JP2024156774A5 - - Google Patents
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- JP2024156774A5 JP2024156774A5 JP2024122258A JP2024122258A JP2024156774A5 JP 2024156774 A5 JP2024156774 A5 JP 2024156774A5 JP 2024122258 A JP2024122258 A JP 2024122258A JP 2024122258 A JP2024122258 A JP 2024122258A JP 2024156774 A5 JP2024156774 A5 JP 2024156774A5
- Authority
- JP
- Japan
- Prior art keywords
- pharma
- acceptable salt
- compound
- ceutically acceptable
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 21
- 150000003839 salts Chemical class 0.000 claims 20
- KHBQMWCZKVMBLN-UHFFFAOYSA-N Benzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=CC=C1 KHBQMWCZKVMBLN-UHFFFAOYSA-N 0.000 claims 11
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 11
- 125000000217 alkyl group Chemical group 0.000 claims 10
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 239000000460 chlorine Substances 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 201000005787 hematologic cancer Diseases 0.000 claims 1
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762584575P | 2017-11-10 | 2017-11-10 | |
| US62/584,575 | 2017-11-10 | ||
| US201862678723P | 2018-05-31 | 2018-05-31 | |
| US62/678,723 | 2018-05-31 | ||
| JP2020526066A JP7271538B2 (ja) | 2017-11-10 | 2018-11-08 | 低分子ｉｒｅ１阻害剤 |
| JP2023071977A JP7535335B2 (ja) | 2017-11-10 | 2023-04-26 | 低分子ｉｒｅ１阻害剤 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023071977A Division JP7535335B2 (ja) | 2017-11-10 | 2023-04-26 | 低分子ｉｒｅ１阻害剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024156774A JP2024156774A (ja) | 2024-11-06 |
| JP2024156774A5 true JP2024156774A5 (enExample) | 2025-02-05 |
Family
ID=64477302
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020526066A Active JP7271538B2 (ja) | 2017-11-10 | 2018-11-08 | 低分子ｉｒｅ１阻害剤 |
| JP2023071977A Active JP7535335B2 (ja) | 2017-11-10 | 2023-04-26 | 低分子ｉｒｅ１阻害剤 |
| JP2024122258A Pending JP2024156774A (ja) | 2017-11-10 | 2024-07-29 | 低分子ｉｒｅ１阻害剤 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020526066A Active JP7271538B2 (ja) | 2017-11-10 | 2018-11-08 | 低分子ｉｒｅ１阻害剤 |
| JP2023071977A Active JP7535335B2 (ja) | 2017-11-10 | 2023-04-26 | 低分子ｉｒｅ１阻害剤 |
Country Status (6)
| Country | Link |
|---|---|
| US (5) | US10745379B2 (enExample) |
| EP (1) | EP3707126B1 (enExample) |
| JP (3) | JP7271538B2 (enExample) |
| CN (1) | CN111566089B (enExample) |
| CA (1) | CA3082363A1 (enExample) |
| WO (1) | WO2019094641A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10934275B2 (en) | 2016-12-02 | 2021-03-02 | Cornell University | IRE1 small molecule inhibitors |
| AU2018278311B2 (en) * | 2017-06-01 | 2021-10-07 | Cornell University | IRE1 small molecule inhibitors |
| JP7271538B2 (ja) | 2017-11-10 | 2023-05-11 | コーネル・ユニバーシティー | 低分子ｉｒｅ１阻害剤 |
| SG11202105690TA (en) * | 2018-12-03 | 2021-06-29 | Univ Cornell | Ire1 small molecule inhibitors |
| US20220265656A1 (en) * | 2019-05-15 | 2022-08-25 | Cornell University | Combination therapies with ire1 small molecule inhibitors |
| CN114302877A (zh) * | 2019-06-11 | 2022-04-08 | 基因泰克公司 | 喹唑啉基化合物及使用方法 |
