JP2010509342A5 - - Google Patents
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- Publication number
- JP2010509342A5 JP2010509342A5 JP2009536338A JP2009536338A JP2010509342A5 JP 2010509342 A5 JP2010509342 A5 JP 2010509342A5 JP 2009536338 A JP2009536338 A JP 2009536338A JP 2009536338 A JP2009536338 A JP 2009536338A JP 2010509342 A5 JP2010509342 A5 JP 2010509342A5
- Authority
- JP
- Japan
- Prior art keywords
- substituent
- methyl
- compound
- pyridin
- tetrahydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000001424 substituent group Chemical group 0.000 claims 57
- 150000001875 compounds Chemical class 0.000 claims 39
- 125000000217 alkyl group Chemical group 0.000 claims 13
- 239000003814 drug Substances 0.000 claims 12
- 125000003118 aryl group Chemical group 0.000 claims 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims 6
- 125000001072 heteroaryl group Chemical group 0.000 claims 6
- 125000000623 heterocyclic group Chemical group 0.000 claims 6
- 125000003342 alkenyl group Chemical group 0.000 claims 5
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 5
- 125000005843 halogen group Chemical group 0.000 claims 5
- 125000004475 heteroaralkyl group Chemical group 0.000 claims 5
- 125000000304 alkynyl group Chemical group 0.000 claims 4
- 125000003710 aryl alkyl group Chemical group 0.000 claims 4
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 4
- 102000004310 Ion Channels Human genes 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 230000005931 immune cell recruitment Effects 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- FGGBQDLVIIWCEN-UHFFFAOYSA-N 2,6-difluoro-n-[4-[4-methyl-1-(1,3-thiazol-2-yl)-3,6-dihydro-2h-pyridin-5-yl]phenyl]benzamide Chemical compound C1CC(C)=C(C=2C=CC(NC(=O)C=3C(=CC=CC=3F)F)=CC=2)CN1C1=NC=CS1 FGGBQDLVIIWCEN-UHFFFAOYSA-N 0.000 claims 2
- SLEWYYKLCSEZDR-UHFFFAOYSA-N 2,6-difluoro-n-[5-[4-methyl-1-(1,3-thiazol-2-yl)-3,6-dihydro-2h-pyridin-5-yl]pyrimidin-2-yl]benzamide Chemical compound C1CC(C)=C(C=2C=NC(NC(=O)C=3C(=CC=CC=3F)F)=NC=2)CN1C1=NC=CS1 SLEWYYKLCSEZDR-UHFFFAOYSA-N 0.000 claims 2
- BWGOFNHLWWSJNB-UHFFFAOYSA-N 3-fluoro-n-[4-[4-methyl-1-(1,3-thiazol-2-yl)-3,6-dihydro-2h-pyridin-5-yl]phenyl]pyridine-4-carboxamide Chemical compound C1CC(C)=C(C=2C=CC(NC(=O)C=3C(=CN=CC=3)F)=CC=2)CN1C1=NC=CS1 BWGOFNHLWWSJNB-UHFFFAOYSA-N 0.000 claims 2
- 206010002198 Anaphylactic reaction Diseases 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 206010009900 Colitis ulcerative Diseases 0.000 claims 2
- 208000011231 Crohn disease Diseases 0.000 claims 2
- 201000004624 Dermatitis Diseases 0.000 claims 2
- 201000004681 Psoriasis Diseases 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 206010052779 Transplant rejections Diseases 0.000 claims 2
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 2
- 206010047115 Vasculitis Diseases 0.000 claims 2
- 208000003455 anaphylaxis Diseases 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims 2
