AU2019346635A1 - Ion channel modulators - Google Patents

Ion channel modulators Download PDF

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Publication number
AU2019346635A1
AU2019346635A1 AU2019346635A AU2019346635A AU2019346635A1 AU 2019346635 A1 AU2019346635 A1 AU 2019346635A1 AU 2019346635 A AU2019346635 A AU 2019346635A AU 2019346635 A AU2019346635 A AU 2019346635A AU 2019346635 A1 AU2019346635 A1 AU 2019346635A1
Authority
AU
Australia
Prior art keywords
mmol
compound
4alkyl
methyl
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2019346635A
Other languages
English (en)
Inventor
Andrew Mark Griffin
Brian Edward Marron
Gabriel Martinez Botella
Kiran Reddy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Praxis Precision Medicines Inc
Original Assignee
Praxis Precision Medicines Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Praxis Precision Medicines Inc filed Critical Praxis Precision Medicines Inc
Publication of AU2019346635A1 publication Critical patent/AU2019346635A1/en
Priority to AU2025204027A priority Critical patent/AU2025204027A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AU2019346635A 2018-09-28 2019-09-27 Ion channel modulators Abandoned AU2019346635A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2025204027A AU2025204027A1 (en) 2018-09-28 2025-05-29 Ion channel modulators

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862738508P 2018-09-28 2018-09-28
US62/738,508 2018-09-28
PCT/US2019/053467 WO2020069322A1 (en) 2018-09-28 2019-09-27 Ion channel modulators

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2025204027A Division AU2025204027A1 (en) 2018-09-28 2025-05-29 Ion channel modulators

Publications (1)

Publication Number Publication Date
AU2019346635A1 true AU2019346635A1 (en) 2021-05-20

Family

ID=69949703

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2019346635A Abandoned AU2019346635A1 (en) 2018-09-28 2019-09-27 Ion channel modulators
AU2025204027A Pending AU2025204027A1 (en) 2018-09-28 2025-05-29 Ion channel modulators

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2025204027A Pending AU2025204027A1 (en) 2018-09-28 2025-05-29 Ion channel modulators

Country Status (12)

Country Link
US (1) US12479844B2 (https=)
EP (1) EP3856193A4 (https=)
JP (2) JP7576539B2 (https=)
KR (1) KR102842377B1 (https=)
CN (1) CN113573713A (https=)
AU (2) AU2019346635A1 (https=)
BR (1) BR112021005913A2 (https=)
CA (1) CA3142470A1 (https=)
EA (2) EA202092908A1 (https=)
IL (1) IL281946A (https=)
MX (1) MX2021003634A (https=)
WO (1) WO2020069322A1 (https=)

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US11773099B2 (en) 2019-05-28 2023-10-03 Praxis Precision Medicines, Inc. Compounds and their methods of use
US11279700B2 (en) 2019-05-31 2022-03-22 Praxis Precision Medicines, Inc. Ion channel modulators
US11505554B2 (en) 2019-05-31 2022-11-22 Praxis Precision Medicines, Inc. Substituted pyridines as ion channel modulators
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Also Published As

Publication number Publication date
US12479844B2 (en) 2025-11-25
AU2025204027A9 (en) 2026-03-19
CN113573713A (zh) 2021-10-29
EP3856193A4 (en) 2022-08-31
KR102842377B1 (ko) 2025-08-06
EA202092908A1 (ru) 2021-05-14
EP3856193A1 (en) 2021-08-04
JP7576539B2 (ja) 2024-10-31
IL281946A (en) 2021-05-31
KR20210113974A (ko) 2021-09-17
CA3142470A1 (en) 2020-04-02
BR112021005913A2 (pt) 2021-06-29
EA202190879A1 (ru) 2021-08-16
MX2021003634A (es) 2021-07-16
JP2024019735A (ja) 2024-02-09
US20210403476A1 (en) 2021-12-30
JP2022502442A (ja) 2022-01-11
AU2025204027A1 (en) 2025-06-19
WO2020069322A1 (en) 2020-04-02

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