|
DE4038932A1
(de)
|
1990-12-06 |
1992-06-11 |
Roehm Gmbh |
Diuretische und antikaliuretisch wirksame pteridinderivate
|
|
US6060477A
(en)
|
1995-06-07 |
2000-05-09 |
Cell Pathways, Inc. |
Method of treating a patient having precancerous lesions with phenyl cycloamino pyrimidinone derivatives
|
|
BR9808281A
(pt)
|
1997-03-19 |
2000-05-16 |
Basf Ag |
Compostos, composições farmacêuticas, processo para tratar doenças proliferativas e/ou distúrbios do sistema imune e para preparar um composto, e, uso de um composto
|
|
CZ2001959A3
(cs)
|
1998-09-18 |
2001-12-12 |
Basf Aktiengesellschaft |
4-Aminopyrrolopyrimidiny jako inhibitory kinasy
|
|
US6713474B2
(en)
|
1998-09-18 |
2004-03-30 |
Abbott Gmbh & Co. Kg |
Pyrrolopyrimidines as therapeutic agents
|
|
US7276506B2
(en)
|
1998-12-28 |
2007-10-02 |
4 Aza Bioscience Nv |
Immunosuppressive effects of pteridine derivatives
|
|
US6921763B2
(en)
|
1999-09-17 |
2005-07-26 |
Abbott Laboratories |
Pyrazolopyrimidines as therapeutic agents
|
|
US7071199B1
(en)
|
1999-09-17 |
2006-07-04 |
Abbott Gmbh & Cco. Kg |
Kinase inhibitors as therapeutic agents
|
|
KR20020088406A
(ko)
|
1999-09-17 |
2002-11-27 |
애보트 게엠베하 운트 콤파니 카게 |
치료제로서의 피라졸로피리미딘
|
|
AU2000240570A1
(en)
|
2000-03-29 |
2001-10-08 |
Knoll Gesellschaft Mit Beschraenkter Haftung |
Pyrrolopyrimidines as tyrosine kinase inhibitors
|
|
US20030225098A1
(en)
|
2002-03-21 |
2003-12-04 |
Hirst Gavin C. |
Kinase inhibitors
|
|
US20030199525A1
(en)
|
2002-03-21 |
2003-10-23 |
Hirst Gavin C. |
Kinase inhibitors
|
|
US7144911B2
(en)
|
2002-12-31 |
2006-12-05 |
Deciphera Pharmaceuticals Llc |
Anti-inflammatory medicaments
|
|
US7279576B2
(en)
|
2002-12-31 |
2007-10-09 |
Deciphera Pharmaceuticals, Llc |
Anti-cancer medicaments
|
|
US7202257B2
(en)
|
2003-12-24 |
2007-04-10 |
Deciphera Pharmaceuticals, Llc |
Anti-inflammatory medicaments
|
|
WO2004100868A2
(en)
|
2003-04-23 |
2004-11-25 |
Abbott Laboratories |
Method of treating transplant rejection
|
|
US7592352B2
(en)
|
2003-05-06 |
2009-09-22 |
Smithkline Beecham Corporation |
Substituted thieno and furo-pyridines
|
|
US7202363B2
(en)
|
2003-07-24 |
2007-04-10 |
Abbott Laboratories |
Thienopyridine and furopyridine kinase inhibitors
|
|
US20050026944A1
(en)
|
2003-07-24 |
2005-02-03 |
Patrick Betschmann |
Thienopyridine and furopyridine kinase inhibitors
|
|
PL1663244T3
(pl)
|
2003-09-12 |
2008-01-31 |
4 Aza Ip Nv |
Pochodne pterydyny do leczenia chorób związanych z TNF-alfa
|
|
WO2005034869A2
(en)
|
2003-10-08 |
2005-04-21 |
Irm Llc |
Compounds and compositions as protein kinase inhibitors
|
|
JP2007513955A
(ja)
|
2003-12-09 |
2007-05-31 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
ナフチリジン誘導体およびそれらのムスカリン受容体の調節剤としての使用
|
|
CA2549641A1
(en)
|
2003-12-19 |
2005-07-21 |
Merck & Co., Inc. |
Mitotic kinesin inhibitors
|
|
WO2005074603A2
(en)
|
2004-02-03 |
2005-08-18 |
Abbott Laboratories |
Aminobenzoxazoles as therapeutic agents
|
|
WO2006002367A1
(en)
|
2004-06-23 |
