JP2024045291A5 - - Google Patents
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- Publication number
- JP2024045291A5 JP2024045291A5 JP2024008397A JP2024008397A JP2024045291A5 JP 2024045291 A5 JP2024045291 A5 JP 2024045291A5 JP 2024008397 A JP2024008397 A JP 2024008397A JP 2024008397 A JP2024008397 A JP 2024008397A JP 2024045291 A5 JP2024045291 A5 JP 2024045291A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- amino
- thiazole
- carboxamide
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762541403P | 2017-08-04 | 2017-08-04 | |
| US62/541,403 | 2017-08-04 | ||
| PCT/US2018/045183 WO2019028362A1 (en) | 2017-08-04 | 2018-08-03 | INHIBITORS OF PLASMATIC KALLIKREIN AND USES THEREOF |
| JP2020505842A JP7210540B2 (ja) | 2017-08-04 | 2018-08-03 | 血漿カリクレインの阻害剤およびその使用 |
| JP2023002547A JP7427812B2 (ja) | 2017-08-04 | 2023-01-11 | 血漿カリクレインの阻害剤およびその使用 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023002547A Division JP7427812B2 (ja) | 2017-08-04 | 2023-01-11 | 血漿カリクレインの阻害剤およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2024045291A JP2024045291A (ja) | 2024-04-02 |
| JP2024045291A5 true JP2024045291A5 (enExample) | 2024-04-24 |
| JP7785108B2 JP7785108B2 (ja) | 2025-12-12 |
Family
ID=63209746
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020505842A Active JP7210540B2 (ja) | 2017-08-04 | 2018-08-03 | 血漿カリクレインの阻害剤およびその使用 |
| JP2023002547A Active JP7427812B2 (ja) | 2017-08-04 | 2023-01-11 | 血漿カリクレインの阻害剤およびその使用 |
| JP2024008397A Active JP7785108B2 (ja) | 2017-08-04 | 2024-01-24 | 血漿カリクレインの阻害剤およびその使用 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020505842A Active JP7210540B2 (ja) | 2017-08-04 | 2018-08-03 | 血漿カリクレインの阻害剤およびその使用 |
| JP2023002547A Active JP7427812B2 (ja) | 2017-08-04 | 2023-01-11 | 血漿カリクレインの阻害剤およびその使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US11168083B2 (enExample) |
| EP (2) | EP4494698A3 (enExample) |
| JP (3) | JP7210540B2 (enExample) |
| AU (3) | AU2018311976B2 (enExample) |
| WO (1) | WO2019028362A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4494698A3 (en) | 2017-08-04 | 2025-04-23 | Takeda Pharmaceutical Company Limited | Inhibitors of plasma kallikrein and uses thereof |
| CN112135825A (zh) * | 2018-03-13 | 2020-12-25 | 夏尔人类遗传性治疗公司 | 血浆激肽释放酶抑制剂及其用途 |
| CN114728962B (zh) | 2019-09-18 | 2025-09-19 | 武田药品工业有限公司 | 血浆激肽释放酶抑制剂及其用途 |
| WO2021055589A1 (en) | 2019-09-18 | 2021-03-25 | Shire Human Genetic Therapies, Inc. | Heteroaryl plasma kallikrein inhibitors |
| AU2021209045A1 (en) | 2020-01-13 | 2022-07-28 | Takeda Pharmaceutical Company Limited | Plasma kallikrein inhibitors and uses thereof for treating pediatric hereditary angioedema attack |
| US20230312542A1 (en) * | 2020-03-31 | 2023-10-05 | Mitsubishi Tanabe Pharma Corporation | Hydroxypyrrolidine derivative and medicinal application thereof |
| WO2021198534A1 (en) | 2020-04-04 | 2021-10-07 | Oxurion NV | Plasma kallikrein inhibitors for use in the treatment of coronaviral disease |
| WO2023144030A1 (en) | 2022-01-31 | 2023-08-03 | Oxurion NV | Plasma kallikrein inhibitor therapy for anti-vegf sensitization |
| WO2023148016A1 (en) | 2022-02-04 | 2023-08-10 | Oxurion NV | Biomarker for plasma kallikrein inhibitor therapy response |
