AU2019247795B2 - Heterotandem bicyclic peptide complexes - Google Patents

Heterotandem bicyclic peptide complexes Download PDF

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Publication number
AU2019247795B2
AU2019247795B2 AU2019247795A AU2019247795A AU2019247795B2 AU 2019247795 B2 AU2019247795 B2 AU 2019247795B2 AU 2019247795 A AU2019247795 A AU 2019247795A AU 2019247795 A AU2019247795 A AU 2019247795A AU 2019247795 B2 AU2019247795 B2 AU 2019247795B2
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Australia
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seq
pya
dap
linker
pmol
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AU2019247795A1 (en
Inventor
Nicholas Keen
Kevin Mcdonnell
Gemma Mudd
Peter Park
Punit UPADHYAYA
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BicycleTx Ltd
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BicycleTx Ltd
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Priority claimed from GBGB1805492.4A external-priority patent/GB201805492D0/en
Priority claimed from GBGB1820981.7A external-priority patent/GB201820981D0/en
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Publication of AU2019247795A1 publication Critical patent/AU2019247795A1/en
Assigned to BICYCLETX LIMITED reassignment BICYCLETX LIMITED Amend patent request/document other than specification (104) Assignors: BICYCLETX LIMITED
Priority to AU2024205105A priority Critical patent/AU2024205105A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • C07K17/08—Peptides being immobilised on, or in, an organic carrier the carrier being a synthetic polymer
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
AU2019247795A 2018-04-04 2019-04-02 Heterotandem bicyclic peptide complexes Active AU2019247795B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2024205105A AU2024205105A1 (en) 2018-04-04 2024-07-25 Heterotandem bicyclic peptide complexes

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB1805492.4 2018-04-04
GBGB1805492.4A GB201805492D0 (en) 2018-04-04 2018-04-04 Heterotandem Bicyclic peptide complexes
GBGB1820981.7A GB201820981D0 (en) 2018-12-21 2018-12-21 Heterotandem bicyclic peptide complexes
GB1820981.7 2018-12-21
PCT/GB2019/050951 WO2019193328A1 (en) 2018-04-04 2019-04-02 Heterotandem bicyclic peptide complexes

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2024205105A Division AU2024205105A1 (en) 2018-04-04 2024-07-25 Heterotandem bicyclic peptide complexes

Publications (2)

Publication Number Publication Date
AU2019247795A1 AU2019247795A1 (en) 2020-11-12
AU2019247795B2 true AU2019247795B2 (en) 2024-08-15

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
AU2019247795A Active AU2019247795B2 (en) 2018-04-04 2019-04-02 Heterotandem bicyclic peptide complexes
AU2024205105A Pending AU2024205105A1 (en) 2018-04-04 2024-07-25 Heterotandem bicyclic peptide complexes

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2024205105A Pending AU2024205105A1 (en) 2018-04-04 2024-07-25 Heterotandem bicyclic peptide complexes

Country Status (12)

Country Link
US (2) US11453703B2 (https=)
EP (1) EP3774851A1 (https=)
JP (2) JP7551500B2 (https=)
KR (1) KR20200139236A (https=)
CN (1) CN112236442A (https=)
AU (2) AU2019247795B2 (https=)
BR (1) BR112020020349A2 (https=)
CA (1) CA3095582A1 (https=)
IL (1) IL277717A (https=)
MX (1) MX2020010444A (https=)
SG (1) SG11202009773VA (https=)
WO (1) WO2019193328A1 (https=)

