KR102842377B1 - 이온 채널 조절인자 - Google Patents

이온 채널 조절인자

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Publication number
KR102842377B1
KR102842377B1 KR1020217012574A KR20217012574A KR102842377B1 KR 102842377 B1 KR102842377 B1 KR 102842377B1 KR 1020217012574 A KR1020217012574 A KR 1020217012574A KR 20217012574 A KR20217012574 A KR 20217012574A KR 102842377 B1 KR102842377 B1 KR 102842377B1
Authority
KR
South Korea
Prior art keywords
mmol
methyl
mixture
phenyl
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020217012574A
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English (en)
Korean (ko)
Other versions
KR20210113974A (ko
Inventor
키란 레디
가브리엘 마르티네즈 보텔라
앤드류 마크 그리핀
브리안 에드워드 마론
Original Assignee
프락시스 프리시젼 메디신즈, 인크.
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Publication of KR20210113974A publication Critical patent/KR20210113974A/ko
Application granted granted Critical
Publication of KR102842377B1 publication Critical patent/KR102842377B1/ko
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR1020217012574A 2018-09-28 2019-09-27 이온 채널 조절인자 Active KR102842377B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862738508P 2018-09-28 2018-09-28
US62/738,508 2018-09-28
PCT/US2019/053467 WO2020069322A1 (en) 2018-09-28 2019-09-27 Ion channel modulators

Publications (2)

Publication Number Publication Date
KR20210113974A KR20210113974A (ko) 2021-09-17
KR102842377B1 true KR102842377B1 (ko) 2025-08-06

Family

ID=69949703

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020217012574A Active KR102842377B1 (ko) 2018-09-28 2019-09-27 이온 채널 조절인자

Country Status (12)

Country Link
US (1) US12479844B2 (https=)
EP (1) EP3856193A4 (https=)
JP (2) JP7576539B2 (https=)
KR (1) KR102842377B1 (https=)
CN (1) CN113573713A (https=)
AU (2) AU2019346635A1 (https=)
BR (1) BR112021005913A2 (https=)
CA (1) CA3142470A1 (https=)
EA (2) EA202092908A1 (https=)
IL (1) IL281946A (https=)
MX (1) MX2021003634A (https=)
WO (1) WO2020069322A1 (https=)

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US11492345B2 (en) 2017-02-13 2022-11-08 Praxis Precision Medicines, Inc. Compounds and their methods of use
WO2018187480A1 (en) 2017-04-04 2018-10-11 Praxis Precision Medicines, Inc. Compounds and their methods of use
WO2019035951A1 (en) 2017-08-15 2019-02-21 Praxis Precision Medicines, Inc. COMPOUNDS AND THEIR METHODS OF USE
WO2019232209A1 (en) 2018-05-30 2019-12-05 Praxis Precision Medicines, Inc. Ion channel modulators
EA202092908A1 (ru) 2018-09-28 2021-05-14 Праксис Пресижн Медсинз, Инк. Модуляторы ионных каналов
US11773099B2 (en) 2019-05-28 2023-10-03 Praxis Precision Medicines, Inc. Compounds and their methods of use
US11279700B2 (en) 2019-05-31 2022-03-22 Praxis Precision Medicines, Inc. Ion channel modulators
US11505554B2 (en) 2019-05-31 2022-11-22 Praxis Precision Medicines, Inc. Substituted pyridines as ion channel modulators
US11767325B2 (en) 2019-11-26 2023-09-26 Praxis Precision Medicines, Inc. Substituted [1,2,4]triazolo[4,3-a]pyrazines as ion channel modulators
US12552797B2 (en) 2019-11-27 2026-02-17 Praxis Precision Medicines, Inc. Process for making (3-[cyclopropylethoxy(difluoro)methyl]-6-6[5-fluoro-6-(2,2,2-trifluoroethoxy-3-pyridyl]- [1,2,4]triazolo[4,3-a]pyrazine
US20250145637A1 (en) 2021-08-10 2025-05-08 Jiangsu Hengrui Pharmaceuticals Co. Ltd. Sulfonamide derivative, preparation method therefor and medical use thereof
MX2024013240A (es) 2022-04-26 2024-12-06 Praxis Prec Medicines Inc Tratamiento de trastornos neurologicos
WO2024033374A1 (en) 2022-08-11 2024-02-15 Syngenta Crop Protection Ag Novel arylcarboxamide or arylthioamide compounds
KR20250173086A (ko) 2024-05-31 2025-12-10 더웨이브컨설팅 주식회사 이온 채널 조절 활성을 갖는 반도비탈거미 유래 펩타이드 및 이의 용도

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Also Published As

Publication number Publication date
US12479844B2 (en) 2025-11-25
AU2025204027A9 (en) 2026-03-19
CN113573713A (zh) 2021-10-29
EP3856193A4 (en) 2022-08-31
EA202092908A1 (ru) 2021-05-14
EP3856193A1 (en) 2021-08-04
JP7576539B2 (ja) 2024-10-31
IL281946A (en) 2021-05-31
KR20210113974A (ko) 2021-09-17
CA3142470A1 (en) 2020-04-02
BR112021005913A2 (pt) 2021-06-29
EA202190879A1 (ru) 2021-08-16
MX2021003634A (es) 2021-07-16
JP2024019735A (ja) 2024-02-09
US20210403476A1 (en) 2021-12-30
AU2019346635A1 (en) 2021-05-20
JP2022502442A (ja) 2022-01-11
AU2025204027A1 (en) 2025-06-19
WO2020069322A1 (en) 2020-04-02

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