其医药用途 |
| WO2023046149A1 (zh) | 2021-09-26 | 2023-03-30 | 张文燕 | 喹喔啉类化合物及其医药用途 |
| EP4410792A4 (en) | 2021-09-30 | 2025-12-03 | Xizang Haisco Pharmaceutical Co Ltd | NITROGEN-CONTAINS HETEROCYCLIC DERIVATIVE FOR USE AS A PARP INHIBITOR AND ITS USE |
| WO2023051716A1 (zh) | 2021-09-30 | 2023-04-06 | 海思科医药集团股份有限公司 | 杂芳基衍生物parp抑制剂及其用途 |
| EP4410791A4 (en) | 2021-09-30 | 2025-10-22 | Xizang Haisco Pharmaceutical Co Ltd | BICYCLIC DERIVATIVE PARP INHIBITOR AND ITS USE |
| KR102867210B1 (ko) | 2021-10-01 | 2025-10-14 | 신테라, 인크. | 아제티딘 및 피롤리딘 parp1 저해제, 및 이의 용도 |
| WO2023061406A1 (zh) | 2021-10-12 | 2023-04-20 | 微境生物医药科技(上海)有限公司 | 含三并环结构的parp抑制剂、及其制备方法和医药用途 |
| US20250289800A1 (en) | 2021-11-19 | 2025-09-18 | Kangbaida (Sichuan) Biotechnology Co., Ltd. | Selective Parp1 Inhibitor And Application Thereof |
| CN116143776A (zh) | 2021-11-22 | 2023-05-23 | 南京圣和药业股份有限公司 | Parp1抑制剂及其应用 |
| KR20240144125A (ko) | 2021-12-17 | 2024-10-02 | 키테라 (쑤저우) 바이오-파마슈티컬스 컴퍼니 리미티드 | Parp 억제제, 이를 포함하는 약제학적 조성물, 및 이의 용도 |
| WO2023133413A1 (en) | 2022-01-07 | 2023-07-13 | Slap Pharmaceuticals Llc | Multicyclic compounds |
| CN118434725B (zh) | 2022-01-20 | 2026-01-02 | 微境生物医药科技(上海)有限公司 | 吡啶酰胺类parp抑制剂、及其制备方法和医药用途 |
| CN120081844A (zh) | 2022-01-21 | 2025-06-03 | 新特拉有限公司 | Parp1抑制剂及其用途 |
| CN116535401A (zh) | 2022-01-25 | 2023-08-04 | 南京圣和药业股份有限公司 | 新的parp1抑制剂及其应用 |
| WO2023143236A1 (zh) | 2022-01-26 | 2023-08-03 | 中国药科大学 | 2h-吲唑-7-甲酰胺类化合物、制备方法、药物组合物和应用 |
| JP7794989B2 (ja) | 2022-01-27 | 2026-01-06 | シンセラ， インコーポレイテッド | Ｐａｒｐ１阻害薬及びその使用 |
| WO2023147009A1 (en) | 2022-01-27 | 2023-08-03 | The Johns Hopkins University | Clinical-grade therapeutic progenitors generated from tankyrase/parp-inhibited pluripotent stem cell banks |
| WO2023146960A1 (en) | 2022-01-28 | 2023-08-03 | Xinthera, Inc. | Parp1 inhibitors and uses thereof |
| KR20230116457A (ko) | 2022-01-28 | 2023-08-04 | 경북대학교 산학협력단 | 작약 추출물을 포함하는 만성폐쇄성폐질환 예방 또는 치료용 약학적 조성물 |
| EP4469046A1 (en) | 2022-01-28 | 2024-12-04 | Oulun Yliopisto | Compounds for use in the treatment of cancer and inflammatory conditions |
| IL314895A (en) | 2022-02-16 | 2024-10-01 | Duke Street Bio Ltd | Pharmaceutical compound |
| CN115232129B (zh) | 2022-08-18 | 2023-12-01 | 上海闻耐医药科技有限公司 | 一种parp1选择性抑制剂及其制备方法和用途 |
-
2022
- 2022-09-30 KR KR1020247013788A patent/KR102867210B1/ko active Active
- 2022-09-30 IL IL311376A patent/IL311376B2/en unknown
- 2022-09-30 CN CN202510199687.4A patent/CN120058698A/zh active Pending
- 2022-09-30 CR CR20240144A patent/CR20240144A/es unknown
- 2022-09-30 JP JP2024518681A patent/JP7592220B2/ja active Active
- 2022-09-30 CN CN202280064954.1A patent/CN118019532B/zh active Active
- 2022-09-30 TW TW111137289A patent/TWI876212B/zh active
- 2022-09-30 MX MX2024003922A patent/MX2024003922A/es unknown
- 2022-09-30 KR KR1020257032459A patent/KR20250145706A/ko active Pending
- 2022-09-30 AU AU2022356286A patent/AU2022356286B2/en active Active
- 2022-09-30 CA CA3232775A patent/CA3232775A1/en active Pending
- 2022-09-30 PE PE2024000584A patent/PE20241129A1/es unknown
- 2022-09-30 IL IL318196A patent/IL318196A/en unknown
- 2022-09-30 US US17/957,584 patent/US20230159525A1/en not_active Abandoned
- 2022-09-30 EP EP22877395.8A patent/EP4408420A4/en active Pending
- 2022-09-30 TW TW114104894A patent/TW202542152A/zh unknown
- 2022-09-30 WO PCT/US2022/045415 patent/WO2023056039A1/en not_active Ceased
-
2023
- 2023-02-28 US US18/115,314 patent/US11802128B2/en active Active
-
2024
- 2024-03-26 CL CL2024000877A patent/CL2024000877A1/es unknown
- 2024-03-26 DO DO2024000060A patent/DOP2024000060A/es unknown
- 2024-03-27 CO CONC2024/0003949A patent/CO2024003949A2/es unknown
- 2024-03-27 MX MX2024012801A patent/MX2024012801A/es unknown
- 2024-06-14 ZA ZA2024/04648A patent/ZA202404648B/en unknown
- 2024-11-19 JP JP2024201685A patent/JP2025024130A/ja active Pending
-
2025
- 2025-01-09 AU AU2025200139A patent/AU2025200139A1/en active Pending
- 2025-03-06 CL CL2025000629A patent/CL2025000629A1/es unknown
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