JP2023522250A5 - - Google Patents
Info
- Publication number
- JP2023522250A5 JP2023522250A5 JP2022564007A JP2022564007A JP2023522250A5 JP 2023522250 A5 JP2023522250 A5 JP 2023522250A5 JP 2022564007 A JP2022564007 A JP 2022564007A JP 2022564007 A JP2022564007 A JP 2022564007A JP 2023522250 A5 JP2023522250 A5 JP 2023522250A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- disease
- cancer
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025062751A JP2025120943A (ja) | 2020-04-24 | 2025-04-04 | 免疫活性化のためのｄｇｋｚｅｔａ阻害剤としての置換アミノチアゾール類 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20171280 | 2020-04-24 | ||
| EP20171280.9 | 2020-04-24 | ||
| PCT/EP2021/060167 WO2021214019A1 (en) | 2020-04-24 | 2021-04-20 | Substituted aminothiazoles as dgkzeta inhibitors for immune activation |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025062751A Division JP2025120943A (ja) | 2020-04-24 | 2025-04-04 | 免疫活性化のためのｄｇｋｚｅｔａ阻害剤としての置換アミノチアゾール類 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023522250A JP2023522250A (ja) | 2023-05-29 |
| JP2023522250A5 true JP2023522250A5 (https=) | 2025-02-25 |
| JP7663603B2 JP7663603B2 (ja) | 2025-04-16 |
Family
ID=70464845
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022564007A Active JP7663603B2 (ja) | 2020-04-24 | 2021-04-20 | 免疫活性化のためのｄｇｋｚｅｔａ阻害剤としての置換アミノチアゾール類 |
| JP2022564009A Pending JP2023522251A (ja) | 2020-04-24 | 2021-04-20 | 免疫活性化のためのｄｇｋｚｅｔａ阻害剤としての置換アミノチアゾール類 |
| JP2025062751A Pending JP2025120943A (ja) | 2020-04-24 | 2025-04-04 | 免疫活性化のためのｄｇｋｚｅｔａ阻害剤としての置換アミノチアゾール類 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022564009A Pending JP2023522251A (ja) | 2020-04-24 | 2021-04-20 | 免疫活性化のためのｄｇｋｚｅｔａ阻害剤としての置換アミノチアゾール類 |
| JP2025062751A Pending JP2025120943A (ja) | 2020-04-24 | 2025-04-04 | 免疫活性化のためのｄｇｋｚｅｔａ阻害剤としての置換アミノチアゾール類 |
Country Status (32)
| Country | Link |
|---|---|
| US (3) | US20230167103A1 (https=) |
| EP (2) | EP4139286B1 (https=) |
| JP (3) | JP7663603B2 (https=) |
| KR (1) | KR20230005247A (https=) |
| CN (6) | CN115697980B (https=) |
| AR (1) | AR121929A1 (https=) |
| AU (1) | AU2021261524A1 (https=) |
| CA (2) | CA3180670A1 (https=) |
| CL (1) | CL2022002919A1 (https=) |
| CO (1) | CO2022014876A2 (https=) |
| CR (1) | CR20220536A (https=) |
| DK (1) | DK4139286T3 (https=) |
| DO (1) | DOP2022000223A (https=) |
| EC (1) | ECSP22080829A (https=) |
| ES (1) | ES3029140T3 (https=) |
| FI (1) | FI4139286T3 (https=) |
| GE (2) | GEAP202416095A (https=) |
| HR (1) | HRP20250519T1 (https=) |
| HU (1) | HUE071024T2 (https=) |
| IL (1) | IL297499A (https=) |
| JO (1) | JOP20220267A1 (https=) |
| LT (1) | LT4139286T (https=) |
