JP2023545274A5 - - Google Patents
Info
- Publication number
- JP2023545274A5 JP2023545274A5 JP2023521512A JP2023521512A JP2023545274A5 JP 2023545274 A5 JP2023545274 A5 JP 2023545274A5 JP 2023521512 A JP2023521512 A JP 2023521512A JP 2023521512 A JP2023521512 A JP 2023521512A JP 2023545274 A5 JP2023545274 A5 JP 2023545274A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- dione
- dioxopiperidine
- amino
- isoindoline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2020/119834 | 2020-10-07 | ||
| CN2020119834 | 2020-10-07 | ||
| PCT/CN2021/122530 WO2022073469A1 (en) | 2020-10-07 | 2021-10-07 | Compounds and methods of treating cancers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023545274A JP2023545274A (ja) | 2023-10-27 |
| JP2023545274A5 true JP2023545274A5 (enExample) | 2024-10-16 |
Family
ID=81125595
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023521512A Pending JP2023545274A (ja) | 2020-10-07 | 2021-10-07 | 癌を処置する化合物および方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20240050428A1 (enExample) |
| EP (1) | EP4225749A4 (enExample) |
| JP (1) | JP2023545274A (enExample) |
| CN (1) | CN116583509A (enExample) |
| WO (1) | WO2022073469A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2024504932A (ja) | 2021-01-13 | 2024-02-02 | モンテ ローザ セラピューティクス， インコーポレイテッド | イソインドリノン化合物 |
| AU2022271290A1 (en) | 2021-05-07 | 2023-11-23 | Kymera Therapeutics, Inc. | Cdk2 degraders and uses thereof |
| MX2023013961A (es) * | 2021-10-01 | 2023-12-11 | Nextgen Bioscience Co Ltd | Nuevos derivados de la piperidina y composiciones farmaceuticas que los contienen, para inhibir la autotaxina. |
| KR20250004694A (ko) * | 2022-04-06 | 2025-01-08 | 클루젠 (상하이), 인크. | 암 치료를 위한 조성물 및 방법 |
| US20250361239A1 (en) * | 2022-06-10 | 2025-11-27 | Zhuhai Yufan Biotechnologies Co., Ltd. | Protein degraders and uses thereof |
| WO2024015855A1 (en) * | 2022-07-13 | 2024-01-18 | Monte Rosa Therapeutics, Inc. | COMBINATION THERAPY COMPRISING GSPT1-DIRECTED MOLECULAR GLUE DEGRADERS AND PI3K/AKT/mTOR PATHWAY INHIBITORS |
| WO2024032689A1 (zh) * | 2022-08-10 | 2024-02-15 | 标新生物医药科技(上海)有限公司 | 基于异吲哚啉取代戊二酰亚胺骨架的化合物及其应用 |
| CN115636811A (zh) * | 2022-08-17 | 2023-01-24 | 成都分迪药业有限公司 | 异吲哚啉苄胺衍生物的合成方法 |
| JP2025531869A (ja) | 2022-09-09 | 2025-09-25 | イノヴォ セラピューティクス、インコーポレイテッド | ＣＫ１αおよびＤＵＡＬ ＣＫ１α／ＧＳＰＴ１分解化合物 |
| WO2024099441A1 (en) * | 2022-11-11 | 2024-05-16 | Jingrui Biopharma (Shandong) Co., Ltd. | Bromodomain and extra-terminal (bet) protein degrader |
| KR20250121114A (ko) | 2022-12-16 | 2025-08-11 | 아스트라제네카 아베 | 2,6,9-삼치환된 퓨린 |
| EP4685141A1 (en) * | 2023-03-21 | 2026-01-28 | Shanghai Helioson Pharmaceutical Co., Ltd. | Isoindoline derivative, benzoindole derivative and use thereof |
| WO2025179161A1 (en) | 2024-02-21 | 2025-08-28 | Innovo Therapeutics, Inc. | Protein degrading compounds |