2006-01-05 |
Irm Llc |
Compounds and compositions as protein kinase inhibitors
|
|
US20070054916A1
(en)
*
|
2004-10-01 |
2007-03-08 |
Amgen Inc. |
Aryl nitrogen-containing bicyclic compounds and methods of use
|
|
CA2592118C
(en)
|
2004-12-23 |
2015-11-17 |
Deciphera Pharmaceuticals, Llc |
Urea derivatives as enzyme modulators
|
|
WO2006102079A1
(en)
|
2005-03-17 |
2006-09-28 |
Novartis Ag |
N- [3- (1-amin0-5, 6, 7, 8-tetrahydro-2 , 4, 4b-triazafluoren-9-yl)-phenyl] benzamides as tyrosine/threonine kinase inhibitors, in particular b-raf kinase
|
|
US20090318456A1
(en)
|
2006-07-06 |
2009-12-24 |
Gilead Sciences, Inc. |
Substituted pteridines for the treatment and prevention of viral infections
|
|
US7897762B2
(en)
|
2006-09-14 |
2011-03-01 |
Deciphera Pharmaceuticals, Llc |
Kinase inhibitors useful for the treatment of proliferative diseases
|
|
US8188113B2
(en)
|
2006-09-14 |
2012-05-29 |
Deciphera Pharmaceuticals, Inc. |
Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
|
|
CA2663401C
(en)
|
2006-09-15 |
2011-07-12 |
Pfizer Products Inc. |
Pyrido (2, 3-d) pyrimidinone compounds and their use as pi3 inhibitors
|
|
RU2009112397A
(ru)
|
2006-10-05 |
2010-10-10 |
Си Ви ТЕРАПЬЮТИКС, ИНК (US) |
Бициклические азотсодержащие гетероциклические соединения для применения в качестве ингибиторов стеароил соа десатуразы
|
|
US7893066B2
(en)
|
2006-10-05 |
2011-02-22 |
Gilead Palo Alto, Inc. |
Pyridol[2,3-B]pyrazinones for use as stearoyl CoA desaturase inhibitors
|
|
US7790756B2
(en)
|
2006-10-11 |
2010-09-07 |
Deciphera Pharmaceuticals, Llc |
Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases
|
|
EP2076513A1
(en)
|
2006-10-20 |
2009-07-08 |
Irm Llc |
Compositions and methods for modulating c-kit and pdgfr receptors
|
|
US8143394B2
(en)
|
2006-12-26 |
2012-03-27 |
Gilead Sciences, Inc. |
Pyrido(3,2-d)pyrimidines useful for treating viral infections
|
|
US7662819B2
(en)
|
2007-04-09 |
2010-02-16 |
Gilead Palo Alto, Inc. |
Pteridinone derivatives for use as stearoyl CoA desaturase inhibitors
|
|
WO2008140895A1
(en)
|
2007-04-20 |
2008-11-20 |
Deciphera Pharmaceuticals, Llc |
Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases
|
|
JP2011511005A
(ja)
|
2008-02-04 |
2011-04-07 |
オーエスアイ・フアーマスーテイカルズ・インコーポレーテツド |
２−アミノピリジン系キナーゼ阻害薬
|
|
WO2009111028A1
(en)
|
2008-03-04 |
2009-09-11 |
Vitae Pharmaceuticals, Inc. |
Aurora kinase inhibitors
|
|
EP2276748A1
(en)
|
2008-04-10 |
2011-01-26 |
Gilead Sciences, Inc. |
Bicyclic nitrogen containing heterocyclic compounds for use as stearoyl coa desaturase inhibitors
|
|
WO2010002998A1
(en)
|
2008-07-03 |
2010-01-07 |
Gilead Sciences, Inc. |
2,4,6-TRISUBSTITUTED PYRIDO (3,2-d) PYRIMIDINES USEFUL FOR TREATING VIRAL INFECTIONS
|
|
UY31984A
(es)
|
2008-07-16 |
2010-02-26 |
Boehringer Ingelheim Int |
DERIVADOS DE 1-(3,4-difluorobencil)-6-oxo-1,6-dihidropirimidin-5-carboxamidas N-sustituidas y de 2-(3,4-difluorobencil)-3-oxo-2,3-dihidro-1H-pirazol-4-carboxamidas N-sustituidas.