- 230000016396 cytokine production Effects 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 201000009890 sinusitis Diseases 0.000 claims 2
- OPXNIJUNTMAHGQ-UHFFFAOYSA-N 2,6-difluoro-n-[4-[4-formyl-1-(1,3-thiazol-2-yl)-3,6-dihydro-2h-pyridin-5-yl]phenyl]benzamide Chemical compound FC1=CC=CC(F)=C1C(=O)NC1=CC=C(C=2CN(CCC=2C=O)C=2SC=CN=2)C=C1 OPXNIJUNTMAHGQ-UHFFFAOYSA-N 0.000 claims 1
- WRHLSTUAPDFNPE-UHFFFAOYSA-N 2,6-difluoro-n-[4-[4-methyl-1-(1,3-oxazol-2-yl)-3,6-dihydro-2h-pyridin-5-yl]phenyl]benzamide Chemical compound C1CC(C)=C(C=2C=CC(NC(=O)C=3C(=CC=CC=3F)F)=CC=2)CN1C1=NC=CO1 WRHLSTUAPDFNPE-UHFFFAOYSA-N 0.000 claims 1
- WCEIFOYMXOCFAC-UHFFFAOYSA-N 2,6-difluoro-n-[4-[4-methyl-1-(1,3-oxazol-2-yl)-3,6-dihydro-2h-pyridin-5-yl]phenyl]benzamide;hydrochloride Chemical compound Cl.C1CC(C)=C(C=2C=CC(NC(=O)C=3C(=CC=CC=3F)F)=CC=2)CN1C1=NC=CO1 WCEIFOYMXOCFAC-UHFFFAOYSA-N 0.000 claims 1
- HEFUMIHZJMWLCH-UHFFFAOYSA-N 2,6-difluoro-n-[4-[4-methyl-1-(1,3-thiazol-2-yl)-3,6-dihydro-2h-pyridin-5-yl]phenyl]benzamide;hydrochloride Chemical compound Cl.C1CC(C)=C(C=2C=CC(NC(=O)C=3C(=CC=CC=3F)F)=CC=2)CN1C1=NC=CS1 HEFUMIHZJMWLCH-UHFFFAOYSA-N 0.000 claims 1
- PYJXEYPSJIICDC-UHFFFAOYSA-N 2,6-difluoro-n-[4-[4-methyl-1-(1-methyltetrazol-5-yl)-3,6-dihydro-2h-pyridin-5-yl]phenyl]benzamide Chemical compound C1CC(C)=C(C=2C=CC(NC(=O)C=3C(=CC=CC=3F)F)=CC=2)CN1C1=NN=NN1C PYJXEYPSJIICDC-UHFFFAOYSA-N 0.000 claims 1
- BCCCDCGGLAACJU-UHFFFAOYSA-N 2,6-difluoro-n-[4-[4-methyl-1-(2-methyltetrazol-5-yl)-3,6-dihydro-2h-pyridin-5-yl]phenyl]benzamide Chemical compound C1CC(C)=C(C=2C=CC(NC(=O)C=3C(=CC=CC=3F)F)=CC=2)CN1C=1N=NN(C)N=1 BCCCDCGGLAACJU-UHFFFAOYSA-N 0.000 claims 1
- FGQWROFZDNQBQR-UHFFFAOYSA-N 2,6-difluoro-n-[4-[4-methyl-1-(2h-tetrazol-5-yl)-3,6-dihydro-2h-pyridin-5-yl]phenyl]benzamide Chemical compound C1CC(C)=C(C=2C=CC(NC(=O)C=3C(=CC=CC=3F)F)=CC=2)CN1C1=NN=NN1 FGQWROFZDNQBQR-UHFFFAOYSA-N 0.000 claims 1
- XFZBUOXFDFLOFN-UHFFFAOYSA-N 2,6-difluoro-n-[4-[4-methyl-1-(4-methyl-1,3-oxazol-2-yl)-3,6-dihydro-2h-pyridin-5-yl]phenyl]benzamide Chemical compound CC1=COC(N2CC(=C(C)CC2)C=2C=CC(NC(=O)C=3C(=CC=CC=3F)F)=CC=2)=N1 XFZBUOXFDFLOFN-UHFFFAOYSA-N 0.000 claims 1
- KYNRZNNDZLLHAS-UHFFFAOYSA-N 2,6-difluoro-n-[5-[4-methyl-1-(1,3-thiazol-2-yl)-3,6-dihydro-2h-pyridin-5-yl]pyridin-2-yl]benzamide;hydrochloride Chemical compound Cl.C1CC(C)=C(C=2C=NC(NC(=O)C=3C(=CC=CC=3F)F)=CC=2)CN1C1=NC=CS1 KYNRZNNDZLLHAS-UHFFFAOYSA-N 0.000 claims 1
- OWUNKIPWLBWUAI-UHFFFAOYSA-N 3-fluoro-n-[4-[4-methyl-1-(1,3-oxazol-2-yl)-3,6-dihydro-2h-pyridin-5-yl]phenyl]pyridine-4-carboxamide Chemical compound C1CC(C)=C(C=2C=CC(NC(=O)C=3C(=CN=CC=3)F)=CC=2)CN1C1=NC=CO1 OWUNKIPWLBWUAI-UHFFFAOYSA-N 0.000 claims 1
- XSOAMLOCFGHNRH-UHFFFAOYSA-N 3-fluoro-n-[4-[4-methyl-1-(1,3-thiazol-2-yl)-3,6-dihydro-2h-pyridin-5-yl]phenyl]pyridine-4-carboxamide;dihydrochloride Chemical compound Cl.Cl.C1CC(C)=C(C=2C=CC(NC(=O)C=3C(=CN=CC=3)F)=CC=2)CN1C1=NC=CS1 XSOAMLOCFGHNRH-UHFFFAOYSA-N 0.000 claims 1
