JP2023545274A5 - - Google Patents
Info
- Publication number
- JP2023545274A5 JP2023545274A5 JP2023521512A JP2023521512A JP2023545274A5 JP 2023545274 A5 JP2023545274 A5 JP 2023545274A5 JP 2023521512 A JP2023521512 A JP 2023521512A JP 2023521512 A JP2023521512 A JP 2023521512A JP 2023545274 A5 JP2023545274 A5 JP 2023545274A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- dione
- dioxopiperidine
- amino
- isoindoline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2020119834 | 2020-10-07 | ||
| CNPCT/CN2020/119834 | 2020-10-07 | ||
| PCT/CN2021/122530 WO2022073469A1 (en) | 2020-10-07 | 2021-10-07 | Compounds and methods of treating cancers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023545274A JP2023545274A (ja) | 2023-10-27 |
| JP2023545274A5 true JP2023545274A5 (enExample) | 2024-10-16 |
Family
ID=81125595
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023521512A Pending JP2023545274A (ja) | 2020-10-07 | 2021-10-07 | 癌を処置する化合物および方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20240050428A1 (enExample) |
| EP (1) | EP4225749A4 (enExample) |
| JP (1) | JP2023545274A (enExample) |
| CN (2) | CN122562781A (enExample) |
| WO (1) | WO2022073469A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117242060B (zh) | 2021-01-13 | 2026-07-17 | 蒙特罗莎治疗股份有限公司 | 异吲哚啉酮化合物 |
| CA3217792A1 (en) | 2021-05-07 | 2022-11-10 | Kymera Therapeutics, Inc | Cdk2 degraders and uses thereof |
| MX2023013961A (es) * | 2021-10-01 | 2023-12-11 | Nextgen Bioscience Co Ltd | Nuevos derivados de la piperidina y composiciones farmaceuticas que los contienen, para inhibir la autotaxina. |
| KR20250004694A (ko) * | 2022-04-06 | 2025-01-08 | 클루젠 (상하이), 인크. | 암 치료를 위한 조성물 및 방법 |
| EP4536651A4 (en) * | 2022-06-10 | 2026-08-05 | Guangzhou Yufan Nantu Biotechnologies Co Ltd | PROTEIN DEGRADING AGENTS AND THEIR USES |
| EP4554581A1 (en) * | 2022-07-13 | 2025-05-21 | Monte Rosa Therapeutics AG | Combination therapy comprising gspt1-directed molecular glue degraders and pi3k/akt/mtor pathway inhibitors |
| US20260028326A1 (en) * | 2022-08-10 | 2026-01-29 | Gluetacs Therapeutics (Shanghai) Co., Ltd. | Compound based on isoindoline-substituted glutarimide backbone and use thereof |
| CN115636811A (zh) * | 2022-08-17 | 2023-01-24 | 成都分迪药业有限公司 | 异吲哚啉苄胺衍生物的合成方法 |
| JP2025531869A (ja) | 2022-09-09 | 2025-09-25 | イノヴォ セラピューティクス、インコーポレイテッド | ＣＫ１αおよびＤＵＡＬ ＣＫ１α／ＧＳＰＴ１分解化合物 |
| WO2024099441A1 (en) * | 2022-11-11 | 2024-05-16 | Jingrui Biopharma (Shandong) Co., Ltd. | Bromodomain and extra-terminal (bet) protein degrader |
| AR131380A1 (es) | 2022-12-16 | 2025-03-12 | Astrazeneca Ab | Purinas 2,6,9-trisustituidas |
| WO2024193641A1 (zh) * | 2023-03-21 | 2024-09-26 | 上海超阳药业有限公司 | 异吲哚啉衍生物和苯并吲哚衍生物及其应用 |