|
|
UY31982A
(es)
|
2008-07-16 |
2010-02-26 |
Boehringer Ingelheim Int |
Derivados de 1,2-dihidropiridin-3-carboxamidas n-sustituidas
|
|
AU2009305669A1
(en)
|
2008-10-16 |
2010-04-22 |
The Regents Of The University Of California |
Fused ring heteroaryl kinase inhibitors
|
|
CA2742007C
(en)
|
2008-10-29 |
2014-07-08 |
Deciphera Pharmaceuticals, Llc |
Cyclopropane amides and analogs exhibiting anti-cancer and anti-proliferative activities
|
|
US8980899B2
(en)
|
2009-10-16 |
2015-03-17 |
The Regents Of The University Of California |
Methods of inhibiting Ire1
|
|
US9765037B2
(en)
|
2010-01-28 |
2017-09-19 |
University Of Washington Through Its Center For Commercialization |
Compositions and methods for treating toxoplasmosis, cryptosporidiosis, and other apicomplexan protozoan related diseases
|
|
EP2563773A1
(en)
|
2010-04-29 |
2013-03-06 |
Deciphera Pharmaceuticals, LLC |
Pyridone amides and analogs exhibiting anti-cancer and anti-proliferative activites
|
|
BR112012027743A2
(pt)
|
2010-04-29 |
2017-03-14 |
Deciphera Pharmaceuticals Llc |
ciclopropil dicarboxamidas e análogos exibindo atividades anticâncer e antiproliferativas
|
|
MX2013007261A
(es)
|
2010-12-23 |
2013-11-04 |
Amgen Inc |
Compuestos heterociclicos y sus usos.
|
|
BR112013025798A2
(pt)
|
2011-04-08 |
2016-12-20 |
Afraxis Holdings Inc |
8-etil-6-(aril)pirido[2,3-d]pirimidin-7(8h)-onas para o tratamento de câncer e distúrbios de sistema nervoso
|
|
WO2012158795A1
(en)
|
2011-05-17 |
2012-11-22 |
Principia Biopharma Inc. |
Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors
|
|
AU2012100477A4
(en)
|
2011-08-26 |
2012-06-14 |
Paul Alan Alessi |
Improvements relating to brush harvesters
|
|
BR112014010631A2
(pt)
|
2011-11-04 |
2017-04-25 |
Afraxis Holdings Inc |
inibidores de pak para o tratamento da síndrome do x frágil
|
|
HK1202450A1
(zh)
|
2011-11-22 |
2015-10-02 |
Deciphera Pharmaceuticals, Llc. |
表現出抗癌和抗增殖活性的吡啶酮酰胺以及類似物
|
|
US9187474B2
(en)
|
2012-03-07 |
2015-11-17 |
Deciphera Pharmaceuticals, Llc |
Raf inhibitor compounds
|
|
AR090151A1
(es)
|
2012-03-07 |
2014-10-22 |
Lilly Co Eli |
Compuestos inhibidores de raf
|
|
US8461179B1
(en)
|
2012-06-07 |
2013-06-11 |
Deciphera Pharmaceuticals, Llc |
Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
|
|
CN104487441B
(zh)
|
2012-06-18 |
2018-06-01 |
普林斯匹亚生物制药公司 |
有用于治疗癌症和自身免疫性疾病的可逆的共价吡咯并嘧啶或吡唑并嘧啶
|
|
CN102746241B
(zh)
|
2012-07-02 |
2014-11-05 |
西安交通大学 |
2,3,5-三取代苯甲酰胺类化合物及其制备方法和用途
|
|
US20140038991A1
(en)
|
2012-08-06 |
2014-02-06 |
Astar Biotech Llc |
Protein Kinase Inhibitors
|
|
GB201216017D0
(en)
|
2012-09-07 |
2012-10-24 |
Cancer Rec Tech Ltd |
Inhibitor compounds
|
|
CA2883386A1
(en)
|
2012-09-14 |
2014-03-20 |
Eternity Bioscience Inc. |
Aminoisoquinoline derivatives as protein kinase inhibitors
