JP2024062998A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2024062998A5 JP2024062998A5 JP2024015762A JP2024015762A JP2024062998A5 JP 2024062998 A5 JP2024062998 A5 JP 2024062998A5 JP 2024015762 A JP2024015762 A JP 2024015762A JP 2024015762 A JP2024015762 A JP 2024015762A JP 2024062998 A5 JP2024062998 A5 JP 2024062998A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- pya
- dap
- linked
- linker
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1805492.4A GB201805492D0 (en) | 2018-04-04 | 2018-04-04 | Heterotandem Bicyclic peptide complexes |
| GB1805492.4 | 2018-04-04 | ||
| GBGB1820981.7A GB201820981D0 (en) | 2018-12-21 | 2018-12-21 | Heterotandem bicyclic peptide complexes |
| GB1820981.7 | 2018-12-21 | ||
| PCT/GB2019/050951 WO2019193328A1 (en) | 2018-04-04 | 2019-04-02 | Heterotandem bicyclic peptide complexes |
| JP2020554265A JP7551500B2 (ja) | 2018-04-04 | 2019-04-02 | ヘテロタンデム二環式ペプチド複合体 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020554265A Division JP7551500B2 (ja) | 2018-04-04 | 2019-04-02 | ヘテロタンデム二環式ペプチド複合体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024062998A JP2024062998A (ja) | 2024-05-10 |
| JP2024062998A5 true JP2024062998A5 (https=) | 2025-06-17 |
Family
ID=66175434
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020554265A Active JP7551500B2 (ja) | 2018-04-04 | 2019-04-02 | ヘテロタンデム二環式ペプチド複合体 |
| JP2024015762A Pending JP2024062998A (ja) | 2018-04-04 | 2024-02-05 | ヘテロタンデム二環式ペプチド複合体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020554265A Active JP7551500B2 (ja) | 2018-04-04 | 2019-04-02 | ヘテロタンデム二環式ペプチド複合体 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US11453703B2 (https=) |
| EP (1) | EP3774851A1 (https=) |
| JP (2) | JP7551500B2 (https=) |
| KR (1) | KR20200139236A (https=) |
| CN (1) | CN112236442A (https=) |
| AU (2) | AU2019247795B2 (https=) |
| BR (1) | BR112020020349A2 (https=) |
| CA (1) | CA3095582A1 (https=) |
| IL (1) | IL277717A (https=) |
| MX (1) | MX2020010444A (https=) |
| SG (1) | SG11202009773VA (https=) |
| WO (1) | WO2019193328A1 (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107148425B (zh) | 2014-10-29 | 2021-08-03 | 拜斯科阿迪有限公司 | 对mt1-mmp特异性的双环肽配体 |
| GB201607827D0 (en) | 2016-05-04 | 2016-06-15 | Bicycle Therapeutics Ltd | Bicyclic peptide-toxin conjugates specific for MT1-MMP |
| WO2018115203A1 (en) | 2016-12-23 | 2018-06-28 | Bicyclerd Limited | Peptide derivatives having novel linkage structures |
| EP3645549A1 (en) | 2017-06-26 | 2020-05-06 | BicycleRD Limited | Bicyclic peptide ligands with detectable moieties and uses thereof |
| JP7670481B2 (ja) | 2017-08-04 | 2025-04-30 | バイスクルテクス・リミテッド | Ｃｄ１３７に対して特異的な二環式ペプチドリガンド |
| TWI825046B (zh) | 2017-12-19 | 2023-12-11 | 英商拜西可泰克斯有限公司 | Epha2特用之雙環胜肽配位基 |
| GB201721265D0 (en) | 2017-12-19 | 2018-01-31 | Bicyclerd Ltd | Bicyclic peptide ligands specific for EphA2 |