| MA (1) | MA59379B1 (https=) |
| MX (1) | MX2022013388A (https=) |
| PE (1) | PE20230322A1 (https=) |
| PH (1) | PH12022552828A1 (https=) |
| PL (1) | PL4139286T3 (https=) |
| PT (1) | PT4139286T (https=) |
| RS (1) | RS66889B1 (https=) |
| SI (1) | SI4139286T1 (https=) |
| TW (1) | TWI894261B (https=) |
| WO (2) | WO2021214019A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL294032A (en) | 2019-12-24 | 2022-08-01 | Carna Biosciences Inc | Compounds that regulate diacylglycerol kinase |
| AR120896A1 (es) | 2019-12-25 | 2022-03-30 | Astellas Pharma Inc | COMPUESTO DE PIRIDAZINIL-TIAZOLCARBOXAMIDA COMO INHIBIDORES DE DGKz |
| CN115697980B (zh) | 2020-04-24 | 2025-03-21 | 拜耳公司 | 作为dgkzeta抑制剂用于免疫活化的取代的氨基噻唑 |
| CR20230415A (es) | 2020-11-30 | 2023-09-08 | Kotobuki Pharmaceutical Co Ltd | Compuesto de heteroarilcarboxamida |
| JP7651018B2 (ja) | 2021-06-23 | 2025-03-25 | ギリアード サイエンシーズ， インコーポレイテッド | ジアシルグリセロールキナーゼ調節化合物 |
| MX2023014762A (es) | 2021-06-23 | 2024-01-15 | Gilead Sciences Inc | Compuestos moduladores de diacilglicerol quinasa. |
| JP7686091B2 (ja) | 2021-06-23 | 2025-05-30 | ギリアード サイエンシーズ， インコーポレイテッド | ジアシルグリセロールキナーゼ調節化合物 |
| AU2022299051B2 (en) | 2021-06-23 | 2025-03-13 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| CN119654312A (zh) * | 2022-08-08 | 2025-03-18 | 百时美施贵宝公司 | 用作t细胞活化剂的取代的四唑基化合物 |
| EP4661869A1 (en) | 2023-02-06 | 2025-12-17 | Bayer Aktiengesellschaft | Combinations of dgk (diacylglycerol kinase) inhibitors and immune checkpoint inhibitors and modulators |
| WO2024200410A1 (en) | 2023-03-31 | 2024-10-03 | Bayer Aktiengesellschaft | Microcrystalline forms of (r)-2-(n-[4-amino-5-(4-methoxybenzoyl)thiazol-2-yl]-4-fluoroanilino)propanamide and processes for their preparation |
| CN120826393A (zh) * | 2023-04-06 | 2025-10-21 | 微境生物医药科技(上海)有限公司 | 作为DGKζ抑制剂的噻唑类化合物 |
| WO2024235203A1 (zh) * | 2023-05-15 | 2024-11-21 | 微境生物医药科技(上海)有限公司 | 作为DGKζ抑制剂的化合物 |
| WO2025061020A1 (zh) * | 2023-09-21 | 2025-03-27 | 楚浦创制（武汉）医药科技有限公司 | 苯并五元杂环衍生物及其制备方法与应用、药物组合物 |
| WO2025067360A1 (zh) * | 2023-09-27 | 2025-04-03 | 海思科医药集团股份有限公司 | 一种DGKzeta拮抗剂及其在医药上的应用 |
| WO2025082274A1 (zh) * | 2023-10-17 | 2025-04-24 | 楚浦创制（武汉）医药科技有限公司 | 硫代羰基化合物及其应用 |
| WO2025082460A1 (zh) * | 2023-10-20 | 2025-04-24 | 上海先祥医药科技有限公司 | 二酰基甘油激酶抑制剂化合物及其应用 |
| WO2025167814A1 (zh) * | 2024-02-06 | 2025-08-14 | 微境生物医药科技(上海)有限公司 | 作为DGKζ抑制剂的化合物 |
| WO2026068294A1 (en) * | 2024-09-24 | 2026-04-02 | Bayer Aktiengesellschaft | Improved nanoseeding process |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001230026A1 (en) * | 2000-02-04 | 2001-08-14 | Novo-Nordisk A/S | 2,4-diaminothiazole derivatives |