- LHZRDXHNDGFXRP-UHFFFAOYSA-N 3-fluoro-n-[4-[4-methyl-1-(1-methyltetrazol-5-yl)-3,6-dihydro-2h-pyridin-5-yl]phenyl]pyridine-4-carboxamide Chemical compound C1CC(C)=C(C=2C=CC(NC(=O)C=3C(=CN=CC=3)F)=CC=2)CN1C1=NN=NN1C LHZRDXHNDGFXRP-UHFFFAOYSA-N 0.000 claims 1
- GTCZZGBKBPGJGH-UHFFFAOYSA-N 3-fluoro-n-[4-[4-methyl-1-(2-methyltetrazol-5-yl)-3,6-dihydro-2h-pyridin-5-yl]phenyl]pyridine-4-carboxamide Chemical compound C1CC(C)=C(C=2C=CC(NC(=O)C=3C(=CN=CC=3)F)=CC=2)CN1C=1N=NN(C)N=1 GTCZZGBKBPGJGH-UHFFFAOYSA-N 0.000 claims 1
- KKDPVJPVRYNODQ-UHFFFAOYSA-N 3-fluoro-n-[4-[4-methyl-1-(2h-tetrazol-5-yl)-3,6-dihydro-2h-pyridin-5-yl]phenyl]pyridine-4-carboxamide Chemical compound C1CC(C)=C(C=2C=CC(NC(=O)C=3C(=CN=CC=3)F)=CC=2)CN1C1=NN=NN1 KKDPVJPVRYNODQ-UHFFFAOYSA-N 0.000 claims 1
- JQKBHOXSGUGZPJ-UHFFFAOYSA-N 3-methyl-n-[4-[4-methyl-1-(1,3-thiazol-2-yl)-3,6-dihydro-2h-pyridin-5-yl]phenyl]pyridine-4-carboxamide Chemical compound C1CC(C)=C(C=2C=CC(NC(=O)C=3C(=CN=CC=3)C)=CC=2)CN1C1=NC=CS1 JQKBHOXSGUGZPJ-UHFFFAOYSA-N 0.000 claims 1
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims 1
- UGWOIYHQWUMROA-UHFFFAOYSA-N 5-methyl-n-[4-[4-methyl-1-(1,3-thiazol-2-yl)-3,6-dihydro-2h-pyridin-5-yl]phenyl]pyrimidine-4-carboxamide Chemical compound C1CC(C)=C(C=2C=CC(NC(=O)C=3C(=CN=CN=3)C)=CC=2)CN1C1=NC=CS1 UGWOIYHQWUMROA-UHFFFAOYSA-N 0.000 claims 1
- 208000030507 AIDS Diseases 0.000 claims 1
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000003343 Antiphospholipid Syndrome Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000030767 Autoimmune encephalitis Diseases 0.000 claims 1
- 206010003827 Autoimmune hepatitis Diseases 0.000 claims 1
- 206010050245 Autoimmune thrombocytopenia Diseases 0.000 claims 1
- 208000023514 Barrett esophagus Diseases 0.000 claims 1
- 208000023328 Basedow disease Diseases 0.000 claims 1
- 208000009137 Behcet syndrome Diseases 0.000 claims 1
- 208000008439 Biliary Liver Cirrhosis Diseases 0.000 claims 1
- 208000033222 Biliary cirrhosis primary Diseases 0.000 claims 1
- 208000006386 Bone Resorption Diseases 0.000 claims 1
- 208000020084 Bone disease Diseases 0.000 claims 1
- 208000031229 Cardiomyopathies Diseases 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 208000002330 Congenital Heart Defects Diseases 0.000 claims 1
- 206010010741 Conjunctivitis Diseases 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 208000016192 Demyelinating disease Diseases 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- 206010014612 Encephalitis viral Diseases 0.000 claims 1
- 208000010334 End Stage Liver Disease Diseases 0.000 claims 1
- 208000004262 Food Hypersensitivity Diseases 0.000 claims 1
- 206010016946 Food allergy Diseases 0.000 claims 1
- 208000007465 Giant cell arteritis Diseases 0.000 claims 1
- 206010018364 Glomerulonephritis Diseases 0.000 claims 1
- 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 claims 1
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 1
- 206010072579 Granulomatosis with polyangiitis Diseases 0.000 claims 1