| WO2024059186A1 (en) * | 2022-09-15 | 2024-03-21 | Takeda Pharmaceutical Company Limited | N-((isoquinolin-6-yl)methyl)-1h-pyrazole-4-carboxamid derivatives as plasma kallikrein inhibitors for the treatment of hereditary angioedema |
| CN116063215A (zh) * | 2023-02-23 | 2023-05-05 | 南京安淮创新药物研究院有限公司 | 一种4-氨基-l-脯氨酸的合成方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3676677B2 (ja) | 1998-06-30 | 2005-07-27 | ファイザー・プロダクツ・インク | 炎症性疾患、自己免疫疾患および呼吸疾患の治療において有用なｖｌａ−４依存性細胞結合の非ペプチジル阻害薬 |
| US7622496B2 (en) * | 2005-12-23 | 2009-11-24 | Zealand Pharma A/S | Modified lysine-mimetic compounds |
| WO2010015090A1 (en) * | 2008-08-07 | 2010-02-11 | Aegera Therapeutics Inc. | Functionalized pyrrolidines and use thereof as iap inhibitors |
| US9079880B2 (en) * | 2010-07-07 | 2015-07-14 | Boehringer Ingelheim International Gmbh | Rho kinase inhibitors |
| US20140378474A1 (en) | 2012-01-27 | 2014-12-25 | Novartis Ag | 5-membered heteroarylcarboxamide derivatives as plasma kallikrein inhibitors |
| CN104185624B (zh) * | 2012-02-24 | 2016-10-12 | 弗·哈夫曼-拉罗切有限公司 | 抗病毒化合物 |
| GB201209138D0 (en) * | 2012-05-24 | 2012-07-04 | Ono Pharmaceutical Co | Compounds |
| JP6337750B2 (ja) * | 2013-11-22 | 2018-06-06 | 小野薬品工業株式会社 | 化合物 |
| ES2931460T3 (es) | 2015-02-27 | 2022-12-29 | Verseon Int Corporation | Compuestos de pirazol sustituido como inhibidores de serina proteasa |
| CA3290174A1 (en) * | 2015-03-30 | 2026-03-02 | Takeda Pharmaceutical Company Limited | Plasma kallikrein inhibitors and uses thereof for preventing hereditary angioedema attack |
| WO2017001936A2 (en) * | 2015-07-01 | 2017-01-05 | Lifesci Pharmaceuticals, Inc. | Therapeutic inhibitory compounds |
| FI4019022T3 (fi) | 2015-10-01 | 2024-04-19 | Biocryst Pharm Inc | Ihmisen plasman kallikreiinin estäjiä |
| EP4494698A3 (en) | 2017-08-04 | 2025-04-23 | Takeda Pharmaceutical Company Limited | Inhibitors of plasma kallikrein and uses thereof |
| CN112135825A (zh) * | 2018-03-13 | 2020-12-25 | 夏尔人类遗传性治疗公司 | 血浆激肽释放酶抑制剂及其用途 |
| CN114728962B (zh) * | 2019-09-18 | 2025-09-19 | 武田药品工业有限公司 | 血浆激肽释放酶抑制剂及其用途 |
| WO2021055589A1 (en) * | 2019-09-18 | 2021-03-25 | Shire Human Genetic Therapies, Inc. | Heteroaryl plasma kallikrein inhibitors |
| EP4136091B1 (en) * | 2020-04-17 | 2025-05-28 | Takeda Pharmaceutical Company Limited | Forms and compositions of inhibitors of plasma kallikrein |
-
2018
- 2018-08-03 EP EP24203482.5A patent/EP4494698A3/en not_active Withdrawn
- 2018-08-03 WO PCT/US2018/045183 patent/WO2019028362A1/en not_active Ceased
- 2018-08-03 JP JP2020505842A patent/JP7210540B2/ja active Active
- 2018-08-03 US US16/636,518 patent/US11168083B2/en active Active
- 2018-08-03 EP EP18755681.6A patent/EP3661922B1/en active Active
- 2018-08-03 AU AU2018311976A patent/AU2018311976B2/en active Active
-
2021
- 2021-11-04 US US17/519,013 patent/US11905285B2/en active Active
-
2023
- 2023-01-11 JP JP2023002547A patent/JP7427812B2/ja active Active
- 2023-01-12 AU AU2023200156A patent/AU2023200156B2/en active Active
- 2023-12-20 US US18/390,137 patent/US20240199602A1/en not_active Abandoned
-
2024
- 2024-01-24 JP JP2024008397A patent/JP7785108B2/ja active Active
-
2025
- 2025-06-26 AU AU2025204840A patent/AU2025204840A1/en active Pending
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