| RU2324685C2 (ru) | 2002-08-07 | 2008-05-20 | Ф.Хоффманн-Ля Рош Аг | Производные тиазола, способ их получения и применение, фармацевтическая композиция, обладающая свойствами антагонистов рецепторов npy |
| US20050137239A1 (en) | 2003-12-17 | 2005-06-23 | Hines Michelle D. | Thiazole derivatives |
| US20080146585A1 (en) | 2004-04-20 | 2008-06-19 | Ab Science | Use Of C-Kit Inhibitors For Treating Inflammatory Muscle Disorders Including Myositis And Muscular Dystrophy |
| WO2005102318A1 (en) | 2004-04-20 | 2005-11-03 | Ab Science | Use of c-kit inhibitors for treating hiv related diseases |
| AU2005236055B2 (en) | 2004-04-20 | 2011-10-06 | Transtech Pharma, Llc | Substituted thiazole and pyrimidine derivatives as melanocortin receptor modulators |
| WO2005102346A2 (en) | 2004-04-23 | 2005-11-03 | Ab Science | Use of c-kit inhibitors for treating fibrosis |
| JP2007533731A (ja) | 2004-04-23 | 2007-11-22 | アブ サイエンス | マラリア原虫関連の疾病を処置するためのｃ−ｋｉｔ阻害剤の使用法 |
| WO2005102326A2 (en) | 2004-04-23 | 2005-11-03 | Ab Science | Use of c-kit inhibitors for treating renal diseases |
| EP1742627A4 (en) | 2004-05-06 | 2009-08-26 | Plexxikon Inc | PDE4B HEMMER AND ITS USE |
| JP2007538064A (ja) | 2004-05-18 | 2007-12-27 | アブ サイエンス | 化学または生物兵器に曝露された患者を処置するための肥満細胞阻害剤の使用法 |
| WO2005115385A1 (en) | 2004-05-24 | 2005-12-08 | Ab Science | Use of c-kit inhibitors for treating acne |
| WO2005115304A2 (en) | 2004-05-24 | 2005-12-08 | Ab Science | Use of c-kit inhibitors for treating fibrodysplasia |
| UA92746C2 (en) | 2005-05-09 | 2010-12-10 | Акилайон Фармасьютикалз, Инк. | Thiazole compounds and methods of use |
| CA2618646A1 (en) | 2005-06-03 | 2007-11-15 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors |
| WO2007022415A2 (en) | 2005-08-18 | 2007-02-22 | Pharmacopeia, Inc. | Substituted 2-aminothiazoles for treating neurodegenerative diseases |
| GB0701426D0 (en) | 2007-01-25 | 2007-03-07 | Univ Sheffield | Compounds and their use |
| KR100903974B1 (ko) | 2007-09-27 | 2009-06-25 | 한국화학연구원 | 2,4,5-삼중치환-1,3-티아졸 유도체 및 약제학적으로 허용가능한 그의 염, 그의 제조방법 및 그를 유효성분으로함유하는 ｓｐｃ 수용체 활성으로 유발되는 염증관련 질환치료제 |
| US9315449B2 (en) | 2008-05-15 | 2016-04-19 | Duke University | Substituted pyrazoles as heat shock transcription factor activators |
| AP2010005480A0 (en) | 2008-06-03 | 2010-12-31 | Siga Technologies Inc | Small molecule inhibitors for the treatment or prevention of denque virus infection. |
| JP5322296B2 (ja) | 2008-08-20 | 2013-10-23 | 日本曹達株式会社 | テトラゾイルオキシム誘導体を含む植物病害防除剤の使用方法 |
| WO2012075393A2 (en) | 2010-12-02 | 2012-06-07 | President And Fellows Of Harvard College | Activators of proteasomal degradation and uses thereof |