- 208000015023 Graves' disease Diseases 0.000 claims 1
- 208000035895 Guillain-Barré syndrome Diseases 0.000 claims 1
- 208000030836 Hashimoto thyroiditis Diseases 0.000 claims 1
- 208000035186 Hemolytic Autoimmune Anemia Diseases 0.000 claims 1
- 208000003923 Hereditary Corneal Dystrophies Diseases 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 208000035150 Hypercholesterolemia Diseases 0.000 claims 1
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 208000006877 Insect Bites and Stings Diseases 0.000 claims 1
- 102100037850 Interferon gamma Human genes 0.000 claims 1
- 108010074328 Interferon-gamma Proteins 0.000 claims 1
- 108090000176 Interleukin-13 Proteins 0.000 claims 1
- 108010002350 Interleukin-2 Proteins 0.000 claims 1
- 108090000978 Interleukin-4 Proteins 0.000 claims 1
- 108010002616 Interleukin-5 Proteins 0.000 claims 1
- 206010026749 Mania Diseases 0.000 claims 1
- 201000009906 Meningitis Diseases 0.000 claims 1
- 206010049567 Miller Fisher syndrome Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 206010029164 Nephrotic syndrome Diseases 0.000 claims 1
- 241000243985 Onchocerca volvulus Species 0.000 claims 1
- 206010033078 Otitis media Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 201000011152 Pemphigus Diseases 0.000 claims 1
- 208000031845 Pernicious anaemia Diseases 0.000 claims 1
- 208000012654 Primary biliary cholangitis Diseases 0.000 claims 1
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- 206010039710 Scleroderma Diseases 0.000 claims 1
- 208000021386 Sjogren Syndrome Diseases 0.000 claims 1
- 206010042742 Sympathetic ophthalmia Diseases 0.000 claims 1
- 208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 208000024780 Urticaria Diseases 0.000 claims 1
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- 206010047642 Vitiligo Diseases 0.000 claims 1
- 230000001919 adrenal effect Effects 0.000 claims 1
- 208000011341 adult acute respiratory distress syndrome Diseases 0.000 claims 1
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- 208000026935 allergic disease Diseases 0.000 claims 1
- 201000010105 allergic rhinitis Diseases 0.000 claims 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
- 229940035676 analgesics Drugs 0.000 claims 1
- 239000000730 antalgic agent Substances 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 229940125715 antihistaminic agent Drugs 0.000 claims 1
- 239000000739 antihistaminic agent Substances 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 201000008937 atopic dermatitis Diseases 0.000 claims 1
- 208000010668 atopic eczema Diseases 0.000 claims 1
- 230000001363 autoimmune Effects 0.000 claims 1
- 201000000448 autoimmune hemolytic anemia Diseases 0.000 claims 1
- 201000004982 autoimmune uveitis Diseases 0.000 claims 1
- 230000024279 bone resorption Effects 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 208000029028 brain injury Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 208000011444 chronic liver failure Diseases 0.000 claims 1
