|
GB8308235D0
(en)
|
1983-03-25 |
1983-05-05 |
Celltech Ltd |
Polypeptides
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US4801687A
(en)
|
1986-10-27 |
1989-01-31 |
Bioprobe International, Inc. |
Monoclonal antibody purification process using protein A
|
|
FI884924A7
(fi)
|
1987-10-28 |
1989-04-29 |
Oncogen |
Yhdistelmä-DNA-tekniikalla tuotettuja ihmisimmunoglobuliineja
|
|
US5151504A
(en)
|
1989-11-17 |
1992-09-29 |
E. R. Squibb & Sons, Inc. |
Method for purification of monoclonal antibodies
|
|
GB9022543D0
(en)
|
1990-10-17 |
1990-11-28 |
Wellcome Found |
Antibody production
|
|
NZ243558A
(en)
|
1991-07-15 |
1994-06-27 |
Wellcome Found |
Recombinant primate antibodies and their production
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
DE29706518U1
(de)
|
1997-04-11 |
1997-05-22 |
E. Missel GmbH & Co., 70374 Stuttgart |
Trägersystem für Bade-, Dusch- oder Whirlwannen
|
|
EP0979281B1
(en)
|
1997-05-02 |
2005-07-20 |
Genentech, Inc. |
A method for making multispecific antibodies having heteromultimeric and common components
|
|
US20020062010A1
(en)
|
1997-05-02 |
2002-05-23 |
Genentech, Inc. |
Method for making multispecific antibodies having heteromultimeric and common components
|
|
ES2378272T3
(es)
|
1999-04-15 |
2012-04-10 |
Crucell Holland B.V. |
Producción de proteína recombinante en una célula humana
|
|
DE29915950U1
(de)
|
1999-09-10 |
1999-12-30 |
CMW Automation GmbH, 65594 Runkel |
Vorrichtung zum Elektrolytbefüllen der Zellen eines Akkumulators
|
|
US20070111201A1
(en)
|
2001-04-30 |
2007-05-17 |
Benjamin Doranz |
Reverse transfection of cell arrays for structural and functional analyses of proteins
|
|
DE60237048D1
(de)
|
2001-07-04 |
2010-08-26 |
Chromagenics Bv |
DNS-Sequenzen mit Anti-Repressor-Aktivität
|
|
US7332580B2
(en)
|
2002-04-05 |
2008-02-19 |
The Regents Of The University Of California |
Bispecific single chain Fv antibody molecules and methods of use thereof
|
|
WO2003107218A1
(ja)
|
2002-05-31 |
2003-12-24 |
セレスター・レキシコ・サイエンシズ株式会社 |
相互作用予測装置
|
|
NZ537277A
(en)
|
2002-07-18 |
2008-04-30 |
Crucell Holland Bv |
Recombinant production of mixtures of antibodies
|
|
EA013225B1
(ru)
|
2003-01-07 |
2010-04-30 |
Симфоген А/С |
Способ получения линии клеток, продуцирующей рекомбинантный поликлональный белок, способ получения поликлонального белка, линия клеток, продуцирующая рекомбинантный поликлональный белок, библиотека векторов, популяция клеток
|
|
NZ543635A
(en)
|
2003-06-25 |
2008-05-30 |
Crucell Holland Bv |
Human C-type lectin: a suitable target molecule for binding molecules, particularly immunoconjugates, in the diagnosis, prevention and/or treatment of myeloid neoplastic diseases such as AML and CML
|
|
AU2005249396B2
(en)
|
2004-05-05 |
2011-10-20 |
Merrimack Pharmaceuticals, Inc. |
Bispecific binding agents for modulating biological activity
|
|
SG188175A1
(en)
|
2004-06-03 |
2013-03-28 |
Novimmune Sa |
Anti-cd3 antibodies and methods of use thereof
|
|
WO2006028936A2
(en)
|
2004-09-02 |
2006-03-16 |
Genentech, Inc. |
Heteromultimeric molecules
|
|
JO3000B1
(ar)
|
2004-10-20 |
2016-09-05 |
Genentech Inc |
مركبات أجسام مضادة .
