JP7895341B2 - Ｇｃｎ２およびｐｅｒｋキナーゼ阻害剤およびその使用方法 - Google Patents

Ｇｃｎ２およびｐｅｒｋキナーゼ阻害剤およびその使用方法

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Publication number
JP7895341B2
JP7895341B2 JP2023528988A JP2023528988A JP7895341B2 JP 7895341 B2 JP7895341 B2 JP 7895341B2 JP 2023528988 A JP2023528988 A JP 2023528988A JP 2023528988 A JP2023528988 A JP 2023528988A JP 7895341 B2 JP7895341 B2 JP 7895341B2
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group
alkyl
cancer
heterocyclyl
haloalkyl
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Japanese (ja)
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JP2023549540A (ja
JP2023549540A5 (enExample
Inventor
フリン，ダニエル・エル
カーニー，パトリック
ツヴィッカー，ジェフリー
アル－アニ，ガダ
ジェーブド，サリム
アン，ユ・ミ
ストルツ，クリステン
ル・ブルドネック，ベルトラン
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デシフェラ・ファーマシューティカルズ，エルエルシー
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2023528988A 2020-11-18 2021-11-17 Ｇｃｎ２およびｐｅｒｋキナーゼ阻害剤およびその使用方法 Active JP7895341B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063115496P 2020-11-18 2020-11-18
US63/115,496 2020-11-18
US202163185846P 2021-05-07 2021-05-07
US63/185,846 2021-05-07
PCT/US2021/059678 WO2022109001A1 (en) 2020-11-18 2021-11-17 Gcn2 and perk kinase inhibitors and methods of use thereof

Publications (3)

Publication Number Publication Date
JP2023549540A JP2023549540A (ja) 2023-11-27
JP2023549540A5 JP2023549540A5 (enExample) 2024-11-25
JP7895341B2 true JP7895341B2 (ja) 2026-07-27

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JP2023528988A Active JP7895341B2 (ja) 2020-11-18 2021-11-17 Ｇｃｎ２およびｐｅｒｋキナーゼ阻害剤およびその使用方法

Country Status (13)

Country Link
US (2) US11912668B2 (enExample)
EP (1) EP4247795A1 (enExample)
JP (1) JP7895341B2 (enExample)
KR (1) KR20230121758A (enExample)
AU (1) AU2021381949B2 (enExample)
BR (1) BR112023009531A2 (enExample)
CA (1) CA3198943A1 (enExample)
CL (1) CL2023001399A1 (enExample)
CO (1) CO2023006705A2 (enExample)
IL (1) IL302807A (enExample)
MX (1) MX2023005747A (enExample)
PE (1) PE20231311A1 (enExample)
WO (1) WO2022109001A1 (enExample)

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GB202008749D0 (en) 2020-06-09 2020-07-22 Ip2Ipo Innovations Ltd Novel compounds
PE20231311A1 (es) 2020-11-18 2023-08-24 Deciphera Pharmaceuticals Llc Inhibidores de gcn2 y perk quinasas y metodos de uso de los mismos
IL310931A (en) * 2021-09-10 2024-04-01 Black Diamond Therapeutics Inc 6-aza-quinoline derivatives and related uses
MX2024006627A (es) 2021-12-03 2024-08-22 Deciphera Pharmaceuticals Llc Inhibidores de gcn2 y perk quinasa y metodos de uso de los mismos.
WO2023159322A1 (en) * 2022-02-25 2023-08-31 Ontario Institute For Cancer Research (Oicr) Quinazoline derivatives as inhibitors of the gcn2 kinase, compositions and uses thereof
US20250263400A1 (en) * 2022-04-08 2025-08-21 Alesta Therapeutics BV Gcn2 modulator compounds
US20250340530A1 (en) * 2022-05-11 2025-11-06 Ip2Ipo Innovations Limited GCN2 INHIBITOR (as amended)
CN119343346A (zh) * 2022-06-08 2025-01-21 韩国化学研究院 苯磺酰胺衍生物、其制备方法及含有其作为活性成分的预防或治疗癌症的药物组合物
IL320217A (en) * 2022-10-14 2025-06-01 Black Diamond Therapeutics Inc Methods for treating cancer using isoquinoline or 6-azaquinoline derivatives
EP4771012A1 (en) * 2023-08-30 2026-07-08 Ontario Institute for Cancer Research (OICR) Triazolopyridopyrimidine and dihydroimidazopyridopyrimidine derivatives as inhibitors of the gcn2 kinase, compositions and uses thereof
CN121986102A (zh) * 2023-08-30 2026-05-05 安大略省癌症研究所(Oicr) 作为gcn2激酶抑制剂的嘧啶并吡啶酮和蝶啶酮衍生物、其组合物和用途
AU2024356374A1 (en) * 2023-10-06 2026-04-16 Alesta Therapeutics BV Compounds of gcn2 modulators

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