MX2020010444A - Complejos de péptidos bicíclicos en heterotándem. - Google Patents

Complejos de péptidos bicíclicos en heterotándem.

Info

Publication number
MX2020010444A
MX2020010444A MX2020010444A MX2020010444A MX2020010444A MX 2020010444 A MX2020010444 A MX 2020010444A MX 2020010444 A MX2020010444 A MX 2020010444A MX 2020010444 A MX2020010444 A MX 2020010444A MX 2020010444 A MX2020010444 A MX 2020010444A
Authority
MX
Mexico
Prior art keywords
peptide complexes
bicyclic peptide
heterotandem bicyclic
heterotandem
binds
Prior art date
Application number
MX2020010444A
Other languages
English (en)
Inventor
Peter Park
Gemma Mudd
Kevin Mcdonnell
Nicholas KEEN
Punit Upadhyaya
Original Assignee
Bicycletx Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1805492.4A external-priority patent/GB201805492D0/en
Priority claimed from GBGB1820981.7A external-priority patent/GB201820981D0/en
Application filed by Bicycletx Ltd filed Critical Bicycletx Ltd
Publication of MX2020010444A publication Critical patent/MX2020010444A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • C07K17/08—Peptides being immobilised on, or in, an organic carrier the carrier being a synthetic polymer
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a complejos de péptido bicíclico en heterotándem que comprenden un primer ligando peptídico que se une a un componente presente sobre una célula inmunitaria, conjugado mediante un enlazador con un segundo ligando peptídico que se une a un componente presente sobre una célula de cáncer; la invención también se refiere al uso de dichos complejos de péptido bicíclico en heterotándem para prevenir, suprimir o tratar el cáncer.
MX2020010444A 2018-04-04 2019-04-02 Complejos de péptidos bicíclicos en heterotándem. MX2020010444A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1805492.4A GB201805492D0 (en) 2018-04-04 2018-04-04 Heterotandem Bicyclic peptide complexes
GBGB1820981.7A GB201820981D0 (en) 2018-12-21 2018-12-21 Heterotandem bicyclic peptide complexes
PCT/GB2019/050951 WO2019193328A1 (en) 2018-04-04 2019-04-02 Heterotandem bicyclic peptide complexes

Publications (1)

Publication Number Publication Date
MX2020010444A true MX2020010444A (es) 2021-01-08

Family

ID=66175434

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020010444A MX2020010444A (es) 2018-04-04 2019-04-02 Complejos de péptidos bicíclicos en heterotándem.

Country Status (12)