|
|
CN101163501A
(zh)
|
2005-02-23 |
2008-04-16 |
梅里麦克制药股份有限公司 |
调节生物活性的双特异性结合剂
|
|
US20060212956A1
(en)
|
2005-03-14 |
2006-09-21 |
Genentech, Inc. |
Animal model of ligand activated HER2 expressing tumors
|
|
KR101374454B1
(ko)
|
2005-03-31 |
2014-03-17 |
추가이 세이야쿠 가부시키가이샤 |
회합제어에 의한 폴리펩티드 제조방법
|
|
DK1999154T3
(da)
|
2006-03-24 |
2012-12-03 |
Merck Patent Gmbh |
Fremstillede heterodimere proteindomæner
|
|
WO2007147901A1
(en)
|
2006-06-22 |
2007-12-27 |
Novo Nordisk A/S |
Production of bispecific antibodies
|
|
EP2471816A1
(en)
|
2006-08-30 |
2012-07-04 |
Genentech, Inc. |
Multispecific antibodies
|
|
US8290739B2
(en)
|
2006-10-20 |
2012-10-16 |
Amfit, Inc. |
Method for determining relative mobility of regions of an object
|
|
AU2007353412A1
(en)
|
2006-11-21 |
2008-11-20 |
Fox Chase Cancer Center |
Anti-EGFR family antibodies, bispecific anti-EGFR family antibodies and methods of use thereof
|
|
NZ579644A
(en)
|
2007-02-16 |
2012-05-25 |
Merrimack Pharmaceuticals Inc |
Antibodies against erbb3 and uses thereof
|
|
EP2626372B1
(en)
|
2007-03-29 |
2018-03-21 |
Genmab A/S |
Bispecific antibodies and methods for production thereof
|
|
PL2155788T3
(pl)
|
2007-04-03 |
2013-02-28 |
Amgen Res Munich Gmbh |
Swoiste międzygatunkowe bispecyficzne czynniki wiążące
|
|
US7705103B2
(en)
|
2007-06-22 |
2010-04-27 |
3M Innovative Properties Company |
Polydiorganosiloxane polyoxamide copolymers
|
|
ES2694018T3
(es)
|
2007-07-02 |
2018-12-17 |
Oncomed Pharmaceuticals, Inc. |
Composiciones y métodos para el tratamiento y el diagnóstico del cáncer
|
|
US8536310B2
(en)
|
2007-10-17 |
2013-09-17 |
Arca Biopharma, Inc. |
Antibodies to CLL-1
|
|
WO2009086197A1
(en)
|
2007-12-20 |
2009-07-09 |
Monogram Biosciences, Inc. |
Her-2 diagnostic methods
|
|
US20090162359A1
(en)
|
2007-12-21 |
2009-06-25 |
Christian Klein |
Bivalent, bispecific antibodies
|
|
US9266967B2
(en)
|
2007-12-21 |
2016-02-23 |
Hoffmann-La Roche, Inc. |
Bivalent, bispecific antibodies
|
|
US8242247B2
(en)
|
2007-12-21 |
2012-08-14 |
Hoffmann-La Roche Inc. |
Bivalent, bispecific antibodies
|
|
EP3663318A1
(en)
|
2008-01-07 |
2020-06-10 |
Amgen Inc. |
Method for making antibody fc-heterodimeric molecules using electrostatic steering effects
|
|
CA2715043C
(en)
|
2008-02-05 |
2021-02-16 |
Zymeworks Inc. |
Methods for determining correlated residues in a protein or other biopolymer using molecular dynamics
|
|
EP3456191A1
(en)
|
2008-06-27 |
2019-03-20 |
Merus N.V. |
Antibody producing non-human mammals
|
|
MX2011001927A
(es)
|
2008-08-29 |
2011-04-21 |
Symphogen As |
Composiciones de anticuerpo recombinante anti-receptor de factor de crecimiento epidermico.
|
|
CN102282168A
(zh)
|
2008-11-18 |
2011-12-14 |
梅里麦克制药股份有限公司 |
人血清白蛋白接头以及其结合物
|
|
US8545839B2
(en)
|
2008-12-02 |
2013-10-01 |
Pierre Fabre Medicament |
Anti-c-Met antibody
|
|
BRPI1007321A2
(en)
|
2009-01-15 |
2018-07-10 |
Laboratory Corporation Of America Holdings |
methods for measuring and / or quantifying the presence and / or amount of her-3 or her-3 in a complex in a patient sample, and to determine if an individual with cancer is likely to respond to treatment with a targeted therapy. and antibody.