| JP2021031420A (ja) * | 2019-08-21 | 2021-03-01 | 日東電工株式会社 | Ｍｙｈ９の阻害物質を用いた、がん転移抑制 |
| WO2021158516A1 (en) * | 2020-02-03 | 2021-08-12 | Nimbus Iaso, Inc. | IRE1α MODULATORS AND USES THEREOF |
| WO2022104148A1 (en) * | 2020-11-13 | 2022-05-19 | The Regents Of The University Of California | Ire1alpha inhibitors and uses thereof |
| EP4247795A1 (en) | 2020-11-18 | 2023-09-27 | Deciphera Pharmaceuticals, LLC | Gcn2 and perk kinase inhibitors and methods of use thereof |
| CN114907350B (zh) * | 2021-02-10 | 2023-12-29 | 上海凌达生物医药有限公司 | 一类含氮稠环类化合物、制备方法和用途 |
| WO2023196659A1 (en) * | 2022-04-08 | 2023-10-12 | Alesta Therapeutics BV | Gcn2 modulator compounds |
| GB202207721D0 (en) | 2022-05-25 | 2022-07-06 | Cerevance Ltd | Novel Compounds |
| WO2025076441A1 (en) * | 2023-10-06 | 2025-04-10 | Alesta Therapeutics BV | Compounds of gcn2 modulators |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070054916A1 (en) | 2004-10-01 | 2007-03-08 | Amgen Inc. | Aryl nitrogen-containing bicyclic compounds and methods of use |
| WO2011047384A2 (en) * | 2009-10-16 | 2011-04-21 | The Regents Of The University Of California | Methods of inhibiting ire1 |
| MX388981B (es) * | 2010-04-05 | 2025-03-20 | Fosun Orinove Pharmatech Inc | Inhibidores de enzima 1 dependiente de inositol (ire-1alfa). |
| US9422298B2 (en) | 2011-03-17 | 2016-08-23 | Cmg Pharmaceutical Co., Ltd. | Pyridopyrimidine derivatives and use thereof |
| AU2013323426A1 (en) | 2012-09-26 | 2015-04-23 | The Regents Of The University Of California | Modulation of ire1 |
| WO2016004254A1 (en) * | 2014-07-01 | 2016-01-07 | The Regents Of The University Of California | Combined modulation of ire1 |
| WO2016022839A1 (en) * | 2014-08-06 | 2016-02-11 | The Regents Of The University Of California | Modulators of ire1 |
| WO2017152117A1 (en) * | 2016-03-03 | 2017-09-08 | Cornell University | Small molecule ire1-alpha inhibitors |
| AU2018278311B2 (en) | 2017-06-01 | 2021-10-07 | Cornell University | IRE1 small molecule inhibitors |
| JP7271538B2 (ja) | 2017-11-10 | 2023-05-11 | コーネル・ユニバーシティー | 低分子ｉｒｅ１阻害剤 |
-
2018
- 2018-11-08 JP JP2020526066A patent/JP7271538B2/ja active Active
- 2018-11-08 CA CA3082363A patent/CA3082363A1/en active Pending
- 2018-11-08 US US16/184,916 patent/US10745379B2/en active Active
- 2018-11-08 WO PCT/US2018/059894 patent/WO2019094641A1/en not_active Ceased
- 2018-11-08 CN CN201880085863.XA patent/CN111566089B/zh active Active
- 2018-11-08 EP EP18808592.2A patent/EP3707126B1/en active Active
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2020
- 2020-07-16 US US16/931,203 patent/US10961218B2/en active Active
-
2021
- 2021-02-15 US US17/175,940 patent/US11634403B2/en active Active
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2023
- 2023-02-28 US US18/176,362 patent/US12071424B2/en active Active
- 2023-04-26 JP JP2023071977A patent/JP7535335B2/ja active Active
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2024
- 2024-06-27 US US18/757,200 patent/US20240425477A1/en active Pending
- 2024-07-29 JP JP2024122258A patent/JP2024156774A/ja active Pending