TW202143984A - 微管相關蛋白TAU (MAPT) iRNA劑組合物及其使用方法 - Google Patents

微管相關蛋白TAU (MAPT) iRNA劑組合物及其使用方法 Download PDF

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TW202143984A
TW202143984A TW110111671A TW110111671A TW202143984A TW 202143984 A TW202143984 A TW 202143984A TW 110111671 A TW110111671 A TW 110111671A TW 110111671 A TW110111671 A TW 110111671A TW 202143984 A TW202143984 A TW 202143984A
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nucleotides
dsrna agent
strand
antisense strand
mapt
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TW110111671A
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曼歌拉 米納科希 桑德拉潘迪恩
詹母士 Ｄ 馬克辛尼克
伊蓮 費雪維克
亞當 克斯拓雷諾
察拉藍伯斯 凱特妮思
馬克 Ｋ 史齊歌
強納森 愛德華 斐爾禮
傑佛瑞 祖伯
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美商艾爾妮蘭製藥公司
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TW110111671A 2020-03-30 2021-03-30 微管相關蛋白TAU (MAPT) iRNA劑組合物及其使用方法 TW202143984A (zh)

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US202063002030P 2020-03-30 2020-03-30
US63/002,030 2020-03-30
US202163164467P 2021-03-22 2021-03-22
US63/164,467 2021-03-22

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US (1) US20230203486A1 (https=)
EP (1) EP4126230A4 (https=)
JP (1) JP2023521604A (https=)
KR (1) KR20230005194A (https=)
CN (1) CN116234585A (https=)
AU (1) AU2021246024A1 (https=)
BR (1) BR112022019606A2 (https=)
CA (1) CA3178304A1 (https=)
IL (1) IL296851A (https=)
MX (1) MX2022012293A (https=)
TW (1) TW202143984A (https=)
WO (1) WO2021202511A2 (https=)

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WO2024201423A2 (en) * 2023-03-30 2024-10-03 Biorchestra Co., Ltd. Microtubule-associated protein tau targeting sirnas and uses thereof
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WO2026017176A1 (zh) * 2024-07-19 2026-01-22 北京安龙生物医药有限公司 靶向微管相关蛋白Tau基因的寡核苷酸及其用途
CN121780524A (zh) * 2024-08-02 2026-04-03 北京尧景基因技术有限公司 抑制MAPT基因表达的siRNA及其缀合物和应用
WO2026067655A1 (zh) * 2024-09-26 2026-04-02 大睿生物医药科技(上海)有限公司 调控TAU表达的dsRNA分子

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EP4126230A2 (en) 2023-02-08
WO2021202511A2 (en) 2021-10-07
IL296851A (en) 2022-11-01
US20230203486A1 (en) 2023-06-29
MX2022012293A (es) 2022-10-27
BR112022019606A2 (pt) 2022-11-16
WO2021202511A3 (en) 2021-11-25
KR20230005194A (ko) 2023-01-09
CA3178304A1 (en) 2021-10-07
JP2023521604A (ja) 2023-05-25
EP4126230A4 (en) 2025-07-30
CN116234585A (zh) 2023-06-06

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