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WO2018115203A1 (en) 2016-12-23 2018-06-28 Bicyclerd Limited Peptide derivatives having novel linkage structures
JP7301757B2 (ja) 2017-06-26 2023-07-03 バイスクルアールディー・リミテッド 検出可能部分を持つ二環式ペプチドリガンドおよびその使用
CN111183147B (zh) 2017-08-04 2024-07-05 拜斯科技术开发有限公司 Cd137特异性的双环肽配体
TWI825046B (zh) 2017-12-19 2023-12-11 英商拜西可泰克斯有限公司 Epha2特用之雙環胜肽配位基
GB201721265D0 (en) 2017-12-19 2018-01-31 Bicyclerd Ltd Bicyclic peptide ligands specific for EphA2
JP2021514953A (ja) 2018-02-23 2021-06-17 バイスクルテクス・リミテッド 多量体二環式ペプチドリガンド
JP7551500B2 (ja) * 2018-04-04 2024-09-17 バイスクルテクス・リミテッド ヘテロタンデム二環式ペプチド複合体
GB201810316D0 (en) 2018-06-22 2018-08-08 Bicyclerd Ltd Peptide ligands for binding to EphA2
IL279489B2 (en) 2018-06-22 2025-10-01 Bicycletx Ltd Bicyclic peptide ligands specific for nectin-4, a drug conjugate containing the peptide ligands and a pharmaceutical composition containing the drug conjugate
GB201820295D0 (en) 2018-12-13 2019-01-30 Bicyclerd Ltd Bicyclic peptide ligands specific for MT1-MMP
GB201820325D0 (en) 2018-12-13 2019-01-30 Bicyclerd Ltd Bicyclic peptide ligands specific for psma
GB201820288D0 (en) 2018-12-13 2019-01-30 Bicycle Tx Ltd Bicycle peptide ligaands specific for MT1-MMP
JP2022514618A (ja) * 2018-12-21 2022-02-14 バイスクルテクス・リミテッド Ｐｄ－ｌ１に特異的な二環式ペプチドリガンド
US12551567B2 (en) 2018-12-21 2026-02-17 Bicyclerd Limited Bicyclic peptide ligands specific for PD-L1
GB201900529D0 (en) 2019-01-15 2019-03-06 Bicycletx Ltd Bicyclic peptide ligands specific for CD38
KR20220007098A (ko) 2019-05-09 2022-01-18 바이사이클티엑스 리미티드 Ox40에 특이적인 이환식 펩티드 리간드
TWI860386B (zh) * 2019-07-30 2024-11-01 英商拜西可泰克斯有限公司 異質雙環肽複合物
WO2021028686A1 (en) * 2019-08-13 2021-02-18 Bicycletx Limited Modified multimeric bicyclic peptide ligands
ES3033517T3 (en) * 2019-10-03 2025-08-05 Bicycletx Ltd Heterotandem bicyclic peptide complexes
GB201914872D0 (en) * 2019-10-15 2019-11-27 Bicycletx Ltd Bicyclic peptide ligand drug conjugates
IL300248A (en) 2020-08-03 2023-03-01 Bicycletx Ltd peptide-based linkers
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GB202016331D0 (en) * 2020-10-15 2020-12-02 Bicyclerd Ltd Bicyclic peptide ligand drug conjugates
KR20230141794A (ko) * 2021-01-08 2023-10-10 바이사이클티엑스 리미티드 헤테로탠덤 바이사이클릭 펩티드 복합체
US20250186539A2 (en) * 2021-01-11 2025-06-12 Bicycletx Limited Methods for treating cancer
CN118215672A (zh) * 2021-06-01 2024-06-18 南京明德新药研发有限公司 多肽偶联药物及其应用
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TWI803993B (zh) * 2021-09-28 2023-06-01 廖嘉鴻 環胜肽自組裝3d微粒裝置及其製造方法
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TWI825046B (zh) 2017-12-19 2023-12-11 英商拜西可泰克斯有限公司 Epha2特用之雙環胜肽配位基
GB201721265D0 (en) 2017-12-19 2018-01-31 Bicyclerd Ltd Bicyclic peptide ligands specific for EphA2
JP2021514953A (ja) 2018-02-23 2021-06-17 バイスクルテクス・リミテッド 多量体二環式ペプチドリガンド
JP7551500B2 (ja) * 2018-04-04 2024-09-17 バイスクルテクス・リミテッド ヘテロタンデム二環式ペプチド複合体
GB201810316D0 (en) 2018-06-22 2018-08-08 Bicyclerd Ltd Peptide ligands for binding to EphA2
IL279489B2 (en) * 2018-06-22 2025-10-01 Bicycletx Ltd Bicyclic peptide ligands specific for nectin-4, a drug conjugate containing the peptide ligands and a pharmaceutical composition containing the drug conjugate
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TWI860386B (zh) 2019-07-30 2024-11-01 英商拜西可泰克斯有限公司 異質雙環肽複合物
ES3033517T3 (en) 2019-10-03 2025-08-05 Bicycletx Ltd Heterotandem bicyclic peptide complexes
CN114760988A (zh) 2019-11-27 2022-07-15 拜斯科技术开发有限公司 对EphA2具有特异性的双环肽配体和其用途

Also Published As

Publication number Publication date
JP2024062998A (ja) 2024-05-10
JP2021520378A (ja) 2021-08-19
US20230008076A1 (en) 2023-01-12
US11453703B2 (en) 2022-09-27
CA3095582A1 (en) 2019-10-10
US20210299210A2 (en) 2021-09-30
AU2024205105A1 (en) 2024-10-10
WO2019193328A1 (en) 2019-10-10
EP3774851A1 (en) 2021-02-17
JP7551500B2 (ja) 2024-09-17
MX2020010444A (es) 2021-01-08
AU2019247795A1 (en) 2020-11-12
BR112020020349A2 (pt) 2021-01-05
SG11202009773VA (en) 2020-10-29
KR20200139236A (ko) 2020-12-11
CN112236442A (zh) 2021-01-15
US20190307836A1 (en) 2019-10-10
IL277717A (en) 2020-11-30

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