| WO2025179161A1 (en) | 2024-02-21 | 2025-08-28 | Innovo Therapeutics, Inc. | Protein degrading compounds |
| WO2025231420A1 (en) * | 2024-05-03 | 2025-11-06 | Albert Einstein College Of Medicine | Small molecule degraders of soluble epoxide hydrolase |
| CN121620373A (zh) * | 2024-07-26 | 2026-03-06 | 上海超阳药业有限公司 | 苯并吲哚衍生物的药物组合物、制备方法及用途 |
| CN119059953A (zh) * | 2024-08-27 | 2024-12-03 | 吉林大学 | 一种快捷合成1-(乙基磺酰基)氮杂环丁烷-3-酮的方法 |
| WO2026061491A1 (zh) * | 2024-09-20 | 2026-03-26 | 上海超阳药业有限公司 | 一种苯并吲哚衍生物的晶型、盐型及其制备方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018011847A1 (ja) * | 2016-07-11 | 2018-01-18 | オリンパス株式会社 | 内視鏡処置具 |
| JP2020504711A (ja) * | 2016-12-21 | 2020-02-13 | バイオセリックス， インコーポレイテッド | タンパク質を標的とすることにおいて使用するための、チエノピロール誘導体、その組成物、方法、および使用 |
| WO2018169777A1 (en) * | 2017-03-14 | 2018-09-20 | Biotheryx, Inc. | Compounds targeting proteins, compositions, methods, and uses thereof |
| EP4201399A3 (en) * | 2017-06-30 | 2023-08-09 | Celgene Corporation | Compositions and methods of use of 2-(4-chlorophenyl)-n-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl) methyl) -2,2-difluoroacetamide |
| TWI793151B (zh) * | 2017-08-23 | 2023-02-21 | 瑞士商諾華公司 | 3-(1-氧異吲哚啉-2-基)之氫吡啶-2,6-二酮衍生物及其用途 |
| CN109422753B (zh) * | 2017-09-03 | 2021-12-31 | 上海美志医药科技有限公司 | 一类具有抑制并降解酪氨酸蛋白激酶jak1或jak2活性的化合物 |
| WO2019114770A1 (zh) * | 2017-12-13 | 2019-06-20 | 上海科技大学 | Alk蛋白降解剂及其抗肿瘤应用 |
| US10905684B2 (en) * | 2018-06-13 | 2021-02-02 | Biotheryx, Inc. | Aminoamide compounds |
| US11191769B2 (en) * | 2018-06-13 | 2021-12-07 | Biotheryx, Inc. | Fused thiophene compounds |
| MX2021001957A (es) * | 2018-08-22 | 2021-07-15 | Cullgen Shanghai Inc | Compuestos de degradacion y metodos de uso del receptor de tropomiosina quinasa (trk). |
| CN113646002A (zh) * | 2019-02-27 | 2021-11-12 | 上海睿跃生物科技有限公司 | 环amp反应元件结合蛋白(cbp)和/或300kda腺病毒e1a结合蛋白(p300)降解化合物和使用方法 |
| WO2020200291A1 (en) * | 2019-04-02 | 2020-10-08 | Cullgen (Shanghai) , Inc. | Compounds and methods of treating cancers |
| CN114502543A (zh) * | 2019-05-24 | 2022-05-13 | 拜欧斯瑞克斯公司 | 靶向蛋白化合物、其药物组合物及治疗应用 |
| JP7724394B2 (ja) * | 2019-10-09 | 2025-08-18 | モンテ ローザ セラピューティクス アーゲー | イソインドリノン化合物 |
-
2021
- 2021-10-07 CN CN202610772277.9A patent/CN122562781A/zh active Pending
- 2021-10-07 EP EP21876987.5A patent/EP4225749A4/en active Pending
- 2021-10-07 JP JP2023521512A patent/JP2023545274A/ja active Pending
- 2021-10-07 US US18/248,035 patent/US20240050428A1/en active Pending
- 2021-10-07 CN CN202180082392.9A patent/CN116583509B/zh active Active
- 2021-10-07 WO PCT/CN2021/122530 patent/WO2022073469A1/en not_active Ceased
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