JP7210540B2 - 血漿カリクレインの阻害剤およびその使用 - Google Patents

血漿カリクレインの阻害剤およびその使用 Download PDF

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Publication number
JP7210540B2
JP7210540B2 JP2020505842A JP2020505842A JP7210540B2 JP 7210540 B2 JP7210540 B2 JP 7210540B2 JP 2020505842 A JP2020505842 A JP 2020505842A JP 2020505842 A JP2020505842 A JP 2020505842A JP 7210540 B2 JP7210540 B2 JP 7210540B2
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substituted
alkyl
unsubstituted
amino
thiazole
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Japanese (ja)
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JP2020529998A5 (enExample
JP2020529998A (ja
Inventor
トラヴィンス，ジェレミー
ミラー，トーマス
パパイオアヌー，ニコラオス
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Takeda Pharmaceutical Co Ltd
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Takeda Pharmaceutical Co Ltd
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Priority to JP2023002547A priority Critical patent/JP7427812B2/ja
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Priority to JP2024008397A priority patent/JP7785108B2/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2020505842A 2017-08-04 2018-08-03 血漿カリクレインの阻害剤およびその使用 Active JP7210540B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023002547A JP7427812B2 (ja) 2017-08-04 2023-01-11 血漿カリクレインの阻害剤およびその使用
JP2024008397A JP7785108B2 (ja) 2017-08-04 2024-01-24 血漿カリクレインの阻害剤およびその使用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762541403P 2017-08-04 2017-08-04
US62/541,403 2017-08-04
PCT/US2018/045183 WO2019028362A1 (en) 2017-08-04 2018-08-03 INHIBITORS OF PLASMATIC KALLIKREIN AND USES THEREOF

Related Child Applications (1)

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JP2023002547A Division JP7427812B2 (ja) 2017-08-04 2023-01-11 血漿カリクレインの阻害剤およびその使用

Publications (3)

Publication Number Publication Date
JP2020529998A JP2020529998A (ja) 2020-10-15
JP2020529998A5 JP2020529998A5 (enExample) 2021-08-26
JP7210540B2 true JP7210540B2 (ja) 2023-01-23

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Family Applications (2)

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JP2020505842A Active JP7210540B2 (ja) 2017-08-04 2018-08-03 血漿カリクレインの阻害剤およびその使用
JP2023002547A Active JP7427812B2 (ja) 2017-08-04 2023-01-11 血漿カリクレインの阻害剤およびその使用

Family Applications After (1)

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JP2023002547A Active JP7427812B2 (ja) 2017-08-04 2023-01-11 血漿カリクレインの阻害剤およびその使用

Country Status (6)

Country Link
US (3) US11168083B2 (enExample)
EP (2) EP3661922B1 (enExample)
JP (2) JP7210540B2 (enExample)
AU (3) AU2018311976B2 (enExample)
CA (1) CA3070717A1 (enExample)
WO (1) WO2019028362A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11168083B2 (en) 2017-08-04 2021-11-09 Takeda Pharmaceutical Company Limited Inhibitors of Plasma Kallikrein and uses thereof
WO2019178129A1 (en) * 2018-03-13 2019-09-19 Shire Human Genetic Therapies, Inc. Substituted imidazopyridines as inhibitors of plasma kallikrein and uses thereof
PT4031547T (pt) * 2019-09-18 2024-08-27 Takeda Pharmaceuticals Co Inibidores de calicreína plasmática e utilizações dos mesmos
WO2021055589A1 (en) 2019-09-18 2021-03-25 Shire Human Genetic Therapies, Inc. Heteroaryl plasma kallikrein inhibitors
CA3167336A1 (en) * 2020-01-13 2021-07-22 Takeda Pharmaceutical Company Limited Plasma kallikrein inhibitors and uses thereof for treating pediatric hereditary angioedema attack
WO2021198534A1 (en) 2020-04-04 2021-10-07 Oxurion NV Plasma kallikrein inhibitors for use in the treatment of coronaviral disease
WO2023144030A1 (en) 2022-01-31 2023-08-03 Oxurion NV Plasma kallikrein inhibitor therapy for anti-vegf sensitization
WO2023148016A1 (en) 2022-02-04 2023-08-10 Oxurion NV Biomarker for plasma kallikrein inhibitor therapy response
WO2024059186A1 (en) * 2022-09-15 2024-03-21 Takeda Pharmaceutical Company Limited N-((isoquinolin-6-yl)methyl)-1h-pyrazole-4-carboxamid derivatives as plasma kallikrein inhibitors for the treatment of hereditary angioedema
CN116063215A (zh) * 2023-02-23 2023-05-05 南京安淮创新药物研究院有限公司 一种4-氨基-l-脯氨酸的合成方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016138532A1 (en) 2015-02-27 2016-09-01 Verseon Corporation Substituted pyrazole compounds as serine protease inhibitors
WO2017059178A1 (en) 2015-10-01 2017-04-06 Biocryst Pharmaceuticals, Inc. Human plasma kallikrein inhibitors