| WO2025231420A1 (en) * | 2024-05-03 | 2025-11-06 | Albert Einstein College Of Medicine | Small molecule degraders of soluble epoxide hydrolase |
| CN121620373A (zh) * | 2024-07-26 | 2026-03-06 | 上海超阳药业有限公司 | 苯并吲哚衍生物的药物组合物、制备方法及用途 |
| CN119059953A (zh) * | 2024-08-27 | 2024-12-03 | 吉林大学 | 一种快捷合成1-(乙基磺酰基)氮杂环丁烷-3-酮的方法 |
| WO2026061491A1 (zh) * | 2024-09-20 | 2026-03-26 | 上海超阳药业有限公司 | 一种苯并吲哚衍生物的晶型、盐型及其制备方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6684907B2 (ja) * | 2016-07-11 | 2020-04-22 | オリンパス株式会社 | 内視鏡用クリップ装置 |
| AU2017382176A1 (en) * | 2016-12-21 | 2019-05-30 | Biotheryx, Inc. | Thienopyrrole derivatives for use in targeting proteins, compositions, methods, and uses thereof |
| WO2018169777A1 (en) * | 2017-03-14 | 2018-09-20 | Biotheryx, Inc. | Compounds targeting proteins, compositions, methods, and uses thereof |
| PL3644999T3 (pl) * | 2017-06-30 | 2023-05-08 | Celgene Corporation | Kompozycje i sposoby zastosowania 2-(4-chlorofenylo)-n-((2-(2,6-dioksopiperydyn-3-ylo)-1-oksoizoindolin-5-ylo)metylo)-2,2-difluoroacetamidu |
| TWI793151B (zh) * | 2017-08-23 | 2023-02-21 | 瑞士商諾華公司 | 3-(1-氧異吲哚啉-2-基)之氫吡啶-2,6-二酮衍生物及其用途 |
| CN109422753B (zh) * | 2017-09-03 | 2021-12-31 | 上海美志医药科技有限公司 | 一类具有抑制并降解酪氨酸蛋白激酶jak1或jak2活性的化合物 |
| EP3725771B1 (en) * | 2017-12-13 | 2026-02-04 | Shanghaitech University | Alk protein degradation agent and anti-tumor application thereof |
| CA3101335C (en) * | 2018-06-13 | 2024-01-09 | Biotheryx, Inc. | Fused thiophene compounds |
| CA3101338A1 (en) * | 2018-06-13 | 2019-12-19 | Biotheryx, Inc. | Aminoamide compounds |
| AU2019323446B2 (en) * | 2018-08-22 | 2025-01-30 | Cullgen (Shanghai), Inc. | Tropomyosin receptor kinase (TRK) degradation compounds and methods of use |
| WO2020173440A1 (en) * | 2019-02-27 | 2020-09-03 | Cullgen (Shanghai), Inc. | Cyclic-amp response element binding protein (cbp) and/or adenoviral e1a binding protein of 300 kda (p300) degradation compounds and methods of use |
| US20230093099A1 (en) * | 2019-04-02 | 2023-03-23 | Cullgen (Shanghai), Inc. | Compounds and methods of treating cancers |
| MX2021014345A (es) * | 2019-05-24 | 2022-01-06 | Biotheryx Inc | Compuestos dirigidos a proteinas y composiciones farmaceuticas de los mismos, y sus aplicaciones terapeuticas. |
| EP4041231A1 (en) * | 2019-10-09 | 2022-08-17 | Monte Rosa Therapeutics AG | Isoindolinone compounds |
-
2021
- 2021-10-07 EP EP21876987.5A patent/EP4225749A4/en active Pending
- 2021-10-07 CN CN202180082392.9A patent/CN116583509A/zh active Pending
- 2021-10-07 US US18/248,035 patent/US20240050428A1/en active Pending
- 2021-10-07 JP JP2023521512A patent/JP2023545274A/ja active Pending
- 2021-10-07 WO PCT/CN2021/122530 patent/WO2022073469A1/en not_active Ceased
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