JP2023544404A5 - - Google Patents
Info
- Publication number
- JP2023544404A5 JP2023544404A5 JP2023520423A JP2023520423A JP2023544404A5 JP 2023544404 A5 JP2023544404 A5 JP 2023544404A5 JP 2023520423 A JP2023520423 A JP 2023520423A JP 2023520423 A JP2023520423 A JP 2023520423A JP 2023544404 A5 JP2023544404 A5 JP 2023544404A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- independently
- alkyl
- cr7r8
- appearance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063088171P | 2020-10-06 | 2020-10-06 | |
| US63/088,171 | 2020-10-06 | ||
| PCT/US2021/053320 WO2022076285A1 (en) | 2020-10-06 | 2021-10-04 | LACTAM COMPOUNDS AS Kv1.3 POTASSIUM SHAKER CHANNEL BLOCKERS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023544404A JP2023544404A (ja) | 2023-10-23 |
| JP2023544404A5 true JP2023544404A5 (https=) | 2024-10-16 |
Family
ID=81126843
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023520423A Pending JP2023544404A (ja) | 2020-10-06 | 2021-10-04 | Ｋｖ１．３カリウムＳＨＡＫＥＲチャネル遮断剤としてのラクタム化合物 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20230373952A1 (https=) |
| EP (1) | EP4225285A4 (https=) |
| JP (1) | JP2023544404A (https=) |
| KR (1) | KR20230082041A (https=) |
| CN (1) | CN116782894A (https=) |
| AU (1) | AU2021358700A1 (https=) |
| BR (1) | BR112023005387A2 (https=) |
| CA (1) | CA3193554A1 (https=) |
| IL (1) | IL301627A (https=) |
| MX (1) | MX2023003841A (https=) |
| WO (1) | WO2022076285A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024088343A1 (zh) * | 2022-10-28 | 2024-05-02 | 上海深势唯思科技有限责任公司 | 一种芳基杂环类Kv1.3抑制剂及其制备方法和用途 |
| WO2024217515A1 (zh) | 2023-04-19 | 2024-10-24 | 上海复宏汉霖生物技术股份有限公司 | 一种杂环取代的芳香化合物、其制备方法及用途 |
| WO2025021167A1 (zh) * | 2023-07-26 | 2025-01-30 | 上海汇伦医药股份有限公司 | 芳基含氮杂环化合物、药物组合物和应用 |
| TW202521512A (zh) | 2023-07-31 | 2025-06-01 | 美商美國禮來大藥廠 | Kv1.3鉀shaker通道阻斷劑之固體形式及其使用方法 |
| WO2025235362A1 (en) * | 2024-05-06 | 2025-11-13 | D. E. Shaw Research, Llc | INDOLINONE COMPOUNDS AS KCa3.1 POTASSIUM CHANNEL BLOCKERS |
| WO2025235367A1 (en) * | 2024-05-06 | 2025-11-13 | D. E. Shaw Research, Llc | Azaindolinone compounds as kca3.1 potassium channel blockers |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3854480A (en) | 1969-04-01 | 1974-12-17 | Alza Corp | Drug-delivery system |
| US4675189A (en) | 1980-11-18 | 1987-06-23 | Syntex (U.S.A.) Inc. | Microencapsulation of water soluble active polypeptides |
| US4452775A (en) | 1982-12-03 | 1984-06-05 | Syntex (U.S.A.) Inc. | Cholesterol matrix delivery system for sustained release of macromolecules |
| US5075109A (en) | 1986-10-24 | 1991-12-24 | Southern Research Institute | Method of potentiating an immune response |
| US5133974A (en) | 1989-05-05 | 1992-07-28 | Kv Pharmaceutical Company | Extended release pharmaceutical formulations |