Family Cites Families (15)

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Publication number Priority date Publication date Assignee Title
EA004792B1 (ru) 1998-06-30 2004-08-26 Пфайзер Продактс Инк. Непептидные ингибиторы vla-4-зависимого клеточного связывания, полезные в лечении воспалительных, аутоиммунных и респираторных заболеваний
CA2634743C (en) * 2005-12-23 2014-07-29 Zealand Pharma A/S Modified lysine-mimetic compounds
WO2010015090A1 (en) * 2008-08-07 2010-02-11 Aegera Therapeutics Inc. Functionalized pyrrolidines and use thereof as iap inhibitors
US9079880B2 (en) * 2010-07-07 2015-07-14 Boehringer Ingelheim International Gmbh Rho kinase inhibitors
EP2807157A1 (en) 2012-01-27 2014-12-03 Novartis AG 5-membered heteroarylcarboxamide derivatives as plasma kallikrein inhibitors
BR112014015582A8 (pt) * 2012-02-24 2017-07-04 Hoffmann La Roche compostos antivirais
GB201209138D0 (en) * 2012-05-24 2012-07-04 Ono Pharmaceutical Co Compounds
JP6337750B2 (ja) * 2013-11-22 2018-06-06 小野薬品工業株式会社 化合物
CN107614532A (zh) * 2015-03-30 2018-01-19 戴埃克斯有限公司 血浆激肽释放酶抑制剂及其预防遗传性血管性水肿发作的用途
WO2017001936A2 (en) * 2015-07-01 2017-01-05 Lifesci Pharmaceuticals, Inc. Therapeutic inhibitory compounds
US11168083B2 (en) 2017-08-04 2021-11-09 Takeda Pharmaceutical Company Limited Inhibitors of Plasma Kallikrein and uses thereof
WO2019178129A1 (en) * 2018-03-13 2019-09-19 Shire Human Genetic Therapies, Inc. Substituted imidazopyridines as inhibitors of plasma kallikrein and uses thereof
PT4031547T (pt) * 2019-09-18 2024-08-27 Takeda Pharmaceuticals Co Inibidores de calicreína plasmática e utilizações dos mesmos
WO2021055589A1 (en) * 2019-09-18 2021-03-25 Shire Human Genetic Therapies, Inc. Heteroaryl plasma kallikrein inhibitors
DK4136091T3 (da) * 2020-04-17 2025-08-18 Takeda Pharmaceuticals Co Former og sammensætninger af plasmakallikreinhæmmere

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016138532A1 (en) 2015-02-27 2016-09-01 Verseon Corporation Substituted pyrazole compounds as serine protease inhibitors
WO2017059178A1 (en) 2015-10-01 2017-04-06 Biocryst Pharmaceuticals, Inc. Human plasma kallikrein inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
GARDELLI, C. et al.，Discovery and Synthesis of HIV Integrase Inhibitors: Development of Potent and Orally Bioavailable N-Methyl Pyrimidones，Journal of Medicinal Chemistry，2007年，Vol.50, No.20，pp.4953-4975

Also Published As

Publication number Publication date
JP2023040213A (ja) 2023-03-22
AU2018311976A1 (en) 2020-02-06
CA3070717A1 (en) 2019-02-07
US20240199602A1 (en) 2024-06-20
JP2020529998A (ja) 2020-10-15
EP4494698A2 (en) 2025-01-22
EP4494698A3 (en) 2025-04-23
AU2023200156B2 (en) 2025-04-24
AU2025204840A1 (en) 2025-07-17
AU2018311976B2 (en) 2022-10-13
EP3661922A1 (en) 2020-06-10
AU2023200156A1 (en) 2023-02-09
US11905285B2 (en) 2024-02-20
JP7427812B2 (ja) 2024-02-05
US20200239463A1 (en) 2020-07-30
EP3661922B1 (en) 2024-10-23
WO2019028362A1 (en) 2019-02-07
US20220056028A1 (en) 2022-02-24
US11168083B2 (en) 2021-11-09
JP2024045291A (ja) 2024-04-02

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