JP2023521604A - 微小管関連タンパク質タウ（ＭＡＰＴ）ｉＲＮＡ剤組成物およびその使用方法 - Google Patents

微小管関連タンパク質タウ（ＭＡＰＴ）ｉＲＮＡ剤組成物およびその使用方法 Download PDF

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JP2023521604A
JP2023521604A JP2022559557A JP2022559557A JP2023521604A JP 2023521604 A JP2023521604 A JP 2023521604A JP 2022559557 A JP2022559557 A JP 2022559557A JP 2022559557 A JP2022559557 A JP 2022559557A JP 2023521604 A JP2023521604 A JP 2023521604A
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nucleotides
dsrna agent
antisense strand
strand
mapt
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JP2023521604A5 (https=
JPWO2021202511A5 (https=
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ミーナクシ スンダラパンディアン，マンガラ
ディ マキニンチ，ジェイムズ
フィシュレビッチ，エラーネ
カストレノ，アダム
カイタニス，チャラランボス
ケイ シュリーゲル，マーク
エドワード ファーリー，ジョナサン
ズーバー，ジェフリー
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Alnylam Pharmaceuticals Inc
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Alnylam Pharmaceuticals Inc
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2022559557A 2020-03-30 2021-03-30 微小管関連タンパク質タウ（ＭＡＰＴ）ｉＲＮＡ剤組成物およびその使用方法 Pending JP2023521604A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063002030P 2020-03-30 2020-03-30
US63/002,030 2020-03-30
US202163164467P 2021-03-22 2021-03-22
US63/164,467 2021-03-22
PCT/US2021/024858 WO2021202511A2 (en) 2020-03-30 2021-03-30 MICROTUBULE ASSOCIATED PROTEIN TAU (MAPT) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF

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JP2023521604A true JP2023521604A (ja) 2023-05-25
JP2023521604A5 JP2023521604A5 (https=) 2024-04-10
JPWO2021202511A5 JPWO2021202511A5 (https=) 2024-04-10

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US (1) US20230203486A1 (https=)
EP (1) EP4126230A4 (https=)
JP (1) JP2023521604A (https=)
KR (1) KR20230005194A (https=)
CN (1) CN116234585A (https=)
AU (1) AU2021246024A1 (https=)
BR (1) BR112022019606A2 (https=)
CA (1) CA3178304A1 (https=)
IL (1) IL296851A (https=)
MX (1) MX2022012293A (https=)
TW (1) TW202143984A (https=)
WO (1) WO2021202511A2 (https=)

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US20250340872A1 (en) * 2021-10-07 2025-11-06 Ionis Pharmaceuticals, Inc. Compounds and methods for reducing tau expression
EP4448765A1 (en) * 2021-12-13 2024-10-23 Eli Lilly and Company Mapt rna interference agents
JP2025507372A (ja) * 2022-02-11 2025-03-18 アルナイラム ファーマシューティカルズ， インコーポレイテッド 微小管関連タンパク質タウ（ＭＡＰＴ）ｉＲＮＡ剤組成物およびその使用方法
EP4493691A2 (en) * 2022-03-16 2025-01-22 JANSSEN Pharmaceutica NV Mapt sirna and uses thereof
KR20250129743A (ko) * 2022-12-29 2025-08-29 보이저 테라퓨틱스, 인크. Mapt를 조절하기 위한 조성물 및 방법
WO2024201423A2 (en) * 2023-03-30 2024-10-03 Biorchestra Co., Ltd. Microtubule-associated protein tau targeting sirnas and uses thereof
WO2024220930A2 (en) * 2023-04-20 2024-10-24 Adarx Pharmaceuticals, Inc. Mapt-modulating compositions and methods of use thereof
AU2024315297A1 (en) * 2023-08-01 2026-02-12 Tuojie Biotech (Shanghai) Co., Ltd. Dsrna targeting mapt and pharmaceutical use thereof
WO2025027577A1 (en) * 2023-08-02 2025-02-06 Consejo Nacional De Investigaciones Científicas Y Técnicas (Conicet) Micrornas designed against the microtubule-associated protein tau for the treatment of tauopathies
TW202515584A (zh) * 2023-10-11 2025-04-16 大陸商上海舶望製藥有限公司 用於抑制微管相關蛋白ｔａｕ（ｍａｐｔ）表達的組合物和方法
US12551569B2 (en) 2024-03-31 2026-02-17 Arrowhead Pharmaceuticals, Inc. RNAi agents for inhibiting expression of microtubule associated protein tau (MAPT), compositions thereof, and methods of use
WO2025233849A2 (en) * 2024-05-07 2025-11-13 Janssen Pharmaceutica Nv MAPT siRNA AND USES THEREOF
WO2026010722A1 (en) * 2024-07-03 2026-01-08 Voyager Therapeutics, Inc. Compositions and methods for regulating mapt
WO2026017176A1 (zh) * 2024-07-19 2026-01-22 北京安龙生物医药有限公司 靶向微管相关蛋白Tau基因的寡核苷酸及其用途
CN121780524A (zh) * 2024-08-02 2026-04-03 北京尧景基因技术有限公司 抑制MAPT基因表达的siRNA及其缀合物和应用
WO2026067655A1 (zh) * 2024-09-26 2026-04-02 大睿生物医药科技(上海)有限公司 调控TAU表达的dsRNA分子

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JP2009530257A (ja) * 2006-03-17 2009-08-27 シレンティス・エセ・ア・ウ Ｃｎｓ状態の治療
JP2019141097A (ja) * 2013-03-14 2019-08-29 アイオーニス ファーマシューティカルズ， インコーポレーテッドＩｏｎｉｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． タウ発現を調節するための組成物および方法
JP2016523980A (ja) * 2013-07-11 2016-08-12 ザ トラスティーズ オブ コロンビア ユニバーシティ イン ザ シティ オブ ニューヨーク タウ発現を抑制するマイクロｒｎａ
JP2018505676A (ja) * 2015-02-04 2018-03-01 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ タウアンチセンスオリゴマー及びその使用
JP2019500428A (ja) * 2015-12-21 2019-01-10 ノバルティス アーゲー タウ発現を減少させるための組成物および方法
WO2021156833A1 (en) * 2020-02-07 2021-08-12 Biorchestra Co., Ltd. Use of mirna-485 inhibitors for treating tauopathy
WO2021188626A1 (en) * 2020-03-18 2021-09-23 University Of Massachusetts Oligonucleotides for mapt modulation

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AU2021246024A1 (en) 2022-10-27
EP4126230A2 (en) 2023-02-08
WO2021202511A2 (en) 2021-10-07
IL296851A (en) 2022-11-01
US20230203486A1 (en) 2023-06-29
MX2022012293A (es) 2022-10-27
TW202143984A (zh) 2021-12-01
BR112022019606A2 (pt) 2022-11-16
WO2021202511A3 (en) 2021-11-25
KR20230005194A (ko) 2023-01-09
CA3178304A1 (en) 2021-10-07
EP4126230A4 (en) 2025-07-30
CN116234585A (zh) 2023-06-06

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