| US8791162B2 (en) | 2011-02-14 | 2014-07-29 | Merck Sharp & Dohme Corp. | Cathepsin cysteine protease inhibitors |
| WO2013033037A2 (en) | 2011-08-26 | 2013-03-07 | The Regents Of The University Of California | Novel antiprion compounds |
| CN103058949A (zh) | 2011-10-18 | 2013-04-24 | 华东理工大学 | 做为dhodh抑制剂的噻唑衍生物及其应用 |
| CN103159695B (zh) | 2011-12-08 | 2015-08-12 | 首都师范大学 | 可抑制hiv复制并对耐药hiv病毒株有效的噻唑类化合物及其制备方法和用途 |
| GB201307233D0 (en) | 2013-04-22 | 2013-05-29 | Vib Vzw | Compounds and uses thereof |
| WO2014181287A1 (en) | 2013-05-09 | 2014-11-13 | Piramal Enterprises Limited | Heterocyclyl compounds and uses thereof |
| WO2015046193A1 (ja) | 2013-09-25 | 2015-04-02 | 塩野義製薬株式会社 | Ｔｒｐｖ４阻害活性を有する芳香族複素環式アミン誘導体 |
| WO2015199206A1 (ja) | 2014-06-27 | 2015-12-30 | 塩野義製薬株式会社 | Ｔｒｐｖ４阻害活性を有する６員環誘導体 |
| CN106109467B (zh) | 2016-06-20 | 2020-04-17 | 中国药科大学 | 三类羧基取代芳香化合物在耐吡嗪酰胺结核病及结核病治疗中的医药用途 |
| WO2018089902A1 (en) | 2016-11-13 | 2018-05-17 | Apogee Biotechnology Corporation | Diaminothiazole compounds, compositions and methods of use |
| WO2019133445A1 (en) * | 2017-12-28 | 2019-07-04 | Inception Ibd, Inc. | Aminothiazoles as inhibitors of vanin-1 |
| CN112585139B (zh) | 2018-06-27 | 2023-12-01 | 百时美施贵宝公司 | 用作t细胞激活剂的萘啶酮化合物 |
| KR102767739B1 (ko) | 2018-06-27 | 2025-02-12 | 브리스톨-마이어스 스큅 컴퍼니 | T 세포 활성화제로서 유용한 치환된 나프티리디논 화합물 |
| WO2021028382A1 (en) | 2019-08-12 | 2021-02-18 | Bayer Aktiengesellschaft | [1,2,4]triazolo[1,5-c]quinazolin-5-amines |
| AR119821A1 (es) | 2019-08-28 | 2022-01-12 | Bristol Myers Squibb Co | Compuestos de piridopirimidinonilo sustituidos útiles como activadores de células t |
| JP2022547882A (ja) | 2019-09-06 | 2022-11-16 | インフレイゾーム リミテッド | Ｎｌｒｐ３阻害剤 |
| WO2021091885A2 (en) | 2019-11-04 | 2021-05-14 | Alector Llc | Siglec-9 ecd fusion molecules and methods of use thereof |
| AR120896A1 (es) | 2019-12-25 | 2022-03-30 | Astellas Pharma Inc | COMPUESTO DE PIRIDAZINIL-TIAZOLCARBOXAMIDA COMO INHIBIDORES DE DGKz |
| KR20230005289A (ko) | 2020-04-24 | 2023-01-09 | 베링거 인겔하임 인터내셔날 게엠베하 | 지방 간 질환 및 지방간염의 치료에서 장시간-작용성 glp-1/글루카곤 수용체 작용제로서 글루카곤 유사체 |
| CN115697980B (zh) | 2020-04-24 | 2025-03-21 | 拜耳公司 | 作为dgkzeta抑制剂用于免疫活化的取代的氨基噻唑 |
-
2021
- 2021-04-20 CN CN202180043311.4A patent/CN115697980B/zh active Active
- 2021-04-20 PT PT217202498T patent/PT4139286T/pt unknown
- 2021-04-20 CR CR20220536A patent/CR20220536A/es unknown
- 2021-04-20 CN CN202510268414.0A patent/CN120093739A/zh active Pending
- 2021-04-20 MA MA59379A patent/MA59379B1/fr unknown
- 2021-04-20 JP JP2022564007A patent/JP7663603B2/ja active Active
- 2021-04-20 PE PE2022002433A patent/PE20230322A1/es unknown