| CN111902429A (zh) | 2018-02-23 | 2020-11-06 | 拜斯科技术开发有限公司 | 多聚体双环肽配体 |
| EP3774851A1 (en) * | 2018-04-04 | 2021-02-17 | BicycleTX Limited | Heterotandem bicyclic peptide complexes |
| GB201810316D0 (en) | 2018-06-22 | 2018-08-08 | Bicyclerd Ltd | Peptide ligands for binding to EphA2 |
| IL279489B2 (en) | 2018-06-22 | 2025-10-01 | Bicycletx Ltd | Bicyclic peptide ligands specific for nectin-4, a drug conjugate containing the peptide ligands and a pharmaceutical composition containing the drug conjugate |
| GB201820295D0 (en) | 2018-12-13 | 2019-01-30 | Bicyclerd Ltd | Bicyclic peptide ligands specific for MT1-MMP |
| GB201820288D0 (en) | 2018-12-13 | 2019-01-30 | Bicycle Tx Ltd | Bicycle peptide ligaands specific for MT1-MMP |
| GB201820325D0 (en) | 2018-12-13 | 2019-01-30 | Bicyclerd Ltd | Bicyclic peptide ligands specific for psma |
| US12492224B2 (en) | 2018-12-21 | 2025-12-09 | Bicycletx Limited | Bicyclic peptide ligands specific for PD-L1 |
| WO2020128527A1 (en) * | 2018-12-21 | 2020-06-25 | Bicyclerd Limited | Bicyclic peptide ligands specific for pd-l1 |
| GB201900529D0 (en) | 2019-01-15 | 2019-03-06 | Bicycletx Ltd | Bicyclic peptide ligands specific for CD38 |
| WO2020225577A1 (en) | 2019-05-09 | 2020-11-12 | Bicycletx Limited | Bicyclic peptide ligands specific for ox40 |
| TWI860386B (zh) * | 2019-07-30 | 2024-11-01 | 英商拜西可泰克斯有限公司 | 異質雙環肽複合物 |
| US20220275053A1 (en) * | 2019-08-13 | 2022-09-01 | Bicycletx Limited | Modified multimeric bicyclic peptide ligands |
| SMT202500247T1 (it) * | 2019-10-03 | 2025-09-12 | Bicycletx Ltd | Complessi peptidici eterotandem biciclici |
| GB201914872D0 (en) * | 2019-10-15 | 2019-11-27 | Bicycletx Ltd | Bicyclic peptide ligand drug conjugates |
| AU2021322934A1 (en) | 2020-08-03 | 2023-03-30 | Bicycletx Limited | Peptide-based linkers |
| CA3186504A1 (en) | 2020-08-17 | 2022-02-24 | Stephen J. Blakemore | Bicycle conjugates specific for nectin-4 and uses thereof |
| GB202016331D0 (en) * | 2020-10-15 | 2020-12-02 | Bicyclerd Ltd | Bicyclic peptide ligand drug conjugates |
| AU2022206577A1 (en) * | 2021-01-08 | 2023-08-24 | Bicycletx Limited | Heterotandem bicyclic peptide complexes |
| US20250186539A2 (en) * | 2021-01-11 | 2025-06-12 | Bicycletx Limited | Methods for treating cancer |
| WO2022253051A1 (zh) * | 2021-06-01 | 2022-12-08 | 南京明德新药研发有限公司 | 多肽偶联药物及其应用 |
| AU2022328932B2 (en) * | 2021-08-17 | 2026-02-19 | Tianjin Conjustar Biologics Co., Ltd. | Polypeptide drug conjugate having novel structure and application thereof |
| TWI803993B (zh) * | 2021-09-28 | 2023-06-01 | 廖嘉鴻 | 環胜肽自組裝3d微粒裝置及其製造方法 |
| MX2024003876A (es) * | 2021-09-29 | 2024-04-19 | Conjustar Zhuhai Biologics Co Ltd | Conjugado farmaco-polipeptido triciclico y sus aplicaciones. |
| CN115819618B (zh) * | 2022-09-16 | 2023-10-27 | 哈尔滨工业大学 | 一种光激活的纳抗偶联物二聚化诱导剂pancid及其应用 |
