JP2024019735A5 - - Google Patents
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- JP2024019735A5 JP2024019735A5 JP2024000336A JP2024000336A JP2024019735A5 JP 2024019735 A5 JP2024019735 A5 JP 2024019735A5 JP 2024000336 A JP2024000336 A JP 2024000336A JP 2024000336 A JP2024000336 A JP 2024000336A JP 2024019735 A5 JP2024019735 A5 JP 2024019735A5
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- JP
- Japan
- Prior art keywords
- compound according
- composition
- alkyl
- pharmaceutical composition
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 36
- 239000008194 pharmaceutical composition Substances 0.000 claims 16
- 125000000217 alkyl group Chemical group 0.000 claims 15
- 239000000203 mixture Substances 0.000 claims 15
- 208000014644 Brain disease Diseases 0.000 claims 8
- 208000032274 Encephalopathy Diseases 0.000 claims 8
- 230000001037 epileptic effect Effects 0.000 claims 8
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- 239000001257 hydrogen Substances 0.000 claims 7
- 230000035772 mutation Effects 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 208000019695 Migraine disease Diseases 0.000 claims 5
- 125000000753 cycloalkyl group Chemical group 0.000 claims 5
- 206010015037 epilepsy Diseases 0.000 claims 5
- 206010027599 migraine Diseases 0.000 claims 5
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 3
- 201000007547 Dravet syndrome Diseases 0.000 claims 3
- 208000036572 Myoclonic epilepsy Diseases 0.000 claims 3
- 208000002193 Pain Diseases 0.000 claims 3
- 206010061334 Partial seizures Diseases 0.000 claims 3
- 206010073677 Severe myoclonic epilepsy of infancy Diseases 0.000 claims 3
- 125000001153 fluoro group Chemical group F* 0.000 claims 3
- 125000001188 haloalkyl group Chemical group 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 206010010904 Convulsion Diseases 0.000 claims 2
- 208000024658 Epilepsy syndrome Diseases 0.000 claims 2
- 208000002877 Epileptic Syndromes Diseases 0.000 claims 2
- 101000631760 Homo sapiens Sodium channel protein type 1 subunit alpha Proteins 0.000 claims 2
- 101000684820 Homo sapiens Sodium channel protein type 3 subunit alpha Proteins 0.000 claims 2
- 208000000060 Migraine with aura Diseases 0.000 claims 2
- 102100028910 Sodium channel protein type 1 subunit alpha Human genes 0.000 claims 2
- 102100023720 Sodium channel protein type 3 subunit alpha Human genes 0.000 claims 2
- 208000023944 Sudden Unexpected Death in Epilepsy Diseases 0.000 claims 2
- 206010067039 familial hemiplegic migraine Diseases 0.000 claims 2
- 201000007186 focal epilepsy Diseases 0.000 claims 2
- 230000002068 genetic effect Effects 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 claims 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- 208000008882 Benign Neonatal Epilepsy Diseases 0.000 claims 1
- 208000020749 Benign familial neonatal-infantile seizures Diseases 0.000 claims 1
- 206010008025 Cerebellar ataxia Diseases 0.000 claims 1
- 208000006561 Cluster Headache Diseases 0.000 claims 1
- 201000008009 Early infantile epileptic encephalopathy Diseases 0.000 claims 1
- 208000010541 Familial or sporadic hemiplegic migraine Diseases 0.000 claims 1
- 208000003078 Generalized Epilepsy Diseases 0.000 claims 1
- 208000027109 Headache disease Diseases 0.000 claims 1
- 206010019233 Headaches Diseases 0.000 claims 1
- 206010019476 Hemiplegic migraine Diseases 0.000 claims 1
- 101000944018 Homo sapiens Potassium channel subfamily T member 1 Proteins 0.000 claims 1
- 101000684826 Homo sapiens Sodium channel protein type 2 subunit alpha Proteins 0.000 claims 1
- 101000654381 Homo sapiens Sodium channel protein type 8 subunit alpha Proteins 0.000 claims 1
- 206010021750 Infantile Spasms Diseases 0.000 claims 1
- 208000035899 Infantile spasms syndrome Diseases 0.000 claims 1
- 102000005453 KCNQ2 Potassium Channel Human genes 0.000 claims 1
- 108010006746 KCNQ2 Potassium Channel Proteins 0.000 claims 1
- 201000006792 Lennox-Gastaut syndrome Diseases 0.000 claims 1
- 208000012902 Nervous system disease Diseases 0.000 claims 1
- 208000037158 Partial Epilepsies Diseases 0.000 claims 1
- 102100033508 Potassium channel subfamily T member 1 Human genes 0.000 claims 1