|
|
CN104262483A
(zh)
|
2009-01-26 |
2015-01-07 |
根马布股份公司 |
用于生成抗体混合物的方法
|
|
KR20150036824A
(ko)
|
2009-03-20 |
2015-04-07 |
제넨테크, 인크. |
이중특이적 항-her 항체
|
|
US9067986B2
(en)
|
2009-04-27 |
2015-06-30 |
Oncomed Pharmaceuticals, Inc. |
Method for making heteromultimeric molecules
|
|
TWI507525B
(zh)
|
2009-06-26 |
2015-11-11 |
Regeneron Pharma |
具天然免疫球蛋白形式之易分離的雙專一性抗體
|
|
US9345661B2
(en)
|
2009-07-31 |
2016-05-24 |
Genentech, Inc. |
Subcutaneous anti-HER2 antibody formulations and uses thereof
|
|
AU2010284018C1
(en)
|
2009-08-21 |
2015-10-15 |
Merrimack Pharmaceuticals, Inc. |
Antibodies against the ectodomain of ErbB3 and uses thereof
|
|
US9493578B2
(en)
|
2009-09-02 |
2016-11-15 |
Xencor, Inc. |
Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
|
|
EP2496598B1
(en)
|
2009-11-04 |
2017-08-02 |
Affibody AB |
Her3 binding polypeptides
|
|
US20130185821A1
(en)
|
2010-02-08 |
2013-07-18 |
Regeneron Pharmaceuticals, Inc. |
Common Light Chain Mouse
|
|
SG183149A1
(en)
|
2010-02-08 |
2012-09-27 |
Regeneron Pharma |
Common light chain mouse
|
|
WO2011143545A1
(en)
|
2010-05-14 |
2011-11-17 |
Rinat Neuroscience Corporation |
Heterodimeric proteins and methods for producing and purifying them
|
|
WO2012023053A2
(en)
|
2010-08-16 |
2012-02-23 |
Novimmune S.A. |
Methods for the generation of multispecific and multivalent antibodies
|
|
ME02637B
(me)
|
2010-08-20 |
2017-06-20 |
Novartis Ag |
Antitela za receptor 3 faktora rasta epiderma (her3)
|
|
TW201302793A
(zh)
|
2010-09-03 |
2013-01-16 |
Glaxo Group Ltd |
新穎之抗原結合蛋白
|
|
US9155802B2
(en)
|
2010-11-01 |
2015-10-13 |
Symphogen A/S |
Pan-HER antibody composition
|
|
CN103429620B
(zh)
|
2010-11-05 |
2018-03-06 |
酵活有限公司 |
在Fc结构域中具有突变的稳定异源二聚的抗体设计
|
|
CA2828099A1
(en)
|
2011-02-24 |
2012-08-30 |
Merrimack Pharmaceuticals, Inc. |
Combination therapies comprising anti-erbb3 agents
|
|
US20140134170A1
(en)
|
2011-03-11 |
2014-05-15 |
Merrimack Pharmaceuticals, Inc. |
Use of inhibitors of egfr-family receptors in the treatment of hormone refractory breast cancers
|
|
EP2815765A1
(en)
|
2011-03-15 |
2014-12-24 |
Merrimack Pharmaceuticals, Inc. |
Overcoming resistance to ERBB pathway inhibitors
|
|
JP2014511836A
(ja)
|
2011-03-25 |
2014-05-19 |
グレンマーク ファーマシューティカルズ, エセ.アー. |
ヘテロ二量体免疫グロブリン
|
|
GB201106395D0
(en)
|
2011-04-14 |
2011-06-01 |
Hubrecht Inst |
Compounds
|
|
NO2707391T3
(enExample)
|
2011-05-13 |
2018-04-07 |
|
|
|
WO2012176779A1
(ja)
|
2011-06-20 |
2012-12-27 |
協和発酵キリン株式会社 |
抗erbB3抗体
|
|
WO2013012747A1
(en)
|
2011-07-15 |
2013-01-24 |
Oncomed Pharmaceuticals, Inc. |
Rspo binding agents and uses thereof
|
|
US9567827B2
(en)
|
2013-07-15 |
2017-02-14 |
Downhole Technology, Llc |
Downhole tool and method of use
|
|
CA2791109C
(en)
|
2011-09-26 |
2021-02-16 |
Merus B.V. |
Generation of binding molecules
|
|
WO2013048883A2
(en)
|
2011-09-30 |
2013-04-04 |
Regeneron Pharmaceuticals, Inc. |
Anti-erbb3 antibodies and uses thereof
|
|
CN108424456B
(zh)
|
2011-11-23 |
2022-04-26 |
医学免疫有限责任公司 |
特异于her3的结合分子及其用途
|
|
EP2788381A2
(en)
|
2011-12-05 |
2014-10-15 |
Novartis AG |
Antibodies for epidermal growth factor receptor 3 (her3) directed to domain iii and domain iv of her3
|
|
CN108341873B
(zh)
|
2011-12-05 |
2022-03-25 |
诺华股份有限公司 |
表皮生长因子受体3(her3)的抗体
|
|
CN102448183A
(zh)
|
2012-01-18 |
2012-05-09 |
大唐移动通信设备有限公司 |
一种Uu接口重配置方法及设备
|
|
EP2823270B1
(en)
|
2012-03-09 |
2022-05-04 |
Promega Corporation |
pH SENSORS
|
|