| WO2025248261A1 (en) | 2024-05-31 | 2025-12-04 | Bicycletx Limited | Method for identifying patients |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1452868A2 (en) | 2003-02-27 | 2004-09-01 | Pepscan Systems B.V. | Method for selecting a candidate drug compound |
| US7288638B2 (en) | 2003-10-10 | 2007-10-30 | Bristol-Myers Squibb Company | Fully human antibodies against human 4-1BB |
| WO2006078161A1 (en) | 2005-01-24 | 2006-07-27 | Pepscan Systems B.V. | Binding compounds, immunogenic compounds and peptidomimetics |
| EP2653545A1 (en) | 2008-02-05 | 2013-10-23 | Bicycle Therapeutics Limited | Methods and compositions |
| GB0913775D0 (en) * | 2009-08-06 | 2009-09-16 | Medical Res Council | Multispecific peptides |
| AU2010306774A1 (en) * | 2009-10-14 | 2012-05-03 | Merrimack Pharmaceuticals, Inc. | Bispecific binding agents targeting IGF-1R and ErbB3 signalling and uses thereof |
| JP2013518807A (ja) * | 2010-02-04 | 2013-05-23 | メディカル リサーチ カウンシル | 多重特異性ペプチド |
| PL2764140T3 (pl) * | 2011-10-07 | 2018-04-30 | Bicyclerd Limited | Modulacja specyficzności polipeptydów ustrukturyzowanych |
| US20140274759A1 (en) * | 2013-03-15 | 2014-09-18 | Bicycle Therapeutics Limited | Modification of polypeptides |
| US20170165334A1 (en) * | 2015-12-11 | 2017-06-15 | Tianxin Wang | Methods to Treat Diseases with Protein, Peptide, Antigen Modification and Hemopurification |
| CN107148425B (zh) * | 2014-10-29 | 2021-08-03 | 拜斯科阿迪有限公司 | 对mt1-mmp特异性的双环肽配体 |
| JP2019513371A (ja) * | 2016-04-01 | 2019-05-30 | アビディティー バイオサイエンシーズ エルエルシー | 核酸ポリペプチド組成物とその使用 |
| EP3445788B1 (en) * | 2016-04-22 | 2022-01-19 | Alligator Bioscience AB | Novel bispecific polypeptides against cd137 |
| JP7670481B2 (ja) | 2017-08-04 | 2025-04-30 | バイスクルテクス・リミテッド | Ｃｄ１３７に対して特異的な二環式ペプチドリガンド |
| GB201721265D0 (en) | 2017-12-19 | 2018-01-31 | Bicyclerd Ltd | Bicyclic peptide ligands specific for EphA2 |
| TWI825046B (zh) | 2017-12-19 | 2023-12-11 | 英商拜西可泰克斯有限公司 | Epha2特用之雙環胜肽配位基 |
| CN111902429A (zh) | 2018-02-23 | 2020-11-06 | 拜斯科技术开发有限公司 | 多聚体双环肽配体 |
| EP3774851A1 (en) * | 2018-04-04 | 2021-02-17 | BicycleTX Limited | Heterotandem bicyclic peptide complexes |
| IL279489B2 (en) * | 2018-06-22 | 2025-10-01 | Bicycletx Ltd | Bicyclic peptide ligands specific for nectin-4, a drug conjugate containing the peptide ligands and a pharmaceutical composition containing the drug conjugate |
| GB201810316D0 (en) | 2018-06-22 | 2018-08-08 | Bicyclerd Ltd | Peptide ligands for binding to EphA2 |
| SG11202110828UA (en) | 2019-04-02 | 2021-10-28 | Bicycletx Ltd | Bicycle toxin conjugates and uses thereof |
| TWI860386B (zh) | 2019-07-30 | 2024-11-01 | 英商拜西可泰克斯有限公司 | 異質雙環肽複合物 |
| SMT202500247T1 (it) | 2019-10-03 | 2025-09-12 | Bicycletx Ltd | Complessi peptidici eterotandem biciclici |
| MX2022006001A (es) | 2019-11-27 | 2022-10-27 | Bicycletx Ltd | Ligandos de peptidos biciclicos especificos para el receptor 2 tipo a de efrina (epha2) y usos de los mismos. |