- 208000024035 chronic otitis media Diseases 0.000 claims 1
- 208000028831 congenital heart disease Diseases 0.000 claims 1
- 206010011005 corneal dystrophy Diseases 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 201000001981 dermatomyositis Diseases 0.000 claims 1
- 125000004212 difluorophenyl group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 201000002491 encephalomyelitis Diseases 0.000 claims 1
- 206010014801 endophthalmitis Diseases 0.000 claims 1
- 235000020932 food allergy Nutrition 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 208000007565 gingivitis Diseases 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 208000009326 ileitis Diseases 0.000 claims 1
- 210000000987 immune system Anatomy 0.000 claims 1
- 208000026278 immune system disease Diseases 0.000 claims 1
- 239000003018 immunosuppressive agent Substances 0.000 claims 1
- 229940125721 immunosuppressive agent Drugs 0.000 claims 1
- 201000001371 inclusion conjunctivitis Diseases 0.000 claims 1
- 208000013256 infectious meningitis Diseases 0.000 claims 1
- 230000004968 inflammatory condition Effects 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 239000004816 latex Substances 0.000 claims 1
- 229920000126 latex Polymers 0.000 claims 1
- 206010025135 lupus erythematosus Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 206010028417 myasthenia gravis Diseases 0.000 claims 1
- VXDSWWDKIGLETA-UHFFFAOYSA-N n-[4-[1-(4,5-dimethyl-1,3-oxazol-2-yl)-4-methyl-3,6-dihydro-2h-pyridin-5-yl]phenyl]-2,6-difluorobenzamide Chemical compound O1C(C)=C(C)N=C1N1CC(C=2C=CC(NC(=O)C=3C(=CC=CC=3F)F)=CC=2)=C(C)CC1 VXDSWWDKIGLETA-UHFFFAOYSA-N 0.000 claims 1
- WUEXCPCQSRZDNC-UHFFFAOYSA-N n-[4-[1-(4,5-dimethyl-1,3-oxazol-2-yl)-4-methyl-3,6-dihydro-2h-pyridin-5-yl]phenyl]-5-methylpyrimidine-4-carboxamide Chemical compound O1C(C)=C(C)N=C1N1CC(C=2C=CC(NC(=O)C=3C(=CN=CN=3)C)=CC=2)=C(C)CC1 WUEXCPCQSRZDNC-UHFFFAOYSA-N 0.000 claims 1
- 208000009928 nephrosis Diseases 0.000 claims 1
- 231100001027 nephrosis Toxicity 0.000 claims 1
- 210000000653 nervous system Anatomy 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 1
- 208000002042 onchocerciasis Diseases 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 201000001976 pemphigus vulgaris Diseases 0.000 claims 1
- 201000001245 periodontitis Diseases 0.000 claims 1
- 208000005987 polymyositis Diseases 0.000 claims 1
- 201000011461 pre-eclampsia Diseases 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 125000002098 pyridazinyl group Chemical group 0.000 claims 1
- 230000000306 recurrent effect Effects 0.000 claims 1
- 230000004044 response Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 208000020431 spinal cord injury Diseases 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- 125000005017 substituted alkenyl group Chemical group 0.000 claims 1
- 125000000547 substituted alkyl group Chemical group 0.000 claims 1
- 125000004426 substituted alkynyl group Chemical group 0.000 claims 1