WO2013148315A1
(en)
|
2012-03-27 |
2013-10-03 |
Genentech, Inc. |
Diagnosis and treatments relating to her3 inhibitors
|
|
AR090549A1
(es)
|
2012-03-30 |
2014-11-19 |
Genentech Inc |
Anticuerpos anti-lgr5 e inmunoconjugados
|
|
WO2013157953A1
(en)
|
2012-04-20 |
2013-10-24 |
Merus B.V. |
Methods and means for the production of ig-like molecules
|
|
TWI641619B
(zh)
|
2012-06-25 |
2018-11-21 |
美商再生元醫藥公司 |
抗-egfr抗體及其用途
|
|
BR112015006824A2
(pt)
|
2012-09-27 |
2017-07-04 |
Merus B V |
anticorpo igg biespecífico, método para produzir um anticorpo igg biespecífico, anticorpo, composição farmacêutica e uso de um anticorpo igg biespecífico
|
|
EP2906591A1
(en)
|
2012-10-15 |
2015-08-19 |
Universität Zürich |
Bispecific her2 ligands for cancer therapy
|
|
KR102373193B1
(ko)
*
|
2012-11-21 |
2022-03-10 |
얀센 바이오테크 인코포레이티드 |
이중특이성 EGFR/c-Met 항체
|
|
CN105073195A
(zh)
|
2013-02-04 |
2015-11-18 |
昂科梅德制药有限公司 |
使用Wnt途径抑制剂进行治疗的方法及对该治疗的监测
|
|
JP2016512533A
(ja)
|
2013-03-14 |
2016-04-28 |
オンコメッド ファーマシューティカルズ インコーポレイテッド |
Met結合剤およびその使用
|
|
CA2908515A1
(en)
|
2013-04-05 |
2014-10-09 |
Laboratory Corporation Of America Holdings |
Systems and methods for facilitating diagnosis, prognosis and treatment of cancer based on detection of her3 activation
|
|
US10239951B2
(en)
|
2013-05-08 |
2019-03-26 |
Zymeworks Inc. |
Bispecific HER2 and HER3 antigen binding constructs
|
|
US11229711B2
(en)
|
2013-06-06 |
2022-01-25 |
Magenta Therapeutics, Inc. |
Linkers for antibody-drug conjugates and related compounds, compositions, and methods of use
|
|
US9879081B2
(en)
|
2013-06-25 |
2018-01-30 |
Samsung Electronics Co., Ltd. |
Protein complex, bispecific antibody including the protein complex, and method of preparation thereof
|
|
US10208354B2
(en)
|
2013-08-07 |
2019-02-19 |
Universität Zu Köln |
NRG1 fusion genes in cancer
|
|
US9551208B2
(en)
|
2013-08-26 |
2017-01-24 |
Halliburton Energy Services, Inc. |
Identifying uncertainty associated with a stimulated reservoir volume (SRV) calculation
|
|
WO2015066543A1
(en)
|
2013-11-01 |
2015-05-07 |
Board Of Regents, The University Of Texas System |
Targeting her2 and her3 with bispecific antibodies in cancerous cells
|
|
DK3805268T3
(da)
|
2014-02-28 |
2025-01-20 |
Merus Nv |
Antistof, der binder erbb-2 og erbb-3
|
|
CA2941030C
(en)
*
|
2014-02-28 |
2025-05-13 |
Merus N.V. |
ANTIBODIES THAT BIND TO EGFR AND ERBB3
|
|
AU2015229591B2
(en)
|
2014-03-11 |
2020-10-22 |
Regeneron Pharmaceuticals, Inc. |
Anti-EGFRvlll antibodies and uses thereof
|
|
CA2944649C
(en)
|
2014-04-04 |
2022-06-21 |
Bionomics, Inc. |
Humanized antibodies that bind lgr5
|
|
US10813952B2
(en)
|
2014-11-14 |
2020-10-27 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
NK cells with an increased antibody-dependent cellular toxicity (ADCC) against tumors
|
|
MA41123A
(fr)
|
2014-12-02 |
2017-10-10 |
Oncomed Pharm Inc |
Polythérapie pour le traitement du cancer
|
|
WO2017010874A1
(en)
|
2015-07-10 |
2017-01-19 |
Merus N.V. |
Human cd3 binding antibody
|
|
MY195059A
(en)
*
|
2015-09-23 |
2023-01-05 |
Regeneron Pharma |
Optimized Anti-CD3 Bispecific Antibodies and Uses Thereof
|
|
JP7296728B2
(ja)
|
2015-10-23 |
2023-06-23 |
メルス ナムローゼ フェンノートシャップ |
癌の成長を抑制する結合分子
|
|
JP7737220B2
(ja)
|
2017-03-31 |
2025-09-10 |
メルス ナムローゼ フェンノートシャップ |
NRG1融合遺伝子を有する細胞の処置における使用のためのErbB-2及びErbB3結合二重特異性抗体
|
|
RS66708B9
(sr)
*
|
2017-08-09 |
2025-08-29 |
Merus Nv |
Antitela koja se vezuju za egfr i cmet
|