-
2019
- 2019-04-02 EP EP19717554.0A patent/EP3774851A1/en active Pending
- 2019-04-02 KR KR1020207031802A patent/KR20200139236A/ko not_active Ceased
- 2019-04-02 SG SG11202009773VA patent/SG11202009773VA/en unknown
- 2019-04-02 WO PCT/GB2019/050951 patent/WO2019193328A1/en not_active Ceased
- 2019-04-02 CN CN201980037963.XA patent/CN112236442A/zh active Pending
- 2019-04-02 CA CA3095582A patent/CA3095582A1/en active Pending
- 2019-04-02 BR BR112020020349-1A patent/BR112020020349A2/pt unknown
- 2019-04-02 JP JP2020554265A patent/JP7551500B2/ja active Active
- 2019-04-02 AU AU2019247795A patent/AU2019247795B2/en active Active
- 2019-04-02 MX MX2020010444A patent/MX2020010444A/es unknown
- 2019-04-02 US US16/372,692 patent/US11453703B2/en active Active
-
2020
- 2020-10-01 IL IL277717A patent/IL277717A/en unknown
-
2022
- 2022-05-12 US US17/663,169 patent/US20230008076A1/en active Pending
-
2024
- 2024-02-05 JP JP2024015762A patent/JP2024062998A/ja active Pending
- 2024-07-25 AU AU2024205105A patent/AU2024205105A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2024062998A5 (https=) | ||
| CA3017926C (en) | Methods for synthesizing .alpha.4.beta.7 peptide antagonists | |
| CN119192401A (zh) | 异串联双环肽复合物 | |
| AU2013312689B2 (en) | Novel compound with effects of thrombolysis, free radical scavenging and thrombus-targeting as well as preparation method and use thereof | |
| HRP20250081T1 (hr) | Biciklični peptidni ligandi specifični za nektin-4 | |
| KR101413051B1 (ko) | 뉴로펩타이드 ｙ 수용체 결합성 화합물을 포함하는 세포독성 접합체 | |
| US9907838B2 (en) | Composition and methods for treating ischemic damage | |
| ES2332590T3 (es) | Dimero peptidico. | |
| JP2017535527A5 (https=) | ||
| ES2406090T3 (es) | Péptidos que tienen actividad farmacológica para tratar los trastornos asociados con la alteración de la migración celular, tal como el cáncer | |
| JP2022514618A5 (https=) | ||
| CN112236442A (zh) | 异源串联双环肽复合物 | |
| JPH05508860A (ja) | 細胞接着制御環状化合物 | |
| JP2017522362A5 (https=) | ||
| CN110461861B (zh) | 人参肽和人参肽类似肽的制备和利用 | |
| CA2309205A1 (en) | Novel conjugates of rgd-containing peptides and endogenous carriers | |
| Bose et al. | Peptide therapeutics in the management of metastatic cancers | |
| IL171204A (en) | Compounds and pharmaceutical compositions containing them and use thereof for the preparation of medicaments | |
| JP2023549229A5 (https=) | ||
| TW202306965A (zh) | Ｐｓｄ－９５抑制劑及其用途 | |
| HU177134B (en) | Process for preparing angiotensin ii analogues containing alpha-hydroxy-acid in position 1 with angiotensin ii antagonist activity | |
| WO2019204402A1 (en) | Compositions and methods for treatment of cancer | |
| JPH06306098A (ja) | 新規なアンジオペプチンシクロペプチド化合物、それらの調製法およびそれらを含む医薬組成物 | |
| TWI234460B (en) | Cyclic pentad-peptide and its preparing method | |
| NZ772052B2 (en) | Bicyclic peptide ligands specific for nectin-4 |