|
|
WO2014145029A2
(en)
|
2013-03-15 |
2014-09-18 |
Deciphera Pharmaceuticals, Llc |
N-acyl-n'-(pyridin-2-yl) ureas and analogs exhibiting anti-cancer and anti-proliferative activities
|
|
BR112015022263B1
(pt)
|
2013-03-15 |
2023-01-03 |
Deciphera Pharmaceuticals Llc |
N-acil-n-(piridin-2-il) uréias e análogos apresentando atividades anticâncer e antiproliferativas, seus usos, e composição farmacêutica
|
|
US9012635B2
(en)
|
2013-03-15 |
2015-04-21 |
Deciphera Pharmaceuticals, Llc |
Pyridone amides and analogs exhibiting anti-cancer and anti-proliferative activities
|
|
CN105120864B
(zh)
|
2013-03-15 |
2017-05-17 |
德西费拉制药有限责任公司 |
表现出抗癌活性和抗增殖活性的2‑氨基嘧啶‑6‑酮及类似物
|
|
US9193719B2
(en)
|
2013-03-15 |
2015-11-24 |
Deciphera Pharmaceuticals, Llc |
1,2,4-triazol-5-ones and analogs exhibiting anti-cancer and anti-proliferative activities
|
|
US9133183B2
(en)
|
2013-03-15 |
2015-09-15 |
Deciphera Pharmaceuticals, Llc |
Imidazolidinones and analogs exhibiting anti-cancer and anti-proliferative activities
|
|
WO2014152114A1
(en)
|
2013-03-15 |
2014-09-25 |
Boehringer Ingelheim International Gmbh |
Heteroaromatic compounds as btk inhibitors
|
|
CN105283454B
(zh)
*
|
2013-04-12 |
2019-10-29 |
阿萨纳生物科技有限责任公司 |
作为ras/raf/mek/erk和pi3k/akt/pten/mtor通路双重抑制剂的喹唑啉和氮杂喹唑啉
|
|
US9457019B2
(en)
|
2013-11-07 |
2016-10-04 |
Deciphera Pharmaceuticals, Llc |
Methods for inhibiting tie-2 kinase useful in the treatment of cancer
|
|
CN105330699B
(zh)
|
2014-08-13 |
2018-12-04 |
山东汇睿迪生物技术有限公司 |
一种含磷吡啶并[2,3-d]嘧啶-7-酮类化合物或其药学上可接受的盐、药物组合物及其应用
|
|
CN105481858B
(zh)
|
2014-10-11 |
2019-05-17 |
上海医药集团股份有限公司 |
一种含氮稠杂环化合物、其制备方法、组合物及应用
|
|
CN105968108B
(zh)
|
2016-05-12 |
2017-07-04 |
淮海工学院 |
一种合成帕布昔利布中间体的方法
|
|
KR102500416B1
(ko)
*
|
2016-06-21 |
2023-02-17 |
네르비아노 메디칼 사이언시스 에스.알.엘. |
키나제 억제제로서의 n-(치환된-페닐)-설폰아미드 유도체
|
|
EP3481831B1
(en)
|
2016-07-07 |
2023-09-06 |
Daewoong Pharmaceutical Co., Ltd. |
4-aminopyrazolo[3,4-d]pyrimidinylazabicyclo derivatives and pharmaceutical composition comprising the same
|
|
ES2906330T3
(es)
|
2016-09-12 |
2022-04-18 |
Covestro Deutschland Ag |
Procedimiento de fabricación aditiva a base de polvo a baja temperatura
|
|
RU2747260C2
(ru)
|
2016-12-19 |
2021-04-29 |
Аббиско Тхерапеутицс Цо., Лтд. |
Ингибитор рфрф4, способ его получения и его фармацевтическое применение
|
|
EP4169918B8
(en)
|
2016-12-26 |
2025-09-24 |
Institute of Materia Medica, Chinese Academy of Medical Sciences |
Quinazoline derivatives as inhibitors of pi3k for the treatment of cancer
|
|
JP6876833B2
(ja)
|
2017-02-27 |
2021-05-26 |
▲貝▼▲達▼▲薬▼▲業▼股▲フン▼有限公司Ｂｅｔｔａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｃｏ．， Ｌｔｄ． |
Ｆｇｆｒ阻害剤およびその使用
|
|
BR112019025346A2
(pt)
|
2017-05-30 |
2020-06-30 |
Deciphera Pharmaceuticals, Inc. |