- 206010071141 Rasmussen encephalitis Diseases 0.000 claims 1
- 208000004160 Rasmussen subacute encephalitis Diseases 0.000 claims 1
- 108010052164 Sodium Channels Proteins 0.000 claims 1
- 102000018674 Sodium Channels Human genes 0.000 claims 1
- 102100023150 Sodium channel protein type 2 subunit alpha Human genes 0.000 claims 1
- 102100031371 Sodium channel protein type 8 subunit alpha Human genes 0.000 claims 1
- 201000006791 West syndrome Diseases 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 208000008233 autosomal dominant nocturnal frontal lobe epilepsy Diseases 0.000 claims 1
- 208000032212 benign familial infantile 3 seizures Diseases 0.000 claims 1
- 208000017888 childhood-onset epilepsy syndrome Diseases 0.000 claims 1
- 208000018912 cluster headache syndrome Diseases 0.000 claims 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 208000013257 developmental and epileptic encephalopathy Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000004064 dysfunction Effects 0.000 claims 1
- 206010014599 encephalitis Diseases 0.000 claims 1
- 201000002933 epilepsy with generalized tonic-clonic seizures Diseases 0.000 claims 1
- 231100000869 headache Toxicity 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 201000001993 idiopathic generalized epilepsy Diseases 0.000 claims 1
- 230000003211 malignant effect Effects 0.000 claims 1
- 230000001617 migratory effect Effects 0.000 claims 1
- 125000002950 monocyclic group Chemical group 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 230000000926 neurological effect Effects 0.000 claims 1
- 208000021722 neuropathic pain Diseases 0.000 claims 1
- 208000020016 psychiatric disease Diseases 0.000 claims 1
- 206010044652 trigeminal neuralgia Diseases 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862738508P | 2018-09-28 | 2018-09-28 | |
| US62/738,508 | 2018-09-28 | ||
| PCT/US2019/053467 WO2020069322A1 (en) | 2018-09-28 | 2019-09-27 | Ion channel modulators |
| JP2021517348A JP7576539B2 (ja) | 2018-09-28 | 2019-09-27 | イオンチャネルモジュレーター |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021517348A Division JP7576539B2 (ja) | 2018-09-28 | 2019-09-27 | イオンチャネルモジュレーター |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024019735A JP2024019735A (ja) | 2024-02-09 |
| JP2024019735A5 true JP2024019735A5 (https=) | 2024-09-06 |
Family
ID=69949703
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021517348A Active JP7576539B2 (ja) | 2018-09-28 | 2019-09-27 | イオンチャネルモジュレーター |
| JP2024000336A Pending JP2024019735A (ja) | 2018-09-28 | 2024-01-04 | イオンチャネルモジュレーター |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021517348A Active JP7576539B2 (ja) | 2018-09-28 | 2019-09-27 | イオンチャネルモジュレーター |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US12479844B2 (https=) |
| EP (1) | EP3856193A4 (https=) |
| JP (2) | JP7576539B2 (https=) |
| KR (1) | KR102842377B1 (https=) |
| CN (1) | CN113573713A (https=) |
| AU (2) | AU2019346635A1 (https=) |
| BR (1) | BR112021005913A2 (https=) |
| CA (1) | CA3142470A1 (https=) |
| EA (2) | EA202092908A1 (https=) |
| IL (1) | IL281946A (https=) |
| MX (1) | MX2021003634A (https=) |
| WO (1) | WO2020069322A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3548033T3 (da) | 2016-11-28 | 2024-07-15 | Praxis Prec Medicines Inc | Forbindelser og deres fremgangsmåde til anvendelse |
| US11261188B2 (en) | 2016-11-28 | 2022-03-01 | Praxis Precision Medicines, Inc. | Fused heteroaryl compounds, and methods thereof for treating diseases, disorders, and conditions relating to aberrant function of a sodium channel |
| US11492345B2 (en) | 2017-02-13 | 2022-11-08 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| WO2018187480A1 (en) | 2017-04-04 | 2018-10-11 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| WO2019035951A1 (en) | 2017-08-15 | 2019-02-21 | Praxis Precision Medicines, Inc. | COMPOUNDS AND THEIR METHODS OF USE |
| WO2019232209A1 (en) | 2018-05-30 | 2019-12-05 | Praxis Precision Medicines, Inc. | Ion channel modulators |
| EA202092908A1 (ru) | 2018-09-28 | 2021-05-14 | Праксис Пресижн Медсинз, Инк. | Модуляторы ионных каналов |
| US11773099B2 (en) | 2019-05-28 | 2023-10-03 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| US11279700B2 (en) | 2019-05-31 | 2022-03-22 | Praxis Precision Medicines, Inc. | Ion channel modulators |
