CN111566089B - Ire1小分子抑制剂 - Google Patents

Ire1小分子抑制剂 Download PDF

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Publication number
CN111566089B
CN111566089B CN201880085863.XA CN201880085863A CN111566089B CN 111566089 B CN111566089 B CN 111566089B CN 201880085863 A CN201880085863 A CN 201880085863A CN 111566089 B CN111566089 B CN 111566089B
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Prior art keywords
amino
pharmaceutically acceptable
acceptable salt
chloro
ethylquinazolin
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CN201880085863.XA
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English (en)
Chinese (zh)
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CN111566089A (zh
Inventor
J·P·瓦卡
D·李
S·贝蒂戈尔
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Cornell University
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Cornell University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
CN201880085863.XA 2017-11-10 2018-11-08 Ire1小分子抑制剂 Active CN111566089B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762584575P 2017-11-10 2017-11-10
US62/584,575 2017-11-10
US201862678723P 2018-05-31 2018-05-31
US62/678,723 2018-05-31
PCT/US2018/059894 WO2019094641A1 (en) 2017-11-10 2018-11-08 Ire1 small molecule inhibitors

Publications (2)

Publication Number Publication Date
CN111566089A CN111566089A (zh) 2020-08-21
CN111566089B true CN111566089B (zh) 2023-11-17

Family

ID=64477302

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880085863.XA Active CN111566089B (zh) 2017-11-10 2018-11-08 Ire1小分子抑制剂

Country Status (6)

Country Link
US (5) US10745379B2 (enExample)
EP (1) EP3707126B1 (enExample)
JP (3) JP7271538B2 (enExample)
CN (1) CN111566089B (enExample)
CA (1) CA3082363A1 (enExample)
WO (1) WO2019094641A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018102751A1 (en) 2016-12-02 2018-06-07 Quentis Therapeutics, Inc. Ire1 small molecule inhibitors
AU2018278311B2 (en) * 2017-06-01 2021-10-07 Cornell University IRE1 small molecule inhibitors
WO2019094641A1 (en) 2017-11-10 2019-05-16 Quentis Therapeutics, Inc. Ire1 small molecule inhibitors
JP7546299B2 (ja) 2018-12-03 2024-09-06 コーネル・ユニバーシティー Ｉｒｅ１小分子阻害物質
US20220265656A1 (en) * 2019-05-15 2022-08-25 Cornell University Combination therapies with ire1 small molecule inhibitors
EP3983400B1 (en) * 2019-06-11 2025-05-28 Genentech, Inc. Quinazolinyl compounds and methods of use
JP2021031420A (ja) * 2019-08-21 2021-03-01 日東電工株式会社 Ｍｙｈ９の阻害物質を用いた、がん転移抑制
US20240262830A1 (en) * 2020-02-03 2024-08-08 Nimbus Iaso, Inc. Ire1a modulators and uses thereof
CN116710429A (zh) * 2020-11-13 2023-09-05 加利福尼亚大学董事会 IRE1α抑制剂及其用途
PE20231311A1 (es) 2020-11-18 2023-08-24 Deciphera Pharmaceuticals Llc Inhibidores de gcn2 y perk quinasas y metodos de uso de los mismos
CN114907350B (zh) * 2021-02-10 2023-12-29 上海凌达生物医药有限公司 一类含氮稠环类化合物、制备方法和用途
MX2024006627A (es) 2021-12-03 2024-08-22 Deciphera Pharmaceuticals Llc Inhibidores de gcn2 y perk quinasa y metodos de uso de los mismos.
US20250263400A1 (en) * 2022-04-08 2025-08-21 Alesta Therapeutics BV Gcn2 modulator compounds
GB202207721D0 (en) 2022-05-25 2022-07-06 Cerevance Ltd Novel Compounds
AU2024356374A1 (en) * 2023-10-06 2026-04-16 Alesta Therapeutics BV Compounds of gcn2 modulators

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011047384A2 (en) * 2009-10-16 2011-04-21 The Regents Of The University Of California Methods of inhibiting ire1
WO2011127070A2 (en) * 2010-04-05 2011-10-13 Mannkind Corporation IRE-1α INHIBITORS
WO2014052669A1 (en) * 2012-09-26 2014-04-03 The Regents Of The University Of California Modulation of ire1
WO2016004254A1 (en) * 2014-07-01 2016-01-07 The Regents Of The University Of California Combined modulation of ire1
WO2016022839A1 (en) * 2014-08-06 2016-02-11 The Regents Of The University Of California Modulators of ire1
WO2017152117A1 (en) * 2016-03-03 2017-09-08 Cornell University Small molecule ire1-alpha inhibitors
WO2018222918A1 (en) * 2017-06-01 2018-12-06 Quentis Therapeutics, Inc. Ire1 small molecule inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070054916A1 (en) * 2004-10-01 2007-03-08 Amgen Inc. Aryl nitrogen-containing bicyclic compounds and methods of use
US9422298B2 (en) 2011-03-17 2016-08-23 Cmg Pharmaceutical Co., Ltd. Pyridopyrimidine derivatives and use thereof
WO2019094641A1 (en) 2017-11-10 2019-05-16 Quentis Therapeutics, Inc. Ire1 small molecule inhibitors

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011047384A2 (en) * 2009-10-16 2011-04-21 The Regents Of The University Of California Methods of inhibiting ire1
WO2011127070A2 (en) * 2010-04-05 2011-10-13 Mannkind Corporation IRE-1α INHIBITORS
WO2014052669A1 (en) * 2012-09-26 2014-04-03 The Regents Of The University Of California Modulation of ire1
CN104995192A (zh) * 2012-09-26 2015-10-21 加利福尼亚大学董事会 Ire1的调节
WO2016004254A1 (en) * 2014-07-01 2016-01-07 The Regents Of The University Of California Combined modulation of ire1
WO2016022839A1 (en) * 2014-08-06 2016-02-11 The Regents Of The University Of California Modulators of ire1
WO2017152117A1 (en) * 2016-03-03 2017-09-08 Cornell University Small molecule ire1-alpha inhibitors
WO2018222918A1 (en) * 2017-06-01 2018-12-06 Quentis Therapeutics, Inc. Ire1 small molecule inhibitors

Also Published As

Publication number Publication date
US20220251065A1 (en) 2022-08-11
US10961218B2 (en) 2021-03-30
CN111566089A (zh) 2020-08-21
US20200392106A1 (en) 2020-12-17
EP3707126B1 (en) 2025-05-14
JP2021502387A (ja) 2021-01-28
EP3707126A1 (en) 2020-09-16
US20240425477A1 (en) 2024-12-26
WO2019094641A1 (en) 2019-05-16
US20190169160A1 (en) 2019-06-06
US20230271935A1 (en) 2023-08-31
JP7271538B2 (ja) 2023-05-11
US10745379B2 (en) 2020-08-18
US12071424B2 (en) 2024-08-27
JP2023100744A (ja) 2023-07-19
US11634403B2 (en) 2023-04-25
JP2024156774A (ja) 2024-11-06
CA3082363A1 (en) 2019-05-16
JP7535335B2 (ja) 2024-08-16

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