Country Link
US (2) US11453703B2 (es)
EP (1) EP3774851A1 (es)
JP (2) JP2021520378A (es)
KR (1) KR20200139236A (es)
CN (1) CN112236442A (es)
AU (1) AU2019247795A1 (es)
BR (1) BR112020020349A2 (es)
CA (1) CA3095582A1 (es)
IL (1) IL277717A (es)
MX (1) MX2020010444A (es)
SG (1) SG11202009773VA (es)
WO (1) WO2019193328A1 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201607827D0 (en) 2016-05-04 2016-06-15 Bicycle Therapeutics Ltd Bicyclic peptide-toxin conjugates specific for MT1-MMP
EP3559018A1 (en) 2016-12-23 2019-10-30 Bicyclerd Limited Peptide derivatives having novel linkage structures
US10899798B2 (en) 2017-06-26 2021-01-26 Bicyclerd Limited Bicyclic peptide ligands with detectable moieties and uses thereof
JP2020529427A (ja) 2017-08-04 2020-10-08 バイスクルテクス・リミテッド Ｃｄ１３７に対して特異的な二環式ペプチドリガンド
GB201721265D0 (en) 2017-12-19 2018-01-31 Bicyclerd Ltd Bicyclic peptide ligands specific for EphA2
TWI825046B (zh) 2017-12-19 2023-12-11 英商拜西可泰克斯有限公司 Epha2特用之雙環胜肽配位基
US10875894B2 (en) 2018-02-23 2020-12-29 Bicycletx Limited Multimeric bicyclic peptide ligands
US11180531B2 (en) * 2018-06-22 2021-11-23 Bicycletx Limited Bicyclic peptide ligands specific for Nectin-4
GB201810316D0 (en) 2018-06-22 2018-08-08 Bicyclerd Ltd Peptide ligands for binding to EphA2
CN113474045A (zh) * 2018-12-21 2021-10-01 拜斯科技术开发有限公司 Pd-l1特异性的双环肽配体
US20220088207A1 (en) * 2018-12-21 2022-03-24 Bicycletx Limited Bicyclic peptide ligands specific for pd-l1
WO2020225577A1 (en) 2019-05-09 2020-11-12 Bicycletx Limited Bicyclic peptide ligands specific for ox40
TW202110485A (zh) * 2019-07-30 2021-03-16 英商拜西可泰克斯有限公司 異質雙環肽複合物
WO2021028686A1 (en) * 2019-08-13 2021-02-18 Bicycletx Limited Modified multimeric bicyclic peptide ligands
EP4038096A1 (en) * 2019-10-03 2022-08-10 BicycleTX Limited Heterotandem bicyclic peptide complexes
GB201914872D0 (en) * 2019-10-15 2019-11-27 Bicycletx Ltd Bicyclic peptide ligand drug conjugates
KR20230074721A (ko) 2020-08-17 2023-05-31 바이사이클티엑스 리미티드 Nectin-4에 특이적인 이환 콘쥬게이트 및 이의 용도
GB202016331D0 (en) * 2020-10-15 2020-12-02 Bicyclerd Ltd Bicyclic peptide ligand drug conjugates
CA3206529A1 (en) * 2021-01-08 2022-07-14 Bicycletx Limited Heterotandem bicyclic peptide complexes
WO2022148979A1 (en) 2021-01-11 2022-07-14 Bicycletx Limited Methods for treating cancer
WO2022253051A1 (zh) * 2021-06-01 2022-12-08 南京明德新药研发有限公司 多肽偶联药物及其应用
KR20240042656A (ko) * 2021-08-17 2024-04-02 메드샤인 디스커버리 아이엔씨. 신규구조를 갖는 폴리펩타이드 접합체 약물 및 그 응용
TWI803993B (zh) * 2021-09-28 2023-06-01 廖嘉鴻 環胜肽自組裝3d微粒裝置及其製造方法
AU2022356942A1 (en) * 2021-09-29 2024-05-09 Conjustar (Zhuhai) Biologics Co., Ltd. Tricyclic polypeptide conjugated drug and use thereof
CN115819618B (zh) * 2022-09-16 2023-10-27 哈尔滨工业大学 一种光激活的纳抗偶联物二聚化诱导剂pancid及其应用

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1452868A2 (en) 2003-02-27 2004-09-01 Pepscan Systems B.V. Method for selecting a candidate drug compound
US7288638B2 (en) 2003-10-10 2007-10-30 Bristol-Myers Squibb Company Fully human antibodies against human 4-1BB
WO2006078161A1 (en) 2005-01-24 2006-07-27 Pepscan Systems B.V. Binding compounds, immunogenic compounds and peptidomimetics
EP2257624B9 (en) 2008-02-05 2012-08-01 Medical Research Council Methods and compositions
GB0913775D0 (en) * 2009-08-06 2009-09-16 Medical Res Council Multispecific peptides
JP2013518807A (ja) * 2010-02-04 2013-05-23 メディカル リサーチ カウンシル 多重特異性ペプチド
WO2013050616A1 (en) * 2011-10-07 2013-04-11 Bicycle Therapeutics Limited Modulation of structured polypeptide specificity
US20140274759A1 (en) * 2013-03-15 2014-09-18 Bicycle Therapeutics Limited Modification of polypeptides
CA3220466A1 (en) * 2014-10-29 2016-05-06 Bicyclerd Limited Bicyclic peptide ligands specific for mt1-mmp
MA45328A (fr) 2016-04-01 2019-02-06 Avidity Biosciences Llc Compositions acide nucléique-polypeptide et utilisations de celles-ci
RU2018139339A (ru) * 2016-04-22 2020-05-22 Эллигейтор Биосайенс Аб Новые биспецифические полипептиды против cd137
JP2020529427A (ja) 2017-08-04 2020-10-08 バイスクルテクス・リミテッド Ｃｄ１３７に対して特異的な二環式ペプチドリガンド
GB201721265D0 (en) 2017-12-19 2018-01-31 Bicyclerd Ltd Bicyclic peptide ligands specific for EphA2
TWI825046B (zh) 2017-12-19 2023-12-11 英商拜西可泰克斯有限公司 Epha2特用之雙環胜肽配位基
US10875894B2 (en) 2018-02-23 2020-12-29 Bicycletx Limited Multimeric bicyclic peptide ligands
GB201810316D0 (en) 2018-06-22 2018-08-08 Bicyclerd Ltd Peptide ligands for binding to EphA2
WO2020201753A1 (en) 2019-04-02 2020-10-08 Bicycletx Limited Bicycle toxin conjugates and uses thereof
TW202110485A (zh) 2019-07-30 2021-03-16 英商拜西可泰克斯有限公司 異質雙環肽複合物
EP4038096A1 (en) 2019-10-03 2022-08-10 BicycleTX Limited Heterotandem bicyclic peptide complexes
CA3158741A1 (en) 2019-11-27 2021-06-03 Gavin Bennett Bicyclic peptide ligands specific for epha2 and uses thereof