| US5407686A (en) | 1991-11-27 | 1995-04-18 | Sidmak Laboratories, Inc. | Sustained release composition for oral administration of active ingredient |
| US5736152A (en) | 1995-10-27 | 1998-04-07 | Atrix Laboratories, Inc. | Non-polymeric sustained release delivery system |
| US6174908B1 (en) * | 1999-05-10 | 2001-01-16 | Icagen, Inc. | Potassium channel inhibitors |
| GB0004297D0 (en) * | 2000-02-23 | 2000-04-12 | Ucb Sa | 2-oxo-1 pyrrolidine derivatives process for preparing them and their uses |
| AU2003285952A1 (en) * | 2002-10-21 | 2004-05-13 | Irm Llc | Pyrrolidones with anti-hiv activity |
| CN101048397A (zh) * | 2004-09-29 | 2007-10-03 | 三菱制药株式会社 | 作为τ蛋白激酶1抑制剂的6－（吡啶基）－4－嘧啶酮衍生物 |
| JP2008528625A (ja) * | 2005-01-28 | 2008-07-31 | アイアールエム・リミテッド・ライアビリティ・カンパニー | アリールピロリドン類の合成 |
| WO2011073273A1 (en) * | 2009-12-16 | 2011-06-23 | Evotec Ag | Benzoxazine aryl sulfonamide derivatives as kv1.3 modulators |
| CN101979378B (zh) * | 2010-10-13 | 2012-06-27 | 中国科学院上海有机化学研究所 | 一种手性γ-内酰胺化合物的合成方法 |
| EP3660016A1 (en) * | 2010-12-20 | 2020-06-03 | Incyte Holdings Corporation | N-(1-(substituted-phenyl)ethyl)-9h-purin-6-amines as pi3k inhibitors |
| JP6599908B2 (ja) * | 2014-06-25 | 2019-10-30 | サンフォード−バーンハム メディカル リサーチ インスティテュート | ニューロテンシン受容体１の小分子アゴニスト |
| CA3157026A1 (en) * | 2019-10-07 | 2021-04-15 | D.E. Shaw Research, Llc | Arylmethylene aromatic compounds as kv1.3 potassium shaker channel blockers |
| AU2020362108A1 (en) * | 2019-10-07 | 2022-04-21 | D. E. Shaw Research, Llc | Aryl heterocyclic compounds as Kv1.3 potassium shaker channel blockers |
| JP7780439B2 (ja) * | 2019-10-07 | 2025-12-04 | ディー．イー．ショウ リサーチ，エルエルシー | Ｋｖ１．３カリウムシェーカーチャネル遮断薬としてのアリール複素二環式化合物 |
| BR112022006507A2 (pt) * | 2019-10-07 | 2022-06-28 | De Shaw Res Llc | Compostos heterocíclicos de arilmetileno como bloqueadores de canais de agitador de potássio kv1.3 |
| CN114727993B (zh) * | 2019-10-07 | 2025-11-14 | D·E·萧尔研究有限责任公司 | 作为Kv1.3钾SHAKER通道阻断剂的芳基亚甲基杂环化合物 |
| KR20220079878A (ko) * | 2019-10-07 | 2022-06-14 | 디.이. 쇼우 리서치, 엘엘씨 | Kv1.3 칼륨 셰이커 채널 차단제로서의 아릴 헤테로비시클릭 화합물 |
-
2021
- 2021-10-04 MX MX2023003841A patent/MX2023003841A/es unknown
- 2021-10-04 WO PCT/US2021/053320 patent/WO2022076285A1/en not_active Ceased
- 2021-10-04 KR KR1020237015183A patent/KR20230082041A/ko not_active Withdrawn
- 2021-10-04 CN CN202180081847.5A patent/CN116782894A/zh active Pending
- 2021-10-04 AU AU2021358700A patent/AU2021358700A1/en not_active Abandoned
- 2021-10-04 BR BR112023005387A patent/BR112023005387A2/pt not_active Application Discontinuation
- 2021-10-04 CA CA3193554A patent/CA3193554A1/en active Pending
- 2021-10-04 JP JP2023520423A patent/JP2023544404A/ja active Pending
- 2021-10-04 EP EP21878284.5A patent/EP4225285A4/en active Pending
- 2021-10-04 US US18/247,521 patent/US20230373952A1/en active Pending
- 2021-10-04 IL IL301627A patent/IL301627A/en unknown
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