JP2023533153A5 - - Google Patents

Info

Publication number
JP2023533153A5
JP2023533153A5 JP2022574424A JP2022574424A JP2023533153A5 JP 2023533153 A5 JP2023533153 A5 JP 2023533153A5 JP 2022574424 A JP2022574424 A JP 2022574424A JP 2022574424 A JP2022574424 A JP 2022574424A JP 2023533153 A5 JP2023533153 A5 JP 2023533153A5
Authority
JP
Japan
Prior art keywords
tds
nucleoside
modified
pharmaceutical composition
modified oligonucleotide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2022574424A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023533153A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2021/039049 external-priority patent/WO2021263082A2/en
Publication of JP2023533153A publication Critical patent/JP2023533153A/ja
Publication of JP2023533153A5 publication Critical patent/JP2023533153A5/ja
Pending legal-status Critical Current

Links

JP2022574424A 2020-06-25 2021-06-25 Ｋｃｎｔ１の発現を低減するための化合物及び方法 Pending JP2023533153A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063044345P 2020-06-25 2020-06-25
US63/044,345 2020-06-25
US202063079438P 2020-09-16 2020-09-16
US63/079,438 2020-09-16
PCT/US2021/039049 WO2021263082A2 (en) 2020-06-25 2021-06-25 Compounds and methods for reducing kcnt1 expression

Publications (2)

Publication Number Publication Date
JP2023533153A JP2023533153A (ja) 2023-08-02
JP2023533153A5 true JP2023533153A5 (https=) 2024-07-02

Family

ID=79281885

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022574424A Pending JP2023533153A (ja) 2020-06-25 2021-06-25 Ｋｃｎｔ１の発現を低減するための化合物及び方法

Country Status (6)

Country Link
US (1) US20240229042A1 (https=)
EP (1) EP4171576A4 (https=)
JP (1) JP2023533153A (https=)
CN (1) CN115701998A (https=)
UY (1) UY39297A (https=)
WO (1) WO2021263082A2 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025117662A1 (en) * 2023-11-29 2025-06-05 Actio Biosciences, Inc. Heterocyclic compounds useful as kcnt1 inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020048787A1 (en) * 2000-06-14 2002-04-25 Ming-Hui Wei Isolated human transporter proteins, nucleic acid molecules encoding human transporter proteins, and uses thereof
WO2005083127A2 (en) * 2004-02-27 2005-09-09 Applera Corporation Genetic polymorphisms associated with stroke, methods of detection and uses thereof
US20200129538A1 (en) * 2017-06-13 2020-04-30 The Florey Institute Of Neuroscience And Mental Health Compositions and methods for treating conditions associated with gain-of-function mutations in kcnt1
AU2019406186A1 (en) * 2018-12-20 2021-07-15 Praxis Precision Medicines, Inc. Compositions and methods for the treatment of KCNT1 related disorders

Similar Documents

Publication Publication Date Title
CN112400019B (zh) 用于减少lrrk2表达的化合物和方法
JP2022544587A5 (https=)
JP2022518929A5 (https=)
AU762212C (en) Oligonucleotides having A-DNA form and B-DNA form conformational geometry
JP2021530204A5 (https=)
JP7780564B2 (ja) プリオン発現を低減するための化合物及び方法
JP2022509625A5 (https=)
JP2021522800A5 (https=)
IL289789B2 (en) Compounds and methods for lowering tau expression
JP2023536472A5 (https=)
CN116322707B (zh) 用于调节scn2a的化合物和方法
CN111373043A (zh) 用于降低snca表达的化合物和方法
JP2022515744A5 (https=)
CN105121452A (zh) 三环核苷和由其制备的寡聚化合物
AU2017297622A1 (en) Compounds and methods for modulation of SMN2
JP2022527105A5 (https=)
JP2023536994A5 (https=)
JP2025500335A5 (https=)
TW202102675A (zh) 降低kcnt1 表現之化合物及方法
CN104321334A (zh) 三环核苷及由其制备的低聚化合物
JP2023533153A5 (https=)
JP2023528755A5 (https=)
TW202329983A (zh) Ｒｎａ編輯
JPH09505307A (ja) 多キラル合成フォスホネートオリゴマー類
JP2024522147A5 (https=)