| US11505554B2 (en) | 2019-05-31 | 2022-11-22 | Praxis Precision Medicines, Inc. | Substituted pyridines as ion channel modulators |
| US11767325B2 (en) | 2019-11-26 | 2023-09-26 | Praxis Precision Medicines, Inc. | Substituted [1,2,4]triazolo[4,3-a]pyrazines as ion channel modulators |
| US12552797B2 (en) | 2019-11-27 | 2026-02-17 | Praxis Precision Medicines, Inc. | Process for making (3-[cyclopropylethoxy(difluoro)methyl]-6-6[5-fluoro-6-(2,2,2-trifluoroethoxy-3-pyridyl]- [1,2,4]triazolo[4,3-a]pyrazine |
| US20250145637A1 (en) | 2021-08-10 | 2025-05-08 | Jiangsu Hengrui Pharmaceuticals Co. Ltd. | Sulfonamide derivative, preparation method therefor and medical use thereof |
| MX2024013240A (es) | 2022-04-26 | 2024-12-06 | Praxis Prec Medicines Inc | Tratamiento de trastornos neurologicos |
| WO2024033374A1 (en) | 2022-08-11 | 2024-02-15 | Syngenta Crop Protection Ag | Novel arylcarboxamide or arylthioamide compounds |
| KR20250173086A (ko) | 2024-05-31 | 2025-12-10 | 더웨이브컨설팅 주식회사 | 이온 채널 조절 활성을 갖는 반도비탈거미 유래 펩타이드 및 이의 용도 |
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| US11261188B2 (en) | 2016-11-28 | 2022-03-01 | Praxis Precision Medicines, Inc. | Fused heteroaryl compounds, and methods thereof for treating diseases, disorders, and conditions relating to aberrant function of a sodium channel |
| DK3548033T3 (da) | 2016-11-28 | 2024-07-15 | Praxis Prec Medicines Inc | Forbindelser og deres fremgangsmåde til anvendelse |
| US20210188839A1 (en) | 2016-11-28 | 2021-06-24 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| US11492345B2 (en) | 2017-02-13 | 2022-11-08 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| WO2018187480A1 (en) | 2017-04-04 | 2018-10-11 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| WO2019035951A1 (en) | 2017-08-15 | 2019-02-21 | Praxis Precision Medicines, Inc. | COMPOUNDS AND THEIR METHODS OF USE |
| EA201991306A1 (ru) | 2017-08-30 | 2020-03-20 | Праксис Пресижн Медсинз, Инк. | Соединения и способы их применения |
| WO2019232209A1 (en) | 2018-05-30 | 2019-12-05 | Praxis Precision Medicines, Inc. | Ion channel modulators |
| EA202092908A1 (ru) | 2018-09-28 | 2021-05-14 | Праксис Пресижн Медсинз, Инк. | Модуляторы ионных каналов |
| US11773099B2 (en) | 2019-05-28 | 2023-10-03 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| US11505554B2 (en) | 2019-05-31 | 2022-11-22 | Praxis Precision Medicines, Inc. | Substituted pyridines as ion channel modulators |
| US11279700B2 (en) | 2019-05-31 | 2022-03-22 | Praxis Precision Medicines, Inc. | Ion channel modulators |
| US11767325B2 (en) | 2019-11-26 | 2023-09-26 | Praxis Precision Medicines, Inc. | Substituted [1,2,4]triazolo[4,3-a]pyrazines as ion channel modulators |
| EP4065124A4 (en) | 2019-11-26 | 2023-12-06 | Praxis Precision Medicines, Inc. | ION CHANNEL MODULATORS |
| US12552797B2 (en) | 2019-11-27 | 2026-02-17 | Praxis Precision Medicines, Inc. | Process for making (3-[cyclopropylethoxy(difluoro)methyl]-6-6[5-fluoro-6-(2,2,2-trifluoroethoxy-3-pyridyl]- [1,2,4]triazolo[4,3-a]pyrazine |
-
2019
- 2019-05-30 EA EA202092908A patent/EA202092908A1/ru unknown
- 2019-09-27 EA EA202190879A patent/EA202190879A1/ru unknown
- 2019-09-27 US US17/280,485 patent/US12479844B2/en active Active
- 2019-09-27 JP JP2021517348A patent/JP7576539B2/ja active Active
- 2019-09-27 CA CA3142470A patent/CA3142470A1/en active Pending
- 2019-09-27 EP EP19865432.9A patent/EP3856193A4/en active Pending
- 2019-09-27 WO PCT/US2019/053467 patent/WO2020069322A1/en not_active Ceased
- 2019-09-27 CN CN201980078653.2A patent/CN113573713A/zh active Pending
- 2019-09-27 MX MX2021003634A patent/MX2021003634A/es unknown
- 2019-09-27 AU AU2019346635A patent/AU2019346635A1/en not_active Abandoned
- 2019-09-27 BR BR112021005913-0A patent/BR112021005913A2/pt unknown
- 2019-09-27 KR KR1020217012574A patent/KR102842377B1/ko active Active
-
2021
- 2021-03-31 IL IL281946A patent/IL281946A/en unknown
-
2024
- 2024-01-04 JP JP2024000336A patent/JP2024019735A/ja active Pending
-
2025
- 2025-05-29 AU AU2025204027A patent/AU2025204027A1/en active Pending
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