- 2021-04-20 WO PCT/EP2021/060167 patent/WO2021214019A1/en not_active Ceased
- 2021-04-20 GE GEAP202416095A patent/GEAP202416095A/en unknown
- 2021-04-20 MX MX2022013388A patent/MX2022013388A/es unknown
- 2021-04-20 FI FIEP21720249.8T patent/FI4139286T3/fi active
- 2021-04-20 PL PL21720249.8T patent/PL4139286T3/pl unknown
- 2021-04-20 CN CN202510268417.4A patent/CN120093740A/zh active Pending
- 2021-04-20 IL IL297499A patent/IL297499A/en unknown
- 2021-04-20 US US17/921,043 patent/US20230167103A1/en not_active Abandoned
- 2021-04-20 CA CA3180670A patent/CA3180670A1/en active Pending
- 2021-04-20 HR HRP20250519TT patent/HRP20250519T1/hr unknown
- 2021-04-20 CA CA3180819A patent/CA3180819A1/en active Pending
- 2021-04-20 WO PCT/EP2021/060170 patent/WO2021214020A1/en not_active Ceased
- 2021-04-20 HU HUE21720249A patent/HUE071024T2/hu unknown
- 2021-04-20 GE GEAP202116095A patent/GEP20257731B/en unknown
- 2021-04-20 CN CN202180037365.XA patent/CN115697979B/zh active Active
- 2021-04-20 LT LTEPPCT/EP2021/060167T patent/LT4139286T/lt unknown
- 2021-04-20 CN CN202510268418.9A patent/CN120093741A/zh active Pending
- 2021-04-20 SI SI202130304T patent/SI4139286T1/sl unknown
- 2021-04-20 PH PH1/2022/552828A patent/PH12022552828A1/en unknown
- 2021-04-20 EP EP21720249.8A patent/EP4139286B1/en active Active
- 2021-04-20 RS RS20250474A patent/RS66889B1/sr unknown
- 2021-04-20 AU AU2021261524A patent/AU2021261524A1/en active Pending
- 2021-04-20 CN CN202510268420.6A patent/CN120093742A/zh active Pending
- 2021-04-20 DK DK21720249.8T patent/DK4139286T3/da active
- 2021-04-20 EP EP21720251.4A patent/EP4139287B1/en active Active
- 2021-04-20 JP JP2022564009A patent/JP2023522251A/ja active Pending
- 2021-04-20 ES ES21720249T patent/ES3029140T3/es active Active
- 2021-04-20 US US17/920,679 patent/US20230167078A1/en active Pending
- 2021-04-20 KR KR1020227040664A patent/KR20230005247A/ko not_active Withdrawn
- 2021-04-23 TW TW110114675A patent/TWI894261B/zh active
- 2021-04-23 AR ARP210101100A patent/AR121929A1/es unknown
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2022
- 2022-09-14 US US17/944,922 patent/US11964953B2/en active Active
- 2022-10-17 DO DO2022000223A patent/DOP2022000223A/es unknown
- 2022-10-17 EC ECSENADI202280829A patent/ECSP22080829A/es unknown
- 2022-10-19 CO CONC2022/0014876A patent/CO2022014876A2/es unknown
- 2022-10-21 CL CL2022002919A patent/CL2022002919A1/es unknown
- 2022-10-24 JO JOJO/P/2022/0267A patent/JOP20220267A1/ar unknown
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2025
- 2025-04-04 JP JP2025062751A patent/JP2025120943A/ja active Pending
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