uso de 1-[4-bromo-5-[1-etil-7-(metilamino)-2-oxo-1,2-dihidro-1,6-naftiridin-3-il]-2-fluorofenil]-3-fenilureia e análogos para o tratamento de cânceres associados a anormalidades genéticas no receptor alfa do fator de crescimento derivado de plaquetas
|
|
AU2018278311B2
(en)
|
2017-06-01 |
2021-10-07 |
Cornell University |
IRE1 small molecule inhibitors
|
|
US11149035B2
(en)
|
2017-06-13 |
2021-10-19 |
Glaxosmithkline Intellectual Property Dfvelopment Limited |
Chemical compounds as H—PGDS inhibitors
|
|
CN109721531B
(zh)
|
2017-10-27 |
2022-07-29 |
中国科学院合肥物质科学研究院 |
一种新型的脂质体激酶抑制剂
|
|
WO2019094641A1
(en)
|
2017-11-10 |
2019-05-16 |
Quentis Therapeutics, Inc. |
Ire1 small molecule inhibitors
|
|
KR102708177B1
(ko)
|
2018-01-31 |
2024-09-23 |
데시페라 파마슈티칼스, 엘엘씨. |
위장관 기질 종양의 치료를 위한 병용 요법
|
|
CN118903436A
(zh)
|
2018-01-31 |
2024-11-08 |
德西费拉制药有限责任公司 |
治疗肥大细胞增多症的组合疗法
|
|
WO2020052349A1
(zh)
|
2018-09-14 |
2020-03-19 |
上海和誉生物医药科技有限公司 |
Fgfr抑制剂、其制备方法和应用
|
|
TW202023558A
(zh)
|
2018-10-03 |
2020-07-01 |
美商建南德克公司 |
8-胺基異喹啉化合物及其用途
|
|
JP7546299B2
(ja)
|
2018-12-03 |
2024-09-06 |
コーネル・ユニバーシティー |
Ｉｒｅ１小分子阻害物質
|
|
SMT202500389T1
(it)
|
2018-12-28 |
2025-11-10 |
Deciphera Pharmaceuticals Llc |
Inibitori di csf1r per l'uso nel trattamento di tumori tenosinoviali a cellule giganti
|
|
WO2020142612A1
(en)
|
2019-01-03 |
2020-07-09 |
Genentech, Inc. |
Pyrido-pyrimidinone and pteridinone compounds as inhibitors of endoribonuclease inositol requiring enzyme i (ire i alpha) for the treatment of cancer diseases.
|
|
WO2020147097A1
(zh)
|
2019-01-18 |
2020-07-23 |
中国科学院合肥物质科学研究院 |
一种新型的脂质体激酶抑制剂
|
|
TWI756636B
(zh)
|
2019-02-18 |
2022-03-01 |
美商建南德克公司 |
嘧啶并嘧啶化合物及使用方法
|
|
KR102747104B1
(ko)
|
2019-02-18 |
2024-12-27 |
한국과학기술연구원 |
단백질 키나아제 저해 활성을 갖는 신규한 피리도[3,4-d]피리미딘-8-온 유도체 및 이를 포함하는 암의 예방, 개선 또는 치료용 약학 조성물
|
|
WO2020177729A1
(zh)
|
2019-03-06 |
2020-09-10 |
江苏恒瑞医药股份有限公司 |
稠合芳香环类衍生物、其制备方法及其在医药上的应用
|
|
WO2020210828A1
(en)
*
|
2019-04-12 |
2020-10-15 |
Hibercell, Inc. |
(aza)indazolyl-aryl sulfonamide and related compounds and their use in treating medical conditions
|
|
HRP20231310T1
(hr)
|
2019-05-10 |
2024-02-02 |
Deciphera Pharmaceuticals, Llc |
Heteroarilaminopirimidin amidni inhibitori autofagije i postupci njihove primjene
|
|
HUE065486T2
(hu)
|
2019-05-10 |
2024-05-28 |
Deciphera Pharmaceuticals Llc |
Fenilaminopirimidinamid autophágia inhibitorok és azok felhasználási eljárásai
|
|
US20220265656A1
(en)
|
2019-05-15 |
2022-08-25 |
Cornell University |
Combination therapies with ire1 small molecule inhibitors
|
|
US12479818B2
(en)
|
2019-05-15 |
2025-11-25 |
Cornell University |
Treatment of fibrosis with IRE1 small molecule inhibitors
|
|
AR119046A1
(es)
|
2019-05-31 |
2021-11-17 |
Agios Pharmaceuticals Inc |
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