- 206010043207 temporal arteritis Diseases 0.000 claims 1
- 210000001550 testis Anatomy 0.000 claims 1
- 125000001113 thiadiazolyl group Chemical group 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 206010044325 trachoma Diseases 0.000 claims 1
- 201000008827 tuberculosis Diseases 0.000 claims 1
- 201000002498 viral encephalitis Diseases 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
- 239000011800 void material Substances 0.000 claims 1
- 0 *[n]1nnnc1N1CC(C(*C(I*)=*)=I)=CCC1 Chemical compound *[n]1nnnc1N1CC(C(*C(I*)=*)=I)=CCC1 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85861006P | 2006-11-13 | 2006-11-13 | |
| US60/858,610 | 2006-11-13 | ||
| PCT/US2007/023853 WO2008063504A2 (en) | 2006-11-13 | 2007-11-12 | Cyclohexenyl-aryl compounds for inflammation and immune-related uses |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010509342A JP2010509342A (ja) | 2010-03-25 |
| JP2010509342A5 true JP2010509342A5 (https=) | 2012-01-05 |
| JP5538894B2 JP5538894B2 (ja) | 2014-07-02 |
Family
ID=39430312
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009536338A Expired - Fee Related JP5538894B2 (ja) | 2006-11-13 | 2007-11-12 | 炎症及び免疫関連使用のためのシクロヘキセニル−アリール化合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20080207641A1 (https=) |
| EP (1) | EP2086326B1 (https=) |
| JP (1) | JP5538894B2 (https=) |
| AU (1) | AU2007322116B2 (https=) |
| CA (1) | CA2669695C (https=) |
| TW (1) | TWI428338B (https=) |
| WO (1) | WO2008063504A2 (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI444187B (zh) * | 2005-01-25 | 2014-07-11 | Synta Pharmaceuticals Corp | 用於炎症及免疫相關用途之噻吩化合物 |
| WO2007087443A2 (en) | 2006-01-25 | 2007-08-02 | Synta Pharmaceuticals Corp. | Vinyl-phenyl derivatives for inflammation and immune-related uses |
| WO2007087442A2 (en) * | 2006-01-25 | 2007-08-02 | Synta Pharmaceuticals Corp. | Substituted biaryl compounds for inflammation and immune-related uses |
| WO2007087441A2 (en) * | 2006-01-25 | 2007-08-02 | Synta Pharmaceuticals Corp. | Substituted aromatic compounds for inflammation and immune-related uses |
| US8119643B2 (en) * | 2006-03-20 | 2012-02-21 | Synta Pharmaceuticals Corp. | Benzoimidazolyl-pyrazine compounds for inflammation and immune-related uses |
| US8779154B2 (en) * | 2006-09-26 | 2014-07-15 | Qinglin Che | Fused ring compounds for inflammation and immune-related uses |
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2007
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- 2007-11-12 EP EP07853118.3A patent/EP2086326B1/en not_active Not-in-force
- 2007-11-12 US US11/938,779 patent/US20080207641A1/en not_active Abandoned
- 2007-11-12 JP JP2009536338A patent/JP5538894B2/ja not_active Expired - Fee Related
- 2007-11-12 WO PCT/US2007/023853 patent/WO2008063504A2/en not_active Ceased
- 2007-11-12 AU AU2007322116A patent/AU2007322116B2/en not_active Ceased
- 2007-11-13 TW TW096142793A patent/TWI428338B/zh not_active IP Right Cessation