Also Published As

Publication number Publication date
JP2021520378A (ja) 2021-08-19
KR20200139236A (ko) 2020-12-11
JP2024062998A (ja) 2024-05-10
WO2019193328A1 (en) 2019-10-10
US20190307836A1 (en) 2019-10-10
IL277717A (en) 2020-11-30
CN112236442A (zh) 2021-01-15
SG11202009773VA (en) 2020-10-29
EP3774851A1 (en) 2021-02-17
BR112020020349A2 (pt) 2021-01-05
US11453703B2 (en) 2022-09-27
US20230008076A1 (en) 2023-01-12
US20210299210A2 (en) 2021-09-30
CA3095582A1 (en) 2019-10-10
AU2019247795A1 (en) 2020-11-12

Similar Documents

Publication Publication Date Title
MX2020010444A (es) Complejos de péptidos bicíclicos en heterotándem.
MX2022001290A (es) Complejos de peptido biciclico en heterotandem.
PH12019502875A1 (en) Antibody molecules to cd73 and uses thereof
NZ753515A (en) Methods for treatment of cancer comprising tigit-binding agents
PH12019500270A1 (en) Combination therapy for cancer
NZ738008A (en) Tigit-binding agents and uses thereof
MX2022011818A (es) Metodos y composiciones para el direccionamiento de canceres de celulas t.
SA518400222B1 (ar) أجسام مضادة لـ وتركيبات tim-3
PH12016501411B1 (en) Bifunctional cytotoxic agents
MY192822A (en) An anti-ctla4 monoclonal antibody or antigen binding fragment thereof, a pharmaceutical composition and use
MX2019001517A (es) Complejos de nanopartículas de albúmina modificada con anticuerpos para el tratamiento del cáncer.
MX2016006726A (es) Composiciones que comprenden anticuerpos anti-molecula de adhesion celular relacionada con antigeno carcinoembrionario 1 y anti-muerte celular programada para la terapia contra el cancer.
WO2017136659A3 (en) Humanized anti-cd3 antibodies, conjugates and uses thereof
MX2021007274A (es) Molecula bifuncional anti-pd-1/sirpa.
MX2023008168A (es) Complejos peptidicos biciclicos heterotandem.
MX2023007809A (es) Compuestos de complejo de hierro para uso terapeutico.
PH12019550233A1 (en) A novel anti-c-met antibody and use thereof
EA201992315A1 (ru) Композиции и способы для лечения рака легкого
WO2019168897A3 (en) Methods for treating cancer using combinations of anti-btnl2 and immune checkpoint blockade agents
MX2021000304A (es) Terapias combinadas dirigidas a cd38 y tgf-beta.
EA202092388A1 (ru) Гетеротандемные бициклические пептидные комплексы
WO2018146390A8 (fr) Utilisation d'un compose appartenant a la famille des diuretiques pour traiter le cancer
MX2019007376A (es) Anticuerpos contra el lif y usos de los mismos.
MX2020013923A (es) Anticuerpos anti molécula de adhesión celular l1 (l1cam) y usos de estos.
MX2019013019A (es) USO DE 3,16-DIACETADO DE 26-AZIDO-22-OXOCOLEST-5-3ß, 16ß-DIILO COMO AGENTE